Incidental Mutation 'R1773:Robo1'
| ID |
196865 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
039804-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1773 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 72801399 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 1008
(I1008F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023600
AA Change: I1008F
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: I1008F
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000232205
AA Change: I1017F
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232264
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232432
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 96.9%
- 10x: 95.4%
- 20x: 92.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
A |
G |
7: 27,280,020 (GRCm39) |
K334E |
probably damaging |
Het |
| Abca12 |
A |
G |
1: 71,327,755 (GRCm39) |
Y1442H |
probably damaging |
Het |
| Acot12 |
A |
G |
13: 91,905,676 (GRCm39) |
T79A |
probably benign |
Het |
| Adipoq |
A |
C |
16: 22,973,988 (GRCm39) |
Q26P |
unknown |
Het |
| Afg2a |
T |
C |
3: 37,493,334 (GRCm39) |
F515L |
probably damaging |
Het |
| Akap13 |
T |
A |
7: 75,333,199 (GRCm39) |
N1582K |
possibly damaging |
Het |
| Alg9 |
A |
G |
9: 50,690,396 (GRCm39) |
T133A |
probably benign |
Het |
| Anks3 |
T |
C |
16: 4,765,158 (GRCm39) |
T418A |
probably benign |
Het |
| Ano3 |
A |
C |
2: 110,591,800 (GRCm39) |
L37R |
probably damaging |
Het |
| Ano9 |
A |
G |
7: 140,688,291 (GRCm39) |
F178L |
possibly damaging |
Het |
| Arhgef12 |
A |
G |
9: 42,916,838 (GRCm39) |
|
probably null |
Het |
| Arl16 |
T |
A |
11: 120,356,589 (GRCm39) |
I137F |
possibly damaging |
Het |
| Brpf1 |
T |
A |
6: 113,296,892 (GRCm39) |
S959T |
possibly damaging |
Het |
| Ccdc27 |
C |
T |
4: 154,126,222 (GRCm39) |
R89Q |
unknown |
Het |
| Cd109 |
A |
C |
9: 78,611,006 (GRCm39) |
Q1207H |
probably benign |
Het |
| Cd14 |
A |
T |
18: 36,858,357 (GRCm39) |
V366D |
possibly damaging |
Het |
| Cep290 |
G |
A |
10: 100,346,435 (GRCm39) |
V538I |
probably benign |
Het |
| Cep57 |
G |
A |
9: 13,727,364 (GRCm39) |
A202V |
probably damaging |
Het |
| Chl1 |
T |
C |
6: 103,624,292 (GRCm39) |
|
probably null |
Het |
| Cmah |
T |
G |
13: 24,601,282 (GRCm39) |
F29L |
probably benign |
Het |
| Cracd |
G |
T |
5: 77,015,052 (GRCm39) |
A42S |
possibly damaging |
Het |
| Crybg1 |
A |
G |
10: 43,868,544 (GRCm39) |
V1378A |
possibly damaging |
Het |
| Cryzl2 |
A |
G |
1: 157,298,292 (GRCm39) |
K227R |
probably benign |
Het |
| D130043K22Rik |
T |
G |
13: 25,066,585 (GRCm39) |
V794G |
possibly damaging |
Het |
| Ddx4 |
T |
A |
13: 112,736,436 (GRCm39) |
T645S |
probably benign |
Het |
| Dhcr7 |
C |
T |
7: 143,401,195 (GRCm39) |
R453C |
possibly damaging |
Het |
| Dhx8 |
T |
C |
11: 101,643,189 (GRCm39) |
Y754H |
possibly damaging |
Het |
| Dip2b |
T |
A |
15: 100,091,842 (GRCm39) |
D860E |
probably benign |
Het |
| Dnah7a |
T |
C |
1: 53,472,046 (GRCm39) |
|
probably null |
Het |
| Dst |
A |
G |
1: 34,330,980 (GRCm39) |
D6937G |
probably damaging |
Het |
| Dusp1 |
A |
G |
17: 26,726,081 (GRCm39) |
I204T |
probably damaging |
Het |
| Dync2h1 |
T |
A |
9: 7,128,256 (GRCm39) |
Q1859L |
probably damaging |
Het |
| E4f1 |
C |
A |
17: 24,665,558 (GRCm39) |
G328V |
probably damaging |
Het |
| Eml5 |
T |
C |
12: 98,765,098 (GRCm39) |
Y1617C |
probably damaging |
Het |
| Espn |
G |
T |
4: 152,212,686 (GRCm39) |
P622Q |
probably damaging |
Het |
| Fam184b |
G |
A |
5: 45,741,676 (GRCm39) |
P185L |
possibly damaging |
Het |
| Fn1 |
T |
A |
1: 71,676,542 (GRCm39) |
D563V |
probably damaging |
Het |
| Gad2 |
A |
G |
2: 22,580,219 (GRCm39) |
Y540C |
probably benign |
Het |
| Garin1b |
T |
C |
6: 29,334,152 (GRCm39) |
S335P |
possibly damaging |
Het |
| Gdf11 |
T |
C |
10: 128,727,163 (GRCm39) |
D131G |
probably damaging |
Het |
| Gm19965 |
T |
A |
1: 116,748,989 (GRCm39) |
Y223* |
probably null |
Het |
| H2-M10.6 |
A |
G |
17: 37,123,076 (GRCm39) |
K3R |
probably benign |
Het |
| Hid1 |
A |
G |
11: 115,239,336 (GRCm39) |
Y776H |
probably damaging |
Het |
| Hivep3 |
A |
T |
4: 119,956,034 (GRCm39) |
K1450I |
probably damaging |
Het |
| Icam5 |
T |
C |
9: 20,944,821 (GRCm39) |
L128P |
possibly damaging |
Het |
| Idnk |
T |
C |
13: 58,305,526 (GRCm39) |
V9A |
probably damaging |
Het |
| Il4ra |
A |
T |
7: 125,166,354 (GRCm39) |
T33S |
possibly damaging |
Het |
| Ino80 |
A |
G |
2: 119,248,890 (GRCm39) |
V990A |
probably benign |
Het |
| Krtap4-9 |
T |
C |
11: 99,676,396 (GRCm39) |
|
probably benign |
Het |
| Lrrk2 |
A |
G |
15: 91,664,184 (GRCm39) |
I1974V |
possibly damaging |
Het |
| Mcm3ap |
C |
T |
10: 76,306,994 (GRCm39) |
A369V |
probably benign |
Het |
| Nek6 |
A |
G |
2: 38,472,431 (GRCm39) |
M252V |
probably benign |
Het |
| Nfasc |
T |
A |
1: 132,538,577 (GRCm39) |
I443F |
probably damaging |
Het |
| Nme8 |
T |
G |
13: 19,881,206 (GRCm39) |
M1L |
probably damaging |
Het |
| Npnt |
T |
A |
3: 132,610,454 (GRCm39) |
Q423L |
possibly damaging |
Het |
| Nup133 |
A |
T |
8: 124,657,722 (GRCm39) |
C404* |
probably null |
Het |
| Or2b7 |
T |
C |
13: 21,739,982 (GRCm39) |
D70G |
probably damaging |
Het |
| Or4c124 |
A |
G |
2: 89,156,086 (GRCm39) |
V146A |
probably benign |
Het |
| Or4f14b |
A |
G |
2: 111,775,204 (GRCm39) |
V199A |
possibly damaging |
Het |
| Or56a4 |
T |
C |
7: 104,806,190 (GRCm39) |
E233G |
probably benign |
Het |
| Or5an1c |
T |
C |
19: 12,219,023 (GRCm39) |
M1V |
probably null |
Het |
| Or6c213 |
A |
G |
10: 129,574,312 (GRCm39) |
L158S |
probably damaging |
Het |
| Otog |
T |
A |
7: 45,937,583 (GRCm39) |
I1764N |
probably benign |
Het |
| Oxa1l |
A |
G |
14: 54,600,909 (GRCm39) |
I127M |
probably benign |
Het |
| P4hb |
C |
A |
11: 120,463,552 (GRCm39) |
V28F |
probably damaging |
Het |
| Pbld2 |
C |
T |
10: 62,890,150 (GRCm39) |
A186V |
probably benign |
Het |
| Pdzph1 |
G |
T |
17: 59,281,808 (GRCm39) |
T158K |
probably damaging |
Het |
| Pgm2 |
T |
A |
5: 64,265,194 (GRCm39) |
|
probably null |
Het |
| Phip |
A |
T |
9: 82,758,242 (GRCm39) |
S1484T |
probably benign |
Het |
| Pikfyve |
T |
C |
1: 65,231,430 (GRCm39) |
L100P |
probably damaging |
Het |
| Pikfyve |
T |
C |
1: 65,285,529 (GRCm39) |
S923P |
probably benign |
Het |
| Pla2g4e |
A |
G |
2: 120,075,202 (GRCm39) |
S63P |
probably benign |
Het |
| Plekhh2 |
A |
G |
17: 84,906,693 (GRCm39) |
E1176G |
probably damaging |
Het |
| Prlr |
T |
A |
15: 10,325,404 (GRCm39) |
Y192* |
probably null |
Het |
| Pten |
T |
A |
19: 32,775,472 (GRCm39) |
C71S |
probably damaging |
Het |
| Rbbp8nl |
A |
G |
2: 179,922,987 (GRCm39) |
L202P |
probably benign |
Het |
| Ripor2 |
T |
A |
13: 24,885,237 (GRCm39) |
S491T |
probably benign |
Het |
| Scg2 |
T |
C |
1: 79,413,352 (GRCm39) |
N417S |
probably benign |
Het |
| Scn8a |
A |
G |
15: 100,937,496 (GRCm39) |
I1581V |
probably damaging |
Het |
| Slc22a8 |
T |
A |
19: 8,571,593 (GRCm39) |
I108N |
probably damaging |
Het |
| Slc9a8 |
A |
T |
2: 167,313,385 (GRCm39) |
T416S |
possibly damaging |
Het |
| Spata32 |
T |
A |
11: 103,099,644 (GRCm39) |
E287V |
probably damaging |
Het |
| Tgfbrap1 |
C |
T |
1: 43,114,512 (GRCm39) |
G196D |
probably damaging |
Het |
| Tgm5 |
G |
T |
2: 120,908,131 (GRCm39) |
T15K |
possibly damaging |
Het |
| Tmc1 |
C |
T |
19: 20,803,865 (GRCm39) |
|
probably null |
Het |
| Tmem177 |
T |
C |
1: 119,838,306 (GRCm39) |
I124M |
possibly damaging |
Het |
| Trim30a |
A |
G |
7: 104,085,108 (GRCm39) |
F34S |
probably damaging |
Het |
| Tsn |
T |
C |
1: 118,232,969 (GRCm39) |
T112A |
probably benign |
Het |
| Tspyl5 |
T |
G |
15: 33,686,922 (GRCm39) |
N341T |
probably benign |
Het |
| Vmn2r108 |
C |
T |
17: 20,689,335 (GRCm39) |
C540Y |
probably damaging |
Het |
| Vrtn |
C |
T |
12: 84,696,998 (GRCm39) |
R583W |
probably damaging |
Het |
| Wnt1 |
T |
C |
15: 98,689,638 (GRCm39) |
S142P |
probably damaging |
Het |
| Wrn |
A |
T |
8: 33,833,589 (GRCm39) |
I108N |
probably damaging |
Het |
| Zfhx2 |
A |
C |
14: 55,310,348 (GRCm39) |
C733G |
possibly damaging |
Het |
| Zfp219 |
T |
C |
14: 52,244,563 (GRCm39) |
T539A |
probably damaging |
Het |
| Zswim8 |
T |
A |
14: 20,761,598 (GRCm39) |
M177K |
probably damaging |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1777:Robo1
|
UTSW |
16 |
72,801,555 (GRCm39) |
missense |
probably benign |
|
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1996:Robo1
|
UTSW |
16 |
72,767,067 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6191:Robo1
|
UTSW |
16 |
72,730,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9246:Robo1
|
UTSW |
16 |
72,769,178 (GRCm39) |
missense |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9509:Robo1
|
UTSW |
16 |
72,759,167 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCCCACTTGTCCTTGATAGACC -3'
(R):5'- GAACACGTCACCTTTGTTCAGCTTG -3'
Sequencing Primer
(F):5'- TTATAACTCAGCAAGCTTAGGAAACC -3'
(R):5'- CAGCTTGTTTTGCTCCATGATG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation