Incidental Mutation 'R1467:Nalcn'
| ID |
197655 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nalcn
|
| Ensembl Gene |
ENSMUSG00000000197 |
| Gene Name |
sodium leak channel, non-selective |
| Synonyms |
Vgcnl1, A530023G15Rik |
| MMRRC Submission |
039520-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1467 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
123514046-123864556 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 123702068 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000000201
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000201]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000000201
|
| SMART Domains |
Protein: ENSMUSP00000000201
Gene: ENSMUSG00000000197
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ion_trans
|
35 |
333 |
2.8e-37 |
PFAM |
|
low complexity region
|
338 |
348 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
383 |
609 |
5.7e-34 |
PFAM |
|
coiled coil region
|
796 |
830 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
885 |
1166 |
2.4e-42 |
PFAM |
|
Pfam:Ion_trans
|
1209 |
1458 |
6.9e-30 |
PFAM |
|
low complexity region
|
1548 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1634 |
1649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000227818
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228860
|
| Coding Region Coverage |
- 1x: 97.5%
- 3x: 97.1%
- 10x: 95.9%
- 20x: 94.1%
|
| Validation Efficiency |
99% (104/105) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal breathing at birth and die within 24 hours. Mice homozygous for a gain of function ENU mutation exhibit reduced the total amount and episode duration of REMS. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 114 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930430O22Rik |
T |
C |
5: 115,574,234 (GRCm39) |
|
probably benign |
Het |
| A630010A05Rik |
C |
A |
16: 14,436,447 (GRCm39) |
L167I |
possibly damaging |
Het |
| Abca14 |
A |
T |
7: 119,815,405 (GRCm39) |
M218L |
possibly damaging |
Het |
| Abca15 |
C |
A |
7: 119,939,761 (GRCm39) |
|
probably null |
Het |
| Acod1 |
T |
C |
14: 103,292,003 (GRCm39) |
F176L |
probably benign |
Het |
| Actr5 |
A |
G |
2: 158,480,617 (GRCm39) |
H545R |
probably benign |
Het |
| Adcy1 |
A |
G |
11: 7,088,396 (GRCm39) |
T472A |
probably damaging |
Het |
| Aldh1l1 |
A |
G |
6: 90,548,910 (GRCm39) |
K469R |
possibly damaging |
Het |
| Ambra1 |
A |
T |
2: 91,716,048 (GRCm39) |
Q853L |
probably damaging |
Het |
| Apol7e |
G |
T |
15: 77,601,966 (GRCm39) |
G188V |
probably damaging |
Het |
| Atg7 |
T |
A |
6: 114,835,943 (GRCm39) |
|
probably benign |
Het |
| AU018091 |
A |
T |
7: 3,214,089 (GRCm39) |
W43R |
probably benign |
Het |
| Baat |
A |
G |
4: 49,503,101 (GRCm39) |
V7A |
probably benign |
Het |
| Bcas1 |
C |
A |
2: 170,229,852 (GRCm39) |
Q249H |
possibly damaging |
Het |
| Bltp1 |
T |
A |
3: 37,090,094 (GRCm39) |
V676D |
probably damaging |
Het |
| Bptf |
G |
T |
11: 106,945,881 (GRCm39) |
Q2453K |
possibly damaging |
Het |
| Brca1 |
A |
T |
11: 101,421,933 (GRCm39) |
|
probably benign |
Het |
| Btg3 |
A |
G |
16: 78,161,688 (GRCm39) |
|
probably null |
Het |
| CAAA01180111.1 |
C |
A |
9: 124,058,093 (GRCm39) |
V9L |
possibly damaging |
Het |
| Cacna2d3 |
T |
C |
14: 29,055,736 (GRCm39) |
N298S |
possibly damaging |
Het |
| Carf |
G |
A |
1: 60,167,152 (GRCm39) |
V127I |
possibly damaging |
Het |
| Catsperg1 |
T |
C |
7: 28,884,433 (GRCm39) |
S916G |
probably damaging |
Het |
| Cers1 |
T |
C |
8: 70,775,819 (GRCm39) |
S274P |
possibly damaging |
Het |
| Ces4a |
T |
A |
8: 105,864,667 (GRCm39) |
V48E |
possibly damaging |
Het |
| Cfap54 |
T |
A |
10: 92,805,625 (GRCm39) |
H1495L |
probably benign |
Het |
| Clec4e |
G |
A |
6: 123,262,420 (GRCm39) |
|
probably benign |
Het |
| Cntnap5a |
T |
A |
1: 115,612,898 (GRCm39) |
L11* |
probably null |
Het |
| Cr2 |
C |
T |
1: 194,839,817 (GRCm39) |
G913R |
probably damaging |
Het |
| Cul9 |
A |
G |
17: 46,836,299 (GRCm39) |
L1155P |
probably damaging |
Het |
| D130052B06Rik |
C |
T |
11: 33,573,622 (GRCm39) |
|
probably benign |
Het |
| Dlec1 |
G |
A |
9: 118,957,071 (GRCm39) |
|
probably benign |
Het |
| Dlec1 |
A |
T |
9: 118,971,646 (GRCm39) |
D1278V |
probably damaging |
Het |
| Dmrt2 |
A |
G |
19: 25,650,970 (GRCm39) |
E52G |
possibly damaging |
Het |
| Dsp |
A |
G |
13: 38,376,688 (GRCm39) |
K1491R |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,832,753 (GRCm39) |
V869A |
probably benign |
Het |
| Eef1d |
A |
T |
15: 75,767,770 (GRCm39) |
D206E |
probably damaging |
Het |
| Erbb2 |
C |
T |
11: 98,327,001 (GRCm39) |
Q1137* |
probably null |
Het |
| Ercc2 |
T |
A |
7: 19,119,811 (GRCm39) |
D157E |
probably benign |
Het |
| Eri1 |
A |
G |
8: 35,936,284 (GRCm39) |
*346Q |
probably null |
Het |
| Espl1 |
A |
G |
15: 102,228,293 (GRCm39) |
E1689G |
probably benign |
Het |
| Fap |
C |
T |
2: 62,347,964 (GRCm39) |
V539I |
probably benign |
Het |
| Fasn |
A |
G |
11: 120,701,866 (GRCm39) |
F1871S |
probably benign |
Het |
| Gabpb1 |
T |
G |
2: 126,494,247 (GRCm39) |
Y126S |
probably damaging |
Het |
| Ganc |
A |
T |
2: 120,261,409 (GRCm39) |
|
probably benign |
Het |
| Gm9839 |
T |
A |
1: 32,559,594 (GRCm39) |
R163* |
probably null |
Het |
| Grm1 |
T |
C |
10: 10,595,702 (GRCm39) |
Y642C |
probably damaging |
Het |
| Heatr4 |
T |
C |
12: 84,024,841 (GRCm39) |
T327A |
possibly damaging |
Het |
| Hmbox1 |
T |
C |
14: 65,099,027 (GRCm39) |
D212G |
possibly damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,565,341 (GRCm39) |
D2262V |
probably damaging |
Het |
| Hoxb9 |
A |
G |
11: 96,162,764 (GRCm39) |
T133A |
probably benign |
Het |
| Insr |
A |
T |
8: 3,219,720 (GRCm39) |
V934E |
probably damaging |
Het |
| Ipo9 |
T |
C |
1: 135,334,281 (GRCm39) |
E315G |
possibly damaging |
Het |
| Itga10 |
C |
T |
3: 96,559,545 (GRCm39) |
Q481* |
probably null |
Het |
| Kifap3 |
T |
C |
1: 163,656,689 (GRCm39) |
|
probably benign |
Het |
| Kntc1 |
T |
A |
5: 123,925,047 (GRCm39) |
M1120K |
probably benign |
Het |
| Krt78 |
A |
G |
15: 101,854,728 (GRCm39) |
Y1028H |
possibly damaging |
Het |
| Lrp1b |
A |
T |
2: 40,547,368 (GRCm39) |
|
probably benign |
Het |
| Lrrc38 |
A |
T |
4: 143,096,450 (GRCm39) |
I254F |
probably damaging |
Het |
| Lyrm7 |
A |
G |
11: 54,741,215 (GRCm39) |
F40L |
probably damaging |
Het |
| Mfsd4b1 |
C |
T |
10: 39,878,631 (GRCm39) |
S422N |
possibly damaging |
Het |
| Mlh3 |
A |
T |
12: 85,284,374 (GRCm39) |
L1380* |
probably null |
Het |
| Mrpl24 |
C |
A |
3: 87,829,744 (GRCm39) |
A110D |
probably benign |
Het |
| Mrps14 |
T |
C |
1: 160,024,520 (GRCm39) |
V17A |
probably benign |
Het |
| Mtcl1 |
T |
C |
17: 66,755,322 (GRCm39) |
D340G |
probably damaging |
Het |
| Neb |
T |
C |
2: 52,120,059 (GRCm39) |
Y3900C |
probably damaging |
Het |
| Neurod4 |
T |
C |
10: 130,106,473 (GRCm39) |
D267G |
probably benign |
Het |
| Nf1 |
A |
T |
11: 79,319,452 (GRCm39) |
I536F |
possibly damaging |
Het |
| Nkg7 |
C |
T |
7: 43,086,857 (GRCm39) |
P44S |
probably damaging |
Het |
| Or14c40 |
T |
C |
7: 86,313,185 (GRCm39) |
V105A |
possibly damaging |
Het |
| Or4a67 |
T |
C |
2: 88,597,832 (GRCm39) |
I276V |
probably benign |
Het |
| P3h2 |
A |
T |
16: 25,784,618 (GRCm39) |
|
probably benign |
Het |
| P4ha2 |
A |
G |
11: 53,997,236 (GRCm39) |
|
probably benign |
Het |
| Pcif1 |
T |
C |
2: 164,731,058 (GRCm39) |
Y404H |
probably benign |
Het |
| Pcnx2 |
A |
T |
8: 126,480,289 (GRCm39) |
L2006Q |
possibly damaging |
Het |
| Pcnx3 |
A |
T |
19: 5,724,922 (GRCm39) |
S821T |
possibly damaging |
Het |
| Pde8b |
T |
A |
13: 95,170,680 (GRCm39) |
D662V |
probably damaging |
Het |
| Pkd1l3 |
C |
T |
8: 110,343,000 (GRCm39) |
P113S |
unknown |
Het |
| Pkd2l1 |
G |
T |
19: 44,142,648 (GRCm39) |
Q465K |
possibly damaging |
Het |
| Plch2 |
G |
T |
4: 155,068,189 (GRCm39) |
P1479Q |
probably benign |
Het |
| Plekhm3 |
A |
T |
1: 64,932,041 (GRCm39) |
I521N |
probably damaging |
Het |
| Pola2 |
A |
T |
19: 5,992,093 (GRCm39) |
Y526* |
probably null |
Het |
| Prdm14 |
C |
A |
1: 13,194,756 (GRCm39) |
|
probably benign |
Het |
| Prss23 |
T |
C |
7: 89,159,217 (GRCm39) |
D284G |
probably damaging |
Het |
| Psme2b |
A |
G |
11: 48,836,467 (GRCm39) |
F160S |
probably damaging |
Het |
| Rap1gap2 |
A |
G |
11: 74,327,853 (GRCm39) |
V139A |
possibly damaging |
Het |
| Rbbp9 |
G |
T |
2: 144,385,777 (GRCm39) |
R163S |
possibly damaging |
Het |
| Rdh12 |
T |
C |
12: 79,260,522 (GRCm39) |
L206P |
probably damaging |
Het |
| Rhou |
T |
C |
8: 124,388,029 (GRCm39) |
W254R |
possibly damaging |
Het |
| Ryr3 |
G |
T |
2: 112,583,347 (GRCm39) |
|
probably benign |
Het |
| Scfd1 |
A |
G |
12: 51,478,281 (GRCm39) |
K498E |
possibly damaging |
Het |
| Scn7a |
A |
G |
2: 66,519,902 (GRCm39) |
Y1001H |
probably benign |
Het |
| Setx |
T |
A |
2: 29,048,917 (GRCm39) |
V1981E |
probably damaging |
Het |
| Sfxn1 |
T |
C |
13: 54,247,890 (GRCm39) |
I205T |
possibly damaging |
Het |
| Shld2 |
G |
T |
14: 33,990,619 (GRCm39) |
H96N |
possibly damaging |
Het |
| Slc5a2 |
T |
C |
7: 127,870,428 (GRCm39) |
|
probably benign |
Het |
| Speer1g |
C |
T |
5: 11,180,337 (GRCm39) |
H82Y |
probably damaging |
Het |
| Spock1 |
G |
A |
13: 57,577,182 (GRCm39) |
R416C |
possibly damaging |
Het |
| Spred2 |
A |
G |
11: 19,968,109 (GRCm39) |
I222V |
probably benign |
Het |
| Stkld1 |
A |
T |
2: 26,839,407 (GRCm39) |
T358S |
probably benign |
Het |
| Strip1 |
T |
C |
3: 107,534,724 (GRCm39) |
E102G |
possibly damaging |
Het |
| Tars3 |
T |
C |
7: 65,305,444 (GRCm39) |
S223P |
probably damaging |
Het |
| Tdpoz1 |
T |
A |
3: 93,578,637 (GRCm39) |
E49V |
probably benign |
Het |
| Tert |
A |
G |
13: 73,776,328 (GRCm39) |
T360A |
probably benign |
Het |
| Tspear |
A |
G |
10: 77,717,026 (GRCm39) |
Y567C |
probably damaging |
Het |
| Ttc28 |
A |
G |
5: 111,433,254 (GRCm39) |
Q2096R |
probably benign |
Het |
| Ttll5 |
A |
G |
12: 85,965,736 (GRCm39) |
|
probably null |
Het |
| Ugt2b38 |
T |
G |
5: 87,560,232 (GRCm39) |
N361H |
probably damaging |
Het |
| Vmn2r111 |
T |
A |
17: 22,790,028 (GRCm39) |
H326L |
probably damaging |
Het |
| Vmn2r18 |
A |
G |
5: 151,510,301 (GRCm39) |
F24S |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,232,133 (GRCm39) |
I711F |
probably benign |
Het |
| Vwa8 |
C |
T |
14: 79,341,134 (GRCm39) |
Q1537* |
probably null |
Het |
| Wdr64 |
G |
A |
1: 175,603,288 (GRCm39) |
V630I |
probably benign |
Het |
| Wnt6 |
G |
T |
1: 74,821,434 (GRCm39) |
W84L |
probably damaging |
Het |
| Zfp11 |
C |
A |
5: 129,735,254 (GRCm39) |
R69L |
probably benign |
Het |
|
| Other mutations in Nalcn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00952:Nalcn
|
APN |
14 |
123,586,201 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00964:Nalcn
|
APN |
14 |
123,532,796 (GRCm39) |
splice site |
probably benign |
|
|
IGL01310:Nalcn
|
APN |
14 |
123,554,661 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01578:Nalcn
|
APN |
14 |
123,809,503 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01925:Nalcn
|
APN |
14 |
123,529,260 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02072:Nalcn
|
APN |
14 |
123,560,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02096:Nalcn
|
APN |
14 |
123,831,915 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02212:Nalcn
|
APN |
14 |
123,752,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02306:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02471:Nalcn
|
APN |
14 |
123,560,726 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02478:Nalcn
|
APN |
14 |
123,558,717 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02551:Nalcn
|
APN |
14 |
123,560,750 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02630:Nalcn
|
APN |
14 |
123,555,291 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02632:Nalcn
|
APN |
14 |
123,555,265 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02661:Nalcn
|
APN |
14 |
123,830,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL02830:Nalcn
|
APN |
14 |
123,530,881 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02939:Nalcn
|
APN |
14 |
123,536,284 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL03035:Nalcn
|
APN |
14 |
123,515,630 (GRCm39) |
nonsense |
probably null |
|
|
IGL03226:Nalcn
|
APN |
14 |
123,518,527 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03242:Nalcn
|
APN |
14 |
123,558,899 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Narnia
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0019:Nalcn
|
UTSW |
14 |
123,744,901 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0144:Nalcn
|
UTSW |
14 |
123,647,251 (GRCm39) |
splice site |
probably benign |
|
|
R0144:Nalcn
|
UTSW |
14 |
123,608,948 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0359:Nalcn
|
UTSW |
14 |
123,536,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Nalcn
|
UTSW |
14 |
123,744,971 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0400:Nalcn
|
UTSW |
14 |
123,528,372 (GRCm39) |
splice site |
probably benign |
|
|
R0467:Nalcn
|
UTSW |
14 |
123,528,459 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0506:Nalcn
|
UTSW |
14 |
123,834,026 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0583:Nalcn
|
UTSW |
14 |
123,531,755 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0620:Nalcn
|
UTSW |
14 |
123,536,553 (GRCm39) |
splice site |
probably benign |
|
|
R0624:Nalcn
|
UTSW |
14 |
123,607,444 (GRCm39) |
missense |
probably benign |
|
|
R0883:Nalcn
|
UTSW |
14 |
123,702,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1381:Nalcn
|
UTSW |
14 |
123,551,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Nalcn
|
UTSW |
14 |
123,522,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1726:Nalcn
|
UTSW |
14 |
123,545,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Nalcn
|
UTSW |
14 |
123,515,678 (GRCm39) |
missense |
probably benign |
|
|
R1854:Nalcn
|
UTSW |
14 |
123,697,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1871:Nalcn
|
UTSW |
14 |
123,831,965 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1873:Nalcn
|
UTSW |
14 |
123,521,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1899:Nalcn
|
UTSW |
14 |
123,553,538 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1915:Nalcn
|
UTSW |
14 |
123,540,181 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2016:Nalcn
|
UTSW |
14 |
123,831,993 (GRCm39) |
splice site |
probably null |
|
|
R2034:Nalcn
|
UTSW |
14 |
123,521,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2087:Nalcn
|
UTSW |
14 |
123,518,557 (GRCm39) |
missense |
probably benign |
|
|
R2149:Nalcn
|
UTSW |
14 |
123,607,429 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2157:Nalcn
|
UTSW |
14 |
123,647,164 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2166:Nalcn
|
UTSW |
14 |
123,607,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2932:Nalcn
|
UTSW |
14 |
123,830,430 (GRCm39) |
missense |
probably benign |
0.06 |
|
R3408:Nalcn
|
UTSW |
14 |
123,834,029 (GRCm39) |
missense |
probably null |
0.98 |
|
R3778:Nalcn
|
UTSW |
14 |
123,702,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3807:Nalcn
|
UTSW |
14 |
123,515,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3835:Nalcn
|
UTSW |
14 |
123,530,834 (GRCm39) |
splice site |
probably benign |
|
|
R3937:Nalcn
|
UTSW |
14 |
123,607,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4001:Nalcn
|
UTSW |
14 |
123,834,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4015:Nalcn
|
UTSW |
14 |
123,723,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4033:Nalcn
|
UTSW |
14 |
123,837,401 (GRCm39) |
splice site |
probably benign |
|
|
R4231:Nalcn
|
UTSW |
14 |
123,837,325 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4464:Nalcn
|
UTSW |
14 |
123,560,762 (GRCm39) |
missense |
probably benign |
|
|
R4512:Nalcn
|
UTSW |
14 |
123,532,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4542:Nalcn
|
UTSW |
14 |
123,558,889 (GRCm39) |
synonymous |
silent |
|
|
R4557:Nalcn
|
UTSW |
14 |
123,558,647 (GRCm39) |
intron |
probably benign |
|
|
R4869:Nalcn
|
UTSW |
14 |
123,837,296 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5083:Nalcn
|
UTSW |
14 |
123,560,706 (GRCm39) |
splice site |
probably null |
|
|
R5109:Nalcn
|
UTSW |
14 |
123,515,650 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5131:Nalcn
|
UTSW |
14 |
123,753,182 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5158:Nalcn
|
UTSW |
14 |
123,753,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5259:Nalcn
|
UTSW |
14 |
123,753,063 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5422:Nalcn
|
UTSW |
14 |
123,752,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5514:Nalcn
|
UTSW |
14 |
123,521,123 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5523:Nalcn
|
UTSW |
14 |
123,647,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5551:Nalcn
|
UTSW |
14 |
123,515,698 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R5667:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5671:Nalcn
|
UTSW |
14 |
123,532,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5750:Nalcn
|
UTSW |
14 |
123,809,450 (GRCm39) |
missense |
probably benign |
|
|
R5765:Nalcn
|
UTSW |
14 |
123,702,138 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6324:Nalcn
|
UTSW |
14 |
123,647,161 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6523:Nalcn
|
UTSW |
14 |
123,555,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6558:Nalcn
|
UTSW |
14 |
123,723,919 (GRCm39) |
missense |
probably benign |
|
|
R6631:Nalcn
|
UTSW |
14 |
123,697,663 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6667:Nalcn
|
UTSW |
14 |
123,558,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6670:Nalcn
|
UTSW |
14 |
123,702,084 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6724:Nalcn
|
UTSW |
14 |
123,535,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6731:Nalcn
|
UTSW |
14 |
123,837,346 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6957:Nalcn
|
UTSW |
14 |
123,744,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6970:Nalcn
|
UTSW |
14 |
123,551,506 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7010:Nalcn
|
UTSW |
14 |
123,530,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7018:Nalcn
|
UTSW |
14 |
123,647,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7040:Nalcn
|
UTSW |
14 |
123,525,267 (GRCm39) |
missense |
probably benign |
|
|
R7089:Nalcn
|
UTSW |
14 |
123,515,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7128:Nalcn
|
UTSW |
14 |
123,831,914 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7149:Nalcn
|
UTSW |
14 |
123,837,277 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7361:Nalcn
|
UTSW |
14 |
123,529,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7378:Nalcn
|
UTSW |
14 |
123,540,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7408:Nalcn
|
UTSW |
14 |
123,529,272 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7470:Nalcn
|
UTSW |
14 |
123,809,456 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7483:Nalcn
|
UTSW |
14 |
123,551,499 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7521:Nalcn
|
UTSW |
14 |
123,530,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7558:Nalcn
|
UTSW |
14 |
123,723,797 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7585:Nalcn
|
UTSW |
14 |
123,753,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7591:Nalcn
|
UTSW |
14 |
123,561,297 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7761:Nalcn
|
UTSW |
14 |
123,531,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7811:Nalcn
|
UTSW |
14 |
123,536,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7983:Nalcn
|
UTSW |
14 |
123,830,409 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8089:Nalcn
|
UTSW |
14 |
123,537,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8110:Nalcn
|
UTSW |
14 |
123,702,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8190:Nalcn
|
UTSW |
14 |
123,837,351 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8273:Nalcn
|
UTSW |
14 |
123,554,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8407:Nalcn
|
UTSW |
14 |
123,554,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8497:Nalcn
|
UTSW |
14 |
123,752,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Nalcn
|
UTSW |
14 |
123,608,935 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8549:Nalcn
|
UTSW |
14 |
123,607,448 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8731:Nalcn
|
UTSW |
14 |
123,837,266 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8862:Nalcn
|
UTSW |
14 |
123,647,199 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8919:Nalcn
|
UTSW |
14 |
123,561,284 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9072:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9073:Nalcn
|
UTSW |
14 |
123,532,863 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9182:Nalcn
|
UTSW |
14 |
123,834,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Nalcn
|
UTSW |
14 |
123,545,792 (GRCm39) |
nonsense |
probably null |
|
|
R9241:Nalcn
|
UTSW |
14 |
123,809,429 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Nalcn
|
UTSW |
14 |
123,518,567 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9274:Nalcn
|
UTSW |
14 |
123,753,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Nalcn
|
UTSW |
14 |
123,518,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9376:Nalcn
|
UTSW |
14 |
123,515,713 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
X0060:Nalcn
|
UTSW |
14 |
123,522,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,831,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Nalcn
|
UTSW |
14 |
123,531,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCCTTCCCTTTAAGTTTGTGCCAAAA -3'
(R):5'- CGACCTGGAAGCACTCCTGAAGA -3'
Sequencing Primer
(F):5'- AAGTTTGTGCCAAAATCTTATTACG -3'
(R):5'- CTGGAAGCACTCCTGAAGATATGG -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation