Incidental Mutation 'R1469:Wnk1'
ID 197812
Institutional Source Beutler Lab
Gene Symbol Wnk1
Ensembl Gene ENSMUSG00000045962
Gene Name WNK lysine deficient protein kinase 1
Synonyms Prkwnk1, 6430573H23Rik, EG406236, Hsn2
MMRRC Submission 039522-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1469 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 119900930-120015633 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 119927645 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000145304 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060043] [ENSMUST00000088644] [ENSMUST00000088646] [ENSMUST00000177761] [ENSMUST00000203030]
AlphaFold P83741
Predicted Effect probably benign
Transcript: ENSMUST00000060043
SMART Domains Protein: ENSMUSP00000063001
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.5e-44 PFAM
Pfam:Pkinase 221 479 4.4e-58 PFAM
Pfam:OSR1_C 500 537 2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 865 876 N/A INTRINSIC
low complexity region 1018 1028 N/A INTRINSIC
low complexity region 1042 1058 N/A INTRINSIC
internal_repeat_1 1136 1178 2.15e-5 PROSPERO
low complexity region 1289 1305 N/A INTRINSIC
low complexity region 1345 1357 N/A INTRINSIC
low complexity region 1379 1396 N/A INTRINSIC
low complexity region 1398 1428 N/A INTRINSIC
low complexity region 1429 1454 N/A INTRINSIC
low complexity region 1496 1515 N/A INTRINSIC
low complexity region 1542 1556 N/A INTRINSIC
low complexity region 1586 1609 N/A INTRINSIC
low complexity region 1670 1691 N/A INTRINSIC
low complexity region 1698 1712 N/A INTRINSIC
low complexity region 1738 1764 N/A INTRINSIC
low complexity region 1882 1900 N/A INTRINSIC
coiled coil region 2065 2092 N/A INTRINSIC
low complexity region 2103 2114 N/A INTRINSIC
low complexity region 2116 2140 N/A INTRINSIC
low complexity region 2208 2232 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088644
SMART Domains Protein: ENSMUSP00000086017
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 5.5e-44 PFAM
Pfam:Pkinase 221 479 4.3e-56 PFAM
Pfam:OSR1_C 500 537 1.9e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 742 753 N/A INTRINSIC
low complexity region 919 935 N/A INTRINSIC
low complexity region 1050 1063 N/A INTRINSIC
low complexity region 1067 1076 N/A INTRINSIC
low complexity region 1146 1158 N/A INTRINSIC
low complexity region 1276 1286 N/A INTRINSIC
low complexity region 1300 1316 N/A INTRINSIC
internal_repeat_1 1394 1436 2.19e-5 PROSPERO
low complexity region 1547 1563 N/A INTRINSIC
low complexity region 1603 1615 N/A INTRINSIC
low complexity region 1637 1654 N/A INTRINSIC
low complexity region 1656 1686 N/A INTRINSIC
low complexity region 1687 1712 N/A INTRINSIC
low complexity region 1754 1773 N/A INTRINSIC
low complexity region 1800 1814 N/A INTRINSIC
low complexity region 1844 1867 N/A INTRINSIC
low complexity region 1928 1949 N/A INTRINSIC
low complexity region 1956 1970 N/A INTRINSIC
low complexity region 1996 2022 N/A INTRINSIC
low complexity region 2140 2158 N/A INTRINSIC
coiled coil region 2323 2350 N/A INTRINSIC
low complexity region 2361 2372 N/A INTRINSIC
low complexity region 2374 2398 N/A INTRINSIC
low complexity region 2466 2490 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088646
SMART Domains Protein: ENSMUSP00000086019
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.3e-44 PFAM
Pfam:Pkinase 221 479 4e-58 PFAM
Pfam:OSR1_C 500 537 1.8e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 864 874 N/A INTRINSIC
low complexity region 888 904 N/A INTRINSIC
internal_repeat_1 982 1024 7.56e-6 PROSPERO
low complexity region 1135 1151 N/A INTRINSIC
low complexity region 1191 1203 N/A INTRINSIC
low complexity region 1225 1242 N/A INTRINSIC
low complexity region 1244 1274 N/A INTRINSIC
low complexity region 1275 1300 N/A INTRINSIC
low complexity region 1342 1361 N/A INTRINSIC
low complexity region 1388 1402 N/A INTRINSIC
low complexity region 1432 1455 N/A INTRINSIC
low complexity region 1516 1537 N/A INTRINSIC
low complexity region 1544 1558 N/A INTRINSIC
low complexity region 1584 1610 N/A INTRINSIC
low complexity region 1700 1718 N/A INTRINSIC
coiled coil region 1883 1910 N/A INTRINSIC
low complexity region 1921 1932 N/A INTRINSIC
low complexity region 1934 1958 N/A INTRINSIC
low complexity region 2026 2050 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159397
Predicted Effect probably benign
Transcript: ENSMUST00000159785
SMART Domains Protein: ENSMUSP00000124905
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 159 169 N/A INTRINSIC
low complexity region 183 199 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160769
Predicted Effect probably benign
Transcript: ENSMUST00000177761
SMART Domains Protein: ENSMUSP00000136777
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 1.7e-44 PFAM
Pfam:Pkinase 221 479 5.1e-58 PFAM
Pfam:OSR1_C 500 537 2.2e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 710 722 N/A INTRINSIC
low complexity region 828 839 N/A INTRINSIC
low complexity region 1005 1021 N/A INTRINSIC
low complexity region 1136 1149 N/A INTRINSIC
low complexity region 1153 1162 N/A INTRINSIC
low complexity region 1232 1244 N/A INTRINSIC
low complexity region 1291 1307 N/A INTRINSIC
internal_repeat_1 1385 1427 1.91e-5 PROSPERO
low complexity region 1538 1554 N/A INTRINSIC
low complexity region 1594 1606 N/A INTRINSIC
low complexity region 1628 1645 N/A INTRINSIC
low complexity region 1647 1677 N/A INTRINSIC
low complexity region 1678 1703 N/A INTRINSIC
low complexity region 1745 1764 N/A INTRINSIC
low complexity region 1791 1805 N/A INTRINSIC
low complexity region 1835 1858 N/A INTRINSIC
low complexity region 1919 1940 N/A INTRINSIC
low complexity region 1947 1961 N/A INTRINSIC
low complexity region 1987 2013 N/A INTRINSIC
low complexity region 2131 2149 N/A INTRINSIC
coiled coil region 2314 2341 N/A INTRINSIC
low complexity region 2352 2363 N/A INTRINSIC
low complexity region 2365 2389 N/A INTRINSIC
low complexity region 2457 2481 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203030
SMART Domains Protein: ENSMUSP00000145304
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 101 115 N/A INTRINSIC
low complexity region 127 141 N/A INTRINSIC
low complexity region 171 193 N/A INTRINSIC
Pfam:Pkinase_Tyr 221 477 4.1e-44 PFAM
Pfam:Pkinase 221 479 3.2e-56 PFAM
Pfam:OSR1_C 500 537 1.5e-22 PFAM
coiled coil region 563 597 N/A INTRINSIC
low complexity region 734 746 N/A INTRINSIC
low complexity region 793 809 N/A INTRINSIC
internal_repeat_1 887 929 5.8e-6 PROSPERO
low complexity region 1040 1056 N/A INTRINSIC
low complexity region 1096 1108 N/A INTRINSIC
low complexity region 1130 1147 N/A INTRINSIC
low complexity region 1149 1179 N/A INTRINSIC
low complexity region 1180 1205 N/A INTRINSIC
low complexity region 1247 1266 N/A INTRINSIC
low complexity region 1293 1307 N/A INTRINSIC
low complexity region 1337 1360 N/A INTRINSIC
low complexity region 1421 1442 N/A INTRINSIC
low complexity region 1449 1463 N/A INTRINSIC
low complexity region 1489 1515 N/A INTRINSIC
low complexity region 1633 1651 N/A INTRINSIC
coiled coil region 1816 1843 N/A INTRINSIC
low complexity region 1854 1865 N/A INTRINSIC
low complexity region 1867 1891 N/A INTRINSIC
low complexity region 1959 1983 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161185
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204207
Predicted Effect probably benign
Transcript: ENSMUST00000162541
SMART Domains Protein: ENSMUSP00000125193
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 63 84 N/A INTRINSIC
low complexity region 91 105 N/A INTRINSIC
low complexity region 131 157 N/A INTRINSIC
low complexity region 247 265 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162368
SMART Domains Protein: ENSMUSP00000125383
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 83 95 N/A INTRINSIC
low complexity region 142 158 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161048
SMART Domains Protein: ENSMUSP00000125345
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
Blast:S_TKc 2 68 3e-34 BLAST
SCOP:d1phk__ 3 70 2e-7 SMART
Pfam:OSR1_C 89 126 9.5e-21 PFAM
coiled coil region 151 185 N/A INTRINSIC
low complexity region 323 335 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161802
SMART Domains Protein: ENSMUSP00000124724
Gene: ENSMUSG00000045962

DomainStartEndE-ValueType
low complexity region 24 50 N/A INTRINSIC
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.7%
  • 10x: 94.8%
  • 20x: 90.6%
Validation Efficiency 98% (95/97)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutant mice die before birth, whereas heterozygotes survive and exhibit decreased blood pressure. Mice homozygous for an allele that does not produce the kidney isoform exhibit a slight increase in systemic arterial diastolic blood pressure and reduced sensitivity to amiloride. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 103 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,039,526 (GRCm39) V261E probably damaging Het
Abca15 A G 7: 119,981,720 (GRCm39) E1058G probably benign Het
Abcb5 T G 12: 118,831,681 (GRCm39) I1224L possibly damaging Het
Actn4 G A 7: 28,597,691 (GRCm39) probably benign Het
Actn4 A G 7: 28,604,753 (GRCm39) V348A probably benign Het
Agtr1b A T 3: 20,369,664 (GRCm39) L314H probably damaging Het
Ankrd55 T C 13: 112,504,460 (GRCm39) M402T probably benign Het
Antxrl T C 14: 33,789,388 (GRCm39) probably benign Het
Asap2 A G 12: 21,263,180 (GRCm39) Q265R probably benign Het
Atp2b4 G A 1: 133,634,677 (GRCm39) R1124C probably damaging Het
Atp2c1 A T 9: 105,312,351 (GRCm39) C353* probably null Het
Atp8b5 T A 4: 43,291,733 (GRCm39) probably null Het
Baz1b T A 5: 135,246,833 (GRCm39) Y761N probably damaging Het
Bend6 A G 1: 33,903,824 (GRCm39) V38A probably benign Het
Camk1g T C 1: 193,044,399 (GRCm39) E5G possibly damaging Het
Ccdc14 T A 16: 34,527,152 (GRCm39) H352Q probably damaging Het
Cdh2 A G 18: 16,757,324 (GRCm39) V641A possibly damaging Het
Celsr2 C A 3: 108,321,424 (GRCm39) D463Y probably damaging Het
Cldn16 C A 16: 26,292,930 (GRCm39) probably benign Het
Clec7a A C 6: 129,449,535 (GRCm39) probably benign Het
Cnih2 T C 19: 5,143,730 (GRCm39) Y142C probably damaging Het
Coa5 T A 1: 37,459,681 (GRCm39) R71* probably null Het
Csmd3 A T 15: 47,532,598 (GRCm39) Y2532* probably null Het
Cytl1 A T 5: 37,892,991 (GRCm39) M34L probably benign Het
Dctn1 T A 6: 83,169,871 (GRCm39) I590N probably damaging Het
Dhx57 T C 17: 80,561,847 (GRCm39) H889R probably damaging Het
Dock10 A G 1: 80,490,275 (GRCm39) I1948T probably benign Het
Dock3 A T 9: 106,832,908 (GRCm39) N1034K probably benign Het
Dzip1l G A 9: 99,541,829 (GRCm39) probably null Het
Eif4g1 T A 16: 20,498,758 (GRCm39) V439E possibly damaging Het
Eml5 T C 12: 98,825,082 (GRCm39) I712V probably benign Het
Entrep1 G A 19: 23,950,970 (GRCm39) T537I probably benign Het
Epha3 C T 16: 63,473,857 (GRCm39) G300D probably damaging Het
Erbb4 A C 1: 68,599,841 (GRCm39) S79A probably damaging Het
Gclc T C 9: 77,688,419 (GRCm39) V205A probably benign Het
Gdpd4 A G 7: 97,623,673 (GRCm39) probably null Het
Gm11564 C T 11: 99,706,058 (GRCm39) C124Y unknown Het
Gm16494 T C 17: 47,327,770 (GRCm39) E38G probably damaging Het
Gtf2h1 T C 7: 46,454,549 (GRCm39) probably null Het
Gtsf2 G T 15: 103,349,644 (GRCm39) R68S probably benign Het
Heatr5b T C 17: 79,115,813 (GRCm39) Q881R probably damaging Het
Hmox1 C A 8: 75,825,463 (GRCm39) L236I probably benign Het
Ighv8-12 T C 12: 115,611,963 (GRCm39) I7V probably benign Het
Itprip A G 19: 47,885,314 (GRCm39) Y434H probably damaging Het
Izumo1 T C 7: 45,272,437 (GRCm39) S73P probably damaging Het
Kifbp A T 10: 62,395,229 (GRCm39) F471Y probably damaging Het
Knl1 A G 2: 118,901,827 (GRCm39) N1176S possibly damaging Het
Limch1 T C 5: 67,039,323 (GRCm39) probably benign Het
Mecom A T 3: 30,034,197 (GRCm39) L493Q probably damaging Het
Mprip T C 11: 59,650,016 (GRCm39) V1240A probably damaging Het
Mrpl3 T C 9: 104,954,201 (GRCm39) S302P probably damaging Het
Muc19 T C 15: 91,758,498 (GRCm39) noncoding transcript Het
Mycbp2 T C 14: 103,425,956 (GRCm39) T2390A probably damaging Het
Myo1c T C 11: 75,560,787 (GRCm39) S766P probably damaging Het
Myo9b A G 8: 71,743,680 (GRCm39) Q247R probably damaging Het
Nav3 G A 10: 109,596,369 (GRCm39) T1423I probably damaging Het
Nefh A T 11: 4,890,066 (GRCm39) I851N probably benign Het
Nup98 T C 7: 101,788,008 (GRCm39) T1004A probably benign Het
Or1e17 T C 11: 73,831,383 (GRCm39) F104L probably benign Het
Or1e22 G A 11: 73,377,149 (GRCm39) S167L possibly damaging Het
Or5k8 G A 16: 58,644,973 (GRCm39) T33I probably benign Het
Or5p76 T C 7: 108,122,411 (GRCm39) T249A probably benign Het
Osgin1 G T 8: 120,172,124 (GRCm39) R306L possibly damaging Het
Otof A G 5: 30,537,571 (GRCm39) L1246P probably benign Het
Pde8a T A 7: 80,952,019 (GRCm39) N273K probably damaging Het
Phf14 T A 6: 11,933,726 (GRCm39) M196K possibly damaging Het
Pkd1l3 T C 8: 110,373,585 (GRCm39) S1374P possibly damaging Het
Pkhd1l1 T C 15: 44,400,282 (GRCm39) V2142A probably benign Het
Plb1 A G 5: 32,512,170 (GRCm39) E1318G possibly damaging Het
Plekhh2 A G 17: 84,883,199 (GRCm39) I756V probably benign Het
Prag1 A T 8: 36,613,452 (GRCm39) probably benign Het
Primpol A G 8: 47,046,672 (GRCm39) V208A probably benign Het
Ptch2 C A 4: 116,965,662 (GRCm39) A389E probably benign Het
Pzp A G 6: 128,489,319 (GRCm39) Y431H probably benign Het
Rnf43 G A 11: 87,622,233 (GRCm39) G445R probably damaging Het
Scn5a A T 9: 119,362,727 (GRCm39) probably null Het
Sf3a1 A T 11: 4,125,380 (GRCm39) probably benign Het
Shisa9 T A 16: 11,802,935 (GRCm39) M164K probably damaging Het
Skint1 A G 4: 111,882,708 (GRCm39) I251V probably benign Het
Slc16a14 C T 1: 84,907,182 (GRCm39) D31N probably damaging Het
Slc22a13 T C 9: 119,022,361 (GRCm39) S548G possibly damaging Het
Slc4a9 T C 18: 36,664,154 (GRCm39) F316L probably benign Het
Smchd1 C T 17: 71,656,725 (GRCm39) R1914H probably damaging Het
Snx16 C T 3: 10,499,431 (GRCm39) D200N probably damaging Het
Spock3 A G 8: 63,404,934 (GRCm39) D34G probably damaging Het
Sspo T C 6: 48,467,916 (GRCm39) C4154R probably damaging Het
Sytl3 C T 17: 6,954,723 (GRCm39) A131V probably benign Het
Tacc1 T A 8: 25,672,271 (GRCm39) D319V probably benign Het
Tead1 A T 7: 112,475,391 (GRCm39) K234I probably damaging Het
Tgfbrap1 C T 1: 43,114,618 (GRCm39) V161I probably benign Het
Tmem94 T C 11: 115,685,917 (GRCm39) probably benign Het
Tnfaip3 A G 10: 18,884,017 (GRCm39) V121A probably damaging Het
Tnnt2 A G 1: 135,779,793 (GRCm39) T297A possibly damaging Het
Trappc11 G A 8: 47,957,000 (GRCm39) L809F probably damaging Het
Ttn T C 2: 76,601,869 (GRCm39) I18598V probably benign Het
Ube2o A G 11: 116,436,650 (GRCm39) probably benign Het
Unc5a A G 13: 55,144,232 (GRCm39) N186D probably damaging Het
Uqcrfs1 C A 13: 30,724,784 (GRCm39) G252V probably damaging Het
Vmn2r115 T C 17: 23,564,992 (GRCm39) I293T probably damaging Het
Vmn2r9 T C 5: 108,991,694 (GRCm39) T556A probably benign Het
Ythdc2 T A 18: 44,997,529 (GRCm39) Y1029N probably benign Het
Zfp451 T A 1: 33,808,894 (GRCm39) K989M possibly damaging Het
Zfpm1 C T 8: 123,062,585 (GRCm39) T548M probably damaging Het
Other mutations in Wnk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Wnk1 APN 6 119,937,669 (GRCm39) missense probably damaging 1.00
IGL01364:Wnk1 APN 6 119,914,372 (GRCm39) missense probably damaging 1.00
IGL01715:Wnk1 APN 6 119,925,358 (GRCm39) missense probably damaging 1.00
IGL01951:Wnk1 APN 6 119,940,446 (GRCm39) missense probably damaging 0.99
IGL02043:Wnk1 APN 6 119,926,039 (GRCm39) unclassified probably benign
IGL02268:Wnk1 APN 6 119,914,334 (GRCm39) nonsense probably null
IGL02348:Wnk1 APN 6 119,940,289 (GRCm39) missense probably damaging 0.98
IGL02425:Wnk1 APN 6 119,940,415 (GRCm39) missense probably damaging 1.00
IGL02850:Wnk1 APN 6 119,914,823 (GRCm39) missense probably benign 0.26
IGL03160:Wnk1 APN 6 119,903,594 (GRCm39) missense probably damaging 1.00
IGL03387:Wnk1 APN 6 119,931,148 (GRCm39) missense possibly damaging 0.76
IGL03405:Wnk1 APN 6 119,930,856 (GRCm39) missense probably benign 0.41
Actor UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
Bad UTSW 6 119,942,639 (GRCm39) intron probably benign
Blink UTSW 6 119,979,234 (GRCm39) nonsense probably null
Knock UTSW 6 119,920,839 (GRCm39) splice site probably null
Narrow UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
nictitate UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
opportunity UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
path UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
Stormy UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
tear UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
Tic UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
Unforgiving UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
Window UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
Woke UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
IGL03052:Wnk1 UTSW 6 119,921,760 (GRCm39) splice site probably benign
PIT4480001:Wnk1 UTSW 6 119,940,328 (GRCm39) nonsense probably null
R0044:Wnk1 UTSW 6 120,014,110 (GRCm39) missense probably damaging 0.99
R0207:Wnk1 UTSW 6 119,929,694 (GRCm39) missense probably damaging 1.00
R0333:Wnk1 UTSW 6 119,905,124 (GRCm39) intron probably benign
R0453:Wnk1 UTSW 6 119,940,112 (GRCm39) missense probably damaging 0.99
R0457:Wnk1 UTSW 6 119,946,293 (GRCm39) missense probably damaging 1.00
R0501:Wnk1 UTSW 6 119,939,764 (GRCm39) missense probably damaging 1.00
R0525:Wnk1 UTSW 6 119,903,525 (GRCm39) missense probably damaging 1.00
R0526:Wnk1 UTSW 6 119,928,953 (GRCm39) missense probably damaging 0.99
R0606:Wnk1 UTSW 6 119,903,644 (GRCm39) missense probably damaging 1.00
R0658:Wnk1 UTSW 6 119,925,466 (GRCm39) missense probably damaging 0.98
R1148:Wnk1 UTSW 6 119,928,967 (GRCm39) splice site probably benign
R1188:Wnk1 UTSW 6 119,925,670 (GRCm39) nonsense probably null
R1245:Wnk1 UTSW 6 119,925,418 (GRCm39) missense probably benign 0.26
R1449:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R1869:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1871:Wnk1 UTSW 6 119,928,050 (GRCm39) missense probably damaging 1.00
R1928:Wnk1 UTSW 6 119,929,884 (GRCm39) missense probably damaging 1.00
R1959:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1961:Wnk1 UTSW 6 119,946,208 (GRCm39) missense probably damaging 0.98
R1964:Wnk1 UTSW 6 119,911,343 (GRCm39) missense possibly damaging 0.86
R1983:Wnk1 UTSW 6 119,914,539 (GRCm39) missense probably damaging 1.00
R2062:Wnk1 UTSW 6 119,905,118 (GRCm39) splice site probably null
R2144:Wnk1 UTSW 6 119,925,949 (GRCm39) unclassified probably benign
R2186:Wnk1 UTSW 6 119,925,528 (GRCm39) missense probably benign 0.26
R2281:Wnk1 UTSW 6 119,940,601 (GRCm39) splice site probably null
R2338:Wnk1 UTSW 6 119,946,495 (GRCm39) missense probably benign 0.42
R2420:Wnk1 UTSW 6 119,913,328 (GRCm39) critical splice donor site probably null
R3727:Wnk1 UTSW 6 119,969,414 (GRCm39) missense probably damaging 1.00
R3773:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R3836:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3837:Wnk1 UTSW 6 119,927,004 (GRCm39) missense probably damaging 1.00
R3847:Wnk1 UTSW 6 119,946,315 (GRCm39) missense possibly damaging 0.70
R3903:Wnk1 UTSW 6 119,926,012 (GRCm39) missense probably damaging 1.00
R4031:Wnk1 UTSW 6 119,928,029 (GRCm39) missense probably damaging 1.00
R4095:Wnk1 UTSW 6 119,925,087 (GRCm39) missense probably damaging 1.00
R4232:Wnk1 UTSW 6 119,926,222 (GRCm39) missense possibly damaging 0.90
R4422:Wnk1 UTSW 6 119,930,856 (GRCm39) missense probably benign 0.41
R4423:Wnk1 UTSW 6 119,903,387 (GRCm39) missense probably damaging 1.00
R4572:Wnk1 UTSW 6 119,928,872 (GRCm39) missense possibly damaging 0.49
R4704:Wnk1 UTSW 6 119,942,705 (GRCm39) missense possibly damaging 0.83
R4755:Wnk1 UTSW 6 119,940,431 (GRCm39) missense probably damaging 0.98
R4812:Wnk1 UTSW 6 119,929,732 (GRCm39) missense probably benign 0.16
R4822:Wnk1 UTSW 6 119,939,399 (GRCm39) missense probably benign 0.02
R4879:Wnk1 UTSW 6 119,926,338 (GRCm39) missense probably damaging 1.00
R4970:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5002:Wnk1 UTSW 6 119,914,924 (GRCm39) missense probably benign 0.13
R5037:Wnk1 UTSW 6 119,942,696 (GRCm39) intron probably benign
R5152:Wnk1 UTSW 6 119,979,241 (GRCm39) missense possibly damaging 0.88
R5257:Wnk1 UTSW 6 120,014,149 (GRCm39) missense probably benign 0.00
R5354:Wnk1 UTSW 6 119,945,484 (GRCm39) missense probably benign 0.01
R5421:Wnk1 UTSW 6 119,929,779 (GRCm39) missense probably damaging 1.00
R5564:Wnk1 UTSW 6 119,925,852 (GRCm39) unclassified probably benign
R5600:Wnk1 UTSW 6 119,926,319 (GRCm39) missense probably damaging 1.00
R5847:Wnk1 UTSW 6 119,969,369 (GRCm39) missense probably damaging 1.00
R6083:Wnk1 UTSW 6 120,014,562 (GRCm39) missense probably damaging 0.99
R6110:Wnk1 UTSW 6 119,949,958 (GRCm39) intron probably benign
R6128:Wnk1 UTSW 6 119,940,747 (GRCm39) splice site probably null
R6237:Wnk1 UTSW 6 119,929,728 (GRCm39) missense probably damaging 1.00
R6341:Wnk1 UTSW 6 119,925,546 (GRCm39) missense probably damaging 1.00
R6467:Wnk1 UTSW 6 119,939,916 (GRCm39) missense probably benign 0.12
R6696:Wnk1 UTSW 6 119,925,243 (GRCm39) missense probably damaging 1.00
R6888:Wnk1 UTSW 6 119,925,742 (GRCm39) missense probably benign 0.26
R6923:Wnk1 UTSW 6 119,942,639 (GRCm39) intron probably benign
R7024:Wnk1 UTSW 6 119,942,687 (GRCm39) intron probably benign
R7072:Wnk1 UTSW 6 119,914,822 (GRCm39) missense unknown
R7087:Wnk1 UTSW 6 120,014,491 (GRCm39) missense possibly damaging 0.94
R7102:Wnk1 UTSW 6 119,925,268 (GRCm39) missense unknown
R7134:Wnk1 UTSW 6 119,903,389 (GRCm39) missense unknown
R7137:Wnk1 UTSW 6 120,015,173 (GRCm39) unclassified probably benign
R7142:Wnk1 UTSW 6 119,926,240 (GRCm39) missense probably benign 0.09
R7174:Wnk1 UTSW 6 119,947,939 (GRCm39) missense probably damaging 1.00
R7205:Wnk1 UTSW 6 119,920,839 (GRCm39) splice site probably null
R7218:Wnk1 UTSW 6 119,979,234 (GRCm39) nonsense probably null
R7498:Wnk1 UTSW 6 119,904,157 (GRCm39) missense unknown
R7599:Wnk1 UTSW 6 119,906,789 (GRCm39) missense possibly damaging 0.83
R7615:Wnk1 UTSW 6 119,909,699 (GRCm39) missense probably benign 0.27
R7799:Wnk1 UTSW 6 119,926,137 (GRCm39) missense probably benign 0.04
R7979:Wnk1 UTSW 6 120,014,409 (GRCm39) missense probably damaging 1.00
R8075:Wnk1 UTSW 6 119,909,675 (GRCm39) missense probably damaging 0.99
R8331:Wnk1 UTSW 6 119,930,794 (GRCm39) missense probably benign 0.09
R8343:Wnk1 UTSW 6 119,940,454 (GRCm39) missense probably damaging 0.99
R8348:Wnk1 UTSW 6 119,906,960 (GRCm39) splice site probably null
R8359:Wnk1 UTSW 6 119,969,408 (GRCm39) missense probably damaging 1.00
R8424:Wnk1 UTSW 6 119,911,388 (GRCm39) missense unknown
R8519:Wnk1 UTSW 6 119,927,044 (GRCm39) missense probably damaging 1.00
R8930:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8932:Wnk1 UTSW 6 119,940,226 (GRCm39) missense probably damaging 0.99
R8933:Wnk1 UTSW 6 120,013,959 (GRCm39) missense probably damaging 1.00
R9005:Wnk1 UTSW 6 119,939,393 (GRCm39) missense probably damaging 1.00
R9147:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9148:Wnk1 UTSW 6 119,925,631 (GRCm39) missense unknown
R9354:Wnk1 UTSW 6 119,942,660 (GRCm39) missense unknown
R9379:Wnk1 UTSW 6 119,928,678 (GRCm39) missense probably damaging 1.00
X0064:Wnk1 UTSW 6 120,013,993 (GRCm39) missense possibly damaging 0.93
Z1177:Wnk1 UTSW 6 119,925,166 (GRCm39) missense unknown
Predicted Primers
Posted On 2014-05-23