Incidental Mutation 'R0084:Acp3'
ID 19817
Institutional Source Beutler Lab
Gene Symbol Acp3
Ensembl Gene ENSMUSG00000032561
Gene Name acid phosphatase 3
Synonyms A030005E02Rik, Acpp, PAP
MMRRC Submission 038371-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R0084 (G1)
Quality Score 167
Status Validated
Chromosome 9
Chromosomal Location 104165439-104214921 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 104191564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 241 (S241T)
Ref Sequence ENSEMBL: ENSMUSP00000108209 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062723] [ENSMUST00000112590]
AlphaFold Q8CE08
Predicted Effect probably benign
Transcript: ENSMUST00000062723
AA Change: S241T

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000059889
Gene: ENSMUSG00000032561
AA Change: S241T

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:His_Phos_2 33 331 3.8e-35 PFAM
transmembrane domain 382 404 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112590
AA Change: S241T

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000108209
Gene: ENSMUSG00000032561
AA Change: S241T

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:His_Phos_2 33 331 1.8e-64 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125800
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128635
Meta Mutation Damage Score 0.1920 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.0%
  • 10x: 94.5%
  • 20x: 86.0%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased thermal nociceptive threshold and mechanical allodynia in chronic inflammatory and nerve injury pain models. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a A G 11: 109,927,423 (GRCm39) probably benign Het
Abcc9 A G 6: 142,604,277 (GRCm39) Y653H probably damaging Het
Acvr1 A G 2: 58,348,895 (GRCm39) probably null Het
Adgb T C 10: 10,272,088 (GRCm39) N832S possibly damaging Het
AI182371 A G 2: 34,975,714 (GRCm39) probably null Het
Anapc1 G A 2: 128,465,886 (GRCm39) probably benign Het
Apba1 T C 19: 23,889,861 (GRCm39) S420P possibly damaging Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Bpifb2 A T 2: 153,733,011 (GRCm39) M365L probably benign Het
Btnl9 A T 11: 49,069,606 (GRCm39) N224K possibly damaging Het
Cntn1 A T 15: 92,215,798 (GRCm39) I944L probably benign Het
Cpa3 T C 3: 20,296,265 (GRCm39) probably benign Het
Dcaf11 C T 14: 55,806,700 (GRCm39) R468C probably benign Het
E4f1 T C 17: 24,663,056 (GRCm39) T750A possibly damaging Het
Ercc5 A G 1: 44,215,136 (GRCm39) K890E possibly damaging Het
Fbrsl1 A G 5: 110,527,381 (GRCm39) L262P probably damaging Het
Flnb A G 14: 7,935,979 (GRCm38) D2273G probably benign Het
Gm9848 A T 13: 113,244,776 (GRCm39) noncoding transcript Het
Hcrtr1 T A 4: 130,031,059 (GRCm39) H75L possibly damaging Het
Heatr9 A T 11: 83,403,721 (GRCm39) probably benign Het
Htatip2 G A 7: 49,409,420 (GRCm39) G58D probably damaging Het
Jkampl A T 6: 73,445,918 (GRCm39) Y210* probably null Het
Lmntd1 G A 6: 145,350,254 (GRCm39) H234Y unknown Het
Ly6g2 T A 15: 75,089,624 (GRCm39) M44K probably benign Het
Map4k3 T C 17: 80,963,343 (GRCm39) K85E possibly damaging Het
Moxd2 T C 6: 40,856,342 (GRCm39) D510G probably null Het
Mpv17l2 A T 8: 71,217,190 (GRCm39) probably benign Het
Nbeal2 A G 9: 110,472,778 (GRCm39) probably null Het
Ncapd3 A G 9: 26,967,407 (GRCm39) D581G probably damaging Het
Ndufb5 T C 3: 32,791,352 (GRCm39) V33A probably benign Het
Or10a49 A T 7: 108,468,007 (GRCm39) M118K probably damaging Het
Osbpl1a T C 18: 12,890,669 (GRCm39) T524A probably benign Het
Otogl A C 10: 107,737,202 (GRCm39) S71A probably damaging Het
Ovol2 G T 2: 144,147,808 (GRCm39) N180K probably damaging Het
Pam A G 1: 97,823,774 (GRCm39) V219A probably benign Het
Paox C T 7: 139,712,359 (GRCm39) R197* probably null Het
Pax2 T A 19: 44,806,874 (GRCm39) Y290N probably damaging Het
Pik3ca T C 3: 32,516,937 (GRCm39) M933T possibly damaging Het
Ppfia4 G T 1: 134,227,164 (GRCm39) R1124S possibly damaging Het
Prkch T C 12: 73,744,761 (GRCm39) F258S possibly damaging Het
Rhob G A 12: 8,549,107 (GRCm39) R176C probably benign Het
Sbf2 A T 7: 110,041,573 (GRCm39) I326N possibly damaging Het
Scgb2b2 A T 7: 31,003,041 (GRCm39) E45D probably benign Het
Scube3 T A 17: 28,381,935 (GRCm39) D320E probably benign Het
Serpina1f A G 12: 103,659,847 (GRCm39) V145A possibly damaging Het
Slc28a2b A G 2: 122,353,314 (GRCm39) Y498C possibly damaging Het
Slc6a5 A C 7: 49,579,761 (GRCm39) I380L probably benign Het
Spag16 A G 1: 70,035,998 (GRCm39) N342S probably benign Het
Spata16 A G 3: 26,721,559 (GRCm39) T27A possibly damaging Het
Spock3 A C 8: 63,596,963 (GRCm39) K89T probably damaging Het
Tbc1d1 T C 5: 64,481,797 (GRCm39) V795A probably damaging Het
Tirap G T 9: 35,100,458 (GRCm39) H75Q probably benign Het
Tpk1 C A 6: 43,323,763 (GRCm39) V229L possibly damaging Het
Tshz2 A G 2: 169,726,286 (GRCm39) H294R probably damaging Het
Ttn A T 2: 76,703,043 (GRCm39) probably benign Het
Unc13d C T 11: 115,954,657 (GRCm39) V984M probably damaging Het
Zbtb43 A T 2: 33,343,996 (GRCm39) Y373N probably damaging Het
Zfp646 T A 7: 127,480,476 (GRCm39) H884Q possibly damaging Het
Other mutations in Acp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02580:Acp3 APN 9 104,204,147 (GRCm39) missense probably damaging 1.00
IGL02994:Acp3 APN 9 104,186,602 (GRCm39) splice site probably benign
IGL03069:Acp3 APN 9 104,197,204 (GRCm39) missense possibly damaging 0.78
R0076:Acp3 UTSW 9 104,201,417 (GRCm39) splice site probably benign
R0076:Acp3 UTSW 9 104,201,417 (GRCm39) splice site probably benign
R0098:Acp3 UTSW 9 104,197,144 (GRCm39) splice site probably null
R0119:Acp3 UTSW 9 104,197,201 (GRCm39) missense probably damaging 1.00
R0299:Acp3 UTSW 9 104,197,201 (GRCm39) missense probably damaging 1.00
R0362:Acp3 UTSW 9 104,191,626 (GRCm39) missense probably damaging 1.00
R0499:Acp3 UTSW 9 104,197,201 (GRCm39) missense probably damaging 1.00
R0514:Acp3 UTSW 9 104,197,177 (GRCm39) missense probably damaging 1.00
R0964:Acp3 UTSW 9 104,204,174 (GRCm39) missense possibly damaging 0.94
R1506:Acp3 UTSW 9 104,201,373 (GRCm39) missense probably damaging 1.00
R1624:Acp3 UTSW 9 104,197,200 (GRCm39) missense probably benign 0.39
R2019:Acp3 UTSW 9 104,201,901 (GRCm39) missense probably damaging 1.00
R3821:Acp3 UTSW 9 104,201,916 (GRCm39) missense probably damaging 0.99
R3822:Acp3 UTSW 9 104,201,916 (GRCm39) missense probably damaging 0.99
R4896:Acp3 UTSW 9 104,184,174 (GRCm39) missense probably damaging 1.00
R5084:Acp3 UTSW 9 104,204,116 (GRCm39) missense probably damaging 1.00
R5257:Acp3 UTSW 9 104,186,674 (GRCm39) missense probably benign 0.24
R5258:Acp3 UTSW 9 104,186,674 (GRCm39) missense probably benign 0.24
R5519:Acp3 UTSW 9 104,168,687 (GRCm39) missense probably damaging 1.00
R5795:Acp3 UTSW 9 104,186,688 (GRCm39) missense probably benign 0.04
R6909:Acp3 UTSW 9 104,178,164 (GRCm39) missense probably damaging 1.00
R7315:Acp3 UTSW 9 104,193,423 (GRCm39) critical splice donor site probably null
R7349:Acp3 UTSW 9 104,168,657 (GRCm39) missense probably benign 0.01
R7792:Acp3 UTSW 9 104,204,165 (GRCm39) missense probably damaging 1.00
R8355:Acp3 UTSW 9 104,204,174 (GRCm39) missense possibly damaging 0.94
R8455:Acp3 UTSW 9 104,204,174 (GRCm39) missense possibly damaging 0.94
R9556:Acp3 UTSW 9 104,197,178 (GRCm39) missense probably damaging 1.00
Z1177:Acp3 UTSW 9 104,191,617 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCAGGCGCTGTTTGTGCTAAG -3'
(R):5'- TTCAGGCTACAGCATCTGACCCTC -3'

Sequencing Primer
(F):5'- CTGCAAGACGATAATAaagtgatctg -3'
(R):5'- gcttactgcctttctccctc -3'
Posted On 2013-04-11