Incidental Mutation 'R0078:Nynrin'
ID |
19574 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nynrin
|
Ensembl Gene |
ENSMUSG00000075592 |
Gene Name |
NYN domain and retroviral integrase containing |
Synonyms |
|
MMRRC Submission |
038365-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0078 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
14 |
Chromosomal Location |
56091572-56112193 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 56100789 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Aspartic acid
at position 193
(V193D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129557
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100529]
[ENSMUST00000168479]
[ENSMUST00000227465]
|
AlphaFold |
Q5DTZ0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000100529
AA Change: V193D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000098098 Gene: ENSMUSG00000075592 AA Change: V193D
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
1.6e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000168479
AA Change: V193D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000129557 Gene: ENSMUSG00000075592 AA Change: V193D
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
5.5e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181218
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227465
|
Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 95.1%
- 20x: 89.2%
|
Validation Efficiency |
81% (203/250) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 80 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb5 |
T |
A |
12: 118,891,129 (GRCm39) |
Q456L |
probably benign |
Het |
Abcf1 |
A |
G |
17: 36,268,954 (GRCm39) |
|
probably benign |
Het |
Adamts7 |
A |
T |
9: 90,061,464 (GRCm39) |
S357C |
probably damaging |
Het |
Ankrd26 |
A |
G |
6: 118,512,030 (GRCm39) |
|
probably benign |
Het |
Asb17 |
T |
A |
3: 153,550,301 (GRCm39) |
V111E |
probably damaging |
Het |
C1qtnf4 |
C |
A |
2: 90,719,893 (GRCm39) |
N55K |
probably damaging |
Het |
Cacng5 |
G |
T |
11: 107,768,259 (GRCm39) |
D249E |
probably benign |
Het |
Camkk2 |
C |
A |
5: 122,895,622 (GRCm39) |
|
probably null |
Het |
Ccdc27 |
T |
G |
4: 154,120,195 (GRCm39) |
|
probably benign |
Het |
Cfap251 |
G |
A |
5: 123,436,633 (GRCm39) |
R1054H |
probably benign |
Het |
Cngb1 |
T |
A |
8: 95,991,173 (GRCm39) |
|
probably null |
Het |
Col7a1 |
A |
G |
9: 108,803,981 (GRCm39) |
|
probably benign |
Het |
Corin |
T |
A |
5: 72,611,816 (GRCm39) |
D148V |
possibly damaging |
Het |
Cstdc1 |
T |
A |
2: 148,627,745 (GRCm39) |
*131K |
probably null |
Het |
Defb26 |
A |
C |
2: 152,349,988 (GRCm39) |
D97E |
possibly damaging |
Het |
Dgkb |
A |
G |
12: 38,186,540 (GRCm39) |
N237D |
probably benign |
Het |
Dsp |
A |
G |
13: 38,379,993 (GRCm39) |
N1647S |
probably benign |
Het |
Dtna |
G |
A |
18: 23,754,499 (GRCm39) |
A438T |
probably damaging |
Het |
Erbb3 |
G |
T |
10: 128,419,310 (GRCm39) |
F219L |
probably damaging |
Het |
EU599041 |
G |
A |
7: 42,875,275 (GRCm39) |
|
noncoding transcript |
Het |
Fat1 |
A |
G |
8: 45,406,336 (GRCm39) |
N1029S |
probably damaging |
Het |
Fat4 |
T |
C |
3: 38,943,080 (GRCm39) |
S658P |
probably benign |
Het |
Fgfr2 |
C |
T |
7: 129,802,805 (GRCm39) |
D168N |
possibly damaging |
Het |
Fstl5 |
T |
A |
3: 76,566,952 (GRCm39) |
|
probably benign |
Het |
Glmn |
C |
T |
5: 107,705,836 (GRCm39) |
V451I |
probably benign |
Het |
Gm9938 |
T |
A |
19: 23,701,988 (GRCm39) |
|
probably benign |
Het |
Gpat2 |
T |
C |
2: 127,270,169 (GRCm39) |
S61P |
probably damaging |
Het |
Gpr22 |
T |
A |
12: 31,761,640 (GRCm39) |
M6L |
probably benign |
Het |
Grm5 |
T |
C |
7: 87,724,185 (GRCm39) |
L825P |
probably damaging |
Het |
Gstz1 |
A |
T |
12: 87,206,477 (GRCm39) |
I66F |
probably benign |
Het |
H2-T22 |
A |
G |
17: 36,351,501 (GRCm39) |
V243A |
probably damaging |
Het |
H2-T5 |
A |
T |
17: 36,476,353 (GRCm39) |
S304T |
possibly damaging |
Het |
Hivep1 |
C |
T |
13: 42,309,517 (GRCm39) |
L586F |
probably damaging |
Het |
Hmcn2 |
T |
G |
2: 31,278,356 (GRCm39) |
L1686R |
probably damaging |
Het |
Ice1 |
T |
C |
13: 70,751,467 (GRCm39) |
R1540G |
probably damaging |
Het |
Igha |
T |
A |
12: 113,223,547 (GRCm39) |
|
probably benign |
Het |
Kif3a |
C |
A |
11: 53,469,812 (GRCm39) |
T141K |
probably benign |
Het |
Knl1 |
G |
A |
2: 118,900,373 (GRCm39) |
M691I |
probably benign |
Het |
L3mbtl1 |
T |
C |
2: 162,789,146 (GRCm39) |
V13A |
probably benign |
Het |
Lamc1 |
T |
A |
1: 153,104,936 (GRCm39) |
N1282I |
probably damaging |
Het |
Lemd2 |
G |
T |
17: 27,422,702 (GRCm39) |
L231I |
probably benign |
Het |
Lrrk2 |
G |
A |
15: 91,618,212 (GRCm39) |
V904M |
probably benign |
Het |
Lyzl6 |
C |
T |
11: 103,524,795 (GRCm39) |
S103N |
probably benign |
Het |
Macf1 |
T |
A |
4: 123,367,661 (GRCm39) |
R2367W |
probably damaging |
Het |
Mapk3 |
T |
C |
7: 126,358,977 (GRCm39) |
Y54H |
probably damaging |
Het |
Mlh3 |
A |
T |
12: 85,315,592 (GRCm39) |
V198D |
probably damaging |
Het |
Myocd |
T |
C |
11: 65,078,290 (GRCm39) |
S374G |
possibly damaging |
Het |
Ngef |
T |
C |
1: 87,468,387 (GRCm39) |
E124G |
probably benign |
Het |
Nhsl3 |
T |
C |
4: 129,121,516 (GRCm39) |
|
probably null |
Het |
Nr4a2 |
T |
C |
2: 57,002,240 (GRCm39) |
Y8C |
probably damaging |
Het |
Or10ak9 |
T |
A |
4: 118,726,424 (GRCm39) |
S148T |
probably benign |
Het |
Or10w1 |
G |
T |
19: 13,632,179 (GRCm39) |
V129F |
probably benign |
Het |
Or1p1 |
A |
T |
11: 74,180,092 (GRCm39) |
I207F |
probably damaging |
Het |
Or4k36 |
A |
T |
2: 111,146,249 (GRCm39) |
I142F |
probably benign |
Het |
Or6d15 |
A |
G |
6: 116,559,701 (GRCm39) |
S69P |
probably damaging |
Het |
Pcdh18 |
T |
C |
3: 49,710,793 (GRCm39) |
Y174C |
probably damaging |
Het |
Pcf11 |
T |
C |
7: 92,318,767 (GRCm39) |
D21G |
possibly damaging |
Het |
Pdia4 |
A |
C |
6: 47,775,344 (GRCm39) |
F489V |
possibly damaging |
Het |
Pitrm1 |
C |
T |
13: 6,625,068 (GRCm39) |
P849S |
probably damaging |
Het |
Plcz1 |
T |
C |
6: 139,935,510 (GRCm39) |
Y644C |
probably damaging |
Het |
Ppp5c |
T |
C |
7: 16,761,650 (GRCm39) |
E28G |
probably benign |
Het |
Prkcb |
A |
G |
7: 122,189,393 (GRCm39) |
Y507C |
probably damaging |
Het |
Rims2 |
A |
G |
15: 39,398,251 (GRCm39) |
D1072G |
probably benign |
Het |
Scarf1 |
A |
G |
11: 75,405,988 (GRCm39) |
|
probably benign |
Het |
Scoc |
T |
A |
8: 84,184,887 (GRCm39) |
|
probably null |
Het |
Sh2d4a |
A |
T |
8: 68,734,973 (GRCm39) |
M31L |
probably damaging |
Het |
Spta1 |
T |
A |
1: 174,034,598 (GRCm39) |
|
probably benign |
Het |
Stard7 |
A |
G |
2: 127,134,127 (GRCm39) |
Y270C |
probably damaging |
Het |
Svs3b |
T |
C |
2: 164,097,881 (GRCm39) |
T147A |
probably benign |
Het |
Tmtc3 |
A |
G |
10: 100,284,823 (GRCm39) |
L604P |
probably damaging |
Het |
Trim30b |
A |
T |
7: 104,015,102 (GRCm39) |
N95K |
probably benign |
Het |
Trpm8 |
C |
A |
1: 88,255,870 (GRCm39) |
|
probably benign |
Het |
Tspan9 |
T |
C |
6: 127,943,448 (GRCm39) |
|
probably null |
Het |
Tubgcp5 |
C |
T |
7: 55,468,643 (GRCm39) |
R713C |
probably damaging |
Het |
Tyro3 |
A |
T |
2: 119,647,487 (GRCm39) |
Q872L |
probably damaging |
Het |
Vmn1r204 |
G |
A |
13: 22,740,379 (GRCm39) |
M3I |
probably benign |
Het |
Vmn1r28 |
G |
A |
6: 58,242,702 (GRCm39) |
A182T |
probably benign |
Het |
Wdfy3 |
A |
G |
5: 102,035,971 (GRCm39) |
I2149T |
possibly damaging |
Het |
Zfp668 |
A |
T |
7: 127,467,210 (GRCm39) |
M122K |
possibly damaging |
Het |
Zkscan1 |
A |
T |
5: 138,091,363 (GRCm39) |
D32V |
probably damaging |
Het |
|
Other mutations in Nynrin |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01020:Nynrin
|
APN |
14 |
56,105,905 (GRCm39) |
missense |
probably benign |
0.38 |
IGL01131:Nynrin
|
APN |
14 |
56,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01357:Nynrin
|
APN |
14 |
56,107,874 (GRCm39) |
missense |
probably benign |
|
IGL01537:Nynrin
|
APN |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01583:Nynrin
|
APN |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01726:Nynrin
|
APN |
14 |
56,101,611 (GRCm39) |
missense |
probably benign |
|
IGL02161:Nynrin
|
APN |
14 |
56,101,441 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02167:Nynrin
|
APN |
14 |
56,100,792 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02247:Nynrin
|
APN |
14 |
56,109,167 (GRCm39) |
nonsense |
probably null |
|
IGL02302:Nynrin
|
APN |
14 |
56,105,962 (GRCm39) |
missense |
probably benign |
0.43 |
IGL02524:Nynrin
|
APN |
14 |
56,108,931 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL02600:Nynrin
|
APN |
14 |
56,101,449 (GRCm39) |
missense |
probably benign |
0.38 |
IGL02639:Nynrin
|
APN |
14 |
56,108,112 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02654:Nynrin
|
APN |
14 |
56,100,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02659:Nynrin
|
APN |
14 |
56,103,554 (GRCm39) |
unclassified |
probably benign |
|
IGL02736:Nynrin
|
APN |
14 |
56,108,366 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02949:Nynrin
|
APN |
14 |
56,109,837 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4458001:Nynrin
|
UTSW |
14 |
56,101,425 (GRCm39) |
missense |
probably benign |
0.39 |
R0017:Nynrin
|
UTSW |
14 |
56,109,852 (GRCm39) |
missense |
probably damaging |
1.00 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0413:Nynrin
|
UTSW |
14 |
56,109,648 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0609:Nynrin
|
UTSW |
14 |
56,110,218 (GRCm39) |
missense |
probably damaging |
1.00 |
R0626:Nynrin
|
UTSW |
14 |
56,105,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R1205:Nynrin
|
UTSW |
14 |
56,091,646 (GRCm39) |
intron |
probably benign |
|
R1222:Nynrin
|
UTSW |
14 |
56,100,998 (GRCm39) |
missense |
probably benign |
0.02 |
R1385:Nynrin
|
UTSW |
14 |
56,102,356 (GRCm39) |
missense |
probably benign |
0.00 |
R1820:Nynrin
|
UTSW |
14 |
56,107,835 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1829:Nynrin
|
UTSW |
14 |
56,110,404 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1874:Nynrin
|
UTSW |
14 |
56,100,950 (GRCm39) |
missense |
probably benign |
0.04 |
R1927:Nynrin
|
UTSW |
14 |
56,101,049 (GRCm39) |
missense |
probably benign |
0.00 |
R2233:Nynrin
|
UTSW |
14 |
56,109,524 (GRCm39) |
missense |
possibly damaging |
0.83 |
R3018:Nynrin
|
UTSW |
14 |
56,100,867 (GRCm39) |
missense |
probably benign |
0.00 |
R3154:Nynrin
|
UTSW |
14 |
56,101,044 (GRCm39) |
missense |
possibly damaging |
0.46 |
R3853:Nynrin
|
UTSW |
14 |
56,101,562 (GRCm39) |
missense |
probably benign |
0.24 |
R4648:Nynrin
|
UTSW |
14 |
56,110,351 (GRCm39) |
nonsense |
probably null |
|
R4722:Nynrin
|
UTSW |
14 |
56,091,852 (GRCm39) |
missense |
probably damaging |
0.97 |
R4735:Nynrin
|
UTSW |
14 |
56,107,625 (GRCm39) |
missense |
probably benign |
0.03 |
R4736:Nynrin
|
UTSW |
14 |
56,101,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R4780:Nynrin
|
UTSW |
14 |
56,100,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R4804:Nynrin
|
UTSW |
14 |
56,102,326 (GRCm39) |
missense |
probably benign |
|
R4816:Nynrin
|
UTSW |
14 |
56,109,458 (GRCm39) |
missense |
probably damaging |
1.00 |
R5307:Nynrin
|
UTSW |
14 |
56,101,263 (GRCm39) |
missense |
probably damaging |
1.00 |
R5372:Nynrin
|
UTSW |
14 |
56,105,948 (GRCm39) |
missense |
probably benign |
0.01 |
R5432:Nynrin
|
UTSW |
14 |
56,101,923 (GRCm39) |
missense |
possibly damaging |
0.80 |
R5800:Nynrin
|
UTSW |
14 |
56,108,088 (GRCm39) |
missense |
probably damaging |
1.00 |
R5825:Nynrin
|
UTSW |
14 |
56,101,683 (GRCm39) |
missense |
probably benign |
0.00 |
R6149:Nynrin
|
UTSW |
14 |
56,091,780 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6244:Nynrin
|
UTSW |
14 |
56,105,485 (GRCm39) |
missense |
probably damaging |
1.00 |
R6350:Nynrin
|
UTSW |
14 |
56,105,533 (GRCm39) |
missense |
probably benign |
0.19 |
R6379:Nynrin
|
UTSW |
14 |
56,107,848 (GRCm39) |
missense |
probably damaging |
1.00 |
R6437:Nynrin
|
UTSW |
14 |
56,109,227 (GRCm39) |
missense |
probably benign |
0.00 |
R6501:Nynrin
|
UTSW |
14 |
56,100,989 (GRCm39) |
missense |
probably benign |
|
R6702:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6703:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6907:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6908:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6928:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6934:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6935:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R7197:Nynrin
|
UTSW |
14 |
56,109,380 (GRCm39) |
missense |
probably benign |
0.00 |
R7204:Nynrin
|
UTSW |
14 |
56,110,190 (GRCm39) |
missense |
probably damaging |
1.00 |
R7272:Nynrin
|
UTSW |
14 |
56,107,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Nynrin
|
UTSW |
14 |
56,101,371 (GRCm39) |
missense |
probably benign |
|
R7361:Nynrin
|
UTSW |
14 |
56,107,857 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7368:Nynrin
|
UTSW |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
R7443:Nynrin
|
UTSW |
14 |
56,108,873 (GRCm39) |
missense |
probably benign |
0.18 |
R7584:Nynrin
|
UTSW |
14 |
56,109,041 (GRCm39) |
missense |
probably damaging |
1.00 |
R7677:Nynrin
|
UTSW |
14 |
56,107,693 (GRCm39) |
missense |
probably benign |
|
R7723:Nynrin
|
UTSW |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7776:Nynrin
|
UTSW |
14 |
56,103,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R7787:Nynrin
|
UTSW |
14 |
56,107,980 (GRCm39) |
missense |
probably benign |
|
R7842:Nynrin
|
UTSW |
14 |
56,102,553 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Nynrin
|
UTSW |
14 |
56,108,886 (GRCm39) |
missense |
probably damaging |
0.96 |
R8040:Nynrin
|
UTSW |
14 |
56,108,982 (GRCm39) |
missense |
probably benign |
0.01 |
R8159:Nynrin
|
UTSW |
14 |
56,102,517 (GRCm39) |
missense |
probably benign |
|
R8159:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R8258:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8259:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8343:Nynrin
|
UTSW |
14 |
56,101,248 (GRCm39) |
missense |
probably benign |
|
R8504:Nynrin
|
UTSW |
14 |
56,107,703 (GRCm39) |
missense |
probably benign |
0.01 |
R8671:Nynrin
|
UTSW |
14 |
56,107,899 (GRCm39) |
missense |
possibly damaging |
0.52 |
R8691:Nynrin
|
UTSW |
14 |
56,110,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R8777-TAIL:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R9041:Nynrin
|
UTSW |
14 |
56,108,753 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9346:Nynrin
|
UTSW |
14 |
56,100,495 (GRCm39) |
missense |
probably benign |
0.01 |
R9366:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R9690:Nynrin
|
UTSW |
14 |
56,108,204 (GRCm39) |
missense |
probably benign |
0.00 |
RF007:Nynrin
|
UTSW |
14 |
56,103,658 (GRCm39) |
splice site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TATGGAAGGAGGTTCGCTACCCAC -3'
(R):5'- TTCTGAAGCCCGATTCAAGGCTC -3'
Sequencing Primer
(F):5'- CGAGTCTTTTACCATGACACAG -3'
(R):5'- GGCTCCTATCTCTTGGAGCG -3'
|
Posted On |
2013-04-11 |