Mutagenetix > Incidental Mutation

Incidental Mutation 'R0079:Ank2'

19596

Institutional Source

Beutler Lab

Gene Symbol

Ank2

Ensembl Gene

ENSMUSG00000032826

Gene Name

ankyrin 2, brain

Synonyms

Gm4392, Ank-2, ankyrin B, Ankyrin-B, Ankyrin-2

MMRRC Submission

038366-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0079 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

126715261-127292999 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 126728264 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 776 (D776E)

Ref Sequence

ENSEMBL: ENSMUSP00000043765 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044443] [ENSMUST00000182064] [ENSMUST00000182078]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000044443
AA Change: D776E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000043765
Gene: ENSMUSG00000032826
AA Change: D776E

Domain	Start	End	E-Value	Type
low complexity region	9	22	N/A	INTRINSIC
low complexity region	57	69	N/A	INTRINSIC
ZU5	128	232	4.13e-61	SMART
Pfam:ZU5	289	374	2.8e-8	PFAM
low complexity region	587	597	N/A	INTRINSIC
DEATH	603	697	1.52e-27	SMART
low complexity region	732	748	N/A	INTRINSIC
low complexity region	860	873	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182062

Predicted Effect

unknown
Transcript: ENSMUST00000182064
AA Change: D3713E

SMART Domains

Protein: ENSMUSP00000138620
Gene: ENSMUSG00000032826
AA Change: D3713E

Domain	Start	End	E-Value	Type
ANK	9	38	1e1	SMART
ANK	42	71	8.9e-7	SMART
ANK	75	104	4.4e-9	SMART
ANK	108	137	2.8e-9	SMART
ANK	141	169	5.3e-1	SMART
ANK	170	199	7.3e-1	SMART
ANK	211	240	1.1e-7	SMART
ANK	244	273	4.4e-9	SMART
ANK	277	306	9.3e-8	SMART
ANK	310	339	2.1e-8	SMART
ANK	343	372	1.3e-7	SMART
ANK	376	405	6.2e-9	SMART
ANK	409	438	1.1e-7	SMART
ANK	442	471	2.9e-8	SMART
ANK	475	504	1.1e-5	SMART
ANK	508	537	6.5e-6	SMART
ANK	541	570	2.3e-7	SMART
ANK	574	603	2.4e-7	SMART
ANK	607	636	3.2e-9	SMART
ANK	640	669	5.5e-5	SMART
ANK	673	702	1.9e-8	SMART
ANK	706	735	3.3e-9	SMART
low complexity region	755	775	N/A	INTRINSIC
low complexity region	793	806	N/A	INTRINSIC
low complexity region	841	853	N/A	INTRINSIC
ZU5	912	1016	2e-63	SMART
low complexity region	1371	1381	N/A	INTRINSIC
low complexity region	1448	1463	N/A	INTRINSIC
low complexity region	1490	1503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000182078
AA Change: D3626E

SMART Domains

Protein: ENSMUSP00000138753
Gene: ENSMUSG00000032826
AA Change: D3626E

Domain	Start	End	E-Value	Type
low complexity region	7	18	N/A	INTRINSIC
low complexity region	114	125	N/A	INTRINSIC
low complexity region	191	209	N/A	INTRINSIC
low complexity region	304	312	N/A	INTRINSIC
low complexity region	478	493	N/A	INTRINSIC
low complexity region	527	544	N/A	INTRINSIC
DEATH	591	685	1e-29	SMART
low complexity region	720	736	N/A	INTRINSIC
low complexity region	848	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000182118

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182271

Predicted Effect

probably benign
Transcript: ENSMUST00000182571

Meta Mutation Damage Score

0.0909

Coding Region Coverage

1x: 98.8%
3x: 97.8%
10x: 95.4%
20x: 90.7%

Validation Efficiency

78% (155/199)

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in death by postnatal day 8, although some animals survive to P20. Mutant animals display reduced body size, impaired balance and locomotion, brain structure dysmorphologies, abnormal lens, and optic nerve degeneration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410004P03Rik	T	A	12: 17,057,183 (GRCm39)	T105S	possibly damaging	Het
Abca13	G	A	11: 9,243,493 (GRCm39)	M1785I	probably benign	Het
Adamts3	G	C	5: 89,840,912 (GRCm39)	P804A	probably benign	Het
Ahrr	G	A	13: 74,431,143 (GRCm39)		probably benign	Het
Cep152	T	A	2: 125,460,373 (GRCm39)	K193M	possibly damaging	Het
Cep55	C	T	19: 38,048,769 (GRCm39)	L142F	probably benign	Het
Chd5	A	G	4: 152,470,206 (GRCm39)	Y1884C	probably damaging	Het
Clasp1	T	C	1: 118,471,034 (GRCm39)	L890P	probably damaging	Het
Cul9	C	A	17: 46,848,589 (GRCm39)	E716*	probably null	Het
Cytip	T	A	2: 58,050,006 (GRCm39)	D21V	probably benign	Het
Denr	T	G	5: 124,062,908 (GRCm39)	F137C	probably damaging	Het
Dhrs3	A	T	4: 144,646,618 (GRCm39)	S197C	probably damaging	Het
Egr4	A	T	6: 85,489,751 (GRCm39)	M103K	probably damaging	Het
Eif4enif1	C	T	11: 3,192,676 (GRCm39)	Q835*	probably null	Het
Gckr	A	G	5: 31,463,883 (GRCm39)	I268V	probably benign	Het
Glt6d1	C	A	2: 25,684,739 (GRCm39)		probably null	Het
Hpd	T	C	5: 123,319,544 (GRCm39)	Y8C	probably damaging	Het
Il12rb2	A	T	6: 67,338,889 (GRCm39)	F16I	probably benign	Het
Ildr2	A	T	1: 166,135,289 (GRCm39)	Y347F	probably damaging	Het
Kcnv1	T	C	15: 44,976,729 (GRCm39)	D186G	probably damaging	Het
Khdrbs2	A	G	1: 32,558,996 (GRCm39)		probably null	Het
L1cam	G	T	X: 72,913,364 (GRCm39)	P16H	probably damaging	Het
Lyn	A	G	4: 3,746,768 (GRCm39)	H161R	probably damaging	Het
Mctp2	T	A	7: 71,863,864 (GRCm39)		probably benign	Het
Miox	C	T	15: 89,220,477 (GRCm39)	L189F	possibly damaging	Het
Mitf	A	C	6: 97,973,401 (GRCm39)	M220L	probably benign	Het
Mrpl21	T	C	19: 3,334,807 (GRCm39)	Y50H	possibly damaging	Het
Myh1	T	A	11: 67,104,237 (GRCm39)	L968Q	probably damaging	Het
Myo3b	A	G	2: 69,925,502 (GRCm39)	K18E	possibly damaging	Het
Ncoa6	TGC	TGCGC	2: 155,250,211 (GRCm39)		probably null	Het
Nlrp2	T	A	7: 5,330,729 (GRCm39)	T556S	possibly damaging	Het
Nsmf	T	C	2: 24,949,096 (GRCm39)		probably benign	Het
Nsun7	C	T	5: 66,452,856 (GRCm39)	P558S	probably benign	Het
Or10h5	G	A	17: 33,435,079 (GRCm39)	R80C	probably benign	Het
Or1e34	T	G	11: 73,778,563 (GRCm39)	I212L	probably benign	Het
Or56a3	T	C	7: 104,735,135 (GRCm39)	S71P	probably damaging	Het
Or5d40	A	T	2: 88,015,698 (GRCm39)	Y159F	possibly damaging	Het
Phf19	T	C	2: 34,785,966 (GRCm39)	N501S	probably benign	Het
Ranbp17	A	C	11: 33,450,682 (GRCm39)	I85S	probably damaging	Het
Robo1	A	G	16: 72,730,230 (GRCm39)		probably benign	Het
Sntg1	A	G	1: 8,749,286 (GRCm39)		probably benign	Het
Snx15	A	G	19: 6,173,943 (GRCm39)	L58P	probably damaging	Het
Spink5	G	T	18: 44,110,831 (GRCm39)	C134F	probably damaging	Het
Strip2	T	C	6: 29,920,532 (GRCm39)		probably null	Het
Taf1d	C	T	9: 15,221,240 (GRCm39)	A182V	probably benign	Het
Tenm3	A	G	8: 48,796,380 (GRCm39)	V475A	possibly damaging	Het
Tent4b	T	A	8: 88,926,631 (GRCm39)	Y14N	possibly damaging	Het
Tgds	A	T	14: 118,353,647 (GRCm39)	H223Q	possibly damaging	Het
Thoc2	G	T	X: 40,952,985 (GRCm39)	S230Y	probably benign	Het
Tm9sf4	T	A	2: 153,033,065 (GRCm39)	V290E	probably damaging	Het
Trak2	A	T	1: 58,965,883 (GRCm39)	L97Q	probably damaging	Het
Trnau1ap	A	G	4: 132,041,656 (GRCm39)	Y145H	probably damaging	Het
Vars2	A	T	17: 35,970,048 (GRCm39)	D780E	probably damaging	Het
Vmn1r170	T	A	7: 23,305,735 (GRCm39)	S46T	possibly damaging	Het
Vmn1r20	A	T	6: 57,408,777 (GRCm39)	R34S	possibly damaging	Het
Vmn1r28	G	A	6: 58,242,702 (GRCm39)	A182T	probably benign	Het
Wdr64	T	C	1: 175,622,668 (GRCm39)	M805T	probably benign	Het
Xdh	G	A	17: 74,198,213 (GRCm39)	R1225C	probably damaging	Het
Zfp341	T	A	2: 154,466,914 (GRCm39)	Y94*	probably null	Het
Zfp641	T	C	15: 98,186,970 (GRCm39)	N218D	probably benign	Het
Zscan22	T	C	7: 12,638,014 (GRCm39)		probably null	Het

Other mutations in Ank2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01298:Ank2	APN	3	126,753,369 (GRCm39)	missense	possibly damaging	0.80
IGL01652:Ank2	APN	3	126,726,690 (GRCm39)	missense	probably benign	0.00
IGL01969:Ank2	APN	3	126,746,872 (GRCm39)	missense	possibly damaging	0.47
IGL02122:Ank2	APN	3	126,731,523 (GRCm39)	splice site	probably benign
IGL02537:Ank2	APN	3	126,749,565 (GRCm39)	missense	probably damaging	1.00
IGL02858:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL02981:Ank2	APN	3	126,728,211 (GRCm39)	missense	possibly damaging	0.58
IGL02981:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03024:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03074:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03111:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03129:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03174:Ank2	APN	3	126,733,744 (GRCm39)	missense	probably damaging	0.98
IGL03177:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03185:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03188:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03242:Ank2	APN	3	126,722,454 (GRCm39)	missense	possibly damaging	0.90
IGL03244:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03248:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03304:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03358:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03380:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03389:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03400:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
IGL03409:Ank2	APN	3	126,749,519 (GRCm39)	missense	probably damaging	1.00
ballast	UTSW	3	126,736,782 (GRCm39)	missense	unknown
Chain	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
Deadman	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
drag	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
mooring	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
Treasure	UTSW	3	126,740,398 (GRCm39)	missense	unknown
Windlass	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R0033:Ank2	UTSW	3	126,898,397 (GRCm39)	splice site	probably benign
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0042:Ank2	UTSW	3	126,730,280 (GRCm39)	missense	probably damaging	0.99
R0423:Ank2	UTSW	3	126,723,509 (GRCm39)	nonsense	probably null
R0699:Ank2	UTSW	3	126,723,478 (GRCm39)	missense	probably benign	0.00
R0724:Ank2	UTSW	3	126,755,986 (GRCm39)	missense	probably damaging	1.00
R0990:Ank2	UTSW	3	126,728,315 (GRCm39)	missense	possibly damaging	0.64
R1450:Ank2	UTSW	3	126,750,951 (GRCm39)	missense	possibly damaging	0.94
R1500:Ank2	UTSW	3	126,726,631 (GRCm39)	missense	probably benign
R1702:Ank2	UTSW	3	126,749,548 (GRCm39)	missense	probably benign	0.00
R1703:Ank2	UTSW	3	126,723,415 (GRCm39)	missense	probably damaging	1.00
R1710:Ank2	UTSW	3	126,726,709 (GRCm39)	nonsense	probably null
R1743:Ank2	UTSW	3	126,722,324 (GRCm39)	missense	probably damaging	0.99
R1775:Ank2	UTSW	3	126,728,196 (GRCm39)	missense	probably benign	0.00
R1852:Ank2	UTSW	3	126,791,500 (GRCm39)	critical splice donor site	probably null
R2198:Ank2	UTSW	3	126,728,226 (GRCm39)	missense	possibly damaging	0.73
R2892:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2893:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R2894:Ank2	UTSW	3	127,041,892 (GRCm39)	splice site	probably null
R3148:Ank2	UTSW	3	126,726,724 (GRCm39)	missense	probably benign	0.00
R3776:Ank2	UTSW	3	126,735,911 (GRCm39)	intron	probably benign
R3784:Ank2	UTSW	3	126,746,842 (GRCm39)	missense	probably damaging	1.00
R3856:Ank2	UTSW	3	126,723,493 (GRCm39)	missense	probably benign	0.00
R3906:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3907:Ank2	UTSW	3	126,810,547 (GRCm39)	missense	probably damaging	1.00
R3953:Ank2	UTSW	3	126,781,809 (GRCm39)	missense	probably damaging	1.00
R3963:Ank2	UTSW	3	126,728,245 (GRCm39)	missense	probably benign
R4367:Ank2	UTSW	3	126,739,798 (GRCm39)	missense	probably benign
R4414:Ank2	UTSW	3	127,019,411 (GRCm39)	critical splice donor site	probably null
R4432:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4433:Ank2	UTSW	3	126,741,455 (GRCm39)	intron	probably benign
R4579:Ank2	UTSW	3	126,752,612 (GRCm39)	missense	probably damaging	1.00
R4597:Ank2	UTSW	3	126,781,800 (GRCm39)	missense	probably damaging	1.00
R4603:Ank2	UTSW	3	126,825,665 (GRCm39)	missense	probably benign	0.00
R4729:Ank2	UTSW	3	126,770,545 (GRCm39)	nonsense	probably null
R4815:Ank2	UTSW	3	126,730,410 (GRCm39)	missense	probably benign
R4826:Ank2	UTSW	3	126,749,650 (GRCm39)	missense	probably benign	0.35
R4871:Ank2	UTSW	3	126,753,444 (GRCm39)	missense	probably damaging	1.00
R4880:Ank2	UTSW	3	126,840,475 (GRCm39)	splice site	probably null
R4915:Ank2	UTSW	3	126,736,320 (GRCm39)	intron	probably benign
R4935:Ank2	UTSW	3	126,749,713 (GRCm39)	missense	probably damaging	1.00
R4936:Ank2	UTSW	3	126,748,688 (GRCm39)	missense	possibly damaging	0.94
R4937:Ank2	UTSW	3	126,756,050 (GRCm39)	missense	probably damaging	1.00
R4946:Ank2	UTSW	3	126,735,589 (GRCm39)	intron	probably benign
R4963:Ank2	UTSW	3	126,825,745 (GRCm39)	missense	probably benign	0.01
R4989:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5023:Ank2	UTSW	3	126,735,520 (GRCm39)	intron	probably benign
R5060:Ank2	UTSW	3	126,739,570 (GRCm39)	intron	probably benign
R5078:Ank2	UTSW	3	126,736,002 (GRCm39)	intron	probably benign
R5086:Ank2	UTSW	3	126,740,997 (GRCm39)	intron	probably benign
R5134:Ank2	UTSW	3	126,757,094 (GRCm39)	missense	possibly damaging	0.94
R5148:Ank2	UTSW	3	126,819,285 (GRCm39)	splice site	probably null
R5175:Ank2	UTSW	3	126,797,673 (GRCm39)	missense	probably damaging	1.00
R5275:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5295:Ank2	UTSW	3	126,825,832 (GRCm39)	missense	probably damaging	1.00
R5303:Ank2	UTSW	3	126,739,453 (GRCm39)	intron	probably benign
R5309:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5312:Ank2	UTSW	3	126,753,417 (GRCm39)	missense	probably damaging	0.99
R5352:Ank2	UTSW	3	127,292,640 (GRCm39)	utr 5 prime	probably benign
R5355:Ank2	UTSW	3	126,737,698 (GRCm39)	intron	probably benign
R5386:Ank2	UTSW	3	126,775,582 (GRCm39)	missense	probably benign	0.01
R5396:Ank2	UTSW	3	126,746,875 (GRCm39)	missense	probably damaging	1.00
R5518:Ank2	UTSW	3	126,753,348 (GRCm39)	missense	probably damaging	0.98
R5534:Ank2	UTSW	3	126,740,947 (GRCm39)	intron	probably benign
R5554:Ank2	UTSW	3	126,792,622 (GRCm39)	missense	possibly damaging	0.78
R5582:Ank2	UTSW	3	126,739,954 (GRCm39)	intron	probably benign
R5747:Ank2	UTSW	3	126,735,400 (GRCm39)	intron	probably benign
R5794:Ank2	UTSW	3	126,723,669 (GRCm39)	missense	probably benign	0.00
R5831:Ank2	UTSW	3	127,132,808 (GRCm39)	start gained	probably benign
R5925:Ank2	UTSW	3	126,726,612 (GRCm39)	missense	probably benign	0.18
R5954:Ank2	UTSW	3	126,791,510 (GRCm39)	missense	probably benign	0.34
R5956:Ank2	UTSW	3	126,736,337 (GRCm39)	intron	probably benign
R5986:Ank2	UTSW	3	126,806,335 (GRCm39)	missense	possibly damaging	0.94
R5992:Ank2	UTSW	3	126,753,300 (GRCm39)	critical splice donor site	probably null
R6020:Ank2	UTSW	3	126,740,470 (GRCm39)	intron	probably benign
R6027:Ank2	UTSW	3	126,791,528 (GRCm39)	missense	possibly damaging	0.92
R6049:Ank2	UTSW	3	126,736,669 (GRCm39)	missense	possibly damaging	0.95
R6060:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
R6114:Ank2	UTSW	3	126,804,700 (GRCm39)	missense	probably damaging	1.00
R6124:Ank2	UTSW	3	127,041,800 (GRCm39)	missense	probably benign	0.31
R6156:Ank2	UTSW	3	126,737,886 (GRCm39)	missense	probably damaging	1.00
R6173:Ank2	UTSW	3	126,846,395 (GRCm39)	missense	probably damaging	1.00
R6176:Ank2	UTSW	3	126,739,120 (GRCm39)	missense	probably benign	0.05
R6184:Ank2	UTSW	3	126,756,047 (GRCm39)	missense	probably damaging	1.00
R6199:Ank2	UTSW	3	126,797,655 (GRCm39)	missense	probably damaging	1.00
R6241:Ank2	UTSW	3	126,846,397 (GRCm39)	missense	probably damaging	1.00
R6254:Ank2	UTSW	3	126,735,453 (GRCm39)	intron	probably benign
R6259:Ank2	UTSW	3	126,810,635 (GRCm39)	missense	probably benign	0.28
R6260:Ank2	UTSW	3	126,737,206 (GRCm39)	missense	probably benign
R6321:Ank2	UTSW	3	126,740,587 (GRCm39)	intron	probably benign
R6393:Ank2	UTSW	3	126,723,406 (GRCm39)	missense	probably damaging	1.00
R6406:Ank2	UTSW	3	126,825,874 (GRCm39)	missense	probably damaging	1.00
R6544:Ank2	UTSW	3	126,726,871 (GRCm39)	missense	probably damaging	0.99
R6583:Ank2	UTSW	3	126,810,613 (GRCm39)	missense	probably damaging	1.00
R6739:Ank2	UTSW	3	126,873,643 (GRCm39)	missense	probably damaging	1.00
R6754:Ank2	UTSW	3	126,890,488 (GRCm39)	intron	probably benign
R6786:Ank2	UTSW	3	126,752,581 (GRCm39)	missense	probably damaging	0.99
R6798:Ank2	UTSW	3	126,737,913 (GRCm39)	intron	probably benign
R6882:Ank2	UTSW	3	126,739,406 (GRCm39)	intron	probably benign
R6940:Ank2	UTSW	3	126,735,621 (GRCm39)	intron	probably benign
R6949:Ank2	UTSW	3	126,804,533 (GRCm39)	missense	probably benign	0.00
R7001:Ank2	UTSW	3	126,871,230 (GRCm39)	missense	probably damaging	1.00
R7033:Ank2	UTSW	3	126,738,499 (GRCm39)	nonsense	probably null
R7036:Ank2	UTSW	3	126,740,041 (GRCm39)	intron	probably benign
R7045:Ank2	UTSW	3	126,806,393 (GRCm39)	missense	probably damaging	1.00
R7048:Ank2	UTSW	3	126,819,267 (GRCm39)	missense	probably benign	0.03
R7054:Ank2	UTSW	3	126,736,952 (GRCm39)	intron	probably benign
R7069:Ank2	UTSW	3	126,739,947 (GRCm39)	intron	probably benign
R7091:Ank2	UTSW	3	126,817,000 (GRCm39)	missense	probably damaging	0.98
R7107:Ank2	UTSW	3	126,797,631 (GRCm39)	missense	probably damaging	1.00
R7175:Ank2	UTSW	3	126,740,590 (GRCm39)	missense	unknown
R7191:Ank2	UTSW	3	126,740,041 (GRCm39)	missense	unknown
R7272:Ank2	UTSW	3	126,736,782 (GRCm39)	missense	unknown
R7381:Ank2	UTSW	3	126,730,277 (GRCm39)	missense	possibly damaging	0.46
R7394:Ank2	UTSW	3	126,730,302 (GRCm39)	missense	possibly damaging	0.77
R7462:Ank2	UTSW	3	126,736,683 (GRCm39)	missense	unknown
R7490:Ank2	UTSW	3	126,752,538 (GRCm39)	missense	probably damaging	0.99
R7514:Ank2	UTSW	3	126,819,252 (GRCm39)	missense	probably benign	0.06
R7534:Ank2	UTSW	3	126,727,982 (GRCm39)	splice site	probably null
R7540:Ank2	UTSW	3	126,781,808 (GRCm39)	missense	possibly damaging	0.94
R7547:Ank2	UTSW	3	126,738,852 (GRCm39)	missense	unknown
R7579:Ank2	UTSW	3	126,740,047 (GRCm39)	missense	unknown
R7584:Ank2	UTSW	3	126,739,777 (GRCm39)	nonsense	probably null
R7625:Ank2	UTSW	3	126,846,449 (GRCm39)	missense	probably damaging	1.00
R7698:Ank2	UTSW	3	126,825,860 (GRCm39)	missense	probably benign	0.35
R7716:Ank2	UTSW	3	126,736,815 (GRCm39)	missense	unknown
R7718:Ank2	UTSW	3	126,758,662 (GRCm39)	missense	possibly damaging	0.88
R7722:Ank2	UTSW	3	126,822,951 (GRCm39)	missense	probably benign	0.01
R7738:Ank2	UTSW	3	126,741,271 (GRCm39)	missense
R7977:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R7987:Ank2	UTSW	3	126,739,356 (GRCm39)	missense	unknown
R8007:Ank2	UTSW	3	126,730,096 (GRCm39)	intron	probably benign
R8150:Ank2	UTSW	3	126,741,162 (GRCm39)	missense
R8161:Ank2	UTSW	3	126,825,778 (GRCm39)	missense
R8196:Ank2	UTSW	3	126,723,532 (GRCm39)	missense	probably damaging	0.99
R8248:Ank2	UTSW	3	126,731,434 (GRCm39)	missense	possibly damaging	0.78
R8255:Ank2	UTSW	3	126,740,398 (GRCm39)	missense	unknown
R8279:Ank2	UTSW	3	126,726,820 (GRCm39)	missense	probably benign	0.04
R8300:Ank2	UTSW	3	126,804,555 (GRCm39)	missense
R8716:Ank2	UTSW	3	126,736,488 (GRCm39)	nonsense	probably null
R8724:Ank2	UTSW	3	126,737,405 (GRCm39)	missense	unknown
R8765:Ank2	UTSW	3	126,850,731 (GRCm39)	missense	possibly damaging	0.94
R8779:Ank2	UTSW	3	126,758,751 (GRCm39)	missense	probably damaging	0.99
R8783:Ank2	UTSW	3	126,846,455 (GRCm39)	missense	probably damaging	1.00
R8785:Ank2	UTSW	3	126,791,570 (GRCm39)	missense	probably damaging	1.00
R8826:Ank2	UTSW	3	126,740,951 (GRCm39)	missense	unknown
R8872:Ank2	UTSW	3	126,791,525 (GRCm39)	missense	possibly damaging	0.88
R8903:Ank2	UTSW	3	126,840,431 (GRCm39)	missense	probably damaging	1.00
R8906:Ank2	UTSW	3	126,726,720 (GRCm39)	missense	probably benign	0.00
R8918:Ank2	UTSW	3	126,737,380 (GRCm39)	missense	unknown
R8947:Ank2	UTSW	3	126,736,396 (GRCm39)	intron	probably benign
R8977:Ank2	UTSW	3	126,738,575 (GRCm39)	missense	unknown
R8990:Ank2	UTSW	3	126,841,829 (GRCm39)	critical splice donor site	probably null
R8994:Ank2	UTSW	3	126,723,471 (GRCm39)	missense	probably benign	0.19
R9009:Ank2	UTSW	3	126,728,025 (GRCm39)	unclassified	probably benign
R9123:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9125:Ank2	UTSW	3	126,733,744 (GRCm39)	missense	probably damaging	1.00
R9130:Ank2	UTSW	3	126,810,565 (GRCm39)	missense
R9175:Ank2	UTSW	3	126,722,402 (GRCm39)	missense	possibly damaging	0.52
R9220:Ank2	UTSW	3	126,737,086 (GRCm39)	missense	unknown
R9225:Ank2	UTSW	3	126,736,111 (GRCm39)	missense	unknown
R9286:Ank2	UTSW	3	126,846,381 (GRCm39)	missense	probably damaging	0.99
R9325:Ank2	UTSW	3	126,775,504 (GRCm39)	missense	probably damaging	0.98
R9367:Ank2	UTSW	3	126,738,678 (GRCm39)	missense	unknown
R9385:Ank2	UTSW	3	126,753,366 (GRCm39)	missense	probably benign	0.00
R9391:Ank2	UTSW	3	126,731,394 (GRCm39)	missense	probably damaging	0.99
R9422:Ank2	UTSW	3	126,890,505 (GRCm39)	missense	unknown
R9536:Ank2	UTSW	3	126,736,031 (GRCm39)	missense	unknown
R9647:Ank2	UTSW	3	126,792,623 (GRCm39)	missense	possibly damaging	0.93
R9650:Ank2	UTSW	3	126,735,829 (GRCm39)	missense	unknown
R9666:Ank2	UTSW	3	126,726,838 (GRCm39)	nonsense	probably null
R9686:Ank2	UTSW	3	126,740,550 (GRCm39)	missense	unknown
R9730:Ank2	UTSW	3	127,019,493 (GRCm39)	missense
R9738:Ank2	UTSW	3	126,737,121 (GRCm39)	missense	unknown
R9743:Ank2	UTSW	3	126,733,794 (GRCm39)	missense	possibly damaging	0.81
R9747:Ank2	UTSW	3	126,752,667 (GRCm39)	missense	probably damaging	1.00
R9800:Ank2	UTSW	3	126,740,149 (GRCm39)	missense	unknown
R9803:Ank2	UTSW	3	126,752,726 (GRCm39)	missense	possibly damaging	0.64
RF020:Ank2	UTSW	3	126,739,125 (GRCm39)	missense	unknown
Z1088:Ank2	UTSW	3	126,823,158 (GRCm39)	missense	possibly damaging	0.45
Z1177:Ank2	UTSW	3	126,738,006 (GRCm39)	missense	unknown
Z1187:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1190:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00
Z1192:Ank2	UTSW	3	126,749,601 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGGTAGAATGGCCTCACACAACAC -3'
(R):5'- GGATTTTCAGTCCTTCCAGACGAGC -3'

Sequencing Primer
(F):5'- CAGCCTACAGGGCACTATGAG -3'
(R):5'- AGCTCTGTGCTGCCAAG -3'

Posted On

2013-04-11