Mutagenetix > Incidental Mutation

Incidental Mutation 'R1470:Nlrp2'

197951

Institutional Source

Beutler Lab

Gene Symbol

Nlrp2

Ensembl Gene

ENSMUSG00000035177

Gene Name

NLR family, pyrin domain containing 2

Synonyms

Nbs1, Pan1, PYPAF2, E330007A02Rik, Nalp2

MMRRC Submission

039523-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1470 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

5298547-5351035 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 5300951 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 192 (T192S)

Ref Sequence

ENSEMBL: ENSMUSP00000147102 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045022] [ENSMUST00000207520] [ENSMUST00000207685]

AlphaFold

Q4PLS0

Predicted Effect

probably benign
Transcript: ENSMUST00000045022
AA Change: T987S

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000045077
Gene: ENSMUSG00000035177
AA Change: T987S

Domain	Start	End	E-Value	Type
PYRIN	7	90	2.88e-17	SMART
Pfam:NACHT	180	348	6.9e-30	PFAM
internal_repeat_1	676	722	1.74e-5	PROSPERO
LRR	796	823	1.26e1	SMART
LRR	825	852	1.18e1	SMART
LRR	853	880	5.81e-2	SMART
LRR	882	909	3.39e-3	SMART
LRR	910	937	5.06e-2	SMART
LRR	939	966	5.23e0	SMART
LRR	967	994	3.58e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207520
AA Change: T192S

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)

Predicted Effect

probably benign
Transcript: ENSMUST00000207685

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207938

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 97.5%
3x: 97.0%
10x: 95.5%
20x: 93.0%

Validation Efficiency

97% (125/129)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

Allele List at MGI

Other mutations in this stock

Total: 142 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930415O20Rik	T	C	15: 98,585,261 (GRCm38)		probably benign	Het
4932438A13Rik	T	C	3: 36,998,331 (GRCm38)	M3060T	probably benign	Het
Aak1	T	A	6: 86,967,355 (GRCm38)	S749T	unknown	Het
Abcb4	A	T	5: 8,940,968 (GRCm38)	I843F	probably damaging	Het
Abcb6	A	T	1: 75,172,679 (GRCm38)		probably benign	Het
AC161516.2	G	T	5: 67,946,397 (GRCm38)		probably benign	Het
AC238840.1	A	T	7: 38,767,953 (GRCm38)		noncoding transcript	Het
Actr8	T	A	14: 29,986,969 (GRCm38)	H244Q	possibly damaging	Het
Acyp2	A	G	11: 30,506,452 (GRCm38)		probably benign	Het
Adgrv1	A	G	13: 81,382,298 (GRCm38)	Y5886H	probably benign	Het
Afap1	C	T	5: 35,961,737 (GRCm38)		probably benign	Het
Agk	T	A	6: 40,386,817 (GRCm38)	W244R	probably damaging	Het
Akirin1	T	A	4: 123,738,090 (GRCm38)		probably benign	Het
Ankrd11	C	A	8: 122,899,724 (GRCm38)	V161L	probably damaging	Het
Arap3	T	C	18: 37,989,196 (GRCm38)		probably null	Het
Arhgap29	A	G	3: 121,992,319 (GRCm38)		probably benign	Het
Armc3	A	G	2: 19,238,736 (GRCm38)	M88V	probably benign	Het
Atp13a5	G	T	16: 29,349,015 (GRCm38)	P109T	probably benign	Het
Avpr1b	T	A	1: 131,600,585 (GRCm38)	V282D	probably damaging	Het
Baz2b	T	C	2: 59,978,546 (GRCm38)	K120E	possibly damaging	Het
Cacna1a	T	A	8: 84,514,950 (GRCm38)		probably benign	Het
Cacng6	G	A	7: 3,424,888 (GRCm38)	C76Y	probably damaging	Het
Cactin	G	T	10: 81,323,151 (GRCm38)	E279*	probably null	Het
Car9	A	G	4: 43,510,222 (GRCm38)	Y268C	probably damaging	Het
Ccdc146	T	A	5: 21,319,566 (GRCm38)	I263F	probably damaging	Het
Cdc16	A	T	8: 13,758,992 (GRCm38)		probably benign	Het
Cdh16	T	G	8: 104,618,371 (GRCm38)	S429R	probably benign	Het
Cep250	A	G	2: 155,991,075 (GRCm38)	E1639G	probably damaging	Het
Ces1d	A	T	8: 93,195,021 (GRCm38)	V38D	possibly damaging	Het
Chd1	A	T	17: 15,726,283 (GRCm38)	Q97L	possibly damaging	Het
Ciita	G	A	16: 10,514,468 (GRCm38)	D898N	possibly damaging	Het
Clstn1	A	G	4: 149,634,722 (GRCm38)	N336S	possibly damaging	Het
Cntnap5a	A	G	1: 116,259,519 (GRCm38)	D607G	probably damaging	Het
Col1a2	G	A	6: 4,518,822 (GRCm38)		probably benign	Het
Col20a1	C	T	2: 180,994,960 (GRCm38)	H245Y	probably benign	Het
Coq8b	A	T	7: 27,252,309 (GRCm38)	T399S	probably benign	Het
Cpn2	A	G	16: 30,260,185 (GRCm38)	S233P	probably benign	Het
Cryz	G	A	3: 154,606,476 (GRCm38)	G70D	probably damaging	Het
Csmd1	G	T	8: 16,157,204 (GRCm38)		probably benign	Het
Def6	T	A	17: 28,225,982 (GRCm38)	D451E	possibly damaging	Het
Dnah8	T	A	17: 30,747,277 (GRCm38)	C2480*	probably null	Het
Dnah9	T	C	11: 65,927,822 (GRCm38)	N3230S	probably benign	Het
Dyrk4	G	T	6: 126,916,374 (GRCm38)	S15*	probably null	Het
Erc1	T	C	6: 119,694,602 (GRCm38)	R917G	probably damaging	Het
Fgd2	T	A	17: 29,374,108 (GRCm38)		probably benign	Het
Frem3	G	T	8: 80,611,191 (GRCm38)	V38L	probably benign	Het
Gas2l3	T	C	10: 89,413,934 (GRCm38)	I441V	probably benign	Het
Gm14393	T	A	2: 175,063,981 (GRCm38)	Y6F	probably damaging	Het
Gm1527	A	G	3: 28,915,268 (GRCm38)	K256E	possibly damaging	Het
Gtf2ird1	T	A	5: 134,395,802 (GRCm38)		probably null	Het
Hmces	C	A	6: 87,936,139 (GRCm38)	T292K	probably benign	Het
Hpse2	G	A	19: 43,388,253 (GRCm38)	S20L	probably benign	Het
Ikbke	A	T	1: 131,276,487 (GRCm38)	V23E	probably null	Het
Ino80	A	T	2: 119,379,649 (GRCm38)	V1387E	probably damaging	Het
Islr	G	T	9: 58,157,306 (GRCm38)	A306D	probably damaging	Het
Jakmip1	G	A	5: 37,100,838 (GRCm38)	G276D	probably damaging	Het
Jchain	A	G	5: 88,526,120 (GRCm38)	V55A	probably benign	Het
Kalrn	T	C	16: 34,187,471 (GRCm38)	K1350E	probably damaging	Het
Kansl1l	T	C	1: 66,801,997 (GRCm38)	Q48R	possibly damaging	Het
Kmt5a	T	C	5: 124,447,271 (GRCm38)	L23P	probably damaging	Het
Lrba	C	T	3: 86,737,142 (GRCm38)	H381Y	probably damaging	Het
Lrch3	T	C	16: 32,988,495 (GRCm38)		probably benign	Het
Lrrc32	T	C	7: 98,499,357 (GRCm38)	V448A	probably benign	Het
Mapkbp1	T	C	2: 120,017,820 (GRCm38)	M617T	probably damaging	Het
Megf6	C	T	4: 154,252,419 (GRCm38)		probably benign	Het
Mfap1a	T	C	2: 121,502,801 (GRCm38)	M50V	probably benign	Het
Mgam	G	T	6: 40,759,128 (GRCm38)	A854S	probably damaging	Het
Myh3	A	C	11: 67,098,059 (GRCm38)		probably benign	Het
Myo18b	C	A	5: 112,693,033 (GRCm38)	R2298L	probably damaging	Het
Myo1h	T	A	5: 114,319,704 (GRCm38)	M92K	probably damaging	Het
Nfkbib	T	C	7: 28,762,022 (GRCm38)		probably null	Het
Nr2f1	A	T	13: 78,198,165 (GRCm38)	Y137N	possibly damaging	Het
Nup98	T	A	7: 102,147,306 (GRCm38)	D841V	probably damaging	Het
Nvl	A	G	1: 181,139,262 (GRCm38)	V59A	probably damaging	Het
Ogdhl	C	A	14: 32,346,788 (GRCm38)	N948K	probably damaging	Het
Olfr530	A	G	7: 140,373,113 (GRCm38)	S166P	probably benign	Het
Olfr538	A	G	7: 140,574,749 (GRCm38)	T199A	probably benign	Het
Olfr578	A	C	7: 102,984,323 (GRCm38)	Y280*	probably null	Het
Olfr743	T	C	14: 50,533,702 (GRCm38)	S97P	possibly damaging	Het
Orc2	A	C	1: 58,481,158 (GRCm38)		probably benign	Het
Osgin1	G	A	8: 119,444,965 (GRCm38)	R166H	probably damaging	Het
Palb2	G	T	7: 122,107,524 (GRCm38)	Y740*	probably null	Het
Palb2	A	T	7: 122,107,523 (GRCm38)	F741I	probably benign	Het
Parvb	G	A	15: 84,271,308 (GRCm38)	D65N	probably benign	Het
Parvb	G	A	15: 84,271,252 (GRCm38)	G46D	probably damaging	Het
Pcsk2	A	T	2: 143,546,518 (GRCm38)	K10*	probably null	Het
Pde3a	C	T	6: 141,466,206 (GRCm38)	A502V	probably benign	Het
Pfas	T	C	11: 68,991,359 (GRCm38)	I893V	probably benign	Het
Pla2g4a	A	T	1: 149,840,720 (GRCm38)	D663E	probably damaging	Het
Prickle2	G	A	6: 92,458,602 (GRCm38)	P6L	probably damaging	Het
Prx	T	A	7: 27,517,601 (GRCm38)	M648K	probably benign	Het
Ptpn21	T	C	12: 98,688,476 (GRCm38)	N744S	probably benign	Het
Ptprq	C	T	10: 107,718,574 (GRCm38)	V97M	probably damaging	Het
Pvr	T	C	7: 19,918,624 (GRCm38)	E122G	possibly damaging	Het
Racgap1	T	C	15: 99,639,775 (GRCm38)	K15E	probably damaging	Het
Rock1	C	T	18: 10,136,091 (GRCm38)		probably null	Het
Rorc	T	A	3: 94,397,302 (GRCm38)	Y331*	probably null	Het
Rpl37	T	C	15: 5,118,614 (GRCm38)	V91A	probably benign	Het
Rrp36	T	A	17: 46,672,380 (GRCm38)	K103*	probably null	Het
Ryr3	T	A	2: 112,653,007 (GRCm38)	M4142L	probably benign	Het
Sash1	A	T	10: 8,789,593 (GRCm38)	L125H	probably damaging	Het
Scn5a	T	C	9: 119,536,475 (GRCm38)	M369V	possibly damaging	Het
Siglec1	A	T	2: 131,070,387 (GRCm38)	N1678K	probably benign	Het
Slc15a5	A	T	6: 138,072,994 (GRCm38)	V141E	probably benign	Het
Slc43a1	T	C	2: 84,859,676 (GRCm38)		probably benign	Het
Slc8a3	A	T	12: 81,199,710 (GRCm38)	H856Q	probably benign	Het
Sptlc2	T	A	12: 87,355,640 (GRCm38)	M171L	probably benign	Het
Srcap	T	A	7: 127,559,727 (GRCm38)		probably benign	Het
St6gal2	A	G	17: 55,490,943 (GRCm38)	D310G	probably damaging	Het
Susd2	T	A	10: 75,638,054 (GRCm38)	D689V	probably damaging	Het
Suz12	A	T	11: 80,019,732 (GRCm38)	E303V	possibly damaging	Het
Taldo1	C	A	7: 141,398,587 (GRCm38)	T150K	probably damaging	Het
Tex14	T	C	11: 87,549,529 (GRCm38)		probably benign	Het
Tg	T	A	15: 66,849,463 (GRCm38)	F274I	possibly damaging	Het
Tmem151b	T	C	17: 45,545,737 (GRCm38)	D259G	probably damaging	Het
Tmem179	G	T	12: 112,501,854 (GRCm38)	H64Q	probably benign	Het
Tmem236	A	G	2: 14,218,921 (GRCm38)	T174A	probably benign	Het
Tmtc1	T	A	6: 148,305,985 (GRCm38)		probably benign	Het
Tnc	A	T	4: 63,966,574 (GRCm38)	N1821K	probably damaging	Het
Tnfrsf11a	A	G	1: 105,825,048 (GRCm38)	N261S	probably damaging	Het
Traf6	G	T	2: 101,696,649 (GRCm38)		probably benign	Het
Trank1	C	A	9: 111,343,232 (GRCm38)	F96L	possibly damaging	Het
Trim56	T	A	5: 137,113,163 (GRCm38)	I500F	probably damaging	Het
Ttc30b	G	T	2: 75,937,811 (GRCm38)	S199R	probably benign	Het
Ttll5	A	G	12: 85,879,394 (GRCm38)	I321V	possibly damaging	Het
Ttn	C	A	2: 76,778,023 (GRCm38)	W17852L	probably damaging	Het
Twnk	G	A	19: 45,009,381 (GRCm38)	V450M	probably damaging	Het
Uba52	A	G	8: 70,509,556 (GRCm38)	I127T	possibly damaging	Het
Ubr4	T	A	4: 139,421,226 (GRCm38)		probably null	Het
Uggt1	A	T	1: 36,176,796 (GRCm38)	M130K	probably benign	Het
Ulk4	T	A	9: 121,081,656 (GRCm38)	T1101S	probably benign	Het
Urb1	A	G	16: 90,752,014 (GRCm38)	S2269P	probably benign	Het
Ush2a	G	T	1: 188,400,206 (GRCm38)	R875L	probably benign	Het
Usp9y	T	A	Y: 1,332,471 (GRCm38)	H1624L	probably benign	Homo
Vipr1	T	C	9: 121,665,520 (GRCm38)	L308S	possibly damaging	Het
Vps50	G	A	6: 3,517,777 (GRCm38)		probably benign	Het
Xdh	T	G	17: 73,891,112 (GRCm38)	K1260T	probably damaging	Het
Yipf4	A	G	17: 74,493,968 (GRCm38)	I94V	probably benign	Het
Zfhx4	A	G	3: 5,413,146 (GRCm38)	*3582W	probably null	Het
Zfp58	T	C	13: 67,492,025 (GRCm38)	N116D	possibly damaging	Het
Zfp750	C	A	11: 121,511,993 (GRCm38)	R643L	probably benign	Het
Znfx1	A	G	2: 167,042,587 (GRCm38)	V51A	possibly damaging	Het

Other mutations in Nlrp2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00485:Nlrp2	APN	7	5,337,548 (GRCm38)	missense	probably benign	0.00
IGL00545:Nlrp2	APN	7	5,328,252 (GRCm38)	missense	possibly damaging	0.89
IGL01311:Nlrp2	APN	7	5,319,239 (GRCm38)	missense	possibly damaging	0.92
IGL01345:Nlrp2	APN	7	5,317,492 (GRCm38)	missense	probably benign	0.16
IGL01583:Nlrp2	APN	7	5,337,770 (GRCm38)	missense	probably damaging	1.00
IGL01659:Nlrp2	APN	7	5,328,035 (GRCm38)	missense	probably damaging	1.00
IGL02240:Nlrp2	APN	7	5,327,823 (GRCm38)	missense	probably damaging	1.00
IGL02353:Nlrp2	APN	7	5,337,599 (GRCm38)	missense	probably damaging	1.00
IGL02360:Nlrp2	APN	7	5,337,599 (GRCm38)	missense	probably damaging	1.00
IGL02399:Nlrp2	APN	7	5,328,810 (GRCm38)	missense	probably damaging	1.00
IGL02441:Nlrp2	APN	7	5,335,567 (GRCm38)	critical splice donor site	probably null
IGL02588:Nlrp2	APN	7	5,327,552 (GRCm38)	nonsense	probably null
IGL02803:Nlrp2	APN	7	5,328,318 (GRCm38)	missense	probably damaging	1.00
IGL02968:Nlrp2	APN	7	5,301,025 (GRCm38)	missense	possibly damaging	0.81
IGL03342:Nlrp2	APN	7	5,317,483 (GRCm38)	missense	probably damaging	1.00
BB006:Nlrp2	UTSW	7	5,327,499 (GRCm38)	missense	probably damaging	1.00
BB016:Nlrp2	UTSW	7	5,327,499 (GRCm38)	missense	probably damaging	1.00
R0027:Nlrp2	UTSW	7	5,322,448 (GRCm38)	missense	probably damaging	1.00
R0051:Nlrp2	UTSW	7	5,322,334 (GRCm38)	unclassified	probably benign
R0079:Nlrp2	UTSW	7	5,327,730 (GRCm38)	missense	possibly damaging	0.81
R0130:Nlrp2	UTSW	7	5,322,418 (GRCm38)	missense	possibly damaging	0.77
R0157:Nlrp2	UTSW	7	5,308,770 (GRCm38)	missense	possibly damaging	0.88
R0201:Nlrp2	UTSW	7	5,328,329 (GRCm38)	missense	probably benign	0.00
R0276:Nlrp2	UTSW	7	5,328,109 (GRCm38)	missense	probably benign	0.00
R0288:Nlrp2	UTSW	7	5,328,545 (GRCm38)	missense	probably benign	0.19
R0332:Nlrp2	UTSW	7	5,317,630 (GRCm38)	missense	probably damaging	1.00
R0724:Nlrp2	UTSW	7	5,319,222 (GRCm38)	missense	probably damaging	1.00
R1241:Nlrp2	UTSW	7	5,328,431 (GRCm38)	missense	probably damaging	1.00
R1355:Nlrp2	UTSW	7	5,327,491 (GRCm38)	missense	possibly damaging	0.81
R1392:Nlrp2	UTSW	7	5,329,015 (GRCm38)	splice site	probably benign
R1470:Nlrp2	UTSW	7	5,300,951 (GRCm38)	missense	probably benign	0.18
R1563:Nlrp2	UTSW	7	5,308,725 (GRCm38)	missense	probably damaging	1.00
R1866:Nlrp2	UTSW	7	5,327,716 (GRCm38)	nonsense	probably null
R1942:Nlrp2	UTSW	7	5,322,448 (GRCm38)	missense	probably damaging	1.00
R1959:Nlrp2	UTSW	7	5,327,738 (GRCm38)	missense	probably damaging	1.00
R1960:Nlrp2	UTSW	7	5,327,738 (GRCm38)	missense	probably damaging	1.00
R1961:Nlrp2	UTSW	7	5,327,738 (GRCm38)	missense	probably damaging	1.00
R2072:Nlrp2	UTSW	7	5,325,006 (GRCm38)	missense	probably damaging	1.00
R2161:Nlrp2	UTSW	7	5,325,042 (GRCm38)	missense	probably damaging	1.00
R2190:Nlrp2	UTSW	7	5,319,238 (GRCm38)	missense	possibly damaging	0.95
R2243:Nlrp2	UTSW	7	5,335,598 (GRCm38)	missense	probably benign	0.03
R2277:Nlrp2	UTSW	7	5,328,129 (GRCm38)	missense	probably benign
R2334:Nlrp2	UTSW	7	5,337,535 (GRCm38)	missense	probably benign	0.39
R3030:Nlrp2	UTSW	7	5,327,748 (GRCm38)	missense	probably damaging	1.00
R3404:Nlrp2	UTSW	7	5,319,287 (GRCm38)	missense	probably benign	0.01
R3941:Nlrp2	UTSW	7	5,327,552 (GRCm38)	nonsense	probably null
R4021:Nlrp2	UTSW	7	5,325,012 (GRCm38)	missense	probably benign	0.40
R4518:Nlrp2	UTSW	7	5,325,056 (GRCm38)	missense	possibly damaging	0.85
R4666:Nlrp2	UTSW	7	5,319,189 (GRCm38)	missense	probably benign	0.18
R4767:Nlrp2	UTSW	7	5,328,024 (GRCm38)	missense	probably damaging	1.00
R4827:Nlrp2	UTSW	7	5,328,951 (GRCm38)	missense	possibly damaging	0.60
R4873:Nlrp2	UTSW	7	5,298,859 (GRCm38)	missense	probably benign	0.09
R4875:Nlrp2	UTSW	7	5,298,859 (GRCm38)	missense	probably benign	0.09
R5020:Nlrp2	UTSW	7	5,328,077 (GRCm38)	missense	probably damaging	1.00
R5293:Nlrp2	UTSW	7	5,327,615 (GRCm38)	missense	probably damaging	1.00
R5310:Nlrp2	UTSW	7	5,325,008 (GRCm38)	missense	probably benign	0.00
R5336:Nlrp2	UTSW	7	5,328,119 (GRCm38)	missense	probably benign
R5390:Nlrp2	UTSW	7	5,300,909 (GRCm38)	missense	probably benign	0.00
R5864:Nlrp2	UTSW	7	5,322,381 (GRCm38)	missense	probably damaging	1.00
R5913:Nlrp2	UTSW	7	5,324,903 (GRCm38)	splice site	probably null
R6173:Nlrp2	UTSW	7	5,337,809 (GRCm38)	missense	probably damaging	0.96
R6274:Nlrp2	UTSW	7	5,317,555 (GRCm38)	missense	probably damaging	1.00
R6303:Nlrp2	UTSW	7	5,337,761 (GRCm38)	missense	probably damaging	1.00
R6343:Nlrp2	UTSW	7	5,300,926 (GRCm38)	missense	possibly damaging	0.82
R6704:Nlrp2	UTSW	7	5,325,041 (GRCm38)	nonsense	probably null
R6814:Nlrp2	UTSW	7	5,308,710 (GRCm38)	missense	probably benign	0.01
R6872:Nlrp2	UTSW	7	5,308,710 (GRCm38)	missense	probably benign	0.01
R7023:Nlrp2	UTSW	7	5,328,229 (GRCm38)	nonsense	probably null
R7028:Nlrp2	UTSW	7	5,328,572 (GRCm38)	missense	possibly damaging	0.93
R7109:Nlrp2	UTSW	7	5,328,617 (GRCm38)	missense	probably damaging	1.00
R7203:Nlrp2	UTSW	7	5,317,534 (GRCm38)	missense	probably damaging	1.00
R7322:Nlrp2	UTSW	7	5,308,645 (GRCm38)	missense	possibly damaging	0.94
R7339:Nlrp2	UTSW	7	5,327,628 (GRCm38)	missense	possibly damaging	0.95
R7573:Nlrp2	UTSW	7	5,317,469 (GRCm38)	critical splice donor site	probably null
R7657:Nlrp2	UTSW	7	5,319,168 (GRCm38)	missense	probably benign	0.01
R7929:Nlrp2	UTSW	7	5,327,499 (GRCm38)	missense	probably damaging	1.00
R7964:Nlrp2	UTSW	7	5,328,528 (GRCm38)	missense	probably damaging	1.00
R8097:Nlrp2	UTSW	7	5,327,651 (GRCm38)	missense	probably damaging	1.00
R8276:Nlrp2	UTSW	7	5,317,495 (GRCm38)	missense	probably benign	0.40
R8785:Nlrp2	UTSW	7	5,327,549 (GRCm38)	missense	probably damaging	0.99
R8798:Nlrp2	UTSW	7	5,327,888 (GRCm38)	missense	possibly damaging	0.86
R8982:Nlrp2	UTSW	7	5,324,979 (GRCm38)	missense	probably damaging	1.00
R9030:Nlrp2	UTSW	7	5,322,458 (GRCm38)	missense	probably null	0.00
R9038:Nlrp2	UTSW	7	5,327,479 (GRCm38)	missense	probably benign	0.14
R9149:Nlrp2	UTSW	7	5,327,573 (GRCm38)	missense	probably benign	0.01
R9229:Nlrp2	UTSW	7	5,301,053 (GRCm38)	missense	possibly damaging	0.81
R9584:Nlrp2	UTSW	7	5,319,216 (GRCm38)	missense	probably damaging	1.00
X0027:Nlrp2	UTSW	7	5,327,642 (GRCm38)	missense	probably benign	0.03

Predicted Primers

Posted On

2014-05-23