Mutagenetix > Incidental Mutation

Incidental Mutation 'R1785:Chil1'

196211

Institutional Source

Beutler Lab

Gene Symbol

Chil1

Ensembl Gene

ENSMUSG00000064246

Gene Name

chitinase-like 1

Synonyms

Brp39, Gp39, Chi3l1

MMRRC Submission

039816-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R1785 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

134182176-134190181 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 134188529 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 250 (A250V)

Ref Sequence

ENSEMBL: ENSMUSP00000117117 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038445] [ENSMUST00000082060] [ENSMUST00000132873] [ENSMUST00000133701] [ENSMUST00000153856] [ENSMUST00000156873] [ENSMUST00000191577]

AlphaFold

Q61362

Predicted Effect

probably benign
Transcript: ENSMUST00000038445

SMART Domains

Protein: ENSMUSP00000042195
Gene: ENSMUSG00000042451

Domain	Start	End	E-Value	Type
low complexity region	41	66	N/A	INTRINSIC
FN3	77	160	4.84e-9	SMART
IG	187	270	9.78e-7	SMART
FN3	273	355	1.1e-7	SMART
IGc2	400	467	1.38e-6	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000082060
AA Change: A258V

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000080717
Gene: ENSMUSG00000064246
AA Change: A258V

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
Glyco_18	30	366	1.2e-143	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132873

SMART Domains

Protein: ENSMUSP00000118289
Gene: ENSMUSG00000064246

Domain	Start	End	E-Value	Type
Pfam:Glyco_hydro_18	2	110	4.4e-33	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000133701

SMART Domains

Protein: ENSMUSP00000121471
Gene: ENSMUSG00000064246

Domain	Start	End	E-Value	Type
Pfam:Glyco_hydro_18	2	106	2e-32	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134812

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139254

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144819

Predicted Effect

probably damaging
Transcript: ENSMUST00000153856
AA Change: A250V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000117117
Gene: ENSMUSG00000064246
AA Change: A250V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Glyco_18	22	358	1.2e-143	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000156873
AA Change: A248V

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000119205
Gene: ENSMUSG00000064246
AA Change: A248V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Glyco_18	20	356	1.2e-143	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000191577

SMART Domains

Protein: ENSMUSP00000141104
Gene: ENSMUSG00000042451

Domain	Start	End	E-Value	Type
low complexity region	41	66	N/A	INTRINSIC
FN3	77	160	4.84e-9	SMART
IG	187	270	9.78e-7	SMART
FN3	273	355	1.1e-7	SMART
IGc2	400	467	1.38e-6	SMART

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.6%
20x: 93.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygous null mice show impaired OVA-induced Th2 responses with reduced splenocyte proliferation, cytokine production and IgE levels, impaired dendritic cell recruitment, higher CD4 T cell, macrophage and eosinophil apoptosis, and reduced CD4 T cell and alternatively activated macrophage numbers. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 243 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9030624J02Rik	T	C	7: 118,794,575	Y516H	probably damaging	Het
Abcc4	G	A	14: 118,553,349	R749C	probably damaging	Het
Acot11	T	C	4: 106,762,035	E201G	probably damaging	Het
Adgrf4	C	T	17: 42,666,898	R518Q	possibly damaging	Het
Akap13	G	T	7: 75,611,434	A1269S	probably benign	Het
Aldh4a1	T	C	4: 139,644,128	V451A	probably benign	Het
Aox3	A	G	1: 58,169,843	H845R	probably damaging	Het
Arhgap23	A	G	11: 97,451,561	D223G	possibly damaging	Het
Asb6	G	A	2: 30,827,076	R46W	probably damaging	Het
Aspm	A	G	1: 139,473,574	I1111V	probably benign	Het
C4bp	C	G	1: 130,642,988	V284L	probably benign	Het
Cacna1s	T	C	1: 136,118,716	F1761S	probably benign	Het
Cad	T	A	5: 31,058,072	F76I	probably damaging	Het
Camsap2	C	T	1: 136,281,315	R802Q	probably benign	Het
Capn11	A	G	17: 45,638,697	S448P	probably benign	Het
Capn9	G	A	8: 124,605,711	G430R	possibly damaging	Het
Cbx5	G	A	15: 103,213,124	R29C	probably null	Het
Ccdc93	C	T	1: 121,456,126	P192L	probably benign	Het
Ccdc93	T	C	1: 121,461,939	V237A	probably benign	Het
Cd55	C	T	1: 130,449,423	V333I	probably benign	Het
Cd55	C	A	1: 130,459,633	A143S	probably benign	Het
Cdh19	C	A	1: 110,893,384	E541D	probably damaging	Het
Cdh7	C	G	1: 110,065,735	L307V	possibly damaging	Het
Cfh	C	T	1: 140,147,697	V268I	possibly damaging	Het
Cfh	T	C	1: 140,136,788	K374R	probably benign	Het
Cfhr2	A	G	1: 139,813,442	M265T	probably benign	Het
Cfhr2	A	C	1: 139,813,459	N259K	probably benign	Het
Cntnap5a	C	A	1: 116,455,004	L1001I	probably benign	Het
Cntnap5a	T	C	1: 116,455,101	L1033S	probably benign	Het
Cntnap5a	C	T	1: 116,455,143	T1047I	probably benign	Het
Cntnap5c	A	G	17: 58,162,291	I623V	probably benign	Het
Cntrl	CAGAG	CAG	2: 35,122,806		probably null	Het
Crb1	T	C	1: 139,234,779	M1214V	probably benign	Het
Crb1	A	T	1: 139,237,622	H921Q	probably benign	Het
Crb1	G	A	1: 139,241,138	P881S	probably damaging	Het
Crb1	C	T	1: 139,242,995	G825R	probably damaging	Het
Crb1	C	T	1: 139,243,417	R684H	probably benign	Het
Crocc	T	C	4: 141,021,802	D1564G	probably damaging	Het
Csf1r	A	T	18: 61,129,077	M802L	probably damaging	Het
Cxcr4	C	T	1: 128,589,277	V216I	probably benign	Het
Cyb5r1	C	T	1: 134,407,667	R147W	probably damaging	Het
Daxx	T	C	17: 33,911,842	I277T	probably damaging	Het
Dctn4	T	C	18: 60,546,335		probably null	Het
Ddx59	T	C	1: 136,417,053	V154A	probably benign	Het
Dnah5	A	G	15: 28,313,786	Q1916R	probably damaging	Het
Dnah8	T	C	17: 30,722,937	V1719A	probably damaging	Het
Dsel	T	C	1: 111,859,457	N1116S	probably benign	Het
Dsel	G	C	1: 111,859,994	T937S	probably benign	Het
Dstyk	C	T	1: 132,456,984	L739F	probably damaging	Het
En1	A	G	1: 120,603,621	S197G	unknown	Het
Enah	A	T	1: 181,956,429	M105K	unknown	Het
Epm2a	A	G	10: 11,343,682	E71G	probably benign	Het
Etnk2	C	A	1: 133,365,587	D89E	probably benign	Het
Etnk2	G	T	1: 133,365,765	G149W	probably damaging	Het
Etnk2	C	T	1: 133,365,816	R166*	probably null	Het
Etnk2	G	A	1: 133,365,817	R166Q	probably benign	Het
Etnk2	T	A	1: 133,376,915	V292E	probably benign	Het
Etnk2	A	G	1: 133,363,923	S54G	probably benign	Het
Eya1	A	G	1: 14,170,974	V573A	probably benign	Het
Faim2	A	G	15: 99,512,542	L235P	probably damaging	Het
Fam221b	T	A	4: 43,665,537	H307L	probably damaging	Het
Fam72a	T	C	1: 131,530,668	I56T	probably benign	Het
Fam72a	C	T	1: 131,538,895	T139M	probably benign	Het
Fbxw10	T	A	11: 62,859,857	I422N	probably damaging	Het
Fcamr	A	G	1: 130,804,569	R98G	probably benign	Het
Fcamr	A	C	1: 130,804,627	N117T	probably benign	Het
Fcamr	A	G	1: 130,811,580	I206V	probably benign	Het
Fcamr	G	A	1: 130,812,629	G262S	probably benign	Het
Fcamr	A	G	1: 130,812,692	I283V	probably benign	Het
Fcamr	T	C	1: 130,812,738	V298A	probably benign	Het
Fcamr	A	G	1: 130,812,809	M322V	probably benign	Het
Fcamr	C	T	1: 130,812,816	P324L	probably benign	Het
Fcamr	A	G	1: 130,814,597	N574D	probably benign	Het
Fcmr	A	G	1: 130,875,974	T172A	probably benign	Het
Fcmr	T	C	1: 130,878,269	S321P	probably benign	Het
Foxn4	C	T	5: 114,263,132	D37N	probably damaging	Het
Gabarap	C	T	11: 69,991,689		probably benign	Het
Gemin4	G	C	11: 76,211,050	P962A	probably damaging	Het
Gli2	C	T	1: 118,868,087	A113T	possibly damaging	Het
Gli2	G	T	1: 119,002,044	H44Q	probably benign	Het
Glrx2	C	T	1: 143,739,740	A27V	possibly damaging	Het
Gm10563	C	T	4: 155,635,880		probably benign	Het
Gm28040	AGTG	AGTGGCACCTTTGGTG	1: 133,327,321		probably benign	Het
Gm8374	T	C	14: 7,364,194	T49A	probably damaging	Het
Golim4	A	T	3: 75,908,149	V116D	probably damaging	Het
Gper1	C	T	5: 139,426,722	P274L	probably damaging	Het
Gpr132	A	G	12: 112,852,403	S268P	probably damaging	Het
Gpr25	G	A	1: 136,260,710	P55L	probably benign	Het
Grm7	G	C	6: 111,358,295	D556H	probably damaging	Het
H2-K1	C	A	17: 33,997,348	E275*	probably null	Het
Ift20	G	A	11: 78,540,034	E68K	probably damaging	Het
Igfn1	G	A	1: 135,959,928	P2466L	probably damaging	Het
Igfn1	G	A	1: 135,968,199	A1543V	probably benign	Het
Igfn1	T	C	1: 135,970,411	S806G	probably benign	Het
Igfn1	C	T	1: 135,972,127	R482Q	probably benign	Het
Igfn1	C	T	1: 135,979,915	A231T	probably benign	Het
Igfn1	G	A	1: 135,982,475	R124W	probably benign	Het
Igfn1	T	C	1: 135,998,625	E29G	probably benign	Het
Igfn1	T	C	1: 135,998,683	I10V	unknown	Het
Ikbke	C	A	1: 131,265,937	A459S	probably benign	Het
Ikbke	T	C	1: 131,269,823	S447G	probably benign	Het
Insrr	G	A	3: 87,810,572		probably null	Het
Ipo9	TCC	TCCGCC	1: 135,386,281		probably benign	Het
Ipo9	ATCCTCCTCCTCCTCCTC	ATCCTCCTCCTCCTCCTCCTC	1: 135,386,268		probably benign	Het
Ipo9	A	G	1: 135,402,250	V484A	probably benign	Het
Jarid2	T	A	13: 44,906,276	N661K	probably damaging	Het
Kcnt2	G	A	1: 140,354,547	S90N	probably benign	Het
Kif14	A	G	1: 136,468,279	N108D	probably benign	Het
Kif14	A	G	1: 136,468,975	K340E	probably damaging	Het
Kif14	G	A	1: 136,478,365	A556T	probably benign	Het
Kif14	A	G	1: 136,490,332	S868G	probably benign	Het
Kif14	C	T	1: 136,503,431	L1189F	probably benign	Het
Kif14	T	C	1: 136,515,961	F1291L	probably benign	Het
Kif14	T	C	1: 136,525,783	V1433A	probably benign	Het
Kmt2a	G	A	9: 44,819,675		probably benign	Het
Krtap16-1	A	T	11: 99,985,776	C267*	probably null	Het
Lad1	C	T	1: 135,827,381	P132S	possibly damaging	Het
Lad1	C	T	1: 135,828,023	R346C	probably damaging	Het
Lax1	T	C	1: 133,679,978	R342G	probably benign	Het
Lax1	T	C	1: 133,680,569	N145D	probably benign	Het
Lax1	G	A	1: 133,683,634	P67S	probably damaging	Het
Lgr6	C	T	1: 134,987,088	V641I	probably benign	Het
Lgr6	G	T	1: 134,990,635	H263N	probably benign	Het
Lgr6	C	T	1: 135,003,476	S3N	probably benign	Het
Lgr6	A	T	1: 134,988,009	S334T	probably benign	Het
Lhx6	G	T	2: 36,087,458	C327*	probably null	Het
Lifr	A	G	15: 7,181,856	D625G	possibly damaging	Het
Lman1	A	T	18: 65,991,582	M362K	probably damaging	Het
Lmod1	C	T	1: 135,364,073	T222I	probably benign	Het
Lmtk2	C	T	5: 144,174,988	T842I	possibly damaging	Het
Lpin3	T	A	2: 160,896,809	L227*	probably null	Het
Magel2	A	T	7: 62,377,738	H130L	unknown	Het
Mki67	T	A	7: 135,704,241		probably null	Het
Mnx1	T	A	5: 29,474,189	S299C	unknown	Het
Mov10	A	T	3: 104,818,116	I59N	possibly damaging	Het
Mpo	A	G	11: 87,797,361	D282G	possibly damaging	Het
Mroh3	G	C	1: 136,192,144	Q440E	possibly damaging	Het
Mybph	C	T	1: 134,197,480	R249C	probably benign	Het
Myo7b	T	C	18: 31,994,897	I581V	probably benign	Het
Nav1	A	T	1: 135,584,727	D198E	possibly damaging	Het
Ncdn	T	A	4: 126,745,273		probably null	Het
Ndufa4	A	T	6: 11,900,575	V37E	probably benign	Het
Nop9	T	C	14: 55,751,142	L347P	probably damaging	Het
Nr5a2	C	A	1: 136,952,125	R35L	probably benign	Het
Nrp1	A	T	8: 128,498,516	E782D	probably damaging	Het
Obsl1	G	A	1: 75,486,756	T1764M	probably benign	Het
Olfr1240	C	T	2: 89,439,583	R232H	probably benign	Het
Olfr195	A	G	16: 59,149,297	Y149C	probably damaging	Het
Olfr279	A	T	15: 98,497,835	D121V	probably damaging	Het
Olfr341	A	G	2: 36,480,047	S28P	possibly damaging	Het
Olfr372	A	G	8: 72,058,436	Y252C	probably damaging	Het
Optc	A	T	1: 133,903,796		probably null	Het
Optc	C	G	1: 133,905,170	S64T	probably benign	Het
Pard6g	T	C	18: 80,117,308	V212A	probably damaging	Het
Pbx1	T	G	1: 168,431,378	I43L	probably benign	Het
Phf2	T	C	13: 48,817,567	D543G	unknown	Het
Pigr	C	T	1: 130,844,522	A159V	possibly damaging	Het
Pik3c2b	C	T	1: 133,066,627	P110S	probably benign	Het
Pkd1	T	C	17: 24,591,099	V3558A	probably benign	Het
Pla2g6	T	C	15: 79,306,345	Y339C	probably benign	Het
Plcb1	T	A	2: 135,325,667	Y460*	probably null	Het
Plekha6	C	G	1: 133,287,846	T792S	probably benign	Het
Ppard	T	G	17: 28,298,481		probably null	Het
Ppfia4	G	A	1: 134,299,321	P1159S	probably benign	Het
Ppm1f	A	G	16: 16,910,970	T79A	probably benign	Het
Prelp	C	T	1: 133,915,131	R92K	probably benign	Het
Ptgdr	A	T	14: 44,858,579	Y225*	probably null	Het
Ptpn22	A	G	3: 103,874,052	I90V	probably damaging	Het
Ptpn7	A	G	1: 135,134,475	Q53R	probably benign	Het
Ptprc	T	G	1: 138,099,676	N478T	probably benign	Het
Ptprc	A	G	1: 138,107,823	S405P	probably benign	Het
Ptprc	C	A	1: 138,107,824	E402D	probably benign	Het
Ptprc	A	G	1: 138,107,837	V400A	probably benign	Het
Ptprc	T	C	1: 138,112,254	K212E	possibly damaging	Het
Pus7l	T	C	15: 94,540,637	N109S	probably benign	Het
Rab29	A	G	1: 131,872,110	Q141R	probably benign	Het
Ren1	C	G	1: 133,350,778		probably null	Het
Ren1	T	A	1: 133,354,206	W22R	probably damaging	Het
Ren1	C	T	1: 133,354,237	T32I	probably benign	Het
Ren1	A	T	1: 133,359,079	E315D	probably benign	Het
Ren1	A	T	1: 133,359,983	N352Y	probably benign	Het
Ren1	C	G	1: 133,360,007	L360V	probably benign	Het
Rfwd3	A	T	8: 111,297,402	V96E	probably benign	Het
Ripk4	A	C	16: 97,750,131	V149G	probably damaging	Het
Rnpep	C	T	1: 135,263,096	A571T	possibly damaging	Het
Rnpep	G	C	1: 135,283,977	A11G	probably benign	Het
Rora	G	A	9: 69,376,837	A396T	probably benign	Het
Scap	C	T	9: 110,374,055	L266F	probably damaging	Het
Scn5a	A	T	9: 119,521,129	I893N	probably damaging	Het
Sctr	G	T	1: 120,063,246	E453D	probably benign	Het
Sctr	T	C	1: 120,031,656	F110L	probably benign	Het
Sctr	G	A	1: 120,063,257	S440N	possibly damaging	Het
Sept4	A	T	11: 87,583,436	Q60L	probably benign	Het
Serpinb10	C	T	1: 107,538,473	S63F	probably damaging	Het
Serpinb2	G	A	1: 107,515,635	A55T	probably damaging	Het
Serpinb2	C	A	1: 107,523,834	A239E	probably benign	Het
Serpinb2	C	T	1: 107,523,890	H258Y	probably benign	Het
Serpinb2	C	T	1: 107,523,894	T259I	probably benign	Het
Serpinb2	A	C	1: 107,524,543	S284R	probably benign	Het
Serpinb8	A	G	1: 107,597,527	S20G	probably benign	Het
Serpinb8	G	A	1: 107,598,954	A75T	probably benign	Het
Serpinb8	A	C	1: 107,607,004	L268F	probably benign	Het
Slc26a9	C	T	1: 131,763,870	A617V	probably benign	Het
Slc26a9	C	A	1: 131,766,012	R747S	probably benign	Het
Slc9a4	T	G	1: 40,607,741		probably null	Het
Slc9a9	A	T	9: 95,019,193	N393I	possibly damaging	Het
Stard13	T	C	5: 151,045,168	Y879C	probably damaging	Het
Steap3	T	C	1: 120,227,750	N493S	probably benign	Het
Steap3	G	A	1: 120,234,378	A350V	probably benign	Het
Synj1	G	T	16: 90,964,517	A687D	probably damaging	Het
Tacc1	A	T	8: 25,164,493	N271K	probably damaging	Het
Tbx1	A	C	16: 18,585,129	F138V	probably damaging	Het
Tecpr1	T	A	5: 144,208,645	T595S	probably benign	Het
Thsd7b	C	T	1: 129,628,891	T328I	probably damaging	Het
Thsd7b	T	A	1: 129,667,937	F498Y	probably benign	Het
Thsd7b	G	C	1: 129,678,183	A554P	probably benign	Het
Thsd7b	A	C	1: 130,116,631	Q1116P	probably benign	Het
Tnnt2	C	T	1: 135,845,506		probably benign	Het
Trappc8	A	G	18: 20,834,940		probably null	Het
Trim33	AGACTG	A	3: 103,329,220		probably null	Het
Trim41	C	A	11: 48,807,592	G516W	probably damaging	Het
Trove2	C	T	1: 143,760,014	V465I	probably benign	Het
Trove2	T	C	1: 143,760,034	D458G	probably benign	Het
Ttn	C	T	2: 76,813,339	G11436R	probably damaging	Het
Ttn	A	C	2: 76,885,926		probably null	Het
Txk	T	A	5: 72,696,579	T472S	probably damaging	Het
Ube2t	C	T	1: 134,972,167	A149V	probably benign	Het
Ubr4	T	A	4: 139,423,945	M1897K	probably damaging	Het
Uggt2	A	G	14: 119,061,376	L391P	probably damaging	Het
Vmn2r55	A	T	7: 12,668,184	D392E	probably damaging	Het
Vps13b	A	G	15: 35,879,791	Y3004C	probably damaging	Het
Vps26a	A	T	10: 62,468,397	D180E	probably benign	Het
Wisp1	G	A	15: 66,906,489	C53Y	probably damaging	Het
Xirp1	T	G	9: 120,016,907	Q970P	probably benign	Het
Zbtb46	C	T	2: 181,391,431	C479Y	probably damaging	Het
Zc3h11a	G	A	1: 133,622,154	P695S	probably benign	Het
Zc3h11a	C	T	1: 133,624,621	V583I	probably benign	Het
Zdhhc13	T	A	7: 48,824,644	L548Q	possibly damaging	Het
Zfp236	T	C	18: 82,621,304	M1225V	probably benign	Het
Zfp281	GCGGCAGCTCCGGCAGC	GCGGCAGCTCCGGCAGCTCCGGCAGC	1: 136,625,353		probably benign	Het
Zfyve26	T	A	12: 79,268,434	I1423F	possibly damaging	Het
Zp3r	A	G	1: 130,596,814	L164P	probably benign	Het
Zp3r	C	A	1: 130,619,414	E8D	possibly damaging	Het

Other mutations in Chil1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00977:Chil1	APN	1	134187973	missense	possibly damaging	0.89
IGL01305:Chil1	APN	1	134182816	splice site	probably benign
IGL02051:Chil1	APN	1	134184149	missense	probably damaging	1.00
IGL02724:Chil1	APN	1	134189243	missense	probably damaging	1.00
IGL02754:Chil1	APN	1	134183601	missense	probably damaging	1.00
R0071:Chil1	UTSW	1	134185279	missense	probably benign	0.08
R0071:Chil1	UTSW	1	134185279	missense	probably benign	0.08
R0662:Chil1	UTSW	1	134188573	missense	probably damaging	1.00
R1263:Chil1	UTSW	1	134189242	missense	probably benign	0.02
R1728:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1729:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1730:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1739:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1762:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1783:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R1784:Chil1	UTSW	1	134188529	missense	probably damaging	1.00
R4992:Chil1	UTSW	1	134188626	missense	probably benign	0.03
R5860:Chil1	UTSW	1	134185171	missense	probably benign	0.00
R6019:Chil1	UTSW	1	134189572	missense	probably benign	0.00
R6320:Chil1	UTSW	1	134182258	start codon destroyed	probably null	0.07
R7748:Chil1	UTSW	1	134189228	missense	probably benign	0.00
R8419:Chil1	UTSW	1	134189542	missense	probably damaging	1.00
R8992:Chil1	UTSW	1	134187924	missense	probably benign	0.01
R9051:Chil1	UTSW	1	134184181	critical splice donor site	probably null
R9238:Chil1	UTSW	1	134187947	missense	probably damaging	1.00
R9509:Chil1	UTSW	1	134188675	missense	probably damaging	1.00
RF012:Chil1	UTSW	1	134185171	missense	probably benign
X0025:Chil1	UTSW	1	134183632	missense	possibly damaging	0.62
Z1088:Chil1	UTSW	1	134189500	missense	probably benign	0.00
Z1176:Chil1	UTSW	1	134182779	critical splice acceptor site	probably null
Z1176:Chil1	UTSW	1	134189230	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- TTGCACCACGTAACTGTCTTCGCTG -3'
(R):5'- GCTGCTATTGCCCAAGGGCTTTAG -3'

Sequencing Primer
(F):5'- GCATCTGTCTCAGCAGGATTAG -3'
(R):5'- GTCCACAGAGATTCTTGACCATTG -3'

Posted On

2014-05-23