Mutagenetix > Incidental Mutation

Incidental Mutation 'R1773:Otog'

196809

Institutional Source

Beutler Lab

Gene Symbol

Otog

Ensembl Gene

ENSMUSG00000009487

Gene Name

otogelin

Synonyms

Otgn

MMRRC Submission

039804-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.844) question?

Stock #

R1773 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

46240987-46311434 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 46288159 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 1764 (I1764N)

Ref Sequence

ENSEMBL: ENSMUSP00000130949 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164538]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000164538
AA Change: I1764N

PolyPhen 2 Score 0.285 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000130949
Gene: ENSMUSG00000009487
AA Change: I1764N

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
low complexity region	72	85	N/A	INTRINSIC
VWD	128	288	7.98e-45	SMART
C8	330	404	1.05e-13	SMART
VWC	463	505	1.24e0	SMART
VWD	490	655	4.94e-50	SMART
C8	693	758	1.23e-5	SMART
Pfam:TIL	767	831	3.4e-13	PFAM
VWC	935	983	1.83e0	SMART
VWD	962	1118	6.05e-45	SMART
C8	1153	1227	1.02e-34	SMART
Pfam:AbfB	1270	1384	7.5e-10	PFAM
low complexity region	1488	1513	N/A	INTRINSIC
low complexity region	1524	1536	N/A	INTRINSIC
low complexity region	1560	1578	N/A	INTRINSIC
low complexity region	1637	1644	N/A	INTRINSIC
low complexity region	1677	1696	N/A	INTRINSIC
low complexity region	1731	1748	N/A	INTRINSIC
VWD	2087	2251	2.37e-29	SMART
C8	2287	2356	4.93e-19	SMART
low complexity region	2443	2449	N/A	INTRINSIC
CT	2828	2911	3.46e-28	SMART

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Homozygotes for a number of different spontaneous and targeted mutations exhibit vestibular dysfunction, including circling, head tilt, impaired balance, coordination, and placing response. Mutants have impaired hearing, decreased brain stem auditory evoked potential, and ear abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 96 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310022A10Rik	A	G	7: 27,580,595 (GRCm38)	K334E	probably damaging	Het
Abca12	A	G	1: 71,288,596 (GRCm38)	Y1442H	probably damaging	Het
Acot12	A	G	13: 91,757,557 (GRCm38)	T79A	probably benign	Het
Adipoq	A	C	16: 23,155,238 (GRCm38)	Q26P	unknown	Het
Akap13	T	A	7: 75,683,451 (GRCm38)	N1582K	possibly damaging	Het
Alg9	A	G	9: 50,779,096 (GRCm38)	T133A	probably benign	Het
Anks3	T	C	16: 4,947,294 (GRCm38)	T418A	probably benign	Het
Ano3	A	C	2: 110,761,455 (GRCm38)	L37R	probably damaging	Het
Ano9	A	G	7: 141,108,378 (GRCm38)	F178L	possibly damaging	Het
Arhgef12	A	G	9: 43,005,542 (GRCm38)		probably null	Het
Arl16	T	A	11: 120,465,763 (GRCm38)	I137F	possibly damaging	Het
Brpf1	T	A	6: 113,319,931 (GRCm38)	S959T	possibly damaging	Het
C530008M17Rik	G	T	5: 76,867,205 (GRCm38)	A42S	possibly damaging	Het
Ccdc27	C	T	4: 154,041,765 (GRCm38)	R89Q	unknown	Het
Cd109	A	C	9: 78,703,724 (GRCm38)	Q1207H	probably benign	Het
Cd14	A	T	18: 36,725,304 (GRCm38)	V366D	possibly damaging	Het
Cep290	G	A	10: 100,510,573 (GRCm38)	V538I	probably benign	Het
Cep57	G	A	9: 13,816,068 (GRCm38)	A202V	probably damaging	Het
Chl1	T	C	6: 103,647,331 (GRCm38)		probably null	Het
Cmah	T	G	13: 24,417,299 (GRCm38)	F29L	probably benign	Het
Crybg1	A	G	10: 43,992,548 (GRCm38)	V1378A	possibly damaging	Het
Cryzl2	A	G	1: 157,470,722 (GRCm38)	K227R	probably benign	Het
D130043K22Rik	T	G	13: 24,882,602 (GRCm38)	V794G	possibly damaging	Het
Ddx4	T	A	13: 112,599,902 (GRCm38)	T645S	probably benign	Het
Dhcr7	C	T	7: 143,847,458 (GRCm38)	R453C	possibly damaging	Het
Dhx8	T	C	11: 101,752,363 (GRCm38)	Y754H	possibly damaging	Het
Dip2b	T	A	15: 100,193,961 (GRCm38)	D860E	probably benign	Het
Dnah7a	T	C	1: 53,432,887 (GRCm38)		probably null	Het
Dst	A	G	1: 34,291,899 (GRCm38)	D6937G	probably damaging	Het
Dusp1	A	G	17: 26,507,107 (GRCm38)	I204T	probably damaging	Het
Dync2h1	T	A	9: 7,128,256 (GRCm38)	Q1859L	probably damaging	Het
E4f1	C	A	17: 24,446,584 (GRCm38)	G328V	probably damaging	Het
Eml5	T	C	12: 98,798,839 (GRCm38)	Y1617C	probably damaging	Het
Espn	G	T	4: 152,128,229 (GRCm38)	P622Q	probably damaging	Het
Fam184b	G	A	5: 45,584,334 (GRCm38)	P185L	possibly damaging	Het
Fam71f1	T	C	6: 29,334,153 (GRCm38)	S335P	possibly damaging	Het
Fn1	T	A	1: 71,637,383 (GRCm38)	D563V	probably damaging	Het
Gad2	A	G	2: 22,690,207 (GRCm38)	Y540C	probably benign	Het
Gdf11	T	C	10: 128,891,294 (GRCm38)	D131G	probably damaging	Het
Gm19965	T	A	1: 116,821,259 (GRCm38)	Y223*	probably null	Het
H2-M10.6	A	G	17: 36,812,184 (GRCm38)	K3R	probably benign	Het
Hid1	A	G	11: 115,348,510 (GRCm38)	Y776H	probably damaging	Het
Hivep3	A	T	4: 120,098,837 (GRCm38)	K1450I	probably damaging	Het
Icam5	T	C	9: 21,033,525 (GRCm38)	L128P	possibly damaging	Het
Idnk	T	C	13: 58,157,712 (GRCm38)	V9A	probably damaging	Het
Il4ra	A	T	7: 125,567,182 (GRCm38)	T33S	possibly damaging	Het
Ino80	A	G	2: 119,418,409 (GRCm38)	V990A	probably benign	Het
Krtap4-9	T	C	11: 99,785,570 (GRCm38)		probably benign	Het
Lrrk2	A	G	15: 91,779,981 (GRCm38)	I1974V	possibly damaging	Het
Mcm3ap	C	T	10: 76,471,160 (GRCm38)	A369V	probably benign	Het
Nek6	A	G	2: 38,582,419 (GRCm38)	M252V	probably benign	Het
Nfasc	T	A	1: 132,610,839 (GRCm38)	I443F	probably damaging	Het
Nme8	T	G	13: 19,697,036 (GRCm38)	M1L	probably damaging	Het
Npnt	T	A	3: 132,904,693 (GRCm38)	Q423L	possibly damaging	Het
Nup133	A	T	8: 123,930,983 (GRCm38)	C404*	probably null	Het
Olfr1232	A	G	2: 89,325,742 (GRCm38)	V146A	probably benign	Het
Olfr1307	A	G	2: 111,944,859 (GRCm38)	V199A	possibly damaging	Het
Olfr1535	T	C	13: 21,555,812 (GRCm38)	D70G	probably damaging	Het
Olfr262	T	C	19: 12,241,659 (GRCm38)	M1V	probably null	Het
Olfr684	T	C	7: 105,156,983 (GRCm38)	E233G	probably benign	Het
Olfr806	A	G	10: 129,738,443 (GRCm38)	L158S	probably damaging	Het
Oxa1l	A	G	14: 54,363,452 (GRCm38)	I127M	probably benign	Het
P4hb	C	A	11: 120,572,726 (GRCm38)	V28F	probably damaging	Het
Pbld2	C	T	10: 63,054,371 (GRCm38)	A186V	probably benign	Het
Pdzph1	G	T	17: 58,974,813 (GRCm38)	T158K	probably damaging	Het
Pgm1	T	A	5: 64,107,851 (GRCm38)		probably null	Het
Phip	A	T	9: 82,876,189 (GRCm38)	S1484T	probably benign	Het
Pikfyve	T	C	1: 65,246,370 (GRCm38)	S923P	probably benign	Het
Pikfyve	T	C	1: 65,192,271 (GRCm38)	L100P	probably damaging	Het
Pla2g4e	A	G	2: 120,244,721 (GRCm38)	S63P	probably benign	Het
Plekhh2	A	G	17: 84,599,265 (GRCm38)	E1176G	probably damaging	Het
Prlr	T	A	15: 10,325,318 (GRCm38)	Y192*	probably null	Het
Pten	T	A	19: 32,798,072 (GRCm38)	C71S	probably damaging	Het
Rbbp8nl	A	G	2: 180,281,194 (GRCm38)	L202P	probably benign	Het
Ripor2	T	A	13: 24,701,254 (GRCm38)	S491T	probably benign	Het
Robo1	A	T	16: 73,004,511 (GRCm38)	I1008F	probably benign	Het
Scg2	T	C	1: 79,435,635 (GRCm38)	N417S	probably benign	Het
Scn8a	A	G	15: 101,039,615 (GRCm38)	I1581V	probably damaging	Het
Slc22a8	T	A	19: 8,594,229 (GRCm38)	I108N	probably damaging	Het
Slc9a8	A	T	2: 167,471,465 (GRCm38)	T416S	possibly damaging	Het
Spata32	T	A	11: 103,208,818 (GRCm38)	E287V	probably damaging	Het
Spata5	T	C	3: 37,439,185 (GRCm38)	F515L	probably damaging	Het
Tgfbrap1	C	T	1: 43,075,352 (GRCm38)	G196D	probably damaging	Het
Tgm5	G	T	2: 121,077,650 (GRCm38)	T15K	possibly damaging	Het
Tmc1	C	T	19: 20,826,501 (GRCm38)		probably null	Het
Tmem177	T	C	1: 119,910,576 (GRCm38)	I124M	possibly damaging	Het
Trim30a	A	G	7: 104,435,901 (GRCm38)	F34S	probably damaging	Het
Tsn	T	C	1: 118,305,239 (GRCm38)	T112A	probably benign	Het
Tspyl5	T	G	15: 33,686,776 (GRCm38)	N341T	probably benign	Het
Vmn2r108	C	T	17: 20,469,073 (GRCm38)	C540Y	probably damaging	Het
Vrtn	C	T	12: 84,650,224 (GRCm38)	R583W	probably damaging	Het
Wnt1	T	C	15: 98,791,757 (GRCm38)	S142P	probably damaging	Het
Wrn	A	T	8: 33,343,561 (GRCm38)	I108N	probably damaging	Het
Zfhx2	A	C	14: 55,072,891 (GRCm38)	C733G	possibly damaging	Het
Zfp219	T	C	14: 52,007,106 (GRCm38)	T539A	probably damaging	Het
Zswim8	T	A	14: 20,711,530 (GRCm38)	M177K	probably damaging	Het

Other mutations in Otog

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00516:Otog	APN	7	46,251,282 (GRCm38)	missense	probably damaging	1.00
IGL00725:Otog	APN	7	46,274,092 (GRCm38)	missense	probably damaging	1.00
IGL00757:Otog	APN	7	46,290,128 (GRCm38)	missense	probably damaging	1.00
IGL00822:Otog	APN	7	46,295,880 (GRCm38)	missense	probably benign	0.24
IGL01354:Otog	APN	7	46,289,726 (GRCm38)	missense	probably damaging	1.00
IGL01567:Otog	APN	7	46,276,615 (GRCm38)	splice site	probably benign
IGL02034:Otog	APN	7	46,295,993 (GRCm38)	nonsense	probably null
IGL02090:Otog	APN	7	46,300,147 (GRCm38)	missense	probably damaging	1.00
IGL02132:Otog	APN	7	46,305,479 (GRCm38)	missense	probably damaging	0.99
IGL02148:Otog	APN	7	46,300,587 (GRCm38)	missense	probably damaging	1.00
IGL02173:Otog	APN	7	46,276,741 (GRCm38)	splice site	probably benign
IGL02199:Otog	APN	7	46,277,351 (GRCm38)	missense	possibly damaging	0.90
IGL02216:Otog	APN	7	46,301,468 (GRCm38)	missense	probably damaging	1.00
IGL02322:Otog	APN	7	46,301,457 (GRCm38)	missense	probably benign	0.01
IGL02330:Otog	APN	7	46,288,069 (GRCm38)	missense	possibly damaging	0.84
IGL02529:Otog	APN	7	46,259,957 (GRCm38)	missense	probably damaging	0.99
IGL02898:Otog	APN	7	46,310,138 (GRCm38)	missense	probably damaging	1.00
IGL02970:Otog	APN	7	46,295,867 (GRCm38)	missense	probably benign	0.11
IGL03085:Otog	APN	7	46,305,922 (GRCm38)	critical splice donor site	probably null
IGL03108:Otog	APN	7	46,251,338 (GRCm38)	missense	probably damaging	1.00
IGL03275:Otog	APN	7	46,306,230 (GRCm38)	missense	probably damaging	1.00
R0282_Otog_616	UTSW	7	46,277,493 (GRCm38)	missense	possibly damaging	0.93
R0636_otog_678	UTSW	7	46,264,228 (GRCm38)	critical splice donor site	probably null
R1029_otog_141	UTSW	7	46,274,595 (GRCm38)	missense	probably damaging	1.00
BB010:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
BB020:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
I1329:Otog	UTSW	7	46,246,503 (GRCm38)	missense	probably benign	0.02
IGL02984:Otog	UTSW	7	46,305,508 (GRCm38)	missense	probably damaging	0.98
PIT4472001:Otog	UTSW	7	46,295,849 (GRCm38)	missense	probably damaging	1.00
R0032:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0032:Otog	UTSW	7	46,288,213 (GRCm38)	nonsense	probably null
R0105:Otog	UTSW	7	46,288,366 (GRCm38)	missense	possibly damaging	0.79
R0164:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0164:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0165:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0166:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0167:Otog	UTSW	7	46,304,231 (GRCm38)	missense	probably damaging	0.97
R0240:Otog	UTSW	7	46,264,032 (GRCm38)	splice site	probably null
R0240:Otog	UTSW	7	46,264,032 (GRCm38)	splice site	probably null
R0242:Otog	UTSW	7	46,267,381 (GRCm38)	missense	probably damaging	0.98
R0242:Otog	UTSW	7	46,267,381 (GRCm38)	missense	probably damaging	0.98
R0282:Otog	UTSW	7	46,277,493 (GRCm38)	missense	possibly damaging	0.93
R0392:Otog	UTSW	7	46,250,075 (GRCm38)	missense	probably benign	0.00
R0436:Otog	UTSW	7	46,265,936 (GRCm38)	splice site	probably benign
R0441:Otog	UTSW	7	46,305,877 (GRCm38)	missense	probably damaging	1.00
R0499:Otog	UTSW	7	46,273,832 (GRCm38)	missense	probably damaging	1.00
R0530:Otog	UTSW	7	46,298,244 (GRCm38)	missense	probably damaging	0.98
R0541:Otog	UTSW	7	46,269,249 (GRCm38)	splice site	probably benign
R0600:Otog	UTSW	7	46,251,395 (GRCm38)	splice site	probably benign
R0626:Otog	UTSW	7	46,271,373 (GRCm38)	missense	possibly damaging	0.95
R0636:Otog	UTSW	7	46,264,228 (GRCm38)	critical splice donor site	probably null
R0764:Otog	UTSW	7	46,300,494 (GRCm38)	missense	probably benign	0.00
R0833:Otog	UTSW	7	46,269,362 (GRCm38)	missense	possibly damaging	0.94
R0836:Otog	UTSW	7	46,269,362 (GRCm38)	missense	possibly damaging	0.94
R0844:Otog	UTSW	7	46,287,828 (GRCm38)	missense	possibly damaging	0.53
R1029:Otog	UTSW	7	46,274,595 (GRCm38)	missense	probably damaging	1.00
R1116:Otog	UTSW	7	46,300,601 (GRCm38)	splice site	probably benign
R1134:Otog	UTSW	7	46,298,514 (GRCm38)	missense	probably damaging	1.00
R1183:Otog	UTSW	7	46,289,755 (GRCm38)	missense	probably benign	0.41
R1204:Otog	UTSW	7	46,259,911 (GRCm38)	missense	probably benign	0.16
R1301:Otog	UTSW	7	46,289,689 (GRCm38)	missense	probably damaging	1.00
R1344:Otog	UTSW	7	46,274,615 (GRCm38)	missense	probably damaging	1.00
R1384:Otog	UTSW	7	46,273,695 (GRCm38)	splice site	probably benign
R1418:Otog	UTSW	7	46,274,615 (GRCm38)	missense	probably damaging	1.00
R1432:Otog	UTSW	7	46,300,583 (GRCm38)	missense	probably damaging	1.00
R1479:Otog	UTSW	7	46,295,978 (GRCm38)	missense	possibly damaging	0.75
R1521:Otog	UTSW	7	46,259,264 (GRCm38)	missense	possibly damaging	0.71
R1589:Otog	UTSW	7	46,283,908 (GRCm38)	missense	probably benign	0.18
R1671:Otog	UTSW	7	46,261,786 (GRCm38)	missense	probably damaging	1.00
R1806:Otog	UTSW	7	46,290,937 (GRCm38)	critical splice acceptor site	probably null
R1843:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R1873:Otog	UTSW	7	46,269,343 (GRCm38)	missense	probably damaging	1.00
R1923:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R1927:Otog	UTSW	7	46,246,283 (GRCm38)	missense	probably damaging	1.00
R2008:Otog	UTSW	7	46,264,074 (GRCm38)	missense	probably benign	0.43
R2048:Otog	UTSW	7	46,287,639 (GRCm38)	missense	probably damaging	1.00
R2131:Otog	UTSW	7	46,250,100 (GRCm38)	missense	probably damaging	1.00
R2153:Otog	UTSW	7	46,302,904 (GRCm38)	missense	probably damaging	1.00
R2240:Otog	UTSW	7	46,241,029 (GRCm38)	start codon destroyed	probably null
R2278:Otog	UTSW	7	46,300,044 (GRCm38)	missense	probably damaging	1.00
R2407:Otog	UTSW	7	46,241,540 (GRCm38)	missense	probably benign	0.10
R2424:Otog	UTSW	7	46,298,169 (GRCm38)	nonsense	probably null
R2513:Otog	UTSW	7	46,305,590 (GRCm38)	critical splice donor site	probably null
R2863:Otog	UTSW	7	46,269,306 (GRCm38)	missense	probably damaging	1.00
R3148:Otog	UTSW	7	46,290,169 (GRCm38)	missense	probably damaging	1.00
R3732:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3732:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3733:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3734:Otog	UTSW	7	46,288,368 (GRCm38)	missense	probably benign	0.03
R3855:Otog	UTSW	7	46,273,760 (GRCm38)	missense	possibly damaging	0.65
R3880:Otog	UTSW	7	46,288,021 (GRCm38)	missense	possibly damaging	0.93
R4081:Otog	UTSW	7	46,288,299 (GRCm38)	missense	possibly damaging	0.92
R4349:Otog	UTSW	7	46,274,189 (GRCm38)	missense	probably damaging	0.99
R4382:Otog	UTSW	7	46,289,698 (GRCm38)	missense	probably damaging	1.00
R4392:Otog	UTSW	7	46,285,124 (GRCm38)	missense	probably damaging	0.98
R4520:Otog	UTSW	7	46,241,053 (GRCm38)	unclassified	probably benign
R4569:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R4580:Otog	UTSW	7	46,287,801 (GRCm38)	missense	possibly damaging	0.78
R4672:Otog	UTSW	7	46,289,786 (GRCm38)	missense	probably damaging	0.98
R4764:Otog	UTSW	7	46,288,519 (GRCm38)	missense	probably benign	0.29
R4910:Otog	UTSW	7	46,298,534 (GRCm38)	missense	probably damaging	1.00
R4910:Otog	UTSW	7	46,264,062 (GRCm38)	missense	probably damaging	1.00
R4913:Otog	UTSW	7	46,264,102 (GRCm38)	missense	probably benign	0.31
R4975:Otog	UTSW	7	46,287,991 (GRCm38)	missense	probably benign	0.00
R4996:Otog	UTSW	7	46,305,510 (GRCm38)	nonsense	probably null
R4996:Otog	UTSW	7	46,298,606 (GRCm38)	missense	possibly damaging	0.51
R5116:Otog	UTSW	7	46,273,767 (GRCm38)	missense	probably benign	0.34
R5138:Otog	UTSW	7	46,250,006 (GRCm38)	missense	possibly damaging	0.61
R5169:Otog	UTSW	7	46,298,148 (GRCm38)	missense	probably benign	0.06
R5239:Otog	UTSW	7	46,287,435 (GRCm38)	missense	probably benign	0.15
R5277:Otog	UTSW	7	46,246,621 (GRCm38)	missense	possibly damaging	0.89
R5287:Otog	UTSW	7	46,269,329 (GRCm38)	missense	probably damaging	0.98
R5299:Otog	UTSW	7	46,288,851 (GRCm38)	missense	probably benign	0.16
R5378:Otog	UTSW	7	46,255,004 (GRCm38)	missense	probably damaging	1.00
R5382:Otog	UTSW	7	46,249,004 (GRCm38)	missense	probably damaging	1.00
R5487:Otog	UTSW	7	46,288,768 (GRCm38)	missense	probably benign	0.27
R5507:Otog	UTSW	7	46,261,699 (GRCm38)	missense	probably damaging	1.00
R5517:Otog	UTSW	7	46,274,571 (GRCm38)	missense	probably damaging	1.00
R5643:Otog	UTSW	7	46,287,447 (GRCm38)	missense	probably damaging	1.00
R5757:Otog	UTSW	7	46,241,121 (GRCm38)	critical splice donor site	probably null
R5910:Otog	UTSW	7	46,298,598 (GRCm38)	missense	possibly damaging	0.94
R6019:Otog	UTSW	7	46,288,950 (GRCm38)	missense	probably benign	0.00
R6150:Otog	UTSW	7	46,264,059 (GRCm38)	missense	possibly damaging	0.82
R6225:Otog	UTSW	7	46,249,034 (GRCm38)	missense	possibly damaging	0.67
R6271:Otog	UTSW	7	46,252,040 (GRCm38)	missense	probably damaging	1.00
R6317:Otog	UTSW	7	46,301,215 (GRCm38)	missense	probably damaging	1.00
R6454:Otog	UTSW	7	46,305,817 (GRCm38)	missense	probably damaging	1.00
R6640:Otog	UTSW	7	46,261,743 (GRCm38)	missense	possibly damaging	0.92
R6753:Otog	UTSW	7	46,249,071 (GRCm38)	missense	probably benign	0.06
R6788:Otog	UTSW	7	46,298,317 (GRCm38)	missense	probably damaging	1.00
R6859:Otog	UTSW	7	46,273,781 (GRCm38)	missense	probably damaging	0.96
R7033:Otog	UTSW	7	46,267,398 (GRCm38)	critical splice donor site	probably null
R7071:Otog	UTSW	7	46,267,323 (GRCm38)	missense	probably damaging	1.00
R7084:Otog	UTSW	7	46,298,566 (GRCm38)	nonsense	probably null
R7116:Otog	UTSW	7	46,298,265 (GRCm38)	missense	probably damaging	0.99
R7202:Otog	UTSW	7	46,288,050 (GRCm38)	missense	probably damaging	0.97
R7365:Otog	UTSW	7	46,298,308 (GRCm38)	missense	probably damaging	1.00
R7468:Otog	UTSW	7	46,264,119 (GRCm38)	missense	probably benign
R7475:Otog	UTSW	7	46,267,276 (GRCm38)	missense	probably damaging	0.99
R7502:Otog	UTSW	7	46,298,615 (GRCm38)	missense	probably damaging	1.00
R7558:Otog	UTSW	7	46,303,160 (GRCm38)	missense	probably damaging	0.99
R7577:Otog	UTSW	7	46,287,855 (GRCm38)	missense	possibly damaging	0.62
R7651:Otog	UTSW	7	46,241,761 (GRCm38)	missense	probably benign	0.00
R7689:Otog	UTSW	7	46,252,056 (GRCm38)	missense	probably damaging	1.00
R7806:Otog	UTSW	7	46,285,776 (GRCm38)	missense	probably benign
R7933:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R8021:Otog	UTSW	7	46,267,342 (GRCm38)	missense	probably damaging	0.98
R8082:Otog	UTSW	7	46,289,719 (GRCm38)	missense	probably damaging	1.00
R8531:Otog	UTSW	7	46,252,049 (GRCm38)	missense	probably damaging	0.99
R8772:Otog	UTSW	7	46,284,928 (GRCm38)	missense	probably damaging	1.00
R8816:Otog	UTSW	7	46,301,481 (GRCm38)	missense	possibly damaging	0.92
R8842:Otog	UTSW	7	46,246,524 (GRCm38)	missense	probably damaging	1.00
R8987:Otog	UTSW	7	46,287,454 (GRCm38)	missense	probably benign	0.43
R8988:Otog	UTSW	7	46,310,147 (GRCm38)	missense	probably damaging	1.00
R9010:Otog	UTSW	7	46,300,470 (GRCm38)	missense	probably benign	0.00
R9025:Otog	UTSW	7	46,288,096 (GRCm38)	missense	probably benign	0.13
R9131:Otog	UTSW	7	46,303,173 (GRCm38)	nonsense	probably null
R9179:Otog	UTSW	7	46,288,461 (GRCm38)	missense	possibly damaging	0.65
R9334:Otog	UTSW	7	46,259,929 (GRCm38)	missense	possibly damaging	0.95
R9365:Otog	UTSW	7	46,271,264 (GRCm38)	missense	probably damaging	1.00
R9408:Otog	UTSW	7	46,267,297 (GRCm38)	missense	possibly damaging	0.79
R9418:Otog	UTSW	7	46,288,600 (GRCm38)	missense	probably benign	0.41
R9465:Otog	UTSW	7	46,305,875 (GRCm38)	missense	possibly damaging	0.80
R9496:Otog	UTSW	7	46,241,081 (GRCm38)	missense	unknown
R9632:Otog	UTSW	7	46,265,719 (GRCm38)	missense	probably benign	0.27
R9656:Otog	UTSW	7	46,310,143 (GRCm38)	missense	probably damaging	1.00
RF024:Otog	UTSW	7	46,287,669 (GRCm38)	missense	probably damaging	1.00
X0062:Otog	UTSW	7	46,259,921 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,289,740 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,274,538 (GRCm38)	missense	probably damaging	1.00
Z1177:Otog	UTSW	7	46,262,852 (GRCm38)	missense	possibly damaging	0.80
Z1177:Otog	UTSW	7	46,309,985 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GACAATGACATCCCTGTCTGTCCTG -3'
(R):5'- CCAAAGTTGTAGCCTGGTGCTGAG -3'

Sequencing Primer
(F):5'- TGGCCCAGAGCACTTCAAG -3'
(R):5'- GGGGATATAGCCTTTGGAGCC -3'

Posted On

2014-05-23