Mutagenetix > Incidental Mutation

Incidental Mutation 'R0081:Dock10'

19653

Institutional Source

Beutler Lab

Gene Symbol

Dock10

Ensembl Gene

ENSMUSG00000038608

Gene Name

dedicator of cytokinesis 10

Synonyms

Zizimin3, A630054M16Rik, Jr5, ZIZ3, Jr4, 9330153B10Rik

MMRRC Submission

038368-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.487) question?

Stock #

R0081 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

80478790-80736244 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 80584295 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 137 (D137G)

Ref Sequence

ENSEMBL: ENSMUSP00000140513 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077946] [ENSMUST00000186087] [ENSMUST00000187774] [ENSMUST00000190983] [ENSMUST00000191449]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077946
AA Change: D155G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000077099
Gene: ENSMUSG00000038608
AA Change: D155G

Domain	Start	End	E-Value	Type
low complexity region	25	42	N/A	INTRINSIC
Pfam:DUF3398	61	153	1.7e-36	PFAM
PH	182	292	8.5e-17	SMART
Blast:PH	350	458	7e-18	BLAST
Pfam:DOCK-C2	668	859	1e-50	PFAM
low complexity region	1269	1279	N/A	INTRINSIC
low complexity region	1284	1295	N/A	INTRINSIC
Pfam:DHR-2	1592	2143	1.3e-216	PFAM
low complexity region	2174	2187	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000186087
AA Change: D168G

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000140102
Gene: ENSMUSG00000038608
AA Change: D168G

Domain	Start	End	E-Value	Type
Pfam:DUF3398	71	166	1.5e-29	PFAM
PH	195	305	3.9e-19	SMART
Blast:PH	363	475	3e-18	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000187774
AA Change: D143G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000140085
Gene: ENSMUSG00000038608
AA Change: D143G

Domain	Start	End	E-Value	Type
Pfam:DUF3398	46	141	9e-29	PFAM
PH	170	280	3.9e-19	SMART
Blast:PH	338	446	7e-18	BLAST
Pfam:DOCK-C2	655	848	1.5e-54	PFAM
low complexity region	1257	1267	N/A	INTRINSIC
low complexity region	1272	1283	N/A	INTRINSIC
low complexity region	1870	1890	N/A	INTRINSIC
Pfam:Ded_cyto	1954	2131	3.4e-65	PFAM
low complexity region	2162	2175	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000190983
AA Change: D142G

PolyPhen 2 Score 0.857 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000140719
Gene: ENSMUSG00000038608
AA Change: D142G

Domain	Start	End	E-Value	Type
Pfam:DUF3398	45	140	8.9e-29	PFAM
PH	169	279	3.9e-19	SMART
Blast:PH	337	445	7e-18	BLAST
Pfam:DOCK-C2	654	847	1.5e-54	PFAM
low complexity region	1256	1266	N/A	INTRINSIC
low complexity region	1271	1282	N/A	INTRINSIC
low complexity region	1869	1889	N/A	INTRINSIC
Pfam:Ded_cyto	1953	2130	3.4e-65	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000191449
AA Change: D137G

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000140513
Gene: ENSMUSG00000038608
AA Change: D137G

Domain	Start	End	E-Value	Type
Pfam:DUF3398	40	135	1.1e-32	PFAM
PH	164	274	8.5e-17	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191505

Meta Mutation Damage Score

0.6925

Coding Region Coverage

1x: 99.0%
3x: 97.2%
10x: 88.5%
20x: 63.6%

Validation Efficiency

94% (159/169)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,271,703 (GRCm39)	D485G	probably damaging	Het
Adamts19	T	C	18: 59,036,137 (GRCm39)		probably null	Het
Adgrd1	A	T	5: 129,255,146 (GRCm39)	I598F	probably damaging	Het
Adh5	A	G	3: 138,157,174 (GRCm39)	D245G	probably benign	Het
Adra2b	T	C	2: 127,206,212 (GRCm39)	V238A	probably benign	Het
Ank1	G	A	8: 23,606,258 (GRCm39)	V1188I	possibly damaging	Het
Asap1	C	T	15: 63,971,413 (GRCm39)	G905D	probably damaging	Het
AW554918	T	C	18: 25,477,959 (GRCm39)	V428A	probably benign	Het
Birc6	T	A	17: 74,950,436 (GRCm39)	S3226T	probably benign	Het
Cdh17	A	T	4: 11,785,280 (GRCm39)		probably benign	Het
Cyfip2	A	T	11: 46,144,825 (GRCm39)	Y676*	probably null	Het
Dcaf17	T	A	2: 70,908,812 (GRCm39)		probably benign	Het
Dclre1a	A	G	19: 56,531,139 (GRCm39)	F736L	probably damaging	Het
Ddx41	A	T	13: 55,683,193 (GRCm39)	H171Q	possibly damaging	Het
Dennd5b	G	T	6: 148,895,257 (GRCm39)	Q1258K	probably benign	Het
Dpyd	G	A	3: 118,737,904 (GRCm39)	V482I	probably benign	Het
Erich6	A	T	3: 58,543,547 (GRCm39)		probably benign	Het
Fam193b	A	G	13: 55,702,024 (GRCm39)		probably benign	Het
Foxp2	T	C	6: 15,405,643 (GRCm39)		probably benign	Het
Frmd4a	T	C	2: 4,577,252 (GRCm39)		probably null	Het
Gas2l2	A	G	11: 83,313,693 (GRCm39)	S540P	possibly damaging	Het
Glis2	T	C	16: 4,431,517 (GRCm39)	V348A	probably benign	Het
Gm14443	C	A	2: 175,011,729 (GRCm39)	G239V	probably damaging	Het
Gpr158	T	C	2: 21,831,528 (GRCm39)	V876A	probably damaging	Het
H1f8	A	G	6: 115,926,942 (GRCm39)	E273G	probably benign	Het
Hadh	C	T	3: 131,029,285 (GRCm39)	D245N	probably damaging	Het
Hk2	A	T	6: 82,711,957 (GRCm39)		probably benign	Het
Ice1	A	T	13: 70,767,163 (GRCm39)	Y108*	probably null	Het
Il10ra	T	G	9: 45,167,247 (GRCm39)	M435L	probably benign	Het
Inpp5k	GT	G	11: 75,521,973 (GRCm39)		probably null	Het
Kank4	G	T	4: 98,666,567 (GRCm39)	P627T	probably benign	Het
Kif16b	A	G	2: 142,549,346 (GRCm39)		probably benign	Het
Lipn	A	G	19: 34,054,376 (GRCm39)	I205V	probably benign	Het
Miox	C	T	15: 89,220,477 (GRCm39)	L189F	possibly damaging	Het
Myh1	T	C	11: 67,106,683 (GRCm39)	M1255T	probably benign	Het
Myl3	A	C	9: 110,596,997 (GRCm39)	D119A	probably damaging	Het
Myo1d	T	G	11: 80,448,349 (GRCm39)	K925N	probably benign	Het
Myoz1	T	A	14: 20,699,622 (GRCm39)	M239L	probably benign	Het
Ncoa6	TGC	TGCGC	2: 155,250,211 (GRCm39)		probably null	Het
Nf1	C	A	11: 79,344,805 (GRCm39)		probably benign	Het
Npepl1	C	T	2: 173,957,879 (GRCm39)	P239S	probably damaging	Het
Olfml1	A	G	7: 107,170,506 (GRCm39)	K131R	probably benign	Het
Or12k5	G	A	2: 36,895,462 (GRCm39)	L55F	probably damaging	Het
Or1e29	A	G	11: 73,667,935 (GRCm39)	F73L	possibly damaging	Het
Or1j15	T	A	2: 36,458,893 (GRCm39)	Y94*	probably null	Het
Or1j20	T	C	2: 36,760,022 (GRCm39)	L148S	possibly damaging	Het
Or4c10	T	A	2: 89,760,423 (GRCm39)	I90K	possibly damaging	Het
Or4f7	A	C	2: 111,644,213 (GRCm39)	I286S	probably damaging	Het
Or5p52	C	T	7: 107,502,212 (GRCm39)	T96I	probably benign	Het
Or6c202	C	T	10: 128,996,707 (GRCm39)	D49N	possibly damaging	Het
Pde7a	T	C	3: 19,295,697 (GRCm39)		probably benign	Het
Pik3c2g	T	C	6: 139,903,519 (GRCm39)	C591R	probably benign	Het
Pkn2	T	G	3: 142,559,343 (GRCm39)	K61Q	probably damaging	Het
Ppfia1	C	A	7: 144,058,711 (GRCm39)	G722C	probably damaging	Het
Ppp1cb	T	C	5: 32,644,958 (GRCm39)	V263A	probably damaging	Het
Rab11fip2	A	T	19: 59,895,567 (GRCm39)	N440K	possibly damaging	Het
Rbm34	T	A	8: 127,676,234 (GRCm39)	K340N	probably damaging	Het
Samd3	T	C	10: 26,147,399 (GRCm39)		probably benign	Het
Sfi1	TCGC	TC	11: 3,096,254 (GRCm39)		probably null	Het
Sigirr	T	C	7: 140,671,285 (GRCm39)	D399G	probably damaging	Het
Slc17a7	A	G	7: 44,824,371 (GRCm39)	E554G	probably benign	Het
Smc3	A	G	19: 53,589,993 (GRCm39)		probably benign	Het
Tdrd1	T	C	19: 56,819,703 (GRCm39)	Y68H	probably benign	Het
Tespa1	T	A	10: 130,196,719 (GRCm39)	L219Q	probably damaging	Het
Tmem144	G	A	3: 79,746,580 (GRCm39)		probably benign	Het
Ttc38	A	G	15: 85,740,673 (GRCm39)	S436G	probably benign	Het
Ttn	T	A	2: 76,581,423 (GRCm39)	I23157F	probably damaging	Het
Ubxn2b	T	A	4: 6,203,875 (GRCm39)		probably benign	Het
Vmn1r28	G	A	6: 58,242,702 (GRCm39)	A182T	probably benign	Het
Vmn2r72	T	C	7: 85,401,044 (GRCm39)	E125G	probably benign	Het
Vmn2r78	A	T	7: 86,572,235 (GRCm39)	D532V	probably benign	Het
Vwa8	C	A	14: 79,320,222 (GRCm39)	L1078I	probably benign	Het
Vwce	A	T	19: 10,641,453 (GRCm39)		probably null	Het
Zpr1	A	G	9: 46,190,995 (GRCm39)	D300G	probably damaging	Het

Other mutations in Dock10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00569:Dock10	APN	1	80,562,729 (GRCm39)	missense	probably damaging	1.00
IGL00783:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00784:Dock10	APN	1	80,550,166 (GRCm39)	splice site	probably benign
IGL00858:Dock10	APN	1	80,545,720 (GRCm39)	missense	possibly damaging	0.48
IGL01298:Dock10	APN	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
IGL01351:Dock10	APN	1	80,570,876 (GRCm39)	missense	probably damaging	1.00
IGL01356:Dock10	APN	1	80,501,459 (GRCm39)	missense	probably damaging	1.00
IGL01584:Dock10	APN	1	80,511,567 (GRCm39)	missense	probably damaging	0.99
IGL01619:Dock10	APN	1	80,612,015 (GRCm39)	splice site	probably benign
IGL01678:Dock10	APN	1	80,521,069 (GRCm39)	missense	probably damaging	1.00
IGL01759:Dock10	APN	1	80,503,990 (GRCm39)	missense	probably damaging	1.00
IGL02238:Dock10	APN	1	80,511,510 (GRCm39)	missense	probably damaging	0.99
IGL02352:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02359:Dock10	APN	1	80,483,378 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dock10	APN	1	80,562,711 (GRCm39)	critical splice donor site	probably null
IGL02433:Dock10	APN	1	80,507,905 (GRCm39)	missense	probably damaging	1.00
IGL02471:Dock10	APN	1	80,493,339 (GRCm39)	missense	probably damaging	0.99
IGL02645:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02646:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02648:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02649:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02650:Dock10	APN	1	80,551,840 (GRCm39)	missense	probably damaging	1.00
IGL02652:Dock10	APN	1	80,570,561 (GRCm39)	splice site	probably null
IGL02718:Dock10	APN	1	80,501,535 (GRCm39)	missense	probably benign	0.00
IGL02998:Dock10	APN	1	80,551,259 (GRCm39)	missense	probably damaging	1.00
IGL03057:Dock10	APN	1	80,545,088 (GRCm39)	missense	probably damaging	1.00
IGL03066:Dock10	APN	1	80,562,758 (GRCm39)	missense	probably benign	0.00
IGL03106:Dock10	APN	1	80,546,551 (GRCm39)	missense	probably damaging	0.98
IGL03148:Dock10	APN	1	80,518,075 (GRCm39)	missense	probably benign	0.01
IGL03271:Dock10	APN	1	80,483,126 (GRCm39)	missense	probably damaging	1.00
IGL03352:Dock10	APN	1	80,584,013 (GRCm39)	splice site	probably benign
LCD18:Dock10	UTSW	1	80,716,623 (GRCm38)	intron	probably benign
PIT4366001:Dock10	UTSW	1	80,573,438 (GRCm39)	missense	probably benign	0.30
PIT4581001:Dock10	UTSW	1	80,483,163 (GRCm39)	missense	probably damaging	1.00
R0019:Dock10	UTSW	1	80,583,642 (GRCm39)	missense	probably damaging	1.00
R0095:Dock10	UTSW	1	80,501,788 (GRCm39)	missense	probably benign	0.00
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0241:Dock10	UTSW	1	80,556,340 (GRCm39)	missense	probably benign
R0255:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R0267:Dock10	UTSW	1	80,490,171 (GRCm39)	missense	probably damaging	1.00
R0299:Dock10	UTSW	1	80,514,646 (GRCm39)	missense	probably damaging	0.99
R0365:Dock10	UTSW	1	80,573,400 (GRCm39)	missense	probably damaging	1.00
R0387:Dock10	UTSW	1	80,517,993 (GRCm39)	missense	probably damaging	1.00
R0403:Dock10	UTSW	1	80,501,787 (GRCm39)	missense	possibly damaging	0.94
R0408:Dock10	UTSW	1	80,518,193 (GRCm39)	missense	probably benign	0.03
R0414:Dock10	UTSW	1	80,513,650 (GRCm39)	missense	possibly damaging	0.93
R0591:Dock10	UTSW	1	80,518,936 (GRCm39)	splice site	probably benign
R0698:Dock10	UTSW	1	80,507,895 (GRCm39)	missense	probably damaging	1.00
R0711:Dock10	UTSW	1	80,501,692 (GRCm39)	missense	probably damaging	1.00
R0925:Dock10	UTSW	1	80,514,657 (GRCm39)	missense	probably benign	0.20
R1162:Dock10	UTSW	1	80,546,559 (GRCm39)	missense	possibly damaging	0.58
R1370:Dock10	UTSW	1	80,518,060 (GRCm39)	missense	probably damaging	1.00
R1440:Dock10	UTSW	1	80,526,853 (GRCm39)	missense	probably benign	0.03
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1469:Dock10	UTSW	1	80,490,275 (GRCm39)	missense	probably benign	0.05
R1525:Dock10	UTSW	1	80,583,881 (GRCm39)	critical splice donor site	probably null
R1544:Dock10	UTSW	1	80,570,352 (GRCm39)	missense	probably benign	0.00
R1601:Dock10	UTSW	1	80,527,519 (GRCm39)	missense	probably benign	0.00
R1757:Dock10	UTSW	1	80,511,586 (GRCm39)	missense	probably damaging	1.00
R1765:Dock10	UTSW	1	80,583,540 (GRCm39)	missense	probably damaging	1.00
R1783:Dock10	UTSW	1	80,551,897 (GRCm39)	missense	probably benign	0.17
R1823:Dock10	UTSW	1	80,520,814 (GRCm39)	splice site	probably null
R1827:Dock10	UTSW	1	80,508,009 (GRCm39)	missense	probably benign	0.07
R1844:Dock10	UTSW	1	80,520,918 (GRCm39)	missense	probably damaging	0.99
R1856:Dock10	UTSW	1	80,584,285 (GRCm39)	missense	possibly damaging	0.46
R1974:Dock10	UTSW	1	80,488,143 (GRCm39)	missense	possibly damaging	0.50
R2006:Dock10	UTSW	1	80,527,506 (GRCm39)	missense	possibly damaging	0.95
R2112:Dock10	UTSW	1	80,483,360 (GRCm39)	missense	probably damaging	0.99
R2112:Dock10	UTSW	1	80,483,359 (GRCm39)	missense	probably damaging	1.00
R2113:Dock10	UTSW	1	80,584,280 (GRCm39)	missense	probably damaging	1.00
R2439:Dock10	UTSW	1	80,510,149 (GRCm39)	missense	probably damaging	1.00
R2566:Dock10	UTSW	1	80,517,970 (GRCm39)	missense	possibly damaging	0.88
R3086:Dock10	UTSW	1	80,510,074 (GRCm39)	missense	possibly damaging	0.91
R3766:Dock10	UTSW	1	80,514,643 (GRCm39)	missense	probably damaging	0.99
R3768:Dock10	UTSW	1	80,510,085 (GRCm39)	missense	probably damaging	1.00
R4009:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R4016:Dock10	UTSW	1	80,584,286 (GRCm39)	missense	probably damaging	1.00
R4179:Dock10	UTSW	1	80,488,134 (GRCm39)	missense	probably benign	0.00
R4243:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4244:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4245:Dock10	UTSW	1	80,544,472 (GRCm39)	missense	probably benign	0.00
R4674:Dock10	UTSW	1	80,584,337 (GRCm39)	missense	possibly damaging	0.79
R4696:Dock10	UTSW	1	80,493,330 (GRCm39)	missense	possibly damaging	0.95
R4789:Dock10	UTSW	1	80,518,998 (GRCm39)	missense	probably damaging	1.00
R4851:Dock10	UTSW	1	80,526,874 (GRCm39)	missense	probably benign	0.33
R4911:Dock10	UTSW	1	80,583,953 (GRCm39)	missense	probably damaging	1.00
R4976:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5086:Dock10	UTSW	1	80,529,189 (GRCm39)	missense	possibly damaging	0.89
R5119:Dock10	UTSW	1	80,545,711 (GRCm39)	critical splice donor site	probably null
R5301:Dock10	UTSW	1	80,625,973 (GRCm39)	missense	probably benign	0.41
R5404:Dock10	UTSW	1	80,481,630 (GRCm39)	intron	probably benign
R5457:Dock10	UTSW	1	80,501,781 (GRCm39)	missense	probably damaging	1.00
R5790:Dock10	UTSW	1	80,482,887 (GRCm39)	missense	probably benign	0.00
R5845:Dock10	UTSW	1	80,483,459 (GRCm39)	intron	probably benign
R5871:Dock10	UTSW	1	80,519,057 (GRCm39)	critical splice acceptor site	probably null
R5873:Dock10	UTSW	1	80,551,855 (GRCm39)	missense	probably damaging	1.00
R5881:Dock10	UTSW	1	80,538,640 (GRCm39)	missense	probably benign	0.19
R5895:Dock10	UTSW	1	80,514,676 (GRCm39)	missense	probably benign
R5935:Dock10	UTSW	1	80,483,304 (GRCm39)	intron	probably benign
R5965:Dock10	UTSW	1	80,546,461 (GRCm39)	splice site	probably null
R5966:Dock10	UTSW	1	80,546,225 (GRCm39)	missense	possibly damaging	0.84
R6008:Dock10	UTSW	1	80,583,890 (GRCm39)	missense	probably damaging	0.98
R6029:Dock10	UTSW	1	80,514,663 (GRCm39)	missense	possibly damaging	0.68
R6083:Dock10	UTSW	1	80,510,148 (GRCm39)	missense	probably damaging	1.00
R6145:Dock10	UTSW	1	80,553,621 (GRCm39)	nonsense	probably null
R6257:Dock10	UTSW	1	80,481,413 (GRCm39)	intron	probably benign
R6274:Dock10	UTSW	1	80,516,540 (GRCm39)	missense	probably damaging	1.00
R6324:Dock10	UTSW	1	80,482,893 (GRCm39)	missense	probably benign	0.03
R6346:Dock10	UTSW	1	80,553,573 (GRCm39)	splice site	probably null
R6476:Dock10	UTSW	1	80,518,959 (GRCm39)	nonsense	probably null
R6516:Dock10	UTSW	1	80,518,178 (GRCm39)	missense	probably damaging	1.00
R6526:Dock10	UTSW	1	80,564,068 (GRCm39)	missense	probably damaging	0.97
R6534:Dock10	UTSW	1	80,481,388 (GRCm39)	missense	probably benign	0.01
R6620:Dock10	UTSW	1	80,570,355 (GRCm39)	missense	probably benign	0.01
R6640:Dock10	UTSW	1	80,511,555 (GRCm39)	nonsense	probably null
R6669:Dock10	UTSW	1	80,570,572 (GRCm39)	missense	probably damaging	1.00
R6672:Dock10	UTSW	1	80,490,248 (GRCm39)	missense	probably benign	0.00
R6679:Dock10	UTSW	1	80,544,514 (GRCm39)	missense	probably benign	0.11
R6682:Dock10	UTSW	1	80,490,338 (GRCm39)	missense	probably damaging	1.00
R6712:Dock10	UTSW	1	80,514,583 (GRCm39)	missense	probably benign	0.00
R6726:Dock10	UTSW	1	80,490,147 (GRCm39)	missense	probably damaging	1.00
R6788:Dock10	UTSW	1	80,508,962 (GRCm39)	missense	probably damaging	1.00
R6805:Dock10	UTSW	1	80,564,407 (GRCm39)	missense	probably benign
R6815:Dock10	UTSW	1	80,516,576 (GRCm39)	missense	possibly damaging	0.94
R6818:Dock10	UTSW	1	80,593,082 (GRCm39)	missense	possibly damaging	0.95
R6867:Dock10	UTSW	1	80,508,976 (GRCm39)	missense	probably damaging	1.00
R6964:Dock10	UTSW	1	80,481,365 (GRCm39)	intron	probably benign
R7026:Dock10	UTSW	1	80,479,504 (GRCm39)	missense	probably benign	0.40
R7084:Dock10	UTSW	1	80,481,573 (GRCm39)	missense
R7087:Dock10	UTSW	1	80,570,543 (GRCm39)	missense	probably benign
R7158:Dock10	UTSW	1	80,564,589 (GRCm39)	critical splice acceptor site	probably null
R7191:Dock10	UTSW	1	80,518,048 (GRCm39)	missense	possibly damaging	0.93
R7214:Dock10	UTSW	1	80,546,246 (GRCm39)	missense	probably benign	0.01
R7255:Dock10	UTSW	1	80,520,816 (GRCm39)	critical splice donor site	probably null
R7320:Dock10	UTSW	1	80,527,421 (GRCm39)	critical splice donor site	probably null
R7359:Dock10	UTSW	1	80,687,065 (GRCm39)	missense	probably benign	0.01
R7423:Dock10	UTSW	1	80,501,497 (GRCm39)	missense	possibly damaging	0.67
R7464:Dock10	UTSW	1	80,518,032 (GRCm39)	missense	probably damaging	0.99
R7483:Dock10	UTSW	1	80,493,283 (GRCm39)	missense	probably benign	0.01
R7487:Dock10	UTSW	1	80,562,765 (GRCm39)	missense	probably benign	0.00
R7789:Dock10	UTSW	1	80,536,930 (GRCm39)	missense	possibly damaging	0.82
R7943:Dock10	UTSW	1	80,626,006 (GRCm39)	missense	probably damaging	0.98
R7962:Dock10	UTSW	1	80,564,085 (GRCm39)	missense	possibly damaging	0.88
R8079:Dock10	UTSW	1	80,556,421 (GRCm39)	missense	probably benign	0.00
R8086:Dock10	UTSW	1	80,481,707 (GRCm39)	missense	probably benign	0.17
R8184:Dock10	UTSW	1	80,530,469 (GRCm39)	missense	probably damaging	1.00
R8220:Dock10	UTSW	1	80,506,366 (GRCm39)	missense	probably null	1.00
R8225:Dock10	UTSW	1	80,481,447 (GRCm39)	nonsense	probably null
R8267:Dock10	UTSW	1	80,518,045 (GRCm39)	missense	probably benign	0.00
R8276:Dock10	UTSW	1	80,505,998 (GRCm39)	missense	probably benign
R8294:Dock10	UTSW	1	80,488,079 (GRCm39)	missense	possibly damaging	0.88
R8298:Dock10	UTSW	1	80,514,654 (GRCm39)	missense	probably benign	0.00
R8326:Dock10	UTSW	1	80,583,892 (GRCm39)	missense	possibly damaging	0.77
R8724:Dock10	UTSW	1	80,570,344 (GRCm39)	missense	probably benign	0.00
R8828:Dock10	UTSW	1	80,521,134 (GRCm39)	missense	probably damaging	1.00
R8846:Dock10	UTSW	1	80,545,786 (GRCm39)	missense	possibly damaging	0.93
R8919:Dock10	UTSW	1	80,483,147 (GRCm39)	missense	probably benign	0.00
R8950:Dock10	UTSW	1	80,519,016 (GRCm39)	missense	probably benign
R8993:Dock10	UTSW	1	80,551,888 (GRCm39)	missense	probably benign	0.21
R9028:Dock10	UTSW	1	80,584,012 (GRCm39)	splice site	probably benign
R9115:Dock10	UTSW	1	80,490,156 (GRCm39)	missense	probably damaging	1.00
R9327:Dock10	UTSW	1	80,510,184 (GRCm39)	missense	probably damaging	1.00
R9342:Dock10	UTSW	1	80,570,360 (GRCm39)	missense	probably benign
R9421:Dock10	UTSW	1	80,501,509 (GRCm39)	missense	probably damaging	1.00
R9431:Dock10	UTSW	1	80,583,593 (GRCm39)	missense	probably damaging	1.00
R9486:Dock10	UTSW	1	80,479,452 (GRCm39)	missense	unknown
R9521:Dock10	UTSW	1	80,501,763 (GRCm39)	missense	probably damaging	1.00
R9598:Dock10	UTSW	1	80,625,939 (GRCm39)	missense	probably benign	0.15
R9629:Dock10	UTSW	1	80,481,389 (GRCm39)	missense
R9703:Dock10	UTSW	1	80,517,540 (GRCm39)	missense	probably damaging	0.98
RF021:Dock10	UTSW	1	80,542,290 (GRCm39)	critical splice acceptor site	probably null
X0025:Dock10	UTSW	1	80,514,637 (GRCm39)	missense	probably damaging	0.98
X0065:Dock10	UTSW	1	80,518,977 (GRCm39)	missense	probably damaging	1.00
Z1088:Dock10	UTSW	1	80,510,064 (GRCm39)	missense	probably damaging	1.00
Z1176:Dock10	UTSW	1	80,538,671 (GRCm39)	missense	probably benign
Z1177:Dock10	UTSW	1	80,536,917 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- GAGCCCAGATCTTAGACACTGCAC -3'
(R):5'- AGGTTGCAAAGCTTACAAAACCTGAAAC -3'

Sequencing Primer
(F):5'- AATCGTGTTCCCTGTCAAAAC -3'
(R):5'- ACAATGTTAATGGAATCGGTGTG -3'

Posted On

2013-04-11