Mutagenetix > Incidental Mutation

Incidental Mutation 'R1778:Fpr-rs7'

197285

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

039809-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R1778 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20114015 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 71 (D71G)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably damaging
Transcript: ENSMUST00000095637
AA Change: D71G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: D71G

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000176711

Meta Mutation Damage Score

0.9197

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.6%
20x: 93.3%

Validation Efficiency

98% (107/109)

Allele List at MGI

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810043G02Rik	G	T	10: 77,982,944	A150S	probably benign	Het
4930432E11Rik	T	C	7: 29,560,706		noncoding transcript	Het
4930568D16Rik	A	G	2: 35,354,983	M119T	probably damaging	Het
Aadacl2	A	G	3: 60,017,450		probably null	Het
Abca9	C	T	11: 110,130,716	W1056*	probably null	Het
Adam20	A	C	8: 40,796,661	T603P	possibly damaging	Het
Adgrl1	T	C	8: 83,930,037	L323P	probably damaging	Het
Afap1l2	C	T	19: 56,916,206	E628K	possibly damaging	Het
Ahctf1	A	T	1: 179,753,015	L1874Q	possibly damaging	Het
Ak8	A	G	2: 28,712,321	E89G	probably benign	Het
Aldh16a1	G	A	7: 45,147,308	R256C	probably damaging	Het
Anxa5	G	A	3: 36,465,331	T3M	probably damaging	Het
Arhgef16	T	C	4: 154,287,986	K210E	probably benign	Het
Armc4	A	T	18: 7,127,388	C942S	probably damaging	Het
Baz2b	T	C	2: 60,006,136	T18A	unknown	Het
BC037034	T	C	5: 138,262,477		probably null	Het
Bub1	A	C	2: 127,803,122	I960M	possibly damaging	Het
Cbln2	G	T	18: 86,713,147	D27Y	probably benign	Het
Ces2h	C	A	8: 105,014,607	P77Q	possibly damaging	Het
Chga	T	A	12: 102,561,700	M150K	probably benign	Het
Chmp3	A	G	6: 71,577,807	E162G	probably benign	Het
Clip3	A	G	7: 30,297,436	N161S	probably damaging	Het
Col12a1	T	A	9: 79,604,585		probably benign	Het
Cuedc2	C	T	19: 46,331,640	G105D	probably benign	Het
Cyp2j7	A	C	4: 96,199,390	F428V	probably damaging	Het
Ddx60	A	G	8: 61,974,176	I762V	possibly damaging	Het
Def6	G	A	17: 28,220,186	R257Q	probably benign	Het
Dkkl1	A	T	7: 45,211,395		probably null	Het
Dnah3	A	G	7: 120,078,402	L433P	probably damaging	Het
Eif2s3y	C	T	Y: 1,011,287	R33C	probably benign	Het
Elavl2	T	A	4: 91,253,478	Y269F	probably damaging	Het
Esco2	A	G	14: 65,831,262	S200P	possibly damaging	Het
Fam213b	A	T	4: 154,897,357	V151D	probably damaging	Het
Fcrl1	T	A	3: 87,385,319		probably benign	Het
Fhod1	C	A	8: 105,329,677	D1135Y	probably damaging	Het
Fnbp1l	T	C	3: 122,590,147	N41D	possibly damaging	Het
Folh1	A	T	7: 86,761,699		probably null	Het
Gm10271	A	G	10: 116,961,939		probably benign	Het
Gm4841	A	T	18: 60,270,948	Y24*	probably null	Het
Gm9825	A	T	6: 7,983,124		noncoding transcript	Het
Greb1	G	A	12: 16,690,894	R1396C	probably benign	Het
Hectd1	C	T	12: 51,753,807	C2076Y	probably damaging	Het
Hnrnpu	A	G	1: 178,325,241		probably benign	Het
Ice2	T	C	9: 69,415,648	I475T	probably benign	Het
Ifit1bl1	T	A	19: 34,594,193	Q288L	probably damaging	Het
Ik	T	C	18: 36,756,818		probably benign	Het
Kidins220	C	T	12: 25,013,446		probably benign	Het
Kmt2c	T	C	5: 25,372,974	D768G	probably benign	Het
Kmt2e	A	G	5: 23,492,364	T87A	probably damaging	Het
Lama5	G	A	2: 180,195,481		probably benign	Het
Lmbr1l	A	G	15: 98,912,476	S85P	probably damaging	Het
Lrig2	A	G	3: 104,467,366		probably benign	Het
Lrig3	A	G	10: 126,010,075	D791G	probably damaging	Het
Lrrc2	G	A	9: 110,980,840	V315M	probably benign	Het
Lrrc4b	A	G	7: 44,462,399	D565G	probably benign	Het
Mpped1	C	T	15: 83,791,990		probably benign	Het
Msrb2	T	A	2: 19,383,303	D87E	probably benign	Het
Muc20	T	C	16: 32,794,141	T289A	possibly damaging	Het
Myo15	C	A	11: 60,478,412	P666Q	possibly damaging	Het
Nfat5	C	T	8: 107,361,789	P579L	probably damaging	Het
Nipbl	A	C	15: 8,319,488	M1920R	probably damaging	Het
Nuak1	T	C	10: 84,374,874		probably null	Het
Nup210l	A	G	3: 90,189,486	E1334G	probably damaging	Het
Olfr12	G	A	1: 92,620,620	G238E	possibly damaging	Het
Olfr1410	A	T	1: 92,608,109	N91Y	possibly damaging	Het
Olfr262	T	A	19: 12,241,455	I69F	probably benign	Het
Olfr675	A	T	7: 105,024,163	N272K	probably benign	Het
Olfr804	T	C	10: 129,705,705	Y276H	probably benign	Het
P4ha3	A	T	7: 100,300,691		probably null	Het
Pbld2	C	T	10: 63,054,371	A186V	probably benign	Het
Pcdh18	A	T	3: 49,755,634	Y411N	probably benign	Het
Pgf	A	G	12: 85,171,767	S70P	probably benign	Het
Phrf1	T	A	7: 141,232,456	D44E	probably benign	Het
Pla2g4a	A	G	1: 149,902,445		probably benign	Het
Plce1	A	G	19: 38,780,790		probably benign	Het
Plxna2	A	G	1: 194,810,970	N1851S	probably benign	Het
Prl7a2	G	A	13: 27,659,271	T183I	probably damaging	Het
Ptger4	A	T	15: 5,235,095	L335H	probably damaging	Het
Ptgr1	A	G	4: 58,984,865		probably benign	Het
Rdh7	A	G	10: 127,884,721	S261P	probably benign	Het
Reg3a	A	G	6: 78,383,286	T150A	probably benign	Het
Rnf111	A	G	9: 70,476,112	S180P	probably benign	Het
Rnf17	A	G	14: 56,522,399	M1554V	probably damaging	Het
Rnf215	T	A	11: 4,135,873	Y117*	probably null	Het
Rogdi	T	C	16: 5,010,505	T165A	probably benign	Het
Rpe65	A	G	3: 159,622,848	Y431C	probably damaging	Het
Scube1	A	G	15: 83,610,204	F844S	probably damaging	Het
Sdr16c6	T	A	4: 4,058,814	E257D	probably benign	Het
Sim1	C	A	10: 50,981,553	C466*	probably null	Het
Spi1	T	A	2: 91,099,522	H46Q	probably damaging	Het
Sumf2	C	A	5: 129,845,068		probably benign	Het
Tbcb	A	G	7: 30,231,612	Y28H	probably benign	Het
Tecta	C	T	9: 42,343,631	C1752Y	probably damaging	Het
Tep1	T	C	14: 50,829,622		probably benign	Het
Tmem245	A	T	4: 56,903,968	W591R	probably damaging	Het
Tnxb	A	G	17: 34,683,574	I1134V	probably benign	Het
Trim13	G	T	14: 61,605,619	A362S	probably benign	Het
Trim47	T	A	11: 116,109,820	D134V	probably damaging	Het
Ttc26	T	A	6: 38,409,476	D377E	possibly damaging	Het
Utrn	C	A	10: 12,436,364	D616Y	probably damaging	Het
Vnn1	G	T	10: 23,899,517	A222S	possibly damaging	Het
Wdr17	A	G	8: 54,690,214	W110R	probably damaging	Het
Wwp1	G	T	4: 19,627,892	Y700*	probably null	Het
Zbtb21	T	C	16: 97,950,585	S661G	probably benign	Het
Zfp955b	A	G	17: 33,302,814	K419R	probably benign	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
R9134:Fpr-rs7	UTSW	17	20114063	missense	probably damaging	1.00
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- TTCACAGTTCGATGATTCTGAGCCC -3'
(R):5'- AATGTTGCAGGTGCTGACAAAATGG -3'

Sequencing Primer
(F):5'- CGATGATTCTGAGCCCATACTGG -3'
(R):5'- TTCTCCATACCTCAGAATGGATCAG -3'

Posted On

2014-05-23