Mutagenetix > Incidental Mutation

Incidental Mutation 'R1773:Abca12'

196768

Institutional Source

Beutler Lab

Gene Symbol

Abca12

Ensembl Gene

ENSMUSG00000050296

Gene Name

ATP-binding cassette, sub-family A (ABC1), member 12

Synonyms

4833417A11Rik, 4832428G11Rik

MMRRC Submission

039804-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1773 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

71242276-71414910 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71288596 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 1442 (Y1442H)

Ref Sequence

ENSEMBL: ENSMUSP00000084523 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087268]

AlphaFold

E9Q876

Predicted Effect

probably damaging
Transcript: ENSMUST00000087268
AA Change: Y1442H

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000084523
Gene: ENSMUSG00000050296
AA Change: Y1442H

Domain	Start	End	E-Value	Type
transmembrane domain	24	43	N/A	INTRINSIC
low complexity region	246	259	N/A	INTRINSIC
Pfam:ABC2_membrane_3	885	1267	2.9e-24	PFAM
AAA	1370	1554	4.2e-10	SMART
low complexity region	1717	1735	N/A	INTRINSIC
Pfam:ABC2_membrane_3	1744	2206	9.6e-35	PFAM
AAA	2282	2467	4.61e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000188752

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 96 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022A10Rik	A	G	7: 27,580,595 (GRCm38)	K334E	probably damaging	Het
Acot12	A	G	13: 91,757,557 (GRCm38)	T79A	probably benign	Het
Adipoq	A	C	16: 23,155,238 (GRCm38)	Q26P	unknown	Het
Akap13	T	A	7: 75,683,451 (GRCm38)	N1582K	possibly damaging	Het
Alg9	A	G	9: 50,779,096 (GRCm38)	T133A	probably benign	Het
Anks3	T	C	16: 4,947,294 (GRCm38)	T418A	probably benign	Het
Ano3	A	C	2: 110,761,455 (GRCm38)	L37R	probably damaging	Het
Ano9	A	G	7: 141,108,378 (GRCm38)	F178L	possibly damaging	Het
Arhgef12	A	G	9: 43,005,542 (GRCm38)		probably null	Het
Arl16	T	A	11: 120,465,763 (GRCm38)	I137F	possibly damaging	Het
Brpf1	T	A	6: 113,319,931 (GRCm38)	S959T	possibly damaging	Het
C530008M17Rik	G	T	5: 76,867,205 (GRCm38)	A42S	possibly damaging	Het
Ccdc27	C	T	4: 154,041,765 (GRCm38)	R89Q	unknown	Het
Cd109	A	C	9: 78,703,724 (GRCm38)	Q1207H	probably benign	Het
Cd14	A	T	18: 36,725,304 (GRCm38)	V366D	possibly damaging	Het
Cep290	G	A	10: 100,510,573 (GRCm38)	V538I	probably benign	Het
Cep57	G	A	9: 13,816,068 (GRCm38)	A202V	probably damaging	Het
Chl1	T	C	6: 103,647,331 (GRCm38)		probably null	Het
Cmah	T	G	13: 24,417,299 (GRCm38)	F29L	probably benign	Het
Crybg1	A	G	10: 43,992,548 (GRCm38)	V1378A	possibly damaging	Het
Cryzl2	A	G	1: 157,470,722 (GRCm38)	K227R	probably benign	Het
D130043K22Rik	T	G	13: 24,882,602 (GRCm38)	V794G	possibly damaging	Het
Ddx4	T	A	13: 112,599,902 (GRCm38)	T645S	probably benign	Het
Dhcr7	C	T	7: 143,847,458 (GRCm38)	R453C	possibly damaging	Het
Dhx8	T	C	11: 101,752,363 (GRCm38)	Y754H	possibly damaging	Het
Dip2b	T	A	15: 100,193,961 (GRCm38)	D860E	probably benign	Het
Dnah7a	T	C	1: 53,432,887 (GRCm38)		probably null	Het
Dst	A	G	1: 34,291,899 (GRCm38)	D6937G	probably damaging	Het
Dusp1	A	G	17: 26,507,107 (GRCm38)	I204T	probably damaging	Het
Dync2h1	T	A	9: 7,128,256 (GRCm38)	Q1859L	probably damaging	Het
E4f1	C	A	17: 24,446,584 (GRCm38)	G328V	probably damaging	Het
Eml5	T	C	12: 98,798,839 (GRCm38)	Y1617C	probably damaging	Het
Espn	G	T	4: 152,128,229 (GRCm38)	P622Q	probably damaging	Het
Fam184b	G	A	5: 45,584,334 (GRCm38)	P185L	possibly damaging	Het
Fam71f1	T	C	6: 29,334,153 (GRCm38)	S335P	possibly damaging	Het
Fn1	T	A	1: 71,637,383 (GRCm38)	D563V	probably damaging	Het
Gad2	A	G	2: 22,690,207 (GRCm38)	Y540C	probably benign	Het
Gdf11	T	C	10: 128,891,294 (GRCm38)	D131G	probably damaging	Het
Gm19965	T	A	1: 116,821,259 (GRCm38)	Y223*	probably null	Het
H2-M10.6	A	G	17: 36,812,184 (GRCm38)	K3R	probably benign	Het
Hid1	A	G	11: 115,348,510 (GRCm38)	Y776H	probably damaging	Het
Hivep3	A	T	4: 120,098,837 (GRCm38)	K1450I	probably damaging	Het
Icam5	T	C	9: 21,033,525 (GRCm38)	L128P	possibly damaging	Het
Idnk	T	C	13: 58,157,712 (GRCm38)	V9A	probably damaging	Het
Il4ra	A	T	7: 125,567,182 (GRCm38)	T33S	possibly damaging	Het
Ino80	A	G	2: 119,418,409 (GRCm38)	V990A	probably benign	Het
Krtap4-9	T	C	11: 99,785,570 (GRCm38)		probably benign	Het
Lrrk2	A	G	15: 91,779,981 (GRCm38)	I1974V	possibly damaging	Het
Mcm3ap	C	T	10: 76,471,160 (GRCm38)	A369V	probably benign	Het
Nek6	A	G	2: 38,582,419 (GRCm38)	M252V	probably benign	Het
Nfasc	T	A	1: 132,610,839 (GRCm38)	I443F	probably damaging	Het
Nme8	T	G	13: 19,697,036 (GRCm38)	M1L	probably damaging	Het
Npnt	T	A	3: 132,904,693 (GRCm38)	Q423L	possibly damaging	Het
Nup133	A	T	8: 123,930,983 (GRCm38)	C404*	probably null	Het
Olfr1232	A	G	2: 89,325,742 (GRCm38)	V146A	probably benign	Het
Olfr1307	A	G	2: 111,944,859 (GRCm38)	V199A	possibly damaging	Het
Olfr1535	T	C	13: 21,555,812 (GRCm38)	D70G	probably damaging	Het
Olfr262	T	C	19: 12,241,659 (GRCm38)	M1V	probably null	Het
Olfr684	T	C	7: 105,156,983 (GRCm38)	E233G	probably benign	Het
Olfr806	A	G	10: 129,738,443 (GRCm38)	L158S	probably damaging	Het
Otog	T	A	7: 46,288,159 (GRCm38)	I1764N	probably benign	Het
Oxa1l	A	G	14: 54,363,452 (GRCm38)	I127M	probably benign	Het
P4hb	C	A	11: 120,572,726 (GRCm38)	V28F	probably damaging	Het
Pbld2	C	T	10: 63,054,371 (GRCm38)	A186V	probably benign	Het
Pdzph1	G	T	17: 58,974,813 (GRCm38)	T158K	probably damaging	Het
Pgm1	T	A	5: 64,107,851 (GRCm38)		probably null	Het
Phip	A	T	9: 82,876,189 (GRCm38)	S1484T	probably benign	Het
Pikfyve	T	C	1: 65,246,370 (GRCm38)	S923P	probably benign	Het
Pikfyve	T	C	1: 65,192,271 (GRCm38)	L100P	probably damaging	Het
Pla2g4e	A	G	2: 120,244,721 (GRCm38)	S63P	probably benign	Het
Plekhh2	A	G	17: 84,599,265 (GRCm38)	E1176G	probably damaging	Het
Prlr	T	A	15: 10,325,318 (GRCm38)	Y192*	probably null	Het
Pten	T	A	19: 32,798,072 (GRCm38)	C71S	probably damaging	Het
Rbbp8nl	A	G	2: 180,281,194 (GRCm38)	L202P	probably benign	Het
Ripor2	T	A	13: 24,701,254 (GRCm38)	S491T	probably benign	Het
Robo1	A	T	16: 73,004,511 (GRCm38)	I1008F	probably benign	Het
Scg2	T	C	1: 79,435,635 (GRCm38)	N417S	probably benign	Het
Scn8a	A	G	15: 101,039,615 (GRCm38)	I1581V	probably damaging	Het
Slc22a8	T	A	19: 8,594,229 (GRCm38)	I108N	probably damaging	Het
Slc9a8	A	T	2: 167,471,465 (GRCm38)	T416S	possibly damaging	Het
Spata32	T	A	11: 103,208,818 (GRCm38)	E287V	probably damaging	Het
Spata5	T	C	3: 37,439,185 (GRCm38)	F515L	probably damaging	Het
Tgfbrap1	C	T	1: 43,075,352 (GRCm38)	G196D	probably damaging	Het
Tgm5	G	T	2: 121,077,650 (GRCm38)	T15K	possibly damaging	Het
Tmc1	C	T	19: 20,826,501 (GRCm38)		probably null	Het
Tmem177	T	C	1: 119,910,576 (GRCm38)	I124M	possibly damaging	Het
Trim30a	A	G	7: 104,435,901 (GRCm38)	F34S	probably damaging	Het
Tsn	T	C	1: 118,305,239 (GRCm38)	T112A	probably benign	Het
Tspyl5	T	G	15: 33,686,776 (GRCm38)	N341T	probably benign	Het
Vmn2r108	C	T	17: 20,469,073 (GRCm38)	C540Y	probably damaging	Het
Vrtn	C	T	12: 84,650,224 (GRCm38)	R583W	probably damaging	Het
Wnt1	T	C	15: 98,791,757 (GRCm38)	S142P	probably damaging	Het
Wrn	A	T	8: 33,343,561 (GRCm38)	I108N	probably damaging	Het
Zfhx2	A	C	14: 55,072,891 (GRCm38)	C733G	possibly damaging	Het
Zfp219	T	C	14: 52,007,106 (GRCm38)	T539A	probably damaging	Het
Zswim8	T	A	14: 20,711,530 (GRCm38)	M177K	probably damaging	Het

Other mutations in Abca12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Abca12	APN	1	71,303,541 (GRCm38)	missense	possibly damaging	0.64
IGL00556:Abca12	APN	1	71,353,757 (GRCm38)	missense	probably benign	0.00
IGL00813:Abca12	APN	1	71,353,762 (GRCm38)	critical splice acceptor site	probably null
IGL00835:Abca12	APN	1	71,302,733 (GRCm38)	missense	probably damaging	1.00
IGL00921:Abca12	APN	1	71,285,729 (GRCm38)	missense	probably damaging	1.00
IGL01011:Abca12	APN	1	71,263,632 (GRCm38)	missense	probably benign	0.02
IGL01066:Abca12	APN	1	71,353,730 (GRCm38)	missense	possibly damaging	0.95
IGL01082:Abca12	APN	1	71,314,114 (GRCm38)	missense	probably damaging	1.00
IGL01310:Abca12	APN	1	71,284,156 (GRCm38)	missense	probably benign	0.00
IGL01360:Abca12	APN	1	71,286,489 (GRCm38)	missense	possibly damaging	0.95
IGL01585:Abca12	APN	1	71,319,886 (GRCm38)	missense	probably benign	0.00
IGL01608:Abca12	APN	1	71,259,442 (GRCm38)	missense	probably damaging	1.00
IGL01687:Abca12	APN	1	71,267,610 (GRCm38)	splice site	probably benign
IGL01700:Abca12	APN	1	71,280,390 (GRCm38)	missense	probably benign
IGL01723:Abca12	APN	1	71,314,168 (GRCm38)	missense	probably benign	0.01
IGL01804:Abca12	APN	1	71,276,183 (GRCm38)	missense	probably benign	0.01
IGL01982:Abca12	APN	1	71,346,698 (GRCm38)	missense	probably benign	0.34
IGL02136:Abca12	APN	1	71,247,142 (GRCm38)	missense	probably damaging	1.00
IGL02172:Abca12	APN	1	71,302,658 (GRCm38)	missense	probably benign	0.09
IGL02222:Abca12	APN	1	71,282,886 (GRCm38)	missense	probably benign	0.40
IGL02266:Abca12	APN	1	71,268,201 (GRCm38)	nonsense	probably null
IGL02449:Abca12	APN	1	71,401,749 (GRCm38)	splice site	probably null
IGL02471:Abca12	APN	1	71,258,198 (GRCm38)	missense	probably benign	0.00
IGL02496:Abca12	APN	1	71,288,553 (GRCm38)	missense	possibly damaging	0.55
IGL02552:Abca12	APN	1	71,294,747 (GRCm38)	missense	probably damaging	0.96
IGL02795:Abca12	APN	1	71,288,748 (GRCm38)	missense	probably damaging	1.00
IGL03000:Abca12	APN	1	71,321,800 (GRCm38)	missense	probably benign	0.01
IGL03031:Abca12	APN	1	71,314,024 (GRCm38)	missense	probably benign	0.00
IGL03131:Abca12	APN	1	71,346,702 (GRCm38)	missense	probably benign
IGL03260:Abca12	APN	1	71,284,099 (GRCm38)	missense	probably damaging	1.00
IGL03324:Abca12	APN	1	71,314,008 (GRCm38)	missense	probably benign
IGL03408:Abca12	APN	1	71,264,795 (GRCm38)	missense	probably damaging	1.00
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0016:Abca12	UTSW	1	71,294,800 (GRCm38)	missense	probably benign	0.35
R0121:Abca12	UTSW	1	71,259,786 (GRCm38)	splice site	probably null
R0172:Abca12	UTSW	1	71,279,402 (GRCm38)	missense	probably damaging	0.99
R0196:Abca12	UTSW	1	71,259,813 (GRCm38)	missense	possibly damaging	0.81
R0400:Abca12	UTSW	1	71,259,776 (GRCm38)	splice site	probably benign
R0466:Abca12	UTSW	1	71,302,663 (GRCm38)	missense	probably damaging	1.00
R0616:Abca12	UTSW	1	71,302,671 (GRCm38)	missense	probably damaging	1.00
R0668:Abca12	UTSW	1	71,263,614 (GRCm38)	missense	probably damaging	1.00
R0928:Abca12	UTSW	1	71,349,174 (GRCm38)	missense	probably benign	0.06
R1036:Abca12	UTSW	1	71,263,410 (GRCm38)	critical splice donor site	probably null
R1086:Abca12	UTSW	1	71,295,061 (GRCm38)	splice site	probably benign
R1300:Abca12	UTSW	1	71,244,808 (GRCm38)	missense	probably damaging	1.00
R1337:Abca12	UTSW	1	71,294,819 (GRCm38)	missense	probably benign	0.03
R1356:Abca12	UTSW	1	71,302,953 (GRCm38)	splice site	probably benign
R1372:Abca12	UTSW	1	71,294,857 (GRCm38)	missense	probably damaging	1.00
R1434:Abca12	UTSW	1	71,309,800 (GRCm38)	missense	probably benign	0.00
R1580:Abca12	UTSW	1	71,265,965 (GRCm38)	missense	possibly damaging	0.65
R1675:Abca12	UTSW	1	71,263,411 (GRCm38)	critical splice donor site	probably null
R1829:Abca12	UTSW	1	71,295,029 (GRCm38)	missense	probably benign	0.26
R1922:Abca12	UTSW	1	71,319,924 (GRCm38)	missense	probably benign	0.10
R1927:Abca12	UTSW	1	71,244,840 (GRCm38)	missense	probably damaging	1.00
R2115:Abca12	UTSW	1	71,244,771 (GRCm38)	missense	probably benign	0.01
R2146:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2148:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2149:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2150:Abca12	UTSW	1	71,263,488 (GRCm38)	missense	probably benign	0.02
R2299:Abca12	UTSW	1	71,258,222 (GRCm38)	missense	probably damaging	1.00
R2392:Abca12	UTSW	1	71,258,105 (GRCm38)	missense	probably damaging	1.00
R2571:Abca12	UTSW	1	71,249,885 (GRCm38)	missense	probably benign	0.00
R3077:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3078:Abca12	UTSW	1	71,267,605 (GRCm38)	missense	probably benign	0.02
R3705:Abca12	UTSW	1	71,285,705 (GRCm38)	missense	probably damaging	1.00
R3800:Abca12	UTSW	1	71,265,887 (GRCm38)	missense	probably damaging	1.00
R3905:Abca12	UTSW	1	71,279,457 (GRCm38)	missense	probably benign	0.02
R3905:Abca12	UTSW	1	71,268,230 (GRCm38)	missense	possibly damaging	0.79
R3962:Abca12	UTSW	1	71,274,515 (GRCm38)	splice site	probably null
R4082:Abca12	UTSW	1	71,267,463 (GRCm38)	missense	possibly damaging	0.64
R4131:Abca12	UTSW	1	71,319,871 (GRCm38)	critical splice donor site	probably null
R4214:Abca12	UTSW	1	71,288,697 (GRCm38)	missense	probably damaging	0.99
R4403:Abca12	UTSW	1	71,267,436 (GRCm38)	missense	probably damaging	1.00
R4524:Abca12	UTSW	1	71,302,917 (GRCm38)	missense	probably benign	0.19
R4615:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4617:Abca12	UTSW	1	71,330,334 (GRCm38)	missense	probably benign
R4714:Abca12	UTSW	1	71,321,450 (GRCm38)	missense	probably benign	0.00
R4809:Abca12	UTSW	1	71,278,856 (GRCm38)	missense	probably benign	0.10
R4810:Abca12	UTSW	1	71,303,612 (GRCm38)	missense	probably benign	0.00
R4825:Abca12	UTSW	1	71,302,685 (GRCm38)	missense	possibly damaging	0.70
R4990:Abca12	UTSW	1	71,294,939 (GRCm38)	missense	possibly damaging	0.61
R5013:Abca12	UTSW	1	71,264,767 (GRCm38)	missense	probably damaging	0.99
R5026:Abca12	UTSW	1	71,317,224 (GRCm38)	missense	probably benign	0.04
R5064:Abca12	UTSW	1	71,300,960 (GRCm38)	missense	probably damaging	1.00
R5188:Abca12	UTSW	1	71,291,492 (GRCm38)	missense	probably benign	0.23
R5234:Abca12	UTSW	1	71,263,664 (GRCm38)	missense	probably damaging	0.99
R5267:Abca12	UTSW	1	71,335,774 (GRCm38)	splice site	probably benign
R5302:Abca12	UTSW	1	71,283,952 (GRCm38)	missense	possibly damaging	0.91
R5441:Abca12	UTSW	1	71,295,056 (GRCm38)	missense	probably damaging	1.00
R5451:Abca12	UTSW	1	71,294,917 (GRCm38)	missense	possibly damaging	0.94
R5526:Abca12	UTSW	1	71,292,446 (GRCm38)	missense	probably benign	0.29
R5529:Abca12	UTSW	1	71,264,881 (GRCm38)	missense	probably damaging	1.00
R5615:Abca12	UTSW	1	71,307,059 (GRCm38)	missense	probably damaging	1.00
R5649:Abca12	UTSW	1	71,291,342 (GRCm38)	missense	probably damaging	1.00
R5800:Abca12	UTSW	1	71,321,432 (GRCm38)	missense	possibly damaging	0.78
R5807:Abca12	UTSW	1	71,303,492 (GRCm38)	missense	probably damaging	1.00
R5878:Abca12	UTSW	1	71,346,633 (GRCm38)	missense	possibly damaging	0.79
R5987:Abca12	UTSW	1	71,258,098 (GRCm38)	missense	probably damaging	1.00
R6280:Abca12	UTSW	1	71,272,460 (GRCm38)	missense	probably benign	0.04
R6316:Abca12	UTSW	1	71,313,959 (GRCm38)	missense	probably benign	0.01
R6337:Abca12	UTSW	1	71,295,013 (GRCm38)	missense	probably damaging	1.00
R6383:Abca12	UTSW	1	71,247,184 (GRCm38)	missense	probably benign	0.03
R6564:Abca12	UTSW	1	71,309,850 (GRCm38)	missense	possibly damaging	0.57
R6582:Abca12	UTSW	1	71,258,225 (GRCm38)	missense	probably benign	0.00
R6756:Abca12	UTSW	1	71,259,353 (GRCm38)	splice site	probably null
R6876:Abca12	UTSW	1	71,263,508 (GRCm38)	missense	probably damaging	0.98
R6999:Abca12	UTSW	1	71,317,162 (GRCm38)	nonsense	probably null
R7145:Abca12	UTSW	1	71,307,053 (GRCm38)	missense	possibly damaging	0.92
R7272:Abca12	UTSW	1	71,248,432 (GRCm38)	missense	probably damaging	0.99
R7285:Abca12	UTSW	1	71,349,155 (GRCm38)	nonsense	probably null
R7421:Abca12	UTSW	1	71,247,136 (GRCm38)	nonsense	probably null
R7531:Abca12	UTSW	1	71,247,173 (GRCm38)	missense	probably damaging	0.99
R7592:Abca12	UTSW	1	71,288,677 (GRCm38)	missense	probably benign	0.01
R7687:Abca12	UTSW	1	71,258,182 (GRCm38)	missense	probably benign	0.00
R7690:Abca12	UTSW	1	71,314,154 (GRCm38)	missense	probably benign	0.00
R7709:Abca12	UTSW	1	71,335,728 (GRCm38)	missense	probably benign	0.00
R7736:Abca12	UTSW	1	71,319,964 (GRCm38)	missense	probably benign	0.01
R7754:Abca12	UTSW	1	71,302,887 (GRCm38)	missense	probably benign
R7761:Abca12	UTSW	1	71,330,288 (GRCm38)	missense	probably damaging	1.00
R7808:Abca12	UTSW	1	71,274,634 (GRCm38)	splice site	probably null
R7816:Abca12	UTSW	1	71,292,429 (GRCm38)	missense	probably benign	0.01
R7821:Abca12	UTSW	1	71,259,791 (GRCm38)	missense	probably benign	0.12
R7827:Abca12	UTSW	1	71,414,678 (GRCm38)	start gained	probably benign
R7829:Abca12	UTSW	1	71,292,421 (GRCm38)	missense	probably benign	0.37
R7863:Abca12	UTSW	1	71,293,497 (GRCm38)	missense	probably damaging	0.96
R8053:Abca12	UTSW	1	71,349,169 (GRCm38)	nonsense	probably null
R8093:Abca12	UTSW	1	71,280,393 (GRCm38)	missense	probably benign	0.00
R8120:Abca12	UTSW	1	71,259,381 (GRCm38)	missense	possibly damaging	0.92
R8136:Abca12	UTSW	1	71,248,397 (GRCm38)	missense	probably benign	0.15
R8155:Abca12	UTSW	1	71,291,338 (GRCm38)	missense	probably damaging	1.00
R8189:Abca12	UTSW	1	71,285,726 (GRCm38)	missense	probably damaging	1.00
R8233:Abca12	UTSW	1	71,351,757 (GRCm38)	missense	probably benign	0.00
R8249:Abca12	UTSW	1	71,321,812 (GRCm38)	missense	probably benign	0.00
R8255:Abca12	UTSW	1	71,319,899 (GRCm38)	missense	probably benign	0.13
R8300:Abca12	UTSW	1	71,313,964 (GRCm38)	missense	possibly damaging	0.77
R8339:Abca12	UTSW	1	71,285,672 (GRCm38)	missense	probably damaging	1.00
R8490:Abca12	UTSW	1	71,284,097 (GRCm38)	missense	probably damaging	1.00
R8494:Abca12	UTSW	1	71,288,662 (GRCm38)	missense	probably benign	0.02
R8527:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8542:Abca12	UTSW	1	71,309,888 (GRCm38)	critical splice acceptor site	probably null
R8692:Abca12	UTSW	1	71,288,715 (GRCm38)	missense	probably damaging	0.96
R8723:Abca12	UTSW	1	71,321,738 (GRCm38)	missense	probably benign	0.04
R8796:Abca12	UTSW	1	71,258,089 (GRCm38)	critical splice donor site	probably benign
R8911:Abca12	UTSW	1	71,341,531 (GRCm38)	missense	probably benign	0.07
R8913:Abca12	UTSW	1	71,264,813 (GRCm38)	missense	probably damaging	1.00
R8957:Abca12	UTSW	1	71,321,625 (GRCm38)	missense	possibly damaging	0.90
R9000:Abca12	UTSW	1	71,314,036 (GRCm38)	missense	probably damaging	1.00
R9137:Abca12	UTSW	1	71,259,366 (GRCm38)	missense	possibly damaging	0.80
R9228:Abca12	UTSW	1	71,293,440 (GRCm38)	missense	probably damaging	1.00
R9237:Abca12	UTSW	1	71,279,398 (GRCm38)	missense	probably damaging	0.97
R9299:Abca12	UTSW	1	71,319,883 (GRCm38)	missense	possibly damaging	0.48
R9419:Abca12	UTSW	1	71,303,490 (GRCm38)	missense	possibly damaging	0.81
R9492:Abca12	UTSW	1	71,258,221 (GRCm38)	missense	possibly damaging	0.81
R9538:Abca12	UTSW	1	71,341,513 (GRCm38)	missense	probably benign	0.04
R9585:Abca12	UTSW	1	71,303,586 (GRCm38)	missense	probably damaging	1.00
R9658:Abca12	UTSW	1	71,286,475 (GRCm38)	missense	probably damaging	0.97
R9763:Abca12	UTSW	1	71,263,558 (GRCm38)	missense	possibly damaging	0.84
X0013:Abca12	UTSW	1	71,248,433 (GRCm38)	missense	probably damaging	0.99
X0018:Abca12	UTSW	1	71,314,510 (GRCm38)	missense	probably benign
X0063:Abca12	UTSW	1	71,349,064 (GRCm38)	missense	probably benign	0.15
X0065:Abca12	UTSW	1	71,341,461 (GRCm38)	critical splice donor site	probably null
Z1176:Abca12	UTSW	1	71,284,070 (GRCm38)	missense	probably damaging	1.00
Z1177:Abca12	UTSW	1	71,292,531 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,282,811 (GRCm38)	missense	probably damaging	0.98
Z1177:Abca12	UTSW	1	71,276,082 (GRCm38)	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- TGGGTCAACATACAAGGCACCAGG -3'
(R):5'- CGTTTGAGGAGAGGCATTGCAAACC -3'

Sequencing Primer
(F):5'- TGACTGTCTGGAGAGGATAATAATGC -3'
(R):5'- GTCAGCATATGAGTTACGCTTAGTC -3'

Posted On

2014-05-23