Incidental Mutation 'R1780:Vmn2r25'
| ID |
197445 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r25
|
| Ensembl Gene |
ENSMUSG00000094672 |
| Gene Name |
vomeronasal 2, receptor 25 |
| Synonyms |
EG545874 |
| MMRRC Submission |
039811-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R1780 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123799773-123830149 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 123805424 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 478
(S478P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124342
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000162046]
|
| AlphaFold |
W4VSP2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162046
AA Change: S478P
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000124342
Gene: ENSMUSG00000094672
AA Change: S478P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
473 |
6e-31 |
PFAM |
|
Pfam:NCD3G
|
519 |
572 |
5.8e-25 |
PFAM |
|
Pfam:7tm_3
|
603 |
840 |
4.8e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.3%
|
| Validation Efficiency |
98% (80/82) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrl2 |
T |
C |
3: 148,558,229 (GRCm39) |
E493G |
probably damaging |
Het |
| Aff3 |
A |
T |
1: 38,574,783 (GRCm39) |
S66T |
probably damaging |
Het |
| Ankrd17 |
T |
A |
5: 90,380,274 (GRCm39) |
K2470N |
probably damaging |
Het |
| Ap3m1 |
T |
C |
14: 21,091,138 (GRCm39) |
T156A |
probably benign |
Het |
| Arhgef4 |
T |
A |
1: 34,763,241 (GRCm39) |
S832R |
possibly damaging |
Het |
| Asb10 |
T |
C |
5: 24,738,674 (GRCm39) |
D423G |
possibly damaging |
Het |
| Ash1l |
A |
G |
3: 88,873,291 (GRCm39) |
T25A |
probably benign |
Het |
| Atp13a2 |
T |
A |
4: 140,729,771 (GRCm39) |
L663I |
possibly damaging |
Het |
| Atp9b |
A |
T |
18: 80,820,112 (GRCm39) |
Y174* |
probably null |
Het |
| Bche |
A |
G |
3: 73,607,953 (GRCm39) |
I491T |
probably benign |
Het |
| Bckdhb |
T |
C |
9: 83,835,836 (GRCm39) |
|
probably null |
Het |
| Cadps2 |
C |
T |
6: 23,320,931 (GRCm39) |
|
probably null |
Het |
| Cdc42bpb |
A |
T |
12: 111,289,341 (GRCm39) |
V468E |
probably damaging |
Het |
| Chrnd |
T |
C |
1: 87,120,270 (GRCm39) |
V33A |
possibly damaging |
Het |
| Col6a5 |
A |
T |
9: 105,814,077 (GRCm39) |
V645D |
unknown |
Het |
| Cpa1 |
C |
T |
6: 30,643,007 (GRCm39) |
L312F |
probably damaging |
Het |
| Cyp2a5 |
A |
G |
7: 26,541,301 (GRCm39) |
|
probably benign |
Het |
| Cyp2c39 |
C |
A |
19: 39,527,295 (GRCm39) |
|
probably benign |
Het |
| Cyp2d26 |
T |
C |
15: 82,678,208 (GRCm39) |
N56S |
probably damaging |
Het |
| Ddx21 |
A |
G |
10: 62,429,926 (GRCm39) |
|
probably benign |
Het |
| Dnah11 |
A |
T |
12: 117,991,293 (GRCm39) |
C2358S |
probably damaging |
Het |
| Entpd8 |
T |
C |
2: 24,974,318 (GRCm39) |
S368P |
probably benign |
Het |
| Epg5 |
A |
T |
18: 78,067,205 (GRCm39) |
Q2222L |
probably damaging |
Het |
| Ercc5 |
T |
A |
1: 44,206,956 (GRCm39) |
V623E |
probably benign |
Het |
| Flg2 |
A |
G |
3: 93,110,306 (GRCm39) |
E778G |
unknown |
Het |
| Gbe1 |
C |
T |
16: 70,292,212 (GRCm39) |
R515* |
probably null |
Het |
| Hsd17b6 |
A |
G |
10: 127,830,196 (GRCm39) |
|
probably null |
Het |
| Hyal6 |
C |
T |
6: 24,734,031 (GRCm39) |
|
probably benign |
Het |
| Ifi27l2b |
A |
G |
12: 103,417,578 (GRCm39) |
I203T |
probably damaging |
Het |
| Kcnk9 |
A |
C |
15: 72,384,250 (GRCm39) |
D309E |
unknown |
Het |
| Lrp6 |
C |
T |
6: 134,441,414 (GRCm39) |
R1184Q |
probably damaging |
Het |
| Mdn1 |
T |
C |
4: 32,700,103 (GRCm39) |
F1399L |
probably damaging |
Het |
| Mroh2a |
C |
T |
1: 88,158,402 (GRCm39) |
R150* |
probably null |
Het |
| Mx1 |
T |
C |
16: 97,252,712 (GRCm39) |
*289W |
probably null |
Het |
| Myo7b |
T |
C |
18: 32,094,238 (GRCm39) |
E1970G |
probably damaging |
Het |
| Mypn |
T |
C |
10: 62,957,743 (GRCm39) |
Y24C |
probably damaging |
Het |
| Naxe |
G |
C |
3: 87,964,440 (GRCm39) |
P167A |
probably benign |
Het |
| Nmnat2 |
A |
T |
1: 152,988,186 (GRCm39) |
K272* |
probably null |
Het |
| Nmnat3 |
C |
T |
9: 98,236,164 (GRCm39) |
T19M |
probably damaging |
Het |
| Or4f52 |
T |
C |
2: 111,062,043 (GRCm39) |
I32V |
probably benign |
Het |
| Or51b17 |
A |
T |
7: 103,542,762 (GRCm39) |
F60Y |
probably damaging |
Het |
| Or51b4 |
A |
G |
7: 103,530,799 (GRCm39) |
V217A |
probably benign |
Het |
| Or5b118 |
A |
G |
19: 13,448,726 (GRCm39) |
T131A |
probably benign |
Het |
| Or9s27 |
G |
A |
1: 92,516,111 (GRCm39) |
V20M |
probably benign |
Het |
| Pgm3 |
T |
G |
9: 86,438,257 (GRCm39) |
E509D |
probably damaging |
Het |
| Phf3 |
A |
T |
1: 30,851,023 (GRCm39) |
D1110E |
probably damaging |
Het |
| Pkd1 |
T |
G |
17: 24,800,543 (GRCm39) |
S3062A |
probably benign |
Het |
| Pogz |
A |
T |
3: 94,777,437 (GRCm39) |
K372N |
possibly damaging |
Het |
| Pou1f1 |
A |
G |
16: 65,320,356 (GRCm39) |
Y15C |
probably benign |
Het |
| Ppfia2 |
A |
G |
10: 106,732,368 (GRCm39) |
T972A |
possibly damaging |
Het |
| Rasip1 |
A |
G |
7: 45,284,742 (GRCm39) |
Y703C |
possibly damaging |
Het |
| Recql |
T |
A |
6: 142,310,324 (GRCm39) |
Q502L |
probably benign |
Het |
| Rgs9 |
A |
T |
11: 109,130,325 (GRCm39) |
Y383* |
probably null |
Het |
| Rimbp3 |
T |
C |
16: 17,030,496 (GRCm39) |
S1307P |
probably benign |
Het |
| Rspo1 |
A |
G |
4: 124,901,538 (GRCm39) |
T200A |
probably damaging |
Het |
| Ryr3 |
C |
T |
2: 112,697,637 (GRCm39) |
M922I |
probably damaging |
Het |
| Samm50 |
C |
T |
15: 84,095,328 (GRCm39) |
A438V |
probably damaging |
Het |
| Sec1 |
A |
C |
7: 45,328,256 (GRCm39) |
S264A |
probably benign |
Het |
| Sec31a |
A |
T |
5: 100,529,195 (GRCm39) |
|
probably null |
Het |
| Slc13a3 |
T |
C |
2: 165,248,619 (GRCm39) |
N553S |
unknown |
Het |
| Smg6 |
T |
A |
11: 74,836,942 (GRCm39) |
L852Q |
probably damaging |
Het |
| Spata13 |
A |
G |
14: 60,929,174 (GRCm39) |
N244S |
probably damaging |
Het |
| Srbd1 |
T |
C |
17: 86,365,113 (GRCm39) |
R648G |
probably damaging |
Het |
| Sugct |
T |
G |
13: 17,627,039 (GRCm39) |
|
probably null |
Het |
| Tmed10 |
A |
G |
12: 85,401,653 (GRCm39) |
Y85H |
probably damaging |
Het |
| Trim68 |
A |
G |
7: 102,333,280 (GRCm39) |
I134T |
possibly damaging |
Het |
| Trio |
A |
G |
15: 27,744,124 (GRCm39) |
C2603R |
possibly damaging |
Het |
| Tspyl3 |
G |
A |
2: 153,067,176 (GRCm39) |
R21W |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,641,043 (GRCm39) |
I11863V |
probably null |
Het |
| Ubp1 |
G |
A |
9: 113,793,647 (GRCm39) |
A283T |
possibly damaging |
Het |
| Ubtf |
A |
T |
11: 102,205,744 (GRCm39) |
F60L |
probably damaging |
Het |
| Vmn1r235 |
T |
C |
17: 21,481,999 (GRCm39) |
I108T |
probably benign |
Het |
| Vmn2r125 |
T |
C |
4: 156,703,668 (GRCm39) |
S349P |
probably damaging |
Het |
| Vmn2r88 |
T |
A |
14: 51,656,029 (GRCm39) |
V746D |
probably damaging |
Het |
| Zcwpw1 |
A |
G |
5: 137,794,914 (GRCm39) |
K37E |
probably damaging |
Het |
| Zdhhc24 |
T |
C |
19: 4,933,794 (GRCm39) |
S284P |
probably damaging |
Het |
| Zswim8 |
C |
A |
14: 20,766,395 (GRCm39) |
H841N |
probably damaging |
Het |
|
| Other mutations in Vmn2r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Vmn2r25
|
APN |
6 |
123,830,130 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL01781:Vmn2r25
|
APN |
6 |
123,816,324 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01843:Vmn2r25
|
APN |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02023:Vmn2r25
|
APN |
6 |
123,816,388 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02502:Vmn2r25
|
APN |
6 |
123,816,392 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02709:Vmn2r25
|
APN |
6 |
123,816,723 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03053:Vmn2r25
|
APN |
6 |
123,800,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4468001:Vmn2r25
|
UTSW |
6 |
123,816,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Vmn2r25
|
UTSW |
6 |
123,800,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Vmn2r25
|
UTSW |
6 |
123,829,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0312:Vmn2r25
|
UTSW |
6 |
123,805,539 (GRCm39) |
splice site |
probably benign |
|
|
R0366:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R0390:Vmn2r25
|
UTSW |
6 |
123,800,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r25
|
UTSW |
6 |
123,829,008 (GRCm39) |
missense |
probably benign |
0.16 |
|
R0541:Vmn2r25
|
UTSW |
6 |
123,816,786 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0612:Vmn2r25
|
UTSW |
6 |
123,816,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1219:Vmn2r25
|
UTSW |
6 |
123,816,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1240:Vmn2r25
|
UTSW |
6 |
123,828,864 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Vmn2r25
|
UTSW |
6 |
123,828,754 (GRCm39) |
splice site |
probably null |
|
|
R1809:Vmn2r25
|
UTSW |
6 |
123,802,337 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1833:Vmn2r25
|
UTSW |
6 |
123,816,643 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1964:Vmn2r25
|
UTSW |
6 |
123,800,254 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2154:Vmn2r25
|
UTSW |
6 |
123,816,805 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r25
|
UTSW |
6 |
123,816,518 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3799:Vmn2r25
|
UTSW |
6 |
123,830,143 (GRCm39) |
missense |
probably benign |
0.12 |
|
R3836:Vmn2r25
|
UTSW |
6 |
123,830,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Vmn2r25
|
UTSW |
6 |
123,817,057 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4282:Vmn2r25
|
UTSW |
6 |
123,800,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4367:Vmn2r25
|
UTSW |
6 |
123,805,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Vmn2r25
|
UTSW |
6 |
123,816,756 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4488:Vmn2r25
|
UTSW |
6 |
123,799,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4631:Vmn2r25
|
UTSW |
6 |
123,829,962 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4765:Vmn2r25
|
UTSW |
6 |
123,800,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Vmn2r25
|
UTSW |
6 |
123,805,406 (GRCm39) |
missense |
probably benign |
|
|
R5207:Vmn2r25
|
UTSW |
6 |
123,817,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Vmn2r25
|
UTSW |
6 |
123,802,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5444:Vmn2r25
|
UTSW |
6 |
123,805,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Vmn2r25
|
UTSW |
6 |
123,802,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5607:Vmn2r25
|
UTSW |
6 |
123,805,318 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r25
|
UTSW |
6 |
123,800,587 (GRCm39) |
missense |
probably benign |
|
|
R6046:Vmn2r25
|
UTSW |
6 |
123,799,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Vmn2r25
|
UTSW |
6 |
123,799,900 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6569:Vmn2r25
|
UTSW |
6 |
123,828,941 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6826:Vmn2r25
|
UTSW |
6 |
123,800,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7054:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7120:Vmn2r25
|
UTSW |
6 |
123,805,394 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R7177:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7287:Vmn2r25
|
UTSW |
6 |
123,829,040 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7397:Vmn2r25
|
UTSW |
6 |
123,800,498 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7486:Vmn2r25
|
UTSW |
6 |
123,800,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7699:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7700:Vmn2r25
|
UTSW |
6 |
123,816,882 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7759:Vmn2r25
|
UTSW |
6 |
123,800,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7802:Vmn2r25
|
UTSW |
6 |
123,828,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7850:Vmn2r25
|
UTSW |
6 |
123,805,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Vmn2r25
|
UTSW |
6 |
123,800,581 (GRCm39) |
nonsense |
probably null |
|
|
R8170:Vmn2r25
|
UTSW |
6 |
123,829,976 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8340:Vmn2r25
|
UTSW |
6 |
123,829,972 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8346:Vmn2r25
|
UTSW |
6 |
123,802,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8395:Vmn2r25
|
UTSW |
6 |
123,799,982 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8889:Vmn2r25
|
UTSW |
6 |
123,800,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9094:Vmn2r25
|
UTSW |
6 |
123,805,391 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9204:Vmn2r25
|
UTSW |
6 |
123,830,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9253:Vmn2r25
|
UTSW |
6 |
123,816,960 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9392:Vmn2r25
|
UTSW |
6 |
123,816,937 (GRCm39) |
missense |
probably benign |
|
|
R9520:Vmn2r25
|
UTSW |
6 |
123,830,066 (GRCm39) |
nonsense |
probably null |
|
|
R9525:Vmn2r25
|
UTSW |
6 |
123,800,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9622:Vmn2r25
|
UTSW |
6 |
123,816,579 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0020:Vmn2r25
|
UTSW |
6 |
123,816,359 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Vmn2r25
|
UTSW |
6 |
123,799,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGGAAGTAACTGCCCAAGTGTTG -3'
(R):5'- GGCCAGAGTCCTTCTTTCATCACTG -3'
Sequencing Primer
(F):5'- TGATGGCACTCAGCAGTCAC -3'
(R):5'- TCTTTCATCACTGAGTGACTGAG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation