Incidental Mutation 'R0082:Vip'
ID 19725
Institutional Source Beutler Lab
Gene Symbol Vip
Ensembl Gene ENSMUSG00000019772
Gene Name vasoactive intestinal polypeptide
Synonyms PHI, peptide histidine isoleucine
MMRRC Submission 038369-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.199) question?
Stock # R0082 (G1)
Quality Score 138
Status Validated
Chromosome 10
Chromosomal Location 5589218-5597617 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to A at 5594953 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Arginine at position 172 (*172R)
Ref Sequence ENSEMBL: ENSMUSP00000019906 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019906]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000019906
AA Change: *172R
SMART Domains Protein: ENSMUSP00000019906
Gene: ENSMUSG00000019772
AA Change: *172R

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
GLUCA 82 108 2.87e-11 SMART
GLUCA 126 152 6.39e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217331
Meta Mutation Damage Score 0.8527 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.3%
  • 10x: 91.7%
  • 20x: 73.7%
Validation Efficiency 94% (136/144)
MGI Phenotype FUNCTION: This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam17 A C 12: 21,379,049 (GRCm39) probably benign Het
Adcy1 T C 11: 7,099,497 (GRCm39) probably benign Het
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Ankrd33b T C 15: 31,297,935 (GRCm39) N274S probably benign Het
Antkmt T C 17: 26,010,548 (GRCm39) I89V probably benign Het
Arhgef1 C T 7: 24,612,030 (GRCm39) Q100* probably null Het
Ccdc180 A G 4: 45,896,205 (GRCm39) D118G probably null Het
Cdh23 T C 10: 60,148,366 (GRCm39) D2667G probably damaging Het
Cdh4 A T 2: 179,535,981 (GRCm39) N844I possibly damaging Het
Cep57 T C 9: 13,722,172 (GRCm39) probably benign Het
Dnah7a A T 1: 53,557,867 (GRCm39) D2182E probably damaging Het
Dync1h1 A G 12: 110,602,880 (GRCm39) T2174A probably benign Het
Eef1akmt2 T A 7: 132,453,201 (GRCm39) R44* probably null Het
Evpl T A 11: 116,125,829 (GRCm39) I43F probably damaging Het
F13a1 G T 13: 37,172,927 (GRCm39) P151Q probably damaging Het
Galnt5 A T 2: 57,889,047 (GRCm39) I216F possibly damaging Het
Glt6d1 C A 2: 25,684,739 (GRCm39) probably null Het
Gpr139 T A 7: 118,744,268 (GRCm39) T106S probably benign Het
Hoatz T C 9: 51,013,102 (GRCm39) T57A probably benign Het
Hoxb3 A G 11: 96,235,097 (GRCm39) D8G probably damaging Het
Hpse T C 5: 100,840,128 (GRCm39) K330E possibly damaging Het
Kcmf1 G T 6: 72,827,470 (GRCm39) probably null Het
Klra2 T C 6: 131,197,210 (GRCm39) N263S possibly damaging Het
Klra8 T C 6: 130,102,018 (GRCm39) D139G probably benign Het
Lrrc46 A C 11: 96,931,903 (GRCm39) probably benign Het
Ly86 A T 13: 37,602,513 (GRCm39) probably null Het
Mmp20 C T 9: 7,642,808 (GRCm39) T214M probably benign Het
Or4k5 A T 14: 50,385,512 (GRCm39) I273K probably damaging Het
Or52s1b G T 7: 102,822,409 (GRCm39) A145E probably benign Het
Or6c1b T C 10: 129,273,140 (GRCm39) I153T possibly damaging Het
Or6c209 G A 10: 129,483,522 (GRCm39) C175Y probably benign Het
Pigg A G 5: 108,460,751 (GRCm39) probably benign Het
Polq C A 16: 36,837,619 (GRCm39) T177K probably benign Het
Pomgnt2 A T 9: 121,811,326 (GRCm39) V485E probably damaging Het
Ppip5k2 A T 1: 97,687,057 (GRCm39) C49* probably null Het
Prkrip1 T C 5: 136,226,682 (GRCm39) N53D possibly damaging Het
Prrc2b T C 2: 32,102,310 (GRCm39) probably benign Het
Qprt T C 7: 126,707,358 (GRCm39) E246G probably damaging Het
Rpl9 A G 5: 65,545,995 (GRCm39) V167A probably benign Het
Rskr T C 11: 78,184,384 (GRCm39) S244P probably damaging Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sgsm1 T C 5: 113,436,702 (GRCm39) I43V probably benign Het
Slc38a7 A G 8: 96,567,109 (GRCm39) probably benign Het
Slc8b1 A G 5: 120,662,265 (GRCm39) probably benign Het
Sp2 T C 11: 96,852,525 (GRCm39) Y133C probably damaging Het
Spdye4b A T 5: 143,181,430 (GRCm39) D95V probably damaging Het
Srek1 T C 13: 103,880,194 (GRCm39) T455A unknown Het
Stox2 A T 8: 47,656,317 (GRCm39) probably benign Het
Synrg T A 11: 83,878,736 (GRCm39) probably benign Het
Tie1 T A 4: 118,341,550 (GRCm39) E254V probably damaging Het
Tmem97 G T 11: 78,433,414 (GRCm39) F160L probably damaging Het
Utp6 A T 11: 79,844,457 (GRCm39) H189Q possibly damaging Het
Wdr91 T C 6: 34,883,620 (GRCm39) R132G possibly damaging Het
Wipi1 T C 11: 109,469,110 (GRCm39) probably benign Het
Zfp445 A G 9: 122,681,421 (GRCm39) V840A probably damaging Het
Other mutations in Vip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01018:Vip APN 10 5,592,480 (GRCm39) missense probably benign 0.28
IGL02182:Vip APN 10 5,593,561 (GRCm39) missense probably benign 0.01
R0267:Vip UTSW 10 5,594,004 (GRCm39) missense possibly damaging 0.67
R1776:Vip UTSW 10 5,594,992 (GRCm39) critical splice donor site probably null
R3973:Vip UTSW 10 5,592,590 (GRCm39) missense possibly damaging 0.57
R4803:Vip UTSW 10 5,594,099 (GRCm39) missense probably damaging 0.99
R5898:Vip UTSW 10 5,593,988 (GRCm39) missense probably damaging 0.96
R6365:Vip UTSW 10 5,594,021 (GRCm39) nonsense probably null
R9571:Vip UTSW 10 5,590,661 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CTCCTTGCCCACTAAATGATGGCTC -3'
(R):5'- ACTTTCCCTCAGCGTGTGACTCAG -3'

Sequencing Primer
(F):5'- CCCACTAAATGATGGCTCTGTAAG -3'
(R):5'- GGCCTAACTCTTTATGGTGAACAG -3'
Posted On 2013-04-11