Incidental Mutation 'R1726:Gm10277'
ID 198156
Institutional Source Beutler Lab
Gene Symbol Gm10277
Ensembl Gene ENSMUSG00000069804
Gene Name predicted gene 10277
Synonyms
MMRRC Submission 039758-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1726 (G1)
Quality Score 217
Status Validated
Chromosome 11
Chromosomal Location 77676279-77678573 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) TC to T at 77676828 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000090559 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000645] [ENSMUST00000092883] [ENSMUST00000092887] [ENSMUST00000102488] [ENSMUST00000108375] [ENSMUST00000108376] [ENSMUST00000168348] [ENSMUST00000130627] [ENSMUST00000169105]
AlphaFold Q6R5C6
Predicted Effect probably benign
Transcript: ENSMUST00000000645
SMART Domains Protein: ENSMUSP00000000645
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 399 1183 1.53e-45 SMART
IQ 1184 1206 1.11e-3 SMART
Pfam:Myosin_tail_1 1219 1867 1.7e-34 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000092883
SMART Domains Protein: ENSMUSP00000090559
Gene: ENSMUSG00000069804

DomainStartEndE-ValueType
low complexity region 84 98 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092887
SMART Domains Protein: ENSMUSP00000090563
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 399 1182 4.16e-47 SMART
IQ 1183 1205 1.11e-3 SMART
Pfam:Myosin_tail_1 1218 1866 3e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102488
SMART Domains Protein: ENSMUSP00000099546
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 399 1182 4.16e-47 SMART
IQ 1183 1205 1.11e-3 SMART
Pfam:Myosin_tail_1 1218 1866 3e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108375
SMART Domains Protein: ENSMUSP00000104012
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 399 1182 4.16e-47 SMART
IQ 1183 1205 1.11e-3 SMART
Pfam:Myosin_tail_1 1218 1838 6.8e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108376
SMART Domains Protein: ENSMUSP00000104013
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 399 1182 4.16e-47 SMART
IQ 1183 1205 1.11e-3 SMART
Blast:MYSc 1258 1387 1e-14 BLAST
low complexity region 1396 1407 N/A INTRINSIC
low complexity region 1743 1762 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168348
SMART Domains Protein: ENSMUSP00000130696
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 447 1230 4.16e-47 SMART
IQ 1231 1253 1.11e-3 SMART
Blast:MYSc 1306 1435 1e-14 BLAST
low complexity region 1444 1455 N/A INTRINSIC
low complexity region 1828 1847 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000130627
SMART Domains Protein: ENSMUSP00000119839
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 411 1194 4.16e-47 SMART
IQ 1195 1217 1.11e-3 SMART
Pfam:Myosin_tail_1 1230 1850 6.9e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169105
SMART Domains Protein: ENSMUSP00000132149
Gene: ENSMUSG00000000631

DomainStartEndE-ValueType
low complexity region 6 27 N/A INTRINSIC
low complexity region 202 227 N/A INTRINSIC
PDZ 229 311 5.72e-10 SMART
MYSc 411 1194 4.16e-47 SMART
IQ 1195 1217 1.11e-3 SMART
Pfam:Myosin_tail_1 1230 1878 7.3e-35 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.4%
  • 20x: 92.6%
Validation Efficiency 97% (63/65)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 G C 12: 118,838,536 (GRCm39) probably null Het
Abcb5 A T 12: 118,871,267 (GRCm39) S711T possibly damaging Het
Acoxl G A 2: 127,722,366 (GRCm39) G216R probably damaging Het
Arhgef18 A T 8: 3,504,228 (GRCm39) N949I possibly damaging Het
Bltp3a C A 17: 28,105,225 (GRCm39) probably null Het
Brip1 A T 11: 85,955,740 (GRCm39) S924R probably benign Het
Btf3 C T 13: 98,452,804 (GRCm39) M1I probably null Het
Ccdc141 A G 2: 76,938,700 (GRCm39) probably benign Het
Ccdc80 A T 16: 44,916,368 (GRCm39) T375S probably benign Het
Ccl11 A G 11: 81,952,546 (GRCm39) K40E possibly damaging Het
Chrnb2 A T 3: 89,668,509 (GRCm39) C269S probably damaging Het
Dgat2 A G 7: 98,831,623 (GRCm39) S33P possibly damaging Het
Dip2c A G 13: 9,625,464 (GRCm39) D608G probably damaging Het
Dnah2 A T 11: 69,388,715 (GRCm39) D889E probably damaging Het
Dvl2 A T 11: 69,900,287 (GRCm39) T694S probably benign Het
Elapor1 A G 3: 108,375,184 (GRCm39) I561T possibly damaging Het
Fbf1 A G 11: 116,036,280 (GRCm39) V1100A probably benign Het
Galt G A 4: 41,756,001 (GRCm39) W22* probably null Het
Garem1 C A 18: 21,281,319 (GRCm39) V346L probably damaging Het
Gm10762 A T 2: 128,809,135 (GRCm39) probably benign Het
Gm21900 A G Y: 10,616,358 (GRCm39) probably null Het
Gm2663 T C 6: 40,974,960 (GRCm39) Y37C probably damaging Het
Gm42791 C A 5: 148,896,311 (GRCm39) probably benign Het
Gm5134 C A 10: 75,828,361 (GRCm39) P314T possibly damaging Het
Gtf3c2 T C 5: 31,326,467 (GRCm39) E348G possibly damaging Het
H2-T24 T A 17: 36,326,513 (GRCm39) M129L probably benign Het
Ikzf2 C A 1: 69,587,847 (GRCm39) R214L probably damaging Het
Insyn2a T C 7: 134,500,867 (GRCm39) probably benign Het
Itpr3 T A 17: 27,330,664 (GRCm39) L1691Q probably damaging Het
Kmt2c C T 5: 25,520,003 (GRCm39) G2036R probably damaging Het
Lrp10 T C 14: 54,707,113 (GRCm39) L650P probably damaging Het
Mcm9 G A 10: 53,413,977 (GRCm39) P368S possibly damaging Het
Mob3b A G 4: 34,954,028 (GRCm39) M214T probably benign Het
Mrpl1 T C 5: 96,371,686 (GRCm39) V71A probably benign Het
Mrpl57 A G 14: 58,064,092 (GRCm39) E40G probably damaging Het
Mtmr9 A G 14: 63,774,547 (GRCm39) V162A possibly damaging Het
Nalcn A T 14: 123,545,816 (GRCm39) V1065E probably damaging Het
Nemp2 A G 1: 52,676,554 (GRCm39) D42G probably damaging Het
Npepps A G 11: 97,115,495 (GRCm39) L623P probably damaging Het
Olig3 A G 10: 19,232,482 (GRCm39) S36G probably benign Het
Or10j5 A G 1: 172,784,658 (GRCm39) T99A probably benign Het
Or11g26 T A 14: 50,753,636 (GRCm39) probably null Het
Or5e1 T C 7: 108,354,215 (GRCm39) S51P probably benign Het
Pcdhb14 T A 18: 37,582,647 (GRCm39) Y584* probably null Het
Pcyox1l T C 18: 61,830,849 (GRCm39) Y341C probably benign Het
Pdxdc1 A C 16: 13,656,164 (GRCm39) probably null Het
Pias4 A C 10: 80,991,689 (GRCm39) V313G probably damaging Het
Pkd1 C T 17: 24,783,150 (GRCm39) T81M probably damaging Het
Ptprm T C 17: 67,349,322 (GRCm39) I40M probably damaging Het
Reep6 T C 10: 80,170,954 (GRCm39) S277P probably benign Het
Shank3 A G 15: 89,442,189 (GRCm39) E1694G probably damaging Het
Shq1 T C 6: 100,613,996 (GRCm39) Y274C probably benign Het
Slc12a6 T A 2: 112,177,771 (GRCm39) I630N probably damaging Het
Slc14a1 T A 18: 78,159,681 (GRCm39) N15Y probably benign Het
Slc17a4 A T 13: 24,089,574 (GRCm39) Y114* probably null Het
Slc26a1 C T 5: 108,821,541 (GRCm39) G116D probably damaging Het
Smg8 G T 11: 86,971,439 (GRCm39) Y777* probably null Het
Tlr11 A T 14: 50,598,998 (GRCm39) H328L probably benign Het
Ube2c G T 2: 164,613,237 (GRCm39) A52S probably damaging Het
Unc5c A G 3: 141,523,864 (GRCm39) S806G probably damaging Het
Zfp874b A T 13: 67,622,839 (GRCm39) I153K probably damaging Het
Zkscan2 T A 7: 123,089,046 (GRCm39) E408D probably damaging Het
Other mutations in Gm10277
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1724:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R1725:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R1741:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R1742:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R1909:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R2023:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R2115:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R2116:Gm10277 UTSW 11 77,676,828 (GRCm39) frame shift probably null
R3008:Gm10277 UTSW 11 77,676,362 (GRCm39) intron probably benign
R3894:Gm10277 UTSW 11 77,676,827 (GRCm39) intron probably benign
R4732:Gm10277 UTSW 11 77,676,923 (GRCm39) intron probably benign
R4733:Gm10277 UTSW 11 77,676,923 (GRCm39) intron probably benign
R4771:Gm10277 UTSW 11 77,676,534 (GRCm39) intron probably benign
R7366:Gm10277 UTSW 11 77,676,584 (GRCm39) missense unknown
R8688:Gm10277 UTSW 11 77,676,405 (GRCm39) missense unknown
R8961:Gm10277 UTSW 11 77,677,826 (GRCm39) intron probably benign
R9012:Gm10277 UTSW 11 77,676,848 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CCGAGGAACCTGAACTGAAGAAGTC -3'
(R):5'- AAACACAGTGTGGCCCAAGCAG -3'

Sequencing Primer
(F):5'- CCTGAACTGAAGAAGTCAGGAGTG -3'
(R):5'- AAGTGAGTCAGCTCCTTACAG -3'
Posted On 2014-05-23