Incidental Mutation 'R1781:Or3a10'
ID 195310
Institutional Source Beutler Lab
Gene Symbol Or3a10
Ensembl Gene ENSMUSG00000047444
Gene Name olfactory receptor family 3 subfamily A member 10
Synonyms GA_x6K02T2P1NL-4202012-4201065, M5, Olfr139, MOR255-2
MMRRC Submission 039812-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R1781 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73935151-73936098 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73935786 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 105 (F105I)
Ref Sequence ENSEMBL: ENSMUSP00000148999 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050678] [ENSMUST00000206280] [ENSMUST00000214111]
AlphaFold Q60891
Predicted Effect probably damaging
Transcript: ENSMUST00000050678
AA Change: F105I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049558
Gene: ENSMUSG00000047444
AA Change: F105I

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.4e-56 PFAM
Pfam:7TM_GPCR_Srsx 38 276 5.3e-6 PFAM
Pfam:7tm_1 44 293 8.1e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206280
AA Change: F105I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214111
AA Change: F105I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 97.3%
  • 3x: 96.7%
  • 10x: 94.6%
  • 20x: 90.1%
Validation Efficiency 97% (88/91)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 A G 3: 59,932,117 (GRCm39) K211E probably damaging Het
Abca13 T A 11: 9,219,194 (GRCm39) L376Q probably damaging Het
Abca17 T C 17: 24,486,531 (GRCm39) T1499A possibly damaging Het
Anks6 A C 4: 47,043,639 (GRCm39) N363K possibly damaging Het
Apob T A 12: 8,059,603 (GRCm39) I2695N possibly damaging Het
Arhgef18 C T 8: 3,430,495 (GRCm39) R123W probably damaging Het
Atg14 T A 14: 47,786,607 (GRCm39) probably null Het
Atg2a A T 19: 6,306,243 (GRCm39) I1368F probably damaging Het
Btbd9 A G 17: 30,732,567 (GRCm39) S373P probably damaging Het
Ccdc83 T C 7: 89,899,749 (GRCm39) E41G probably damaging Het
Ccnh T C 13: 85,354,254 (GRCm39) S233P possibly damaging Het
Cdh8 T C 8: 99,917,094 (GRCm39) probably null Het
Cdh8 A T 8: 100,006,290 (GRCm39) I99N probably damaging Het
Cdr2 G A 7: 120,557,268 (GRCm39) P419L probably benign Het
Cds1 T A 5: 101,960,416 (GRCm39) I289K possibly damaging Het
Cherp G A 8: 73,221,615 (GRCm39) T394I probably damaging Het
Cyp4f17 T G 17: 32,742,993 (GRCm39) I222S possibly damaging Het
Dcc A G 18: 71,511,788 (GRCm39) S856P probably benign Het
Dcp1a C T 14: 30,235,032 (GRCm39) T221I probably benign Het
Ddx10 A G 9: 53,118,845 (GRCm39) S475P probably damaging Het
Dennd5b G T 6: 148,928,896 (GRCm39) A759E probably damaging Het
Disp2 G A 2: 118,623,042 (GRCm39) G1258D probably damaging Het
Fhdc1 A T 3: 84,356,111 (GRCm39) D444E probably damaging Het
Fhod1 T C 8: 106,074,421 (GRCm39) probably benign Het
Gcnt7 T C 2: 172,296,800 (GRCm39) K8R probably benign Het
Gk5 C T 9: 96,015,508 (GRCm39) T108I possibly damaging Het
Gm8214 C A 1: 183,414,129 (GRCm39) noncoding transcript Het
Gnl1 A T 17: 36,298,638 (GRCm39) I434F probably damaging Het
Golga2 T C 2: 32,196,588 (GRCm39) Y986H probably damaging Het
Gpr21 T C 2: 37,407,550 (GRCm39) V32A probably benign Het
Grb14 A T 2: 64,805,899 (GRCm39) probably null Het
H6pd A T 4: 150,080,388 (GRCm39) F144L probably damaging Het
Hunk A G 16: 90,229,448 (GRCm39) Y27C probably damaging Het
Ints7 C T 1: 191,328,396 (GRCm39) T223M possibly damaging Het
Kcnmb2 T C 3: 32,233,152 (GRCm39) probably null Het
Lilra6 A T 7: 3,918,066 (GRCm39) L26H probably benign Het
Mc4r A T 18: 66,992,918 (GRCm39) V65E probably damaging Het
Mgam G A 6: 40,646,797 (GRCm39) G708R probably damaging Het
Mllt6 A G 11: 97,563,395 (GRCm39) D326G probably benign Het
Myo7a A T 7: 97,722,331 (GRCm39) V1198D probably damaging Het
Nampt T C 12: 32,883,037 (GRCm39) V74A probably damaging Het
Nlrp4b G C 7: 10,449,266 (GRCm39) V123L probably benign Het
Ntpcr T A 8: 126,472,141 (GRCm39) L150Q probably damaging Het
Obscn C T 11: 58,997,163 (GRCm39) E1513K probably damaging Het
Ola1 T C 2: 72,987,099 (GRCm39) K178E possibly damaging Het
Opalin T C 19: 41,056,070 (GRCm39) probably null Het
Or10g6 A G 9: 39,934,541 (GRCm39) N284S probably damaging Het
Or13a20 A T 7: 140,232,419 (GRCm39) I176F probably damaging Het
Or2ad1 C T 13: 21,326,934 (GRCm39) V98I probably benign Het
Or2w2 C T 13: 21,757,711 (GRCm39) G305D probably damaging Het
Or51ah3 C T 7: 103,209,773 (GRCm39) P30S probably benign Het
Or52ae9 T C 7: 103,390,028 (GRCm39) M140V probably benign Het
Or52e15 A T 7: 104,645,315 (GRCm39) F265L possibly damaging Het
Or5p62 A G 7: 107,771,090 (GRCm39) V287A probably benign Het
Or7a35 T C 10: 78,853,159 (GRCm39) M1T probably null Het
P2ry12 A G 3: 59,125,199 (GRCm39) F159L probably benign Het
Paqr7 T C 4: 134,234,592 (GRCm39) probably null Het
Parp1 T C 1: 180,415,578 (GRCm39) S466P probably benign Het
Parp4 T A 14: 56,864,838 (GRCm39) probably null Het
Pcdh1 T C 18: 38,322,977 (GRCm39) D952G probably damaging Het
Pde6c T C 19: 38,140,146 (GRCm39) S336P possibly damaging Het
Pgk2 T C 17: 40,519,398 (GRCm39) D10G probably benign Het
Phf20l1 A G 15: 66,504,674 (GRCm39) T771A probably damaging Het
Pkdrej A G 15: 85,705,372 (GRCm39) V188A possibly damaging Het
Plekhm1 A G 11: 103,285,682 (GRCm39) L251P probably damaging Het
Prex2 A T 1: 11,270,179 (GRCm39) N1288I probably benign Het
Sarnp T C 10: 128,669,191 (GRCm39) L16P probably damaging Het
Scgb3a2 T C 18: 43,900,033 (GRCm39) probably benign Het
Scn11a A T 9: 119,584,148 (GRCm39) I1489N probably damaging Het
Scn3a A T 2: 65,302,729 (GRCm39) L1239Q probably damaging Het
Shisa9 T C 16: 12,085,521 (GRCm39) S377P probably benign Het
Slc22a30 T A 19: 8,313,136 (GRCm39) T550S probably damaging Het
Slc25a11 T C 11: 70,535,651 (GRCm39) T296A probably benign Het
Slc35f1 T A 10: 52,938,532 (GRCm39) probably null Het
Slc6a13 A G 6: 121,311,811 (GRCm39) E396G probably damaging Het
Spata31d1c T C 13: 65,183,985 (GRCm39) I509T probably benign Het
Srsf9 C A 5: 115,465,481 (GRCm39) Y9* probably null Het
Tasor2 T C 13: 3,634,759 (GRCm39) T683A possibly damaging Het
Tbx20 T C 9: 24,636,795 (GRCm39) I431V probably benign Het
Tespa1 G A 10: 130,184,119 (GRCm39) G67S probably benign Het
Trhde A T 10: 114,424,405 (GRCm39) V460E possibly damaging Het
Trip12 A T 1: 84,708,342 (GRCm39) F1739I probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Umodl1 G A 17: 31,187,524 (GRCm39) R196H probably damaging Het
Vezf1 G T 11: 87,972,447 (GRCm39) M269I probably benign Het
Vmn1r35 A T 6: 66,656,550 (GRCm39) M40K probably benign Het
Vmn1r9 G T 6: 57,048,300 (GRCm39) C125F probably benign Het
Vmn2r12 C A 5: 109,239,594 (GRCm39) G323V probably benign Het
Vmn2r79 A T 7: 86,651,555 (GRCm39) H318L probably benign Het
Zfhx3 T A 8: 109,520,167 (GRCm39) S430T probably benign Het
Other mutations in Or3a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0276:Or3a10 UTSW 11 73,935,944 (GRCm39) missense probably damaging 1.00
R0545:Or3a10 UTSW 11 73,935,873 (GRCm39) missense possibly damaging 0.90
R1560:Or3a10 UTSW 11 73,935,441 (GRCm39) missense probably damaging 1.00
R1570:Or3a10 UTSW 11 73,935,633 (GRCm39) missense possibly damaging 0.65
R2002:Or3a10 UTSW 11 73,935,865 (GRCm39) missense possibly damaging 0.49
R2857:Or3a10 UTSW 11 73,935,653 (GRCm39) missense possibly damaging 0.93
R2858:Or3a10 UTSW 11 73,935,653 (GRCm39) missense possibly damaging 0.93
R2859:Or3a10 UTSW 11 73,935,653 (GRCm39) missense possibly damaging 0.93
R3874:Or3a10 UTSW 11 73,935,525 (GRCm39) missense probably damaging 1.00
R5023:Or3a10 UTSW 11 73,935,881 (GRCm39) missense probably damaging 1.00
R5057:Or3a10 UTSW 11 73,935,881 (GRCm39) missense probably damaging 1.00
R5242:Or3a10 UTSW 11 73,935,848 (GRCm39) missense possibly damaging 0.89
R5495:Or3a10 UTSW 11 73,935,611 (GRCm39) missense probably damaging 1.00
R5655:Or3a10 UTSW 11 73,935,160 (GRCm39) nonsense probably null
R7220:Or3a10 UTSW 11 73,935,589 (GRCm39) missense possibly damaging 0.63
R7343:Or3a10 UTSW 11 73,935,726 (GRCm39) missense possibly damaging 0.68
R7793:Or3a10 UTSW 11 73,935,614 (GRCm39) missense possibly damaging 0.89
R8169:Or3a10 UTSW 11 73,935,707 (GRCm39) missense possibly damaging 0.95
R8262:Or3a10 UTSW 11 73,935,926 (GRCm39) missense probably damaging 1.00
R8340:Or3a10 UTSW 11 73,935,851 (GRCm39) missense probably damaging 0.96
R8948:Or3a10 UTSW 11 73,935,782 (GRCm39) missense possibly damaging 0.50
R8950:Or3a10 UTSW 11 73,935,782 (GRCm39) missense possibly damaging 0.50
R9046:Or3a10 UTSW 11 73,935,284 (GRCm39) missense probably damaging 1.00
R9202:Or3a10 UTSW 11 73,935,441 (GRCm39) missense probably damaging 1.00
R9575:Or3a10 UTSW 11 73,935,840 (GRCm39) missense probably benign 0.01
R9587:Or3a10 UTSW 11 73,935,360 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCCATTGAGGTAGATGCTGGAG -3'
(R):5'- GCCATCTTTGTGGAACCCAAGCTC -3'

Sequencing Primer
(F):5'- AGACACTGCCACTGTGTGAG -3'
(R):5'- AGCTCCACACTCCTATGTACTAC -3'
Posted On 2014-05-23