Incidental Mutation 'R0081:Vmn2r72'
| ID |
19676 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r72
|
| Ensembl Gene |
ENSMUSG00000051877 |
| Gene Name |
vomeronasal 2, receptor 72 |
| Synonyms |
EG244114, Vmn2r72-ps |
| MMRRC Submission |
038368-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R0081 (G1)
|
| Quality Score |
198 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85386992-85404189 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 85401044 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 125
(E125G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
| AlphaFold |
D3Z4N8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063425
AA Change: E125G
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: E125G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 97.2%
- 10x: 88.5%
- 20x: 63.6%
|
| Validation Efficiency |
94% (159/169) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam5 |
T |
C |
8: 25,271,703 (GRCm39) |
D485G |
probably damaging |
Het |
| Adamts19 |
T |
C |
18: 59,036,137 (GRCm39) |
|
probably null |
Het |
| Adgrd1 |
A |
T |
5: 129,255,146 (GRCm39) |
I598F |
probably damaging |
Het |
| Adh5 |
A |
G |
3: 138,157,174 (GRCm39) |
D245G |
probably benign |
Het |
| Adra2b |
T |
C |
2: 127,206,212 (GRCm39) |
V238A |
probably benign |
Het |
| Ank1 |
G |
A |
8: 23,606,258 (GRCm39) |
V1188I |
possibly damaging |
Het |
| Asap1 |
C |
T |
15: 63,971,413 (GRCm39) |
G905D |
probably damaging |
Het |
| AW554918 |
T |
C |
18: 25,477,959 (GRCm39) |
V428A |
probably benign |
Het |
| Birc6 |
T |
A |
17: 74,950,436 (GRCm39) |
S3226T |
probably benign |
Het |
| Cdh17 |
A |
T |
4: 11,785,280 (GRCm39) |
|
probably benign |
Het |
| Cyfip2 |
A |
T |
11: 46,144,825 (GRCm39) |
Y676* |
probably null |
Het |
| Dcaf17 |
T |
A |
2: 70,908,812 (GRCm39) |
|
probably benign |
Het |
| Dclre1a |
A |
G |
19: 56,531,139 (GRCm39) |
F736L |
probably damaging |
Het |
| Ddx41 |
A |
T |
13: 55,683,193 (GRCm39) |
H171Q |
possibly damaging |
Het |
| Dennd5b |
G |
T |
6: 148,895,257 (GRCm39) |
Q1258K |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,584,295 (GRCm39) |
D137G |
probably damaging |
Het |
| Dpyd |
G |
A |
3: 118,737,904 (GRCm39) |
V482I |
probably benign |
Het |
| Erich6 |
A |
T |
3: 58,543,547 (GRCm39) |
|
probably benign |
Het |
| Fam193b |
A |
G |
13: 55,702,024 (GRCm39) |
|
probably benign |
Het |
| Foxp2 |
T |
C |
6: 15,405,643 (GRCm39) |
|
probably benign |
Het |
| Frmd4a |
T |
C |
2: 4,577,252 (GRCm39) |
|
probably null |
Het |
| Gas2l2 |
A |
G |
11: 83,313,693 (GRCm39) |
S540P |
possibly damaging |
Het |
| Glis2 |
T |
C |
16: 4,431,517 (GRCm39) |
V348A |
probably benign |
Het |
| Gm14443 |
C |
A |
2: 175,011,729 (GRCm39) |
G239V |
probably damaging |
Het |
| Gpr158 |
T |
C |
2: 21,831,528 (GRCm39) |
V876A |
probably damaging |
Het |
| H1f8 |
A |
G |
6: 115,926,942 (GRCm39) |
E273G |
probably benign |
Het |
| Hadh |
C |
T |
3: 131,029,285 (GRCm39) |
D245N |
probably damaging |
Het |
| Hk2 |
A |
T |
6: 82,711,957 (GRCm39) |
|
probably benign |
Het |
| Ice1 |
A |
T |
13: 70,767,163 (GRCm39) |
Y108* |
probably null |
Het |
| Il10ra |
T |
G |
9: 45,167,247 (GRCm39) |
M435L |
probably benign |
Het |
| Inpp5k |
GT |
G |
11: 75,521,973 (GRCm39) |
|
probably null |
Het |
| Kank4 |
G |
T |
4: 98,666,567 (GRCm39) |
P627T |
probably benign |
Het |
| Kif16b |
A |
G |
2: 142,549,346 (GRCm39) |
|
probably benign |
Het |
| Lipn |
A |
G |
19: 34,054,376 (GRCm39) |
I205V |
probably benign |
Het |
| Miox |
C |
T |
15: 89,220,477 (GRCm39) |
L189F |
possibly damaging |
Het |
| Myh1 |
T |
C |
11: 67,106,683 (GRCm39) |
M1255T |
probably benign |
Het |
| Myl3 |
A |
C |
9: 110,596,997 (GRCm39) |
D119A |
probably damaging |
Het |
| Myo1d |
T |
G |
11: 80,448,349 (GRCm39) |
K925N |
probably benign |
Het |
| Myoz1 |
T |
A |
14: 20,699,622 (GRCm39) |
M239L |
probably benign |
Het |
| Ncoa6 |
TGC |
TGCGC |
2: 155,250,211 (GRCm39) |
|
probably null |
Het |
| Nf1 |
C |
A |
11: 79,344,805 (GRCm39) |
|
probably benign |
Het |
| Npepl1 |
C |
T |
2: 173,957,879 (GRCm39) |
P239S |
probably damaging |
Het |
| Olfml1 |
A |
G |
7: 107,170,506 (GRCm39) |
K131R |
probably benign |
Het |
| Or12k5 |
G |
A |
2: 36,895,462 (GRCm39) |
L55F |
probably damaging |
Het |
| Or1e29 |
A |
G |
11: 73,667,935 (GRCm39) |
F73L |
possibly damaging |
Het |
| Or1j15 |
T |
A |
2: 36,458,893 (GRCm39) |
Y94* |
probably null |
Het |
| Or1j20 |
T |
C |
2: 36,760,022 (GRCm39) |
L148S |
possibly damaging |
Het |
| Or4c10 |
T |
A |
2: 89,760,423 (GRCm39) |
I90K |
possibly damaging |
Het |
| Or4f7 |
A |
C |
2: 111,644,213 (GRCm39) |
I286S |
probably damaging |
Het |
| Or5p52 |
C |
T |
7: 107,502,212 (GRCm39) |
T96I |
probably benign |
Het |
| Or6c202 |
C |
T |
10: 128,996,707 (GRCm39) |
D49N |
possibly damaging |
Het |
| Pde7a |
T |
C |
3: 19,295,697 (GRCm39) |
|
probably benign |
Het |
| Pik3c2g |
T |
C |
6: 139,903,519 (GRCm39) |
C591R |
probably benign |
Het |
| Pkn2 |
T |
G |
3: 142,559,343 (GRCm39) |
K61Q |
probably damaging |
Het |
| Ppfia1 |
C |
A |
7: 144,058,711 (GRCm39) |
G722C |
probably damaging |
Het |
| Ppp1cb |
T |
C |
5: 32,644,958 (GRCm39) |
V263A |
probably damaging |
Het |
| Rab11fip2 |
A |
T |
19: 59,895,567 (GRCm39) |
N440K |
possibly damaging |
Het |
| Rbm34 |
T |
A |
8: 127,676,234 (GRCm39) |
K340N |
probably damaging |
Het |
| Samd3 |
T |
C |
10: 26,147,399 (GRCm39) |
|
probably benign |
Het |
| Sfi1 |
TCGC |
TC |
11: 3,096,254 (GRCm39) |
|
probably null |
Het |
| Sigirr |
T |
C |
7: 140,671,285 (GRCm39) |
D399G |
probably damaging |
Het |
| Slc17a7 |
A |
G |
7: 44,824,371 (GRCm39) |
E554G |
probably benign |
Het |
| Smc3 |
A |
G |
19: 53,589,993 (GRCm39) |
|
probably benign |
Het |
| Tdrd1 |
T |
C |
19: 56,819,703 (GRCm39) |
Y68H |
probably benign |
Het |
| Tespa1 |
T |
A |
10: 130,196,719 (GRCm39) |
L219Q |
probably damaging |
Het |
| Tmem144 |
G |
A |
3: 79,746,580 (GRCm39) |
|
probably benign |
Het |
| Ttc38 |
A |
G |
15: 85,740,673 (GRCm39) |
S436G |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,581,423 (GRCm39) |
I23157F |
probably damaging |
Het |
| Ubxn2b |
T |
A |
4: 6,203,875 (GRCm39) |
|
probably benign |
Het |
| Vmn1r28 |
G |
A |
6: 58,242,702 (GRCm39) |
A182T |
probably benign |
Het |
| Vmn2r78 |
A |
T |
7: 86,572,235 (GRCm39) |
D532V |
probably benign |
Het |
| Vwa8 |
C |
A |
14: 79,320,222 (GRCm39) |
L1078I |
probably benign |
Het |
| Vwce |
A |
T |
19: 10,641,453 (GRCm39) |
|
probably null |
Het |
| Zpr1 |
A |
G |
9: 46,190,995 (GRCm39) |
D300G |
probably damaging |
Het |
|
| Other mutations in Vmn2r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00931:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01019:Vmn2r72
|
APN |
7 |
85,387,542 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL01445:Vmn2r72
|
APN |
7 |
85,398,854 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02076:Vmn2r72
|
APN |
7 |
85,387,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02082:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02086:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02089:Vmn2r72
|
APN |
7 |
85,387,374 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02125:Vmn2r72
|
APN |
7 |
85,399,919 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02146:Vmn2r72
|
APN |
7 |
85,387,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02272:Vmn2r72
|
APN |
7 |
85,399,901 (GRCm39) |
missense |
probably benign |
|
|
IGL02514:Vmn2r72
|
APN |
7 |
85,387,907 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02662:Vmn2r72
|
APN |
7 |
85,387,391 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02697:Vmn2r72
|
APN |
7 |
85,387,879 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL02733:Vmn2r72
|
APN |
7 |
85,401,021 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03070:Vmn2r72
|
APN |
7 |
85,401,249 (GRCm39) |
splice site |
probably benign |
|
|
IGL03150:Vmn2r72
|
APN |
7 |
85,400,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03159:Vmn2r72
|
APN |
7 |
85,404,162 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03333:Vmn2r72
|
APN |
7 |
85,400,075 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0090:Vmn2r72
|
UTSW |
7 |
85,404,084 (GRCm39) |
missense |
probably benign |
|
|
R0655:Vmn2r72
|
UTSW |
7 |
85,387,319 (GRCm39) |
nonsense |
probably null |
|
|
R0778:Vmn2r72
|
UTSW |
7 |
85,398,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1169:Vmn2r72
|
UTSW |
7 |
85,400,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1172:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1173:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1175:Vmn2r72
|
UTSW |
7 |
85,401,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1248:Vmn2r72
|
UTSW |
7 |
85,398,396 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1302:Vmn2r72
|
UTSW |
7 |
85,387,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1506:Vmn2r72
|
UTSW |
7 |
85,398,419 (GRCm39) |
missense |
probably benign |
|
|
R1632:Vmn2r72
|
UTSW |
7 |
85,401,000 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1775:Vmn2r72
|
UTSW |
7 |
85,387,378 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r72
|
UTSW |
7 |
85,398,369 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r72
|
UTSW |
7 |
85,387,444 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2290:Vmn2r72
|
UTSW |
7 |
85,387,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2327:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Vmn2r72
|
UTSW |
7 |
85,400,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2655:Vmn2r72
|
UTSW |
7 |
85,400,477 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2860:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2861:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2862:Vmn2r72
|
UTSW |
7 |
85,400,044 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3009:Vmn2r72
|
UTSW |
7 |
85,398,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3798:Vmn2r72
|
UTSW |
7 |
85,387,285 (GRCm39) |
missense |
probably benign |
0.44 |
|
R3902:Vmn2r72
|
UTSW |
7 |
85,398,943 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R3959:Vmn2r72
|
UTSW |
7 |
85,400,339 (GRCm39) |
missense |
probably benign |
0.36 |
|
R3974:Vmn2r72
|
UTSW |
7 |
85,399,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4399:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4421:Vmn2r72
|
UTSW |
7 |
85,387,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Vmn2r72
|
UTSW |
7 |
85,387,036 (GRCm39) |
nonsense |
probably null |
|
|
R4522:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4523:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4533:Vmn2r72
|
UTSW |
7 |
85,401,134 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4691:Vmn2r72
|
UTSW |
7 |
85,387,119 (GRCm39) |
nonsense |
probably null |
|
|
R4781:Vmn2r72
|
UTSW |
7 |
85,387,069 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4863:Vmn2r72
|
UTSW |
7 |
85,399,806 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4952:Vmn2r72
|
UTSW |
7 |
85,400,317 (GRCm39) |
missense |
probably benign |
|
|
R4991:Vmn2r72
|
UTSW |
7 |
85,400,338 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4995:Vmn2r72
|
UTSW |
7 |
85,387,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5095:Vmn2r72
|
UTSW |
7 |
85,387,061 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5174:Vmn2r72
|
UTSW |
7 |
85,387,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5276:Vmn2r72
|
UTSW |
7 |
85,387,462 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5395:Vmn2r72
|
UTSW |
7 |
85,400,105 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5560:Vmn2r72
|
UTSW |
7 |
85,401,150 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5933:Vmn2r72
|
UTSW |
7 |
85,387,058 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,387,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6354:Vmn2r72
|
UTSW |
7 |
85,399,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6362:Vmn2r72
|
UTSW |
7 |
85,400,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6594:Vmn2r72
|
UTSW |
7 |
85,398,892 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6794:Vmn2r72
|
UTSW |
7 |
85,387,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7113:Vmn2r72
|
UTSW |
7 |
85,399,011 (GRCm39) |
splice site |
probably null |
|
|
R7189:Vmn2r72
|
UTSW |
7 |
85,404,125 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7266:Vmn2r72
|
UTSW |
7 |
85,387,482 (GRCm39) |
nonsense |
probably null |
|
|
R7323:Vmn2r72
|
UTSW |
7 |
85,399,771 (GRCm39) |
missense |
probably benign |
|
|
R7426:Vmn2r72
|
UTSW |
7 |
85,400,348 (GRCm39) |
missense |
probably benign |
|
|
R7606:Vmn2r72
|
UTSW |
7 |
85,400,362 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7651:Vmn2r72
|
UTSW |
7 |
85,401,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7688:Vmn2r72
|
UTSW |
7 |
85,404,098 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7753:Vmn2r72
|
UTSW |
7 |
85,399,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7843:Vmn2r72
|
UTSW |
7 |
85,398,838 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8157:Vmn2r72
|
UTSW |
7 |
85,400,441 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8254:Vmn2r72
|
UTSW |
7 |
85,400,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Vmn2r72
|
UTSW |
7 |
85,401,168 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8444:Vmn2r72
|
UTSW |
7 |
85,387,383 (GRCm39) |
missense |
probably benign |
|
|
R8989:Vmn2r72
|
UTSW |
7 |
85,404,134 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9015:Vmn2r72
|
UTSW |
7 |
85,398,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9080:Vmn2r72
|
UTSW |
7 |
85,387,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Vmn2r72
|
UTSW |
7 |
85,400,411 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9317:Vmn2r72
|
UTSW |
7 |
85,404,022 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9509:Vmn2r72
|
UTSW |
7 |
85,404,075 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,398,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATGTTGCTGACTCCCATGCCC -3'
(R):5'- GGTGACACCCAAGACCAACCATTTG -3'
Sequencing Primer
(F):5'- GACTCCCATGCCCATTTATGATAAAG -3'
(R):5'- CCAAGACCAACCATTTGATTTTC -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation