Incidental Mutation 'R1774:Oga'
ID 196982
Institutional Source Beutler Lab
Gene Symbol Oga
Ensembl Gene ENSMUSG00000025220
Gene Name O-GlcNAcase
Synonyms 4833427O07Rik, 5830447M11Rik, Mgea5, 2810009A20Rik, Hy5
MMRRC Submission 039805-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1774 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 45738698-45772274 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45765423 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 128 (E128G)
Ref Sequence ENSEMBL: ENSMUSP00000026243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026243]
AlphaFold Q9EQQ9
Predicted Effect probably benign
Transcript: ENSMUST00000026243
AA Change: E128G

PolyPhen 2 Score 0.369 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000026243
Gene: ENSMUSG00000025220
AA Change: E128G

DomainStartEndE-ValueType
low complexity region 44 57 N/A INTRINSIC
Pfam:NAGidase 62 361 2.5e-84 PFAM
low complexity region 453 458 N/A INTRINSIC
PDB:4BMH|A 700 915 1e-13 PDB
SCOP:d1cjwa_ 715 916 1e-3 SMART
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.2%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit perinatal lethality associated with a developmental delay and respiratory failure. Mouse embryonic fibroblasts exhibit proliferative and mitotic defects, frequent cytokinesis failure, and loss of genomic stability. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 85 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T C 5: 144,982,351 (GRCm39) V312A probably damaging Het
2810408A11Rik A G 11: 69,791,453 (GRCm39) V42A probably damaging Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Angpt1 T A 15: 42,387,012 (GRCm39) Q114L probably damaging Het
Apc2 T C 10: 80,144,964 (GRCm39) I625T probably damaging Het
Atg2a T C 19: 6,300,628 (GRCm39) V735A probably benign Het
Birc6 T A 17: 74,947,008 (GRCm39) I2909N probably damaging Het
C7 C G 15: 5,041,557 (GRCm39) D450H probably damaging Het
Cachd1 C T 4: 100,821,632 (GRCm39) T403I probably damaging Het
Cachd1 T A 4: 100,824,240 (GRCm39) F560L probably benign Het
Cacna2d2 A T 9: 107,403,350 (GRCm39) Y944F probably benign Het
Cdkal1 C T 13: 30,034,031 (GRCm39) D21N probably damaging Het
Col18a1 T C 10: 76,895,815 (GRCm39) R901G probably damaging Het
Col27a1 C T 4: 63,143,950 (GRCm39) P546L probably damaging Het
Cps1 C T 1: 67,210,041 (GRCm39) R624W possibly damaging Het
Cyp11a1 A T 9: 57,925,643 (GRCm39) I93F probably benign Het
Cyp2c40 G C 19: 39,775,250 (GRCm39) T334R probably damaging Het
Cyp4f37 A G 17: 32,848,864 (GRCm39) D244G possibly damaging Het
D630003M21Rik A T 2: 158,062,390 (GRCm39) D43E probably damaging Het
Ep400 C A 5: 110,833,357 (GRCm39) C1955F unknown Het
Ethe1 G A 7: 24,293,371 (GRCm39) V6I probably benign Het
F5 C A 1: 164,020,104 (GRCm39) Q860K probably benign Het
Fasn T C 11: 120,707,997 (GRCm39) Y685C probably damaging Het
Gga2 T G 7: 121,611,444 (GRCm39) D38A probably damaging Het
Gm43302 T A 5: 105,423,660 (GRCm39) I438F probably benign Het
Grm1 T A 10: 10,955,610 (GRCm39) T225S possibly damaging Het
Hic2 G T 16: 17,076,511 (GRCm39) V447L probably damaging Het
Hsf2 G A 10: 57,388,242 (GRCm39) C462Y probably damaging Het
Ice1 T C 13: 70,752,672 (GRCm39) D1138G probably damaging Het
Il6 A G 5: 30,224,433 (GRCm39) T158A probably benign Het
Inpp5d T A 1: 87,595,611 (GRCm39) V120E probably benign Het
Iqca1 T C 1: 90,008,625 (GRCm39) N456S probably benign Het
Itgal T A 7: 126,908,794 (GRCm39) probably null Het
Lrrc66 G C 5: 73,768,198 (GRCm39) Q248E probably benign Het
Lrrc7 T A 3: 157,865,929 (GRCm39) M1271L possibly damaging Het
Lrrc74a T C 12: 86,795,827 (GRCm39) S267P probably damaging Het
Map2 T C 1: 66,453,233 (GRCm39) S550P probably damaging Het
Mapk8ip3 A T 17: 25,143,119 (GRCm39) probably null Het
Mdm4 A C 1: 132,924,384 (GRCm39) S246A probably damaging Het
Med23 A G 10: 24,779,584 (GRCm39) E887G probably damaging Het
Mta1 C T 12: 113,091,659 (GRCm39) A254V probably damaging Het
Myh2 A G 11: 67,064,300 (GRCm39) Y85C possibly damaging Het
Myo1g A G 11: 6,465,988 (GRCm39) Y366H probably damaging Het
Nalcn G A 14: 123,515,678 (GRCm39) P1708S probably benign Het
Nlrp9c A T 7: 26,093,543 (GRCm39) S41T probably benign Het
Nptx2 T A 5: 144,490,248 (GRCm39) S226T possibly damaging Het
Nup85 T A 11: 115,473,771 (GRCm39) S562T probably benign Het
Nxpe5 T C 5: 138,237,797 (GRCm39) V107A probably benign Het
Obi1 A G 14: 104,717,098 (GRCm39) V425A possibly damaging Het
Or10ac1 A T 6: 42,515,453 (GRCm39) F168I probably damaging Het
Or10al7 A G 17: 38,366,328 (GRCm39) V43A probably benign Het
Or13c3 T A 4: 52,855,674 (GRCm39) I280F probably benign Het
Or6p1 A G 1: 174,258,905 (GRCm39) T304A probably benign Het
Pcdhb12 C T 18: 37,569,495 (GRCm39) P214S possibly damaging Het
Pcdhb5 T A 18: 37,455,725 (GRCm39) F702I probably damaging Het
Pcnx1 T C 12: 82,022,094 (GRCm39) F1475S probably damaging Het
Pde5a C A 3: 122,523,013 (GRCm39) T40N probably benign Het
Pnpla2 T A 7: 141,039,481 (GRCm39) V398E probably damaging Het
Pramel19 G A 4: 101,797,655 (GRCm39) V18M probably benign Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Rab20 T C 8: 11,504,223 (GRCm39) K159R probably benign Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rgs12 T A 5: 35,123,747 (GRCm39) V510D probably benign Het
Slamf6 T C 1: 171,770,154 (GRCm39) probably benign Het
Slc27a5 A T 7: 12,731,534 (GRCm39) C23* probably null Het
Slc35e2 T C 4: 155,694,621 (GRCm39) V56A possibly damaging Het
Slx4ip T C 2: 136,909,643 (GRCm39) S143P probably damaging Het
Stat5a C T 11: 100,770,112 (GRCm39) S463F probably damaging Het
Svep1 T C 4: 58,146,562 (GRCm39) D360G possibly damaging Het
Tas2r143 A T 6: 42,377,305 (GRCm39) D45V probably damaging Het
Tdrd5 G T 1: 156,105,079 (GRCm39) R516S probably damaging Het
Thy1 A G 9: 43,958,636 (GRCm39) D126G probably benign Het
Tspear C T 10: 77,709,019 (GRCm39) T415I probably benign Het
Ttll5 C A 12: 85,980,176 (GRCm39) T920K probably benign Het
Tut4 T C 4: 108,365,152 (GRCm39) F542L probably damaging Het
Umod T C 7: 119,076,574 (GRCm39) E64G possibly damaging Het
Usf3 A G 16: 44,036,033 (GRCm39) N171S probably damaging Het
Vmn1r23 T A 6: 57,903,675 (GRCm39) R34S probably damaging Het
Wasf1 C G 10: 40,810,475 (GRCm39) P239R possibly damaging Het
Wdr95 C T 5: 149,487,857 (GRCm39) R164* probably null Het
Zan C A 5: 137,418,251 (GRCm39) C2949F unknown Het
Zbed4 T C 15: 88,665,080 (GRCm39) S383P probably benign Het
Zfand5 T A 19: 21,253,895 (GRCm39) C33S probably damaging Het
Zfp12 A G 5: 143,230,984 (GRCm39) Y437C probably damaging Het
Zfp451 A C 1: 33,852,849 (GRCm39) S22A probably benign Het
Other mutations in Oga
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00671:Oga APN 19 45,753,979 (GRCm39) missense possibly damaging 0.89
IGL01845:Oga APN 19 45,756,301 (GRCm39) missense probably benign 0.00
IGL02039:Oga APN 19 45,762,142 (GRCm39) missense probably damaging 0.98
IGL02428:Oga APN 19 45,753,940 (GRCm39) missense probably damaging 1.00
IGL02581:Oga APN 19 45,740,630 (GRCm39) missense possibly damaging 0.53
IGL02971:Oga APN 19 45,750,682 (GRCm39) missense probably damaging 1.00
R0127:Oga UTSW 19 45,760,327 (GRCm39) missense probably damaging 1.00
R0815:Oga UTSW 19 45,771,425 (GRCm39) missense probably benign 0.00
R0863:Oga UTSW 19 45,771,425 (GRCm39) missense probably benign 0.00
R1127:Oga UTSW 19 45,740,594 (GRCm39) nonsense probably null
R1501:Oga UTSW 19 45,767,079 (GRCm39) missense probably null 1.00
R1514:Oga UTSW 19 45,765,370 (GRCm39) missense probably damaging 1.00
R1586:Oga UTSW 19 45,765,349 (GRCm39) missense possibly damaging 0.94
R1716:Oga UTSW 19 45,740,613 (GRCm39) missense probably benign 0.35
R1755:Oga UTSW 19 45,746,845 (GRCm39) missense possibly damaging 0.93
R2152:Oga UTSW 19 45,746,461 (GRCm39) nonsense probably null
R4403:Oga UTSW 19 45,767,078 (GRCm39) missense probably damaging 1.00
R4664:Oga UTSW 19 45,760,384 (GRCm39) missense probably benign 0.15
R4971:Oga UTSW 19 45,758,485 (GRCm39) splice site probably null
R5377:Oga UTSW 19 45,746,461 (GRCm39) nonsense probably null
R5571:Oga UTSW 19 45,765,445 (GRCm39) missense probably benign
R5639:Oga UTSW 19 45,765,438 (GRCm39) missense probably damaging 1.00
R5665:Oga UTSW 19 45,765,436 (GRCm39) missense probably benign 0.00
R5776:Oga UTSW 19 45,760,363 (GRCm39) missense probably damaging 1.00
R6050:Oga UTSW 19 45,753,919 (GRCm39) missense possibly damaging 0.95
R6054:Oga UTSW 19 45,764,571 (GRCm39) missense probably damaging 1.00
R6317:Oga UTSW 19 45,760,119 (GRCm39) critical splice donor site probably null
R6410:Oga UTSW 19 45,764,484 (GRCm39) splice site probably null
R6990:Oga UTSW 19 45,755,915 (GRCm39) missense probably benign 0.00
R7103:Oga UTSW 19 45,771,605 (GRCm39) start gained probably benign
R7340:Oga UTSW 19 45,755,895 (GRCm39) nonsense probably null
R7437:Oga UTSW 19 45,767,046 (GRCm39) missense possibly damaging 0.76
R7490:Oga UTSW 19 45,755,886 (GRCm39) nonsense probably null
R7741:Oga UTSW 19 45,764,501 (GRCm39) missense probably damaging 1.00
R7823:Oga UTSW 19 45,765,354 (GRCm39) missense possibly damaging 0.51
R8017:Oga UTSW 19 45,762,107 (GRCm39) missense probably damaging 1.00
R8019:Oga UTSW 19 45,762,107 (GRCm39) missense probably damaging 1.00
R8066:Oga UTSW 19 45,760,291 (GRCm39) missense probably damaging 0.99
R8075:Oga UTSW 19 45,749,621 (GRCm39) missense probably damaging 0.97
R8172:Oga UTSW 19 45,765,339 (GRCm39) missense probably damaging 0.99
R8558:Oga UTSW 19 45,746,511 (GRCm39) missense probably benign 0.00
R9050:Oga UTSW 19 45,756,354 (GRCm39) missense probably damaging 1.00
R9150:Oga UTSW 19 45,771,421 (GRCm39) missense probably benign 0.00
R9404:Oga UTSW 19 45,743,096 (GRCm39) frame shift probably null
R9562:Oga UTSW 19 45,743,096 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- AGACAACTGCTTCTCTACCCAAAACTTG -3'
(R):5'- TGCCATTTTGTATAGCCTGCTATCACG -3'

Sequencing Primer
(F):5'- TTTAACATCATAAAGCAAAACGAGC -3'
(R):5'- tcaagtgcccaagagattacc -3'
Posted On 2014-05-23