Incidental Mutation 'R0081:Or5p52'
ID 19679
Institutional Source Beutler Lab
Gene Symbol Or5p52
Ensembl Gene ENSMUSG00000073893
Gene Name olfactory receptor family 5 subfamily P member 52
Synonyms Olfr472, GA_x6K02T2PBJ9-10231953-10232885, MOR204-5
MMRRC Submission 038368-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0081 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 107501926-107502858 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 107502212 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 96 (T96I)
Gene Model predicted gene model for transcript(s): [ENSMUST00000209670] [ENSMUST00000210420] [ENSMUST00000216937]
AlphaFold Q8VG43
Predicted Effect probably benign
Transcript: ENSMUST00000084760
AA Change: T96I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000081815
Gene: ENSMUSG00000063120
AA Change: T96I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.6e-49 PFAM
Pfam:7tm_1 41 290 8.1e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209670
AA Change: T96I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000210420
AA Change: T96I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210856
AA Change: T96I
Predicted Effect probably benign
Transcript: ENSMUST00000216937
AA Change: T96I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.2%
  • 10x: 88.5%
  • 20x: 63.6%
Validation Efficiency 94% (159/169)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 T C 8: 25,271,703 (GRCm39) D485G probably damaging Het
Adamts19 T C 18: 59,036,137 (GRCm39) probably null Het
Adgrd1 A T 5: 129,255,146 (GRCm39) I598F probably damaging Het
Adh5 A G 3: 138,157,174 (GRCm39) D245G probably benign Het
Adra2b T C 2: 127,206,212 (GRCm39) V238A probably benign Het
Ank1 G A 8: 23,606,258 (GRCm39) V1188I possibly damaging Het
Asap1 C T 15: 63,971,413 (GRCm39) G905D probably damaging Het
AW554918 T C 18: 25,477,959 (GRCm39) V428A probably benign Het
Birc6 T A 17: 74,950,436 (GRCm39) S3226T probably benign Het
Cdh17 A T 4: 11,785,280 (GRCm39) probably benign Het
Cyfip2 A T 11: 46,144,825 (GRCm39) Y676* probably null Het
Dcaf17 T A 2: 70,908,812 (GRCm39) probably benign Het
Dclre1a A G 19: 56,531,139 (GRCm39) F736L probably damaging Het
Ddx41 A T 13: 55,683,193 (GRCm39) H171Q possibly damaging Het
Dennd5b G T 6: 148,895,257 (GRCm39) Q1258K probably benign Het
Dock10 T C 1: 80,584,295 (GRCm39) D137G probably damaging Het
Dpyd G A 3: 118,737,904 (GRCm39) V482I probably benign Het
Erich6 A T 3: 58,543,547 (GRCm39) probably benign Het
Fam193b A G 13: 55,702,024 (GRCm39) probably benign Het
Foxp2 T C 6: 15,405,643 (GRCm39) probably benign Het
Frmd4a T C 2: 4,577,252 (GRCm39) probably null Het
Gas2l2 A G 11: 83,313,693 (GRCm39) S540P possibly damaging Het
Glis2 T C 16: 4,431,517 (GRCm39) V348A probably benign Het
Gm14443 C A 2: 175,011,729 (GRCm39) G239V probably damaging Het
Gpr158 T C 2: 21,831,528 (GRCm39) V876A probably damaging Het
H1f8 A G 6: 115,926,942 (GRCm39) E273G probably benign Het
Hadh C T 3: 131,029,285 (GRCm39) D245N probably damaging Het
Hk2 A T 6: 82,711,957 (GRCm39) probably benign Het
Ice1 A T 13: 70,767,163 (GRCm39) Y108* probably null Het
Il10ra T G 9: 45,167,247 (GRCm39) M435L probably benign Het
Inpp5k GT G 11: 75,521,973 (GRCm39) probably null Het
Kank4 G T 4: 98,666,567 (GRCm39) P627T probably benign Het
Kif16b A G 2: 142,549,346 (GRCm39) probably benign Het
Lipn A G 19: 34,054,376 (GRCm39) I205V probably benign Het
Miox C T 15: 89,220,477 (GRCm39) L189F possibly damaging Het
Myh1 T C 11: 67,106,683 (GRCm39) M1255T probably benign Het
Myl3 A C 9: 110,596,997 (GRCm39) D119A probably damaging Het
Myo1d T G 11: 80,448,349 (GRCm39) K925N probably benign Het
Myoz1 T A 14: 20,699,622 (GRCm39) M239L probably benign Het
Ncoa6 TGC TGCGC 2: 155,250,211 (GRCm39) probably null Het
Nf1 C A 11: 79,344,805 (GRCm39) probably benign Het
Npepl1 C T 2: 173,957,879 (GRCm39) P239S probably damaging Het
Olfml1 A G 7: 107,170,506 (GRCm39) K131R probably benign Het
Or12k5 G A 2: 36,895,462 (GRCm39) L55F probably damaging Het
Or1e29 A G 11: 73,667,935 (GRCm39) F73L possibly damaging Het
Or1j15 T A 2: 36,458,893 (GRCm39) Y94* probably null Het
Or1j20 T C 2: 36,760,022 (GRCm39) L148S possibly damaging Het
Or4c10 T A 2: 89,760,423 (GRCm39) I90K possibly damaging Het
Or4f7 A C 2: 111,644,213 (GRCm39) I286S probably damaging Het
Or6c202 C T 10: 128,996,707 (GRCm39) D49N possibly damaging Het
Pde7a T C 3: 19,295,697 (GRCm39) probably benign Het
Pik3c2g T C 6: 139,903,519 (GRCm39) C591R probably benign Het
Pkn2 T G 3: 142,559,343 (GRCm39) K61Q probably damaging Het
Ppfia1 C A 7: 144,058,711 (GRCm39) G722C probably damaging Het
Ppp1cb T C 5: 32,644,958 (GRCm39) V263A probably damaging Het
Rab11fip2 A T 19: 59,895,567 (GRCm39) N440K possibly damaging Het
Rbm34 T A 8: 127,676,234 (GRCm39) K340N probably damaging Het
Samd3 T C 10: 26,147,399 (GRCm39) probably benign Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sigirr T C 7: 140,671,285 (GRCm39) D399G probably damaging Het
Slc17a7 A G 7: 44,824,371 (GRCm39) E554G probably benign Het
Smc3 A G 19: 53,589,993 (GRCm39) probably benign Het
Tdrd1 T C 19: 56,819,703 (GRCm39) Y68H probably benign Het
Tespa1 T A 10: 130,196,719 (GRCm39) L219Q probably damaging Het
Tmem144 G A 3: 79,746,580 (GRCm39) probably benign Het
Ttc38 A G 15: 85,740,673 (GRCm39) S436G probably benign Het
Ttn T A 2: 76,581,423 (GRCm39) I23157F probably damaging Het
Ubxn2b T A 4: 6,203,875 (GRCm39) probably benign Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vmn2r72 T C 7: 85,401,044 (GRCm39) E125G probably benign Het
Vmn2r78 A T 7: 86,572,235 (GRCm39) D532V probably benign Het
Vwa8 C A 14: 79,320,222 (GRCm39) L1078I probably benign Het
Vwce A T 19: 10,641,453 (GRCm39) probably null Het
Zpr1 A G 9: 46,190,995 (GRCm39) D300G probably damaging Het
Other mutations in Or5p52
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00225:Or5p52 APN 7 107,502,311 (GRCm39) missense probably damaging 1.00
IGL02002:Or5p52 APN 7 107,502,497 (GRCm39) missense possibly damaging 0.81
IGL02320:Or5p52 APN 7 107,502,038 (GRCm39) missense possibly damaging 0.78
IGL02701:Or5p52 APN 7 107,502,649 (GRCm39) missense probably benign 0.42
IGL03022:Or5p52 APN 7 107,502,188 (GRCm39) missense probably benign 0.18
IGL03214:Or5p52 APN 7 107,502,173 (GRCm39) missense probably benign 0.00
IGL03257:Or5p52 APN 7 107,501,963 (GRCm39) missense probably benign 0.01
IGL03372:Or5p52 APN 7 107,502,577 (GRCm39) missense probably damaging 1.00
G1Funyon:Or5p52 UTSW 7 107,502,833 (GRCm39) missense probably benign 0.24
R0669:Or5p52 UTSW 7 107,502,446 (GRCm39) missense probably damaging 1.00
R0932:Or5p52 UTSW 7 107,502,397 (GRCm39) missense possibly damaging 0.94
R1158:Or5p52 UTSW 7 107,502,130 (GRCm39) missense possibly damaging 0.75
R1746:Or5p52 UTSW 7 107,502,093 (GRCm39) missense probably benign 0.01
R3777:Or5p52 UTSW 7 107,501,954 (GRCm39) missense probably benign
R3778:Or5p52 UTSW 7 107,501,954 (GRCm39) missense probably benign
R4605:Or5p52 UTSW 7 107,502,445 (GRCm39) missense probably benign 0.24
R4661:Or5p52 UTSW 7 107,502,188 (GRCm39) missense probably benign 0.18
R4675:Or5p52 UTSW 7 107,502,567 (GRCm39) missense probably damaging 1.00
R5374:Or5p52 UTSW 7 107,502,698 (GRCm39) missense possibly damaging 0.52
R5686:Or5p52 UTSW 7 107,502,119 (GRCm39) missense probably damaging 0.99
R6030:Or5p52 UTSW 7 107,502,620 (GRCm39) missense probably benign 0.06
R6030:Or5p52 UTSW 7 107,502,620 (GRCm39) missense probably benign 0.06
R6164:Or5p52 UTSW 7 107,502,595 (GRCm39) missense probably benign 0.01
R6347:Or5p52 UTSW 7 107,502,157 (GRCm39) missense possibly damaging 0.68
R6995:Or5p52 UTSW 7 107,502,829 (GRCm39) missense probably benign 0.13
R7035:Or5p52 UTSW 7 107,502,140 (GRCm39) missense probably benign
R7818:Or5p52 UTSW 7 107,502,230 (GRCm39) missense probably benign 0.01
R7890:Or5p52 UTSW 7 107,502,250 (GRCm39) missense probably benign 0.01
R8189:Or5p52 UTSW 7 107,501,939 (GRCm39) missense probably damaging 0.99
R8301:Or5p52 UTSW 7 107,502,833 (GRCm39) missense probably benign 0.24
R8965:Or5p52 UTSW 7 107,502,314 (GRCm39) missense probably damaging 1.00
R9269:Or5p52 UTSW 7 107,502,527 (GRCm39) missense possibly damaging 0.94
R9478:Or5p52 UTSW 7 107,502,238 (GRCm39) missense probably damaging 0.99
R9566:Or5p52 UTSW 7 107,502,409 (GRCm39) missense possibly damaging 0.52
Z1176:Or5p52 UTSW 7 107,502,265 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATACCACTGTGGCAGAGCTAATC -3'
(R):5'- ACACTTTCAGCAAAGGGGAGAAGTC -3'

Sequencing Primer
(F):5'- ACTGTGGCAGAGCTAATCATCTTG -3'
(R):5'- TATCTGAGTTGGTCCACAGAAG -3'
Posted On 2013-04-11