Incidental Mutation 'R0084:Paox'
ID 19813
Institutional Source Beutler Lab
Gene Symbol Paox
Ensembl Gene ENSMUSG00000025464
Gene Name polyamine oxidase (exo-N4-amino)
Synonyms Pao, 2410012F02Rik
MMRRC Submission 038371-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0084 (G1)
Quality Score 223
Status Validated
Chromosome 7
Chromosomal Location 139693182-139714249 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 139712359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 197 (R197*)
Ref Sequence ENSEMBL: ENSMUSP00000095580 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026537] [ENSMUST00000097967] [ENSMUST00000211757]
AlphaFold Q8C0L6
Predicted Effect probably null
Transcript: ENSMUST00000026537
AA Change: R427*
SMART Domains Protein: ENSMUSP00000026537
Gene: ENSMUSG00000025464
AA Change: R427*

DomainStartEndE-ValueType
Pfam:NAD_binding_8 10 79 4.1e-14 PFAM
Pfam:Amino_oxidase 15 490 4.9e-79 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000097967
AA Change: R197*
SMART Domains Protein: ENSMUSP00000095580
Gene: ENSMUSG00000025464
AA Change: R197*

DomainStartEndE-ValueType
Pfam:NAD_binding_8 10 77 1.4e-8 PFAM
Pfam:Amino_oxidase 52 260 1.5e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209908
Predicted Effect probably benign
Transcript: ENSMUST00000211757
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.0%
  • 10x: 94.5%
  • 20x: 86.0%
Validation Efficiency 99% (77/78)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A G 11: 109,927,423 (GRCm39) probably benign Het
Abcc9 A G 6: 142,604,277 (GRCm39) Y653H probably damaging Het
Acp3 A T 9: 104,191,564 (GRCm39) S241T probably benign Het
Acvr1 A G 2: 58,348,895 (GRCm39) probably null Het
Adgb T C 10: 10,272,088 (GRCm39) N832S possibly damaging Het
AI182371 A G 2: 34,975,714 (GRCm39) probably null Het
Anapc1 G A 2: 128,465,886 (GRCm39) probably benign Het
Apba1 T C 19: 23,889,861 (GRCm39) S420P possibly damaging Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Bpifb2 A T 2: 153,733,011 (GRCm39) M365L probably benign Het
Btnl9 A T 11: 49,069,606 (GRCm39) N224K possibly damaging Het
Cntn1 A T 15: 92,215,798 (GRCm39) I944L probably benign Het
Cpa3 T C 3: 20,296,265 (GRCm39) probably benign Het
Dcaf11 C T 14: 55,806,700 (GRCm39) R468C probably benign Het
E4f1 T C 17: 24,663,056 (GRCm39) T750A possibly damaging Het
Ercc5 A G 1: 44,215,136 (GRCm39) K890E possibly damaging Het
Fbrsl1 A G 5: 110,527,381 (GRCm39) L262P probably damaging Het
Flnb A G 14: 7,935,979 (GRCm38) D2273G probably benign Het
Gm9848 A T 13: 113,244,776 (GRCm39) noncoding transcript Het
Hcrtr1 T A 4: 130,031,059 (GRCm39) H75L possibly damaging Het
Heatr9 A T 11: 83,403,721 (GRCm39) probably benign Het
Htatip2 G A 7: 49,409,420 (GRCm39) G58D probably damaging Het
Jkampl A T 6: 73,445,918 (GRCm39) Y210* probably null Het
Lmntd1 G A 6: 145,350,254 (GRCm39) H234Y unknown Het
Ly6g2 T A 15: 75,089,624 (GRCm39) M44K probably benign Het
Map4k3 T C 17: 80,963,343 (GRCm39) K85E possibly damaging Het
Moxd2 T C 6: 40,856,342 (GRCm39) D510G probably null Het
Mpv17l2 A T 8: 71,217,190 (GRCm39) probably benign Het
Nbeal2 A G 9: 110,472,778 (GRCm39) probably null Het
Ncapd3 A G 9: 26,967,407 (GRCm39) D581G probably damaging Het
Ndufb5 T C 3: 32,791,352 (GRCm39) V33A probably benign Het
Or10a49 A T 7: 108,468,007 (GRCm39) M118K probably damaging Het
Osbpl1a T C 18: 12,890,669 (GRCm39) T524A probably benign Het
Otogl A C 10: 107,737,202 (GRCm39) S71A probably damaging Het
Ovol2 G T 2: 144,147,808 (GRCm39) N180K probably damaging Het
Pam A G 1: 97,823,774 (GRCm39) V219A probably benign Het
Pax2 T A 19: 44,806,874 (GRCm39) Y290N probably damaging Het
Pik3ca T C 3: 32,516,937 (GRCm39) M933T possibly damaging Het
Ppfia4 G T 1: 134,227,164 (GRCm39) R1124S possibly damaging Het
Prkch T C 12: 73,744,761 (GRCm39) F258S possibly damaging Het
Rhob G A 12: 8,549,107 (GRCm39) R176C probably benign Het
Sbf2 A T 7: 110,041,573 (GRCm39) I326N possibly damaging Het
Scgb2b2 A T 7: 31,003,041 (GRCm39) E45D probably benign Het
Scube3 T A 17: 28,381,935 (GRCm39) D320E probably benign Het
Serpina1f A G 12: 103,659,847 (GRCm39) V145A possibly damaging Het
Slc28a2b A G 2: 122,353,314 (GRCm39) Y498C possibly damaging Het
Slc6a5 A C 7: 49,579,761 (GRCm39) I380L probably benign Het
Spag16 A G 1: 70,035,998 (GRCm39) N342S probably benign Het
Spata16 A G 3: 26,721,559 (GRCm39) T27A possibly damaging Het
Spock3 A C 8: 63,596,963 (GRCm39) K89T probably damaging Het
Tbc1d1 T C 5: 64,481,797 (GRCm39) V795A probably damaging Het
Tirap G T 9: 35,100,458 (GRCm39) H75Q probably benign Het
Tpk1 C A 6: 43,323,763 (GRCm39) V229L possibly damaging Het
Tshz2 A G 2: 169,726,286 (GRCm39) H294R probably damaging Het
Ttn A T 2: 76,703,043 (GRCm39) probably benign Het
Unc13d C T 11: 115,954,657 (GRCm39) V984M probably damaging Het
Zbtb43 A T 2: 33,343,996 (GRCm39) Y373N probably damaging Het
Zfp646 T A 7: 127,480,476 (GRCm39) H884Q possibly damaging Het
Other mutations in Paox
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0140:Paox UTSW 7 139,713,971 (GRCm39) missense probably damaging 1.00
R0285:Paox UTSW 7 139,709,053 (GRCm39) missense probably damaging 1.00
R0464:Paox UTSW 7 139,709,195 (GRCm39) unclassified probably benign
R0546:Paox UTSW 7 139,711,591 (GRCm39) missense probably damaging 1.00
R0733:Paox UTSW 7 139,707,440 (GRCm39) missense probably damaging 0.99
R0926:Paox UTSW 7 139,713,951 (GRCm39) missense probably damaging 1.00
R1169:Paox UTSW 7 139,706,244 (GRCm39) missense probably benign 0.04
R1466:Paox UTSW 7 139,709,194 (GRCm39) unclassified probably benign
R2260:Paox UTSW 7 139,713,967 (GRCm39) nonsense probably null
R4172:Paox UTSW 7 139,713,941 (GRCm39) missense probably damaging 1.00
R5914:Paox UTSW 7 139,709,101 (GRCm39) missense probably damaging 1.00
R5951:Paox UTSW 7 139,707,567 (GRCm39) missense probably damaging 1.00
R5960:Paox UTSW 7 139,712,402 (GRCm39) missense probably benign 0.26
R6019:Paox UTSW 7 139,711,655 (GRCm39) missense probably damaging 0.99
R6583:Paox UTSW 7 139,706,291 (GRCm39) missense probably damaging 1.00
R8986:Paox UTSW 7 139,706,503 (GRCm39) missense probably benign 0.03
R9708:Paox UTSW 7 139,712,359 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGACAACTTTCTTCCTGGGCACTG -3'
(R):5'- ACTGGCTCTGTGTCTGTGAGATCC -3'

Sequencing Primer
(F):5'- CCCTAGTCAGATGCTTTCAGGTAAG -3'
(R):5'- TGTCTGTGAGATCCCAGCC -3'
Posted On 2013-04-11