Mutagenetix > Incidental Mutation

Incidental Mutation 'R1774:Vmn1r23'

196920

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r23

Ensembl Gene

ENSMUSG00000093376

Gene Name

vomeronasal 1 receptor 23

Synonyms

V1rc24

MMRRC Submission

039805-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

R1774 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57925842-57926838 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 57926690 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 34 (R34S)

Ref Sequence

ENSEMBL: ENSMUSP00000135676 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175817]

AlphaFold

Q8R2D0

Predicted Effect

probably damaging
Transcript: ENSMUST00000175817
AA Change: R34S

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: R34S

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	3.1e-57	PFAM

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.2%
20x: 92.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700018F24Rik	T	C	5: 145,045,541	V312A	probably damaging	Het
2810408A11Rik	A	G	11: 69,900,627	V42A	probably damaging	Het
Akap8l	C	T	17: 32,332,483	R511H	probably damaging	Het
Angpt1	T	A	15: 42,523,616	Q114L	probably damaging	Het
Apc2	T	C	10: 80,309,130	I625T	probably damaging	Het
Atg2a	T	C	19: 6,250,598	V735A	probably benign	Het
Birc6	T	A	17: 74,640,013	I2909N	probably damaging	Het
C7	C	G	15: 5,012,075	D450H	probably damaging	Het
Cachd1	C	T	4: 100,964,435	T403I	probably damaging	Het
Cachd1	T	A	4: 100,967,043	F560L	probably benign	Het
Cacna2d2	A	T	9: 107,526,151	Y944F	probably benign	Het
Cdkal1	C	T	13: 29,850,048	D21N	probably damaging	Het
Col18a1	T	C	10: 77,059,981	R901G	probably damaging	Het
Col27a1	C	T	4: 63,225,713	P546L	probably damaging	Het
Cps1	C	T	1: 67,170,882	R624W	possibly damaging	Het
Cyp11a1	A	T	9: 58,018,360	I93F	probably benign	Het
Cyp2c40	G	C	19: 39,786,806	T334R	probably damaging	Het
Cyp4f37	A	G	17: 32,629,890	D244G	possibly damaging	Het
D630003M21Rik	A	T	2: 158,220,470	D43E	probably damaging	Het
Ep400	C	A	5: 110,685,491	C1955F	unknown	Het
Ethe1	G	A	7: 24,593,946	V6I	probably benign	Het
F5	C	A	1: 164,192,535	Q860K	probably benign	Het
Fasn	T	C	11: 120,817,171	Y685C	probably damaging	Het
Gga2	T	G	7: 122,012,221	D38A	probably damaging	Het
Gm12794	G	A	4: 101,940,458	V18M	probably benign	Het
Gm14685	G	T	X: 73,127,655	G218C	probably damaging	Het
Gm43302	T	A	5: 105,275,794	I438F	probably benign	Het
Grm1	T	A	10: 11,079,866	T225S	possibly damaging	Het
Hic2	G	T	16: 17,258,647	V447L	probably damaging	Het
Hsf2	G	A	10: 57,512,146	C462Y	probably damaging	Het
Ice1	T	C	13: 70,604,553	D1138G	probably damaging	Het
Il6	A	G	5: 30,019,435	T158A	probably benign	Het
Inpp5d	T	A	1: 87,667,889	V120E	probably benign	Het
Iqca	T	C	1: 90,080,903	N456S	probably benign	Het
Itgal	T	A	7: 127,309,622		probably null	Het
Lrrc66	G	C	5: 73,610,855	Q248E	probably benign	Het
Lrrc7	T	A	3: 158,160,292	M1271L	possibly damaging	Het
Lrrc74a	T	C	12: 86,749,053	S267P	probably damaging	Het
Map2	T	C	1: 66,414,074	S550P	probably damaging	Het
Mapk8ip3	A	T	17: 24,924,145		probably null	Het
Mdm4	A	C	1: 132,996,646	S246A	probably damaging	Het
Med23	A	G	10: 24,903,686	E887G	probably damaging	Het
Mgea5	T	C	19: 45,776,984	E128G	probably benign	Het
Mta1	C	T	12: 113,128,039	A254V	probably damaging	Het
Myh2	A	G	11: 67,173,474	Y85C	possibly damaging	Het
Myo1g	A	G	11: 6,515,988	Y366H	probably damaging	Het
Nalcn	G	A	14: 123,278,266	P1708S	probably benign	Het
Nlrp9c	A	T	7: 26,394,118	S41T	probably benign	Het
Nptx2	T	A	5: 144,553,438	S226T	possibly damaging	Het
Nup85	T	A	11: 115,582,945	S562T	probably benign	Het
Nxpe5	T	C	5: 138,239,535	V107A	probably benign	Het
Olfr129	A	G	17: 38,055,437	V43A	probably benign	Het
Olfr273	T	A	4: 52,855,674	I280F	probably benign	Het
Olfr414	A	G	1: 174,431,339	T304A	probably benign	Het
Olfr455	A	T	6: 42,538,519	F168I	probably damaging	Het
Pcdhb12	C	T	18: 37,436,442	P214S	possibly damaging	Het
Pcdhb5	T	A	18: 37,322,672	F702I	probably damaging	Het
Pcnx	T	C	12: 81,975,320	F1475S	probably damaging	Het
Pde5a	C	A	3: 122,729,364	T40N	probably benign	Het
Pnpla2	T	A	7: 141,459,568	V398E	probably damaging	Het
Rab20	T	C	8: 11,454,223	K159R	probably benign	Het
Rfwd3	C	T	8: 111,288,242	R326Q	probably damaging	Het
Rgs12	T	A	5: 34,966,403	V510D	probably benign	Het
Rnf219	A	G	14: 104,479,662	V425A	possibly damaging	Het
Slamf6	T	C	1: 171,942,587		probably benign	Het
Slc27a5	A	T	7: 12,997,607	C23*	probably null	Het
Slc35e2	T	C	4: 155,610,164	V56A	possibly damaging	Het
Slx4ip	T	C	2: 137,067,723	S143P	probably damaging	Het
Stat5a	C	T	11: 100,879,286	S463F	probably damaging	Het
Svep1	T	C	4: 58,146,562	D360G	possibly damaging	Het
Tas2r143	A	T	6: 42,400,371	D45V	probably damaging	Het
Tdrd5	G	T	1: 156,277,509	R516S	probably damaging	Het
Thy1	A	G	9: 44,047,339	D126G	probably benign	Het
Tspear	C	T	10: 77,873,185	T415I	probably benign	Het
Ttll5	C	A	12: 85,933,402	T920K	probably benign	Het
Umod	T	C	7: 119,477,351	E64G	possibly damaging	Het
Usf3	A	G	16: 44,215,670	N171S	probably damaging	Het
Wasf1	C	G	10: 40,934,479	P239R	possibly damaging	Het
Wdr95	C	T	5: 149,564,392	R164*	probably null	Het
Zan	C	A	5: 137,419,989	C2949F	unknown	Het
Zbed4	T	C	15: 88,780,877	S383P	probably benign	Het
Zcchc11	T	C	4: 108,507,955	F542L	probably damaging	Het
Zfand5	T	A	19: 21,276,531	C33S	probably damaging	Het
Zfp12	A	G	5: 143,245,229	Y437C	probably damaging	Het
Zfp451	A	C	1: 33,813,768	S22A	probably benign	Het

Other mutations in Vmn1r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Vmn1r23	APN	6	57,926,076 (GRCm38)	missense	possibly damaging	0.89
IGL01980:Vmn1r23	APN	6	57,926,490 (GRCm38)	missense	probably damaging	1.00
IGL02934:Vmn1r23	APN	6	57,925,929 (GRCm38)	missense	probably benign	0.26
IGL03153:Vmn1r23	APN	6	57,925,932 (GRCm38)	missense	probably damaging	0.98
R0410:Vmn1r23	UTSW	6	57,926,190 (GRCm38)	missense	probably benign	0.11
R0452:Vmn1r23	UTSW	6	57,926,484 (GRCm38)	missense	possibly damaging	0.90
R0590:Vmn1r23	UTSW	6	57,926,364 (GRCm38)	missense	probably benign	0.43
R0647:Vmn1r23	UTSW	6	57,926,184 (GRCm38)	missense	probably benign
R0692:Vmn1r23	UTSW	6	57,926,125 (GRCm38)	nonsense	probably null
R1674:Vmn1r23	UTSW	6	57,926,061 (GRCm38)	missense	possibly damaging	0.75
R1744:Vmn1r23	UTSW	6	57,925,925 (GRCm38)	missense	possibly damaging	0.81
R2101:Vmn1r23	UTSW	6	57,926,452 (GRCm38)	missense	possibly damaging	0.90
R2202:Vmn1r23	UTSW	6	57,926,619 (GRCm38)	missense	probably benign	0.01
R2204:Vmn1r23	UTSW	6	57,926,619 (GRCm38)	missense	probably benign	0.01
R2205:Vmn1r23	UTSW	6	57,926,619 (GRCm38)	missense	probably benign	0.01
R4282:Vmn1r23	UTSW	6	57,926,467 (GRCm38)	missense	probably benign	0.27
R4408:Vmn1r23	UTSW	6	57,926,368 (GRCm38)	missense	probably benign	0.01
R4532:Vmn1r23	UTSW	6	57,925,929 (GRCm38)	missense	probably benign	0.21
R4690:Vmn1r23	UTSW	6	57,926,025 (GRCm38)	missense	probably benign
R4700:Vmn1r23	UTSW	6	57,926,205 (GRCm38)	missense	probably benign	0.17
R4894:Vmn1r23	UTSW	6	57,926,325 (GRCm38)	missense	probably benign	0.00
R6164:Vmn1r23	UTSW	6	57,926,055 (GRCm38)	missense	possibly damaging	0.90
R6930:Vmn1r23	UTSW	6	57,926,145 (GRCm38)	missense	probably benign
R7129:Vmn1r23	UTSW	6	57,926,076 (GRCm38)	missense	possibly damaging	0.89
R7731:Vmn1r23	UTSW	6	57,926,334 (GRCm38)	missense	probably benign	0.03
R7877:Vmn1r23	UTSW	6	57,926,556 (GRCm38)	missense	probably benign
R8751:Vmn1r23	UTSW	6	57,926,467 (GRCm38)	missense	probably benign	0.27
R8809:Vmn1r23	UTSW	6	57,926,367 (GRCm38)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- CCCATAGAGAGTCCTCTCATCACCC -3'
(R):5'- GGAAGGTACACTAATGGTCTCCCACT -3'

Sequencing Primer
(F):5'- CTCCTGCAGTGAGTAACATCA -3'
(R):5'- CTTGGAGGGTATATAACAATGTAGGC -3'

Posted On

2014-05-23