Mutagenetix > Incidental Mutation

Incidental Mutation 'R1468:Adamts7'

197730

Institutional Source

Beutler Lab

Gene Symbol

Adamts7

Ensembl Gene

ENSMUSG00000032363

Gene Name

ADAM metallopeptidase with thrombospondin type 1 motif 7

Synonyms

ADAM-TS7

MMRRC Submission

039521-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R1468 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

90041420-90082155 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 90070851 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000129292 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113059] [ENSMUST00000113060] [ENSMUST00000134996] [ENSMUST00000147250] [ENSMUST00000167122]

AlphaFold

Q68SA9

Predicted Effect

probably benign
Transcript: ENSMUST00000113059

SMART Domains

Protein: ENSMUSP00000108682
Gene: ENSMUSG00000032363

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Pep_M12B_propep	34	174	1.1e-36	PFAM
low complexity region	203	220	N/A	INTRINSIC
Pfam:Reprolysin_5	224	411	1.3e-16	PFAM
Pfam:Reprolysin_4	224	425	8.5e-9	PFAM
Pfam:Reprolysin	226	437	2.2e-27	PFAM
Pfam:Reprolysin_2	244	427	2.9e-12	PFAM
Pfam:Reprolysin_3	248	383	5.2e-13	PFAM
Blast:ACR	442	513	5e-15	BLAST
TSP1	526	578	4.9e-13	SMART
Pfam:ADAM_spacer1	683	794	2.2e-36	PFAM
TSP1	807	863	1.45e-6	SMART
TSP1	866	908	2.41e-1	SMART
TSP1	929	978	1.45e-6	SMART
low complexity region	1011	1025	N/A	INTRINSIC
low complexity region	1211	1233	N/A	INTRINSIC
TSP1	1385	1435	2.4e-2	SMART
TSP1	1436	1493	1.8e-2	SMART
TSP1	1495	1542	4.82e-2	SMART
TSP1	1543	1600	1.39e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113060

SMART Domains

Protein: ENSMUSP00000108683
Gene: ENSMUSG00000032363

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Pep_M12B_propep	33	174	3.4e-28	PFAM
low complexity region	203	220	N/A	INTRINSIC
Pfam:Reprolysin_5	224	411	1.6e-16	PFAM
Pfam:Reprolysin_4	224	425	8.2e-9	PFAM
Pfam:Reprolysin	226	437	6.4e-30	PFAM
Pfam:Reprolysin_2	244	427	4.6e-12	PFAM
Pfam:Reprolysin_3	248	383	8.1e-13	PFAM
Blast:ACR	442	513	5e-15	BLAST
TSP1	526	578	4.9e-13	SMART
Pfam:ADAM_spacer1	683	794	1.5e-36	PFAM
TSP1	807	863	1.45e-6	SMART
TSP1	866	908	2.41e-1	SMART
low complexity region	969	983	N/A	INTRINSIC
low complexity region	1169	1191	N/A	INTRINSIC
TSP1	1343	1393	2.4e-2	SMART
TSP1	1394	1451	1.8e-2	SMART
TSP1	1453	1500	4.82e-2	SMART
TSP1	1501	1558	1.39e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000134996

SMART Domains

Protein: ENSMUSP00000119744
Gene: ENSMUSG00000032363

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Pep_M12B_propep	33	174	2.4e-29	PFAM
low complexity region	203	220	N/A	INTRINSIC
Pfam:Reprolysin_5	224	412	1e-17	PFAM
Pfam:Reprolysin_4	224	426	5e-10	PFAM
Pfam:Reprolysin	226	437	3.7e-31	PFAM
Pfam:Reprolysin_2	244	427	3.2e-13	PFAM
Pfam:Reprolysin_3	248	383	6.3e-14	PFAM
Blast:ACR	439	505	7e-12	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138227

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144943

Predicted Effect

probably benign
Transcript: ENSMUST00000147250

SMART Domains

Protein: ENSMUSP00000115972
Gene: ENSMUSG00000032363

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:Pep_M12B_propep	33	174	2.7e-26	PFAM
low complexity region	203	220	N/A	INTRINSIC
Pfam:Reprolysin_5	224	411	1.4e-14	PFAM
Pfam:Reprolysin_4	224	425	7e-7	PFAM
Pfam:Reprolysin	226	437	4.9e-28	PFAM
Pfam:Reprolysin_2	244	427	5e-10	PFAM
Pfam:Reprolysin_3	248	383	6.5e-11	PFAM
ACR	439	515	1.7e-5	SMART
TSP1	526	578	2.3e-15	SMART
Pfam:ADAM_spacer1	683	794	3.5e-34	PFAM
TSP1	807	863	6.9e-9	SMART
TSP1	866	908	1.2e-3	SMART
low complexity region	969	983	N/A	INTRINSIC
low complexity region	1169	1191	N/A	INTRINSIC
TSP1	1284	1334	1.2e-4	SMART
TSP1	1335	1392	8.7e-5	SMART
TSP1	1394	1441	2.3e-4	SMART
TSP1	1442	1499	6.5e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000167122

SMART Domains

Protein: ENSMUSP00000129292
Gene: ENSMUSG00000032363

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Pep_M12B_propep	33	174	1.4e-28	PFAM
low complexity region	203	220	N/A	INTRINSIC
Pfam:Reprolysin_5	224	411	7.2e-17	PFAM
Pfam:Reprolysin_4	224	425	3.6e-9	PFAM
Pfam:Reprolysin	226	437	2.9e-30	PFAM
Pfam:Reprolysin_2	244	427	2.2e-12	PFAM
Pfam:Reprolysin_3	248	383	3.7e-13	PFAM
Blast:ACR	442	513	5e-15	BLAST
TSP1	526	578	4.9e-13	SMART
Pfam:ADAM_spacer1	683	794	1.1e-36	PFAM
TSP1	807	863	1.45e-6	SMART
TSP1	866	908	2.41e-1	SMART
TSP1	929	978	1.45e-6	SMART
low complexity region	1011	1025	N/A	INTRINSIC
low complexity region	1211	1233	N/A	INTRINSIC
TSP1	1385	1435	2.4e-2	SMART
TSP1	1436	1493	1.8e-2	SMART
TSP1	1495	1542	4.82e-2	SMART
TSP1	1543	1600	1.39e-3	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.6%
20x: 90.1%

Validation Efficiency

98% (106/108)

MGI Phenotype

FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent enzyme that degrades cartilage oligomeric matrix protein. The deficiency of the encoded protein decreases atherosclerosis in genetically hyperlipidemic mice and in response to vascular injury. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygotes for a null allele show increased lung function parameters, reduced endothelial cell migration and proliferation, increased re-endothelialization and ameliorated neointima formation after carotid artery injury, and increased oval cell activation and biliary fibrosis after liver injury. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 112 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900092C05Rik	T	G	7: 12,246,507 (GRCm39)	M1R	probably null	Het
4933440N22Rik	C	A	6: 117,884,540 (GRCm39)		probably benign	Het
5031439G07Rik	G	T	15: 84,837,345 (GRCm39)	P280T	probably damaging	Het
Abca2	C	T	2: 25,331,308 (GRCm39)	S1267L	probably damaging	Het
Acsl3	A	T	1: 78,684,126 (GRCm39)	R719S	probably benign	Het
Adam1a	A	T	5: 121,657,839 (GRCm39)		probably null	Het
Adgrf3	G	A	5: 30,407,227 (GRCm39)		probably benign	Het
Aldh6a1	T	C	12: 84,488,544 (GRCm39)	E89G	possibly damaging	Het
Ankrd36	A	G	11: 5,525,752 (GRCm39)	Y238C	probably damaging	Het
Ankrd65	G	A	4: 155,877,362 (GRCm39)	R291Q	probably benign	Het
Ano2	C	T	6: 125,773,227 (GRCm39)	R287W	probably damaging	Het
Ap1ar	A	G	3: 127,606,215 (GRCm39)	I125T	probably benign	Het
Arid1b	A	G	17: 5,293,197 (GRCm39)	D705G	probably damaging	Het
Asb18	T	A	1: 89,924,005 (GRCm39)	N86I	probably damaging	Het
Bicral	A	T	17: 47,135,519 (GRCm39)	S564T	probably benign	Het
Bpifa6	A	G	2: 153,831,192 (GRCm39)	M253V	probably benign	Het
Braf	T	C	6: 39,642,017 (GRCm39)	D194G	probably damaging	Het
Brinp3	C	A	1: 146,777,700 (GRCm39)	P716T	probably benign	Het
C7	T	A	15: 5,041,631 (GRCm39)	Y425F	probably damaging	Het
Ccdc102a	T	C	8: 95,632,714 (GRCm39)	K421R	probably benign	Het
Cep89	G	A	7: 35,120,388 (GRCm39)		probably null	Het
Chgb	A	T	2: 132,634,720 (GRCm39)	M221L	probably benign	Het
Chst14	A	G	2: 118,758,145 (GRCm39)	Y313C	probably damaging	Het
Ciita	G	A	16: 10,331,152 (GRCm39)		probably null	Het
Clec12b	A	T	6: 129,357,603 (GRCm39)	I85N	probably damaging	Het
Clec2e	G	T	6: 129,070,459 (GRCm39)	Y187*	probably null	Het
Crbn	T	C	6: 106,767,804 (GRCm39)	K229E	probably benign	Het
Ctdspl2	A	T	2: 121,811,762 (GRCm39)	Q201L	probably benign	Het
Ctrb1	G	T	8: 112,416,041 (GRCm39)		probably benign	Het
Cyp2c55	T	A	19: 38,999,525 (GRCm39)	V77E	probably damaging	Het
Cyp2c69	A	C	19: 39,837,839 (GRCm39)	D414E	probably damaging	Het
Ddx47	T	C	6: 134,988,703 (GRCm39)		probably benign	Het
Dlg1	A	G	16: 31,661,640 (GRCm39)		probably null	Het
Dnah5	C	A	15: 28,230,609 (GRCm39)	S169*	probably null	Het
Dock4	C	A	12: 40,805,809 (GRCm39)	T927K	probably benign	Het
Esrp2	T	G	8: 106,860,453 (GRCm39)	D259A	probably damaging	Het
Fam169a	A	G	13: 97,255,038 (GRCm39)	K418R	probably benign	Het
Fancm	A	T	12: 65,146,067 (GRCm39)	I597F	probably damaging	Het
Fastkd2	G	T	1: 63,771,385 (GRCm39)		probably benign	Het
Fat1	G	A	8: 45,463,582 (GRCm39)	V1375M	probably damaging	Het
Fbxw10	A	T	11: 62,753,464 (GRCm39)	D486V	probably damaging	Het
Fech	C	T	18: 64,603,744 (GRCm39)		probably benign	Het
Fermt1	C	T	2: 132,766,942 (GRCm39)	E342K	probably benign	Het
Foxp1	T	A	6: 98,955,181 (GRCm39)	H195L	possibly damaging	Het
Gfra1	T	A	19: 58,440,407 (GRCm39)	I138L	probably benign	Het
Gm12185	T	C	11: 48,806,501 (GRCm39)	D230G	possibly damaging	Het
Gm14403	T	A	2: 177,199,024 (GRCm39)		probably benign	Het
Gpd2	A	C	2: 57,245,786 (GRCm39)	T439P	probably damaging	Het
Gpm6a	A	T	8: 55,490,385 (GRCm39)	K20N	probably damaging	Het
Hc	A	T	2: 34,873,819 (GRCm39)	Y158*	probably null	Het
Hectd4	A	T	5: 121,487,235 (GRCm39)	D3410V	possibly damaging	Het
Il17b	G	A	18: 61,823,483 (GRCm39)		probably null	Het
Irx4	G	T	13: 73,413,695 (GRCm39)	R55L	possibly damaging	Het
Itgav	A	T	2: 83,596,245 (GRCm39)		probably benign	Het
Lama3	T	C	18: 12,574,164 (GRCm39)	V582A	probably benign	Het
Ldhd	G	T	8: 112,353,925 (GRCm39)	A425E	possibly damaging	Het
Lrp1b	C	T	2: 40,817,841 (GRCm39)		probably null	Het
Lrp5	T	C	19: 3,670,191 (GRCm39)	T638A	possibly damaging	Het
Lrrk1	A	C	7: 65,909,722 (GRCm39)	F1996C	probably damaging	Het
Ly6h	G	A	15: 75,437,986 (GRCm39)	S21L	probably benign	Het
Mctp1	T	C	13: 76,973,392 (GRCm39)	V431A	probably benign	Het
Metap2	C	T	10: 93,707,345 (GRCm39)		probably null	Het
Mfsd2b	T	A	12: 4,920,536 (GRCm39)	K94*	probably null	Het
Micall2	A	G	5: 139,705,097 (GRCm39)	L79P	probably damaging	Het
Mucl2	T	C	15: 103,927,673 (GRCm39)	T95A	possibly damaging	Het
Myo15a	A	T	11: 60,396,832 (GRCm39)	T2634S	probably damaging	Het
Myo5b	G	T	18: 74,873,574 (GRCm39)	V1467L	probably damaging	Het
Nfic	G	T	10: 81,256,414 (GRCm39)	D105E	probably damaging	Het
Nrdc	T	A	4: 108,873,865 (GRCm39)	F227Y	probably benign	Het
Nrp2	A	T	1: 62,777,458 (GRCm39)	I88F	probably damaging	Het
Nup160	A	T	2: 90,530,887 (GRCm39)	H515L	probably benign	Het
Nup205	G	A	6: 35,202,917 (GRCm39)		probably null	Het
Oas1g	G	A	5: 121,020,069 (GRCm39)	T179I	probably benign	Het
Ogfr	A	T	2: 180,236,543 (GRCm39)	E376V	probably damaging	Het
Or2l13	T	G	16: 19,306,378 (GRCm39)	S263R	probably benign	Het
Or4a69	A	T	2: 89,312,855 (GRCm39)	V208D	possibly damaging	Het
Or4c107	T	G	2: 88,789,387 (GRCm39)	Y192*	probably null	Het
Or52d1	G	T	7: 103,755,896 (GRCm39)	V137F	possibly damaging	Het
Or5p6	C	T	7: 107,631,595 (GRCm39)		probably null	Het
Pard3b	T	C	1: 62,384,188 (GRCm39)	V851A	probably benign	Het
Pcdhb16	A	T	18: 37,611,142 (GRCm39)	Y34F	probably damaging	Het
Pikfyve	T	C	1: 65,290,825 (GRCm39)	Y1215H	probably damaging	Het
Pkhd1	A	T	1: 20,593,565 (GRCm39)	V1516E	probably damaging	Het
Pla2g4a	A	T	1: 149,763,344 (GRCm39)		probably benign	Het
Ptprg	A	T	14: 12,190,767 (GRCm38)	I818F	probably benign	Het
Ralgapb	A	G	2: 158,304,173 (GRCm39)	E644G	possibly damaging	Het
Rbm45	A	G	2: 76,202,459 (GRCm39)	I127M	probably damaging	Het
Rtp2	T	C	16: 23,746,220 (GRCm39)	Y157C	probably damaging	Het
Sema3f	A	T	9: 107,564,771 (GRCm39)		probably benign	Het
Sf3b3	A	T	8: 111,564,006 (GRCm39)	Y329N	probably damaging	Het
Sfxn1	A	G	13: 54,239,646 (GRCm39)		probably null	Het
Shkbp1	A	T	7: 27,044,751 (GRCm39)	C447S	probably damaging	Het
Sipa1l3	A	G	7: 29,021,685 (GRCm39)	S689P	possibly damaging	Het
Slc7a8	A	G	14: 54,970,656 (GRCm39)	S332P	probably damaging	Het
Slit1	C	A	19: 41,596,823 (GRCm39)	C1092F	probably damaging	Het
Slx9	A	G	10: 77,333,360 (GRCm39)		probably benign	Het
Stard9	A	G	2: 120,533,678 (GRCm39)	I619V	possibly damaging	Het
Sycp3	T	C	10: 88,305,454 (GRCm39)	V185A	possibly damaging	Het
Taar9	A	T	10: 23,985,382 (GRCm39)	N17K	possibly damaging	Het
Tbkbp1	T	C	11: 97,039,814 (GRCm39)	E102G	probably damaging	Het
Tex44	A	G	1: 86,354,834 (GRCm39)	N248D	probably benign	Het
Tmem63b	C	G	17: 45,989,904 (GRCm39)	R88P	possibly damaging	Het
Tnpo1	C	T	13: 98,986,665 (GRCm39)	V781I	probably benign	Het
Tonsl	C	T	15: 76,520,761 (GRCm39)		probably null	Het
Ttc6	A	G	12: 57,721,463 (GRCm39)	K984R	possibly damaging	Het
Usp34	A	G	11: 23,391,171 (GRCm39)	E2263G	probably damaging	Het
Usp8	A	G	2: 126,596,847 (GRCm39)	K875E	probably damaging	Het
Vapb	C	T	2: 173,603,905 (GRCm39)		probably benign	Het
Vmn1r223	A	G	13: 23,434,038 (GRCm39)	I211V	possibly damaging	Het
Vmn2r81	G	A	10: 79,129,496 (GRCm39)	V796I	probably damaging	Het
Wdr90	A	T	17: 26,073,027 (GRCm39)	V856D	probably damaging	Het
Wnk2	T	A	13: 49,235,571 (GRCm39)	T615S	probably damaging	Het

Other mutations in Adamts7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00547:Adamts7	APN	9	90,076,302 (GRCm39)	missense	possibly damaging	0.71
IGL00673:Adamts7	APN	9	90,075,714 (GRCm39)	missense	possibly damaging	0.78
IGL00902:Adamts7	APN	9	90,070,847 (GRCm39)	critical splice donor site	probably null
IGL01303:Adamts7	APN	9	90,053,787 (GRCm39)	missense	possibly damaging	0.46
IGL01333:Adamts7	APN	9	90,069,032 (GRCm39)	missense	probably damaging	1.00
IGL01431:Adamts7	APN	9	90,089,838 (GRCm39)	missense	possibly damaging	0.89
IGL01595:Adamts7	APN	9	90,075,359 (GRCm39)	missense	probably benign	0.02
IGL02728:Adamts7	APN	9	90,073,880 (GRCm39)	splice site	probably benign
IGL02860:Adamts7	APN	9	90,073,915 (GRCm39)	missense	probably benign
IGL03237:Adamts7	APN	9	90,070,717 (GRCm39)	missense	probably damaging	1.00
PIT4495001:Adamts7	UTSW	9	90,056,675 (GRCm39)	missense	probably damaging	1.00
R0044:Adamts7	UTSW	9	90,053,641 (GRCm39)	missense	possibly damaging	0.58
R0078:Adamts7	UTSW	9	90,061,464 (GRCm39)	missense	probably damaging	1.00
R0107:Adamts7	UTSW	9	90,062,773 (GRCm39)	missense	possibly damaging	0.82
R0122:Adamts7	UTSW	9	90,061,474 (GRCm39)	missense	probably damaging	1.00
R0166:Adamts7	UTSW	9	90,075,745 (GRCm39)	missense	probably benign	0.00
R0517:Adamts7	UTSW	9	90,081,911 (GRCm39)	missense	probably benign	0.01
R1442:Adamts7	UTSW	9	90,070,823 (GRCm39)	missense	probably damaging	0.99
R1554:Adamts7	UTSW	9	90,055,703 (GRCm39)	missense	probably damaging	1.00
R1612:Adamts7	UTSW	9	90,070,750 (GRCm39)	missense	possibly damaging	0.86
R1652:Adamts7	UTSW	9	90,071,697 (GRCm39)	missense	probably damaging	1.00
R2007:Adamts7	UTSW	9	90,059,909 (GRCm39)	missense	probably damaging	1.00
R2091:Adamts7	UTSW	9	90,070,493 (GRCm39)	critical splice donor site	probably null
R2202:Adamts7	UTSW	9	90,062,729 (GRCm39)	missense	probably damaging	1.00
R2204:Adamts7	UTSW	9	90,062,729 (GRCm39)	missense	probably damaging	1.00
R2205:Adamts7	UTSW	9	90,062,729 (GRCm39)	missense	probably damaging	1.00
R2305:Adamts7	UTSW	9	90,062,764 (GRCm39)	missense	probably benign	0.39
R2409:Adamts7	UTSW	9	90,062,740 (GRCm39)	missense	probably damaging	1.00
R4157:Adamts7	UTSW	9	90,070,414 (GRCm39)	missense	probably damaging	1.00
R4210:Adamts7	UTSW	9	90,076,063 (GRCm39)	missense	possibly damaging	0.95
R4368:Adamts7	UTSW	9	90,077,904 (GRCm39)	critical splice donor site	probably null
R4533:Adamts7	UTSW	9	90,062,761 (GRCm39)	missense	probably damaging	1.00
R4608:Adamts7	UTSW	9	90,056,593 (GRCm39)	missense	probably damaging	1.00
R4623:Adamts7	UTSW	9	90,068,515 (GRCm39)	missense	probably benign	0.17
R4661:Adamts7	UTSW	9	90,075,383 (GRCm39)	missense	probably benign	0.02
R4820:Adamts7	UTSW	9	90,071,739 (GRCm39)	missense	possibly damaging	0.62
R4942:Adamts7	UTSW	9	90,045,364 (GRCm39)	missense	probably benign
R4961:Adamts7	UTSW	9	90,067,793 (GRCm39)	missense	probably damaging	1.00
R5064:Adamts7	UTSW	9	90,077,883 (GRCm39)	missense	probably damaging	1.00
R5763:Adamts7	UTSW	9	90,070,462 (GRCm39)	missense	probably damaging	1.00
R5921:Adamts7	UTSW	9	90,070,747 (GRCm39)	missense	probably benign	0.20
R6027:Adamts7	UTSW	9	90,073,078 (GRCm39)	missense	probably damaging	1.00
R6182:Adamts7	UTSW	9	90,074,489 (GRCm39)	missense	probably benign	0.01
R6306:Adamts7	UTSW	9	90,060,331 (GRCm39)	critical splice donor site	probably null
R6404:Adamts7	UTSW	9	90,062,509 (GRCm39)	splice site	probably null
R6488:Adamts7	UTSW	9	90,053,535 (GRCm39)	missense	probably benign	0.00
R6649:Adamts7	UTSW	9	90,073,990 (GRCm39)	missense	probably damaging	1.00
R6658:Adamts7	UTSW	9	90,077,353 (GRCm39)	missense	probably damaging	0.99
R6874:Adamts7	UTSW	9	90,070,784 (GRCm39)	missense	probably damaging	1.00
R6947:Adamts7	UTSW	9	90,073,857 (GRCm39)	splice site	probably null
R7110:Adamts7	UTSW	9	90,076,017 (GRCm39)	missense	possibly damaging	0.92
R7224:Adamts7	UTSW	9	90,067,868 (GRCm39)	missense	probably damaging	1.00
R7239:Adamts7	UTSW	9	90,068,610 (GRCm39)	splice site	probably null
R7519:Adamts7	UTSW	9	90,079,132 (GRCm39)	missense	probably benign	0.22
R7608:Adamts7	UTSW	9	90,055,826 (GRCm39)	missense	possibly damaging	0.68
R7635:Adamts7	UTSW	9	90,077,298 (GRCm39)	missense	probably damaging	1.00
R7699:Adamts7	UTSW	9	90,070,792 (GRCm39)	missense	probably damaging	1.00
R8519:Adamts7	UTSW	9	90,075,610 (GRCm39)	nonsense	probably null
R8680:Adamts7	UTSW	9	90,077,321 (GRCm39)	missense	probably damaging	1.00
R8743:Adamts7	UTSW	9	90,077,296 (GRCm39)	missense	probably damaging	0.99
R8784:Adamts7	UTSW	9	90,075,918 (GRCm39)	missense	probably null	0.00
R8794:Adamts7	UTSW	9	90,076,239 (GRCm39)	nonsense	probably null
R8851:Adamts7	UTSW	9	90,075,163 (GRCm39)	missense	probably benign	0.00
R9025:Adamts7	UTSW	9	90,067,848 (GRCm39)	nonsense	probably null
R9038:Adamts7	UTSW	9	90,056,692 (GRCm39)	missense
R9101:Adamts7	UTSW	9	90,071,794 (GRCm39)	critical splice donor site	probably null
R9256:Adamts7	UTSW	9	90,060,218 (GRCm39)	missense	probably damaging	1.00
R9261:Adamts7	UTSW	9	90,075,397 (GRCm39)	missense	probably benign	0.01
R9385:Adamts7	UTSW	9	90,077,258 (GRCm39)	nonsense	probably null
R9614:Adamts7	UTSW	9	90,077,251 (GRCm39)	missense	probably damaging	1.00
X0028:Adamts7	UTSW	9	90,060,270 (GRCm39)	missense	probably benign	0.30

Predicted Primers

PCR Primer
(F):5'- TGCCCAATGACGGTGAGTTATGC -3'
(R):5'- TGCTAACTGTGGGCTCTCCATTGC -3'

Sequencing Primer
(F):5'- AATGACGGTGAGTTATGCTACCC -3'
(R):5'- GCTCTCCATTGCCAGAGACAG -3'

Posted On

2014-05-23