Incidental Mutation 'R1778:Tecta'
| ID |
197247 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tecta
|
| Ensembl Gene |
ENSMUSG00000037705 |
| Gene Name |
tectorin alpha |
| Synonyms |
[a]-tectorin, Tctna |
| MMRRC Submission |
039809-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.152)
|
| Stock # |
R1778 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
42240915-42311225 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 42254927 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 1752
(C1752Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125370
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042190]
[ENSMUST00000160940]
|
| AlphaFold |
O08523 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042190
AA Change: C1757Y
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000040262
Gene: ENSMUSG00000037705
AA Change: C1757Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
NIDO
|
98 |
254 |
7.88e-77 |
SMART |
|
VWC
|
260 |
314 |
1.04e0 |
SMART |
|
VWD
|
312 |
477 |
1.5e-58 |
SMART |
|
C8
|
517 |
592 |
7.06e-29 |
SMART |
|
EGF_like
|
622 |
645 |
3.87e1 |
SMART |
|
VWC
|
652 |
713 |
1.87e-1 |
SMART |
|
VWD
|
703 |
865 |
4.44e-43 |
SMART |
|
C8
|
905 |
981 |
9.19e-19 |
SMART |
|
Pfam:TIL
|
984 |
1036 |
9.8e-13 |
PFAM |
|
VWD
|
1090 |
1257 |
1.44e-51 |
SMART |
|
C8
|
1294 |
1369 |
4.64e-15 |
SMART |
|
EGF_like
|
1388 |
1420 |
5.34e1 |
SMART |
|
VWC
|
1427 |
1487 |
2.88e-19 |
SMART |
|
VWD
|
1477 |
1638 |
2.72e-38 |
SMART |
|
C8
|
1684 |
1758 |
6.51e-10 |
SMART |
|
ZP
|
1805 |
2059 |
2.95e-85 |
SMART |
|
EGF
|
2087 |
2122 |
2.07e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159603
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000160940
AA Change: C1752Y
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000125370
Gene: ENSMUSG00000037705
AA Change: C1752Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
NIDO
|
98 |
254 |
7.88e-77 |
SMART |
|
VWC
|
260 |
314 |
1.04e0 |
SMART |
|
VWD
|
312 |
477 |
1.5e-58 |
SMART |
|
C8
|
517 |
592 |
7.06e-29 |
SMART |
|
EGF_like
|
622 |
645 |
3.87e1 |
SMART |
|
VWC
|
652 |
713 |
1.87e-1 |
SMART |
|
VWD
|
703 |
865 |
4.44e-43 |
SMART |
|
C8
|
905 |
981 |
9.19e-19 |
SMART |
|
Pfam:TIL
|
984 |
1036 |
6.1e-13 |
PFAM |
|
VWD
|
1090 |
1257 |
1.44e-51 |
SMART |
|
C8
|
1294 |
1369 |
4.64e-15 |
SMART |
|
EGF_like
|
1388 |
1420 |
5.34e1 |
SMART |
|
VWC
|
1427 |
1487 |
2.88e-19 |
SMART |
|
VWD
|
1477 |
1638 |
2.72e-38 |
SMART |
|
C8
|
1679 |
1753 |
6.51e-10 |
SMART |
|
ZP
|
1800 |
2054 |
2.95e-85 |
SMART |
|
EGF
|
2082 |
2117 |
2.07e1 |
SMART |
|
| Meta Mutation Damage Score |
0.9251 |
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.0%
- 10x: 95.6%
- 20x: 93.3%
|
| Validation Efficiency |
98% (107/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice exhibit a tectorial membrane that is detached from the cochlear epithelium. Though the basilar membranes of mutant mice are tuned, sensitivity is attenuated. Mice with an Y1870C mutation have a disrupted tectorial membrane, elevated neural thresholds and broadened neural tuning. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
T |
C |
7: 29,260,131 (GRCm39) |
|
noncoding transcript |
Het |
| 4930568D16Rik |
A |
G |
2: 35,244,995 (GRCm39) |
M119T |
probably damaging |
Het |
| Aadacl2 |
A |
G |
3: 59,924,871 (GRCm39) |
|
probably null |
Het |
| Abca9 |
C |
T |
11: 110,021,542 (GRCm39) |
W1056* |
probably null |
Het |
| Adam20 |
A |
C |
8: 41,249,698 (GRCm39) |
T603P |
possibly damaging |
Het |
| Adgrl1 |
T |
C |
8: 84,656,666 (GRCm39) |
L323P |
probably damaging |
Het |
| Afap1l2 |
C |
T |
19: 56,904,638 (GRCm39) |
E628K |
possibly damaging |
Het |
| Ahctf1 |
A |
T |
1: 179,580,580 (GRCm39) |
L1874Q |
possibly damaging |
Het |
| Ak8 |
A |
G |
2: 28,602,333 (GRCm39) |
E89G |
probably benign |
Het |
| Aldh16a1 |
G |
A |
7: 44,796,732 (GRCm39) |
R256C |
probably damaging |
Het |
| Anxa5 |
G |
A |
3: 36,519,480 (GRCm39) |
T3M |
probably damaging |
Het |
| Arhgef16 |
T |
C |
4: 154,372,443 (GRCm39) |
K210E |
probably benign |
Het |
| Baz2b |
T |
C |
2: 59,836,480 (GRCm39) |
T18A |
unknown |
Het |
| Bub1 |
A |
C |
2: 127,645,042 (GRCm39) |
I960M |
possibly damaging |
Het |
| Cbln2 |
G |
T |
18: 86,731,272 (GRCm39) |
D27Y |
probably benign |
Het |
| Ces2h |
C |
A |
8: 105,741,239 (GRCm39) |
P77Q |
possibly damaging |
Het |
| Cfap410 |
G |
T |
10: 77,818,778 (GRCm39) |
A150S |
probably benign |
Het |
| Chga |
T |
A |
12: 102,527,959 (GRCm39) |
M150K |
probably benign |
Het |
| Chmp3 |
A |
G |
6: 71,554,791 (GRCm39) |
E162G |
probably benign |
Het |
| Clip3 |
A |
G |
7: 29,996,861 (GRCm39) |
N161S |
probably damaging |
Het |
| Col12a1 |
T |
A |
9: 79,511,867 (GRCm39) |
|
probably benign |
Het |
| Cuedc2 |
C |
T |
19: 46,320,079 (GRCm39) |
G105D |
probably benign |
Het |
| Cyp2j7 |
A |
C |
4: 96,087,627 (GRCm39) |
F428V |
probably damaging |
Het |
| Ddx60 |
A |
G |
8: 62,427,210 (GRCm39) |
I762V |
possibly damaging |
Het |
| Def6 |
G |
A |
17: 28,439,160 (GRCm39) |
R257Q |
probably benign |
Het |
| Dkkl1 |
A |
T |
7: 44,860,819 (GRCm39) |
|
probably null |
Het |
| Dnah3 |
A |
G |
7: 119,677,625 (GRCm39) |
L433P |
probably damaging |
Het |
| Eif2s3y |
C |
T |
Y: 1,011,287 (GRCm39) |
R33C |
probably benign |
Het |
| Elavl2 |
T |
A |
4: 91,141,715 (GRCm39) |
Y269F |
probably damaging |
Het |
| Esco2 |
A |
G |
14: 66,068,711 (GRCm39) |
S200P |
possibly damaging |
Het |
| Fcrl1 |
T |
A |
3: 87,292,626 (GRCm39) |
|
probably benign |
Het |
| Fhod1 |
C |
A |
8: 106,056,309 (GRCm39) |
D1135Y |
probably damaging |
Het |
| Fnbp1l |
T |
C |
3: 122,383,796 (GRCm39) |
N41D |
possibly damaging |
Het |
| Folh1 |
A |
T |
7: 86,410,907 (GRCm39) |
|
probably null |
Het |
| Fpr-rs7 |
T |
C |
17: 20,334,277 (GRCm39) |
D71G |
probably damaging |
Het |
| Gm10271 |
A |
G |
10: 116,797,844 (GRCm39) |
|
probably benign |
Het |
| Gm4841 |
A |
T |
18: 60,404,020 (GRCm39) |
Y24* |
probably null |
Het |
| Greb1 |
G |
A |
12: 16,740,895 (GRCm39) |
R1396C |
probably benign |
Het |
| Hectd1 |
C |
T |
12: 51,800,590 (GRCm39) |
C2076Y |
probably damaging |
Het |
| Hnrnpu |
A |
G |
1: 178,152,806 (GRCm39) |
|
probably benign |
Het |
| Ice2 |
T |
C |
9: 69,322,930 (GRCm39) |
I475T |
probably benign |
Het |
| Ifit1bl1 |
T |
A |
19: 34,571,593 (GRCm39) |
Q288L |
probably damaging |
Het |
| Ift56 |
T |
A |
6: 38,386,411 (GRCm39) |
D377E |
possibly damaging |
Het |
| Ik |
T |
C |
18: 36,889,871 (GRCm39) |
|
probably benign |
Het |
| Kidins220 |
C |
T |
12: 25,063,445 (GRCm39) |
|
probably benign |
Het |
| Kmt2c |
T |
C |
5: 25,577,972 (GRCm39) |
D768G |
probably benign |
Het |
| Kmt2e |
A |
G |
5: 23,697,362 (GRCm39) |
T87A |
probably damaging |
Het |
| Lama5 |
G |
A |
2: 179,837,274 (GRCm39) |
|
probably benign |
Het |
| Lmbr1l |
A |
G |
15: 98,810,357 (GRCm39) |
S85P |
probably damaging |
Het |
| Lrig2 |
A |
G |
3: 104,374,682 (GRCm39) |
|
probably benign |
Het |
| Lrig3 |
A |
G |
10: 125,845,944 (GRCm39) |
D791G |
probably damaging |
Het |
| Lrrc2 |
G |
A |
9: 110,809,908 (GRCm39) |
V315M |
probably benign |
Het |
| Lrrc4b |
A |
G |
7: 44,111,823 (GRCm39) |
D565G |
probably benign |
Het |
| Mpped1 |
C |
T |
15: 83,676,191 (GRCm39) |
|
probably benign |
Het |
| Msrb2 |
T |
A |
2: 19,388,114 (GRCm39) |
D87E |
probably benign |
Het |
| Muc20 |
T |
C |
16: 32,614,511 (GRCm39) |
T289A |
possibly damaging |
Het |
| Myo15a |
C |
A |
11: 60,369,238 (GRCm39) |
P666Q |
possibly damaging |
Het |
| Nfat5 |
C |
T |
8: 108,088,421 (GRCm39) |
P579L |
probably damaging |
Het |
| Nipbl |
A |
C |
15: 8,348,972 (GRCm39) |
M1920R |
probably damaging |
Het |
| Nuak1 |
T |
C |
10: 84,210,738 (GRCm39) |
|
probably null |
Het |
| Nup210l |
A |
G |
3: 90,096,793 (GRCm39) |
E1334G |
probably damaging |
Het |
| Odad2 |
A |
T |
18: 7,127,388 (GRCm39) |
C942S |
probably damaging |
Het |
| Or52e8b |
A |
T |
7: 104,673,370 (GRCm39) |
N272K |
probably benign |
Het |
| Or5an1c |
T |
A |
19: 12,218,819 (GRCm39) |
I69F |
probably benign |
Het |
| Or6c6c |
T |
C |
10: 129,541,574 (GRCm39) |
Y276H |
probably benign |
Het |
| Or9s13 |
G |
A |
1: 92,548,342 (GRCm39) |
G238E |
possibly damaging |
Het |
| Or9s14 |
A |
T |
1: 92,535,831 (GRCm39) |
N91Y |
possibly damaging |
Het |
| P4ha3 |
A |
T |
7: 99,949,898 (GRCm39) |
|
probably null |
Het |
| Pbld2 |
C |
T |
10: 62,890,150 (GRCm39) |
A186V |
probably benign |
Het |
| Pcdh18 |
A |
T |
3: 49,710,083 (GRCm39) |
Y411N |
probably benign |
Het |
| Pgf |
A |
G |
12: 85,218,541 (GRCm39) |
S70P |
probably benign |
Het |
| Phrf1 |
T |
A |
7: 140,812,369 (GRCm39) |
D44E |
probably benign |
Het |
| Pla2g4a |
A |
G |
1: 149,778,196 (GRCm39) |
|
probably benign |
Het |
| Plce1 |
A |
G |
19: 38,769,234 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
A |
G |
1: 194,493,278 (GRCm39) |
N1851S |
probably benign |
Het |
| Prl7a2 |
G |
A |
13: 27,843,254 (GRCm39) |
T183I |
probably damaging |
Het |
| Prxl2b |
A |
T |
4: 154,981,814 (GRCm39) |
V151D |
probably damaging |
Het |
| Ptger4 |
A |
T |
15: 5,264,576 (GRCm39) |
L335H |
probably damaging |
Het |
| Ptgr1 |
A |
G |
4: 58,984,865 (GRCm39) |
|
probably benign |
Het |
| Rdh7 |
A |
G |
10: 127,720,590 (GRCm39) |
S261P |
probably benign |
Het |
| Reg3a |
A |
G |
6: 78,360,269 (GRCm39) |
T150A |
probably benign |
Het |
| Rnf111 |
A |
G |
9: 70,383,394 (GRCm39) |
S180P |
probably benign |
Het |
| Rnf17 |
A |
G |
14: 56,759,856 (GRCm39) |
M1554V |
probably damaging |
Het |
| Rnf215 |
T |
A |
11: 4,085,873 (GRCm39) |
Y117* |
probably null |
Het |
| Rnps1-ps |
A |
T |
6: 7,983,124 (GRCm39) |
|
noncoding transcript |
Het |
| Rogdi |
T |
C |
16: 4,828,369 (GRCm39) |
T165A |
probably benign |
Het |
| Rpe65 |
A |
G |
3: 159,328,485 (GRCm39) |
Y431C |
probably damaging |
Het |
| Scube1 |
A |
G |
15: 83,494,405 (GRCm39) |
F844S |
probably damaging |
Het |
| Sdr16c6 |
T |
A |
4: 4,058,814 (GRCm39) |
E257D |
probably benign |
Het |
| Sim1 |
C |
A |
10: 50,857,649 (GRCm39) |
C466* |
probably null |
Het |
| Spi1 |
T |
A |
2: 90,929,867 (GRCm39) |
H46Q |
probably damaging |
Het |
| Sumf2 |
C |
A |
5: 129,873,909 (GRCm39) |
|
probably benign |
Het |
| Tbcb |
A |
G |
7: 29,931,037 (GRCm39) |
Y28H |
probably benign |
Het |
| Tep1 |
T |
C |
14: 51,067,079 (GRCm39) |
|
probably benign |
Het |
| Tmem245 |
A |
T |
4: 56,903,968 (GRCm39) |
W591R |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,902,548 (GRCm39) |
I1134V |
probably benign |
Het |
| Trappc14 |
T |
C |
5: 138,260,739 (GRCm39) |
|
probably null |
Het |
| Trim13 |
G |
T |
14: 61,843,068 (GRCm39) |
A362S |
probably benign |
Het |
| Trim47 |
T |
A |
11: 116,000,646 (GRCm39) |
D134V |
probably damaging |
Het |
| Utrn |
C |
A |
10: 12,312,108 (GRCm39) |
D616Y |
probably damaging |
Het |
| Vnn1 |
G |
T |
10: 23,775,415 (GRCm39) |
A222S |
possibly damaging |
Het |
| Wdr17 |
A |
G |
8: 55,143,249 (GRCm39) |
W110R |
probably damaging |
Het |
| Wwp1 |
G |
T |
4: 19,627,892 (GRCm39) |
Y700* |
probably null |
Het |
| Zbtb21 |
T |
C |
16: 97,751,785 (GRCm39) |
S661G |
probably benign |
Het |
| Zfp955b |
A |
G |
17: 33,521,788 (GRCm39) |
K419R |
probably benign |
Het |
|
| Other mutations in Tecta |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00466:Tecta
|
APN |
9 |
42,243,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00925:Tecta
|
APN |
9 |
42,286,331 (GRCm39) |
missense |
probably benign |
|
|
IGL00960:Tecta
|
APN |
9 |
42,270,376 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL00974:Tecta
|
APN |
9 |
42,242,670 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01070:Tecta
|
APN |
9 |
42,306,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01284:Tecta
|
APN |
9 |
42,256,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01324:Tecta
|
APN |
9 |
42,256,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01694:Tecta
|
APN |
9 |
42,278,475 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01861:Tecta
|
APN |
9 |
42,284,658 (GRCm39) |
missense |
probably benign |
|
|
IGL02010:Tecta
|
APN |
9 |
42,248,489 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02397:Tecta
|
APN |
9 |
42,306,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tecta
|
APN |
9 |
42,256,789 (GRCm39) |
missense |
probably benign |
|
|
IGL03208:Tecta
|
APN |
9 |
42,248,396 (GRCm39) |
splice site |
probably benign |
|
|
IGL03249:Tecta
|
APN |
9 |
42,303,182 (GRCm39) |
missense |
probably benign |
0.20 |
|
cover
|
UTSW |
9 |
42,255,183 (GRCm39) |
missense |
probably benign |
0.05 |
|
lid
|
UTSW |
9 |
42,284,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0004:Tecta
|
UTSW |
9 |
42,256,774 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0045:Tecta
|
UTSW |
9 |
42,286,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0045:Tecta
|
UTSW |
9 |
42,286,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0119:Tecta
|
UTSW |
9 |
42,263,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Tecta
|
UTSW |
9 |
42,278,524 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0157:Tecta
|
UTSW |
9 |
42,286,307 (GRCm39) |
missense |
probably benign |
|
|
R0180:Tecta
|
UTSW |
9 |
42,278,109 (GRCm39) |
missense |
probably benign |
|
|
R0299:Tecta
|
UTSW |
9 |
42,263,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0345:Tecta
|
UTSW |
9 |
42,295,514 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0370:Tecta
|
UTSW |
9 |
42,278,100 (GRCm39) |
missense |
probably benign |
|
|
R0465:Tecta
|
UTSW |
9 |
42,270,714 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R0466:Tecta
|
UTSW |
9 |
42,284,369 (GRCm39) |
missense |
probably benign |
|
|
R0479:Tecta
|
UTSW |
9 |
42,249,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Tecta
|
UTSW |
9 |
42,288,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0499:Tecta
|
UTSW |
9 |
42,263,359 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0519:Tecta
|
UTSW |
9 |
42,259,188 (GRCm39) |
splice site |
probably benign |
|
|
R0584:Tecta
|
UTSW |
9 |
42,259,204 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0589:Tecta
|
UTSW |
9 |
42,256,930 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0607:Tecta
|
UTSW |
9 |
42,299,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0691:Tecta
|
UTSW |
9 |
42,295,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Tecta
|
UTSW |
9 |
42,250,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Tecta
|
UTSW |
9 |
42,289,203 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1239:Tecta
|
UTSW |
9 |
42,243,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1442:Tecta
|
UTSW |
9 |
42,243,778 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1553:Tecta
|
UTSW |
9 |
42,259,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1727:Tecta
|
UTSW |
9 |
42,270,597 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1728:Tecta
|
UTSW |
9 |
42,303,218 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1729:Tecta
|
UTSW |
9 |
42,303,218 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1762:Tecta
|
UTSW |
9 |
42,286,605 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1795:Tecta
|
UTSW |
9 |
42,289,345 (GRCm39) |
missense |
probably benign |
|
|
R1796:Tecta
|
UTSW |
9 |
42,295,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Tecta
|
UTSW |
9 |
42,303,320 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1871:Tecta
|
UTSW |
9 |
42,248,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1871:Tecta
|
UTSW |
9 |
42,248,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1911:Tecta
|
UTSW |
9 |
42,249,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2074:Tecta
|
UTSW |
9 |
42,248,575 (GRCm39) |
nonsense |
probably null |
|
|
R2135:Tecta
|
UTSW |
9 |
42,251,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2171:Tecta
|
UTSW |
9 |
42,270,220 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2220:Tecta
|
UTSW |
9 |
42,303,326 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2372:Tecta
|
UTSW |
9 |
42,299,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2570:Tecta
|
UTSW |
9 |
42,243,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2939:Tecta
|
UTSW |
9 |
42,289,290 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2940:Tecta
|
UTSW |
9 |
42,289,290 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3081:Tecta
|
UTSW |
9 |
42,289,290 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3407:Tecta
|
UTSW |
9 |
42,249,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Tecta
|
UTSW |
9 |
42,303,402 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3771:Tecta
|
UTSW |
9 |
42,242,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3772:Tecta
|
UTSW |
9 |
42,242,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3773:Tecta
|
UTSW |
9 |
42,242,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3832:Tecta
|
UTSW |
9 |
42,250,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4378:Tecta
|
UTSW |
9 |
42,278,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Tecta
|
UTSW |
9 |
42,284,529 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4485:Tecta
|
UTSW |
9 |
42,248,570 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4804:Tecta
|
UTSW |
9 |
42,309,533 (GRCm39) |
missense |
probably benign |
|
|
R4869:Tecta
|
UTSW |
9 |
42,286,830 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4944:Tecta
|
UTSW |
9 |
42,241,573 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5008:Tecta
|
UTSW |
9 |
42,284,358 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5014:Tecta
|
UTSW |
9 |
42,284,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5125:Tecta
|
UTSW |
9 |
42,286,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Tecta
|
UTSW |
9 |
42,286,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5180:Tecta
|
UTSW |
9 |
42,248,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Tecta
|
UTSW |
9 |
42,256,964 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5230:Tecta
|
UTSW |
9 |
42,306,239 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5330:Tecta
|
UTSW |
9 |
42,249,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5387:Tecta
|
UTSW |
9 |
42,286,359 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5614:Tecta
|
UTSW |
9 |
42,250,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Tecta
|
UTSW |
9 |
42,250,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5738:Tecta
|
UTSW |
9 |
42,284,474 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5770:Tecta
|
UTSW |
9 |
42,256,885 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5839:Tecta
|
UTSW |
9 |
42,284,272 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5839:Tecta
|
UTSW |
9 |
42,242,319 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6119:Tecta
|
UTSW |
9 |
42,284,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6246:Tecta
|
UTSW |
9 |
42,289,204 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6377:Tecta
|
UTSW |
9 |
42,255,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6416:Tecta
|
UTSW |
9 |
42,286,563 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6595:Tecta
|
UTSW |
9 |
42,295,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6850:Tecta
|
UTSW |
9 |
42,255,134 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6859:Tecta
|
UTSW |
9 |
42,303,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6861:Tecta
|
UTSW |
9 |
42,248,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6939:Tecta
|
UTSW |
9 |
42,259,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6996:Tecta
|
UTSW |
9 |
42,278,082 (GRCm39) |
missense |
probably benign |
|
|
R7069:Tecta
|
UTSW |
9 |
42,306,237 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7104:Tecta
|
UTSW |
9 |
42,278,239 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7129:Tecta
|
UTSW |
9 |
42,259,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7220:Tecta
|
UTSW |
9 |
42,255,183 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7251:Tecta
|
UTSW |
9 |
42,299,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7307:Tecta
|
UTSW |
9 |
42,289,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Tecta
|
UTSW |
9 |
42,248,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7355:Tecta
|
UTSW |
9 |
42,278,438 (GRCm39) |
nonsense |
probably null |
|
|
R7635:Tecta
|
UTSW |
9 |
42,242,283 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7653:Tecta
|
UTSW |
9 |
42,248,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7723:Tecta
|
UTSW |
9 |
42,278,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7939:Tecta
|
UTSW |
9 |
42,299,519 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7966:Tecta
|
UTSW |
9 |
42,306,258 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7967:Tecta
|
UTSW |
9 |
42,289,251 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8000:Tecta
|
UTSW |
9 |
42,278,480 (GRCm39) |
nonsense |
probably null |
|
|
R8064:Tecta
|
UTSW |
9 |
42,306,251 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8117:Tecta
|
UTSW |
9 |
42,288,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Tecta
|
UTSW |
9 |
42,270,465 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8284:Tecta
|
UTSW |
9 |
42,289,325 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8315:Tecta
|
UTSW |
9 |
42,299,121 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8321:Tecta
|
UTSW |
9 |
42,284,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8332:Tecta
|
UTSW |
9 |
42,286,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8437:Tecta
|
UTSW |
9 |
42,243,856 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8496:Tecta
|
UTSW |
9 |
42,241,547 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8514:Tecta
|
UTSW |
9 |
42,284,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8683:Tecta
|
UTSW |
9 |
42,278,268 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8856:Tecta
|
UTSW |
9 |
42,284,597 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8886:Tecta
|
UTSW |
9 |
42,278,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9047:Tecta
|
UTSW |
9 |
42,286,375 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9106:Tecta
|
UTSW |
9 |
42,278,479 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9332:Tecta
|
UTSW |
9 |
42,284,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9352:Tecta
|
UTSW |
9 |
42,249,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9462:Tecta
|
UTSW |
9 |
42,248,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9535:Tecta
|
UTSW |
9 |
42,270,759 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9564:Tecta
|
UTSW |
9 |
42,249,123 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9592:Tecta
|
UTSW |
9 |
42,250,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9715:Tecta
|
UTSW |
9 |
42,286,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tecta
|
UTSW |
9 |
42,303,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tecta
|
UTSW |
9 |
42,286,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Tecta
|
UTSW |
9 |
42,303,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCATCACTGGATAGGGGCTACAAG -3'
(R):5'- TGACGGCTACTGCCTGAAACTCAC -3'
Sequencing Primer
(F):5'- TACAAGTGGGTCAGGCTCC -3'
(R):5'- ACATGAAGGGCTTCTTCCAG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation