Incidental Mutation 'R1727:Zfp777'
ID 198226
Institutional Source Beutler Lab
Gene Symbol Zfp777
Ensembl Gene ENSMUSG00000071477
Gene Name zinc finger protein 777
Synonyms 2500002G23Rik
MMRRC Submission 039759-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.837) question?
Stock # R1727 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 48001122-48025845 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 48020824 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 266 (F266Y)
Ref Sequence ENSEMBL: ENSMUSP00000093637 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095944] [ENSMUST00000114583] [ENSMUST00000125385] [ENSMUST00000147281]
AlphaFold B9EKF4
Predicted Effect probably damaging
Transcript: ENSMUST00000095944
AA Change: F266Y

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000093637
Gene: ENSMUSG00000071477
AA Change: F266Y

DomainStartEndE-ValueType
Pfam:DUF3669 177 256 4.3e-12 PFAM
KRAB 284 344 1.6e-29 SMART
low complexity region 422 433 N/A INTRINSIC
coiled coil region 454 477 N/A INTRINSIC
low complexity region 489 505 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 539 555 N/A INTRINSIC
ZnF_C2H2 557 579 1.2e-5 SMART
ZnF_C2H2 585 607 3.8e-5 SMART
ZnF_C2H2 646 668 1.1e-6 SMART
ZnF_C2H2 674 696 4.6e-6 SMART
ZnF_C2H2 704 726 3.2e-7 SMART
ZnF_C2H2 732 754 3.3e-6 SMART
ZnF_C2H2 760 782 8.4e-6 SMART
ZnF_C2H2 788 810 4.9e-5 SMART
ZnF_C2H2 816 838 1.1e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000114583
AA Change: F310Y

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000110230
Gene: ENSMUSG00000071477
AA Change: F310Y

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
Pfam:DUF3669 231 298 4.7e-12 PFAM
KRAB 328 388 3.96e-27 SMART
low complexity region 466 477 N/A INTRINSIC
coiled coil region 498 521 N/A INTRINSIC
low complexity region 533 549 N/A INTRINSIC
low complexity region 564 576 N/A INTRINSIC
low complexity region 583 599 N/A INTRINSIC
ZnF_C2H2 601 623 2.95e-3 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 690 712 2.43e-4 SMART
ZnF_C2H2 718 740 1.12e-3 SMART
ZnF_C2H2 748 770 7.49e-5 SMART
ZnF_C2H2 776 798 7.9e-4 SMART
ZnF_C2H2 804 826 1.95e-3 SMART
ZnF_C2H2 832 854 1.18e-2 SMART
ZnF_C2H2 860 882 2.53e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125385
Predicted Effect probably benign
Transcript: ENSMUST00000147281
Predicted Effect unknown
Transcript: ENSMUST00000148362
AA Change: F118Y
SMART Domains Protein: ENSMUSP00000116303
Gene: ENSMUSG00000071477
AA Change: F118Y

DomainStartEndE-ValueType
Pfam:DUF3669 40 107 6.1e-13 PFAM
KRAB 137 197 3.96e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175187
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203645
Meta Mutation Damage Score 0.1541 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.3%
Validation Efficiency 96% (98/102)
Allele List at MGI
Other mutations in this stock
Total: 96 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 T C 13: 104,565,472 (GRCm39) probably benign Het
Ak2 C T 4: 128,901,556 (GRCm39) P159L probably damaging Het
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Akr1a1 A G 4: 116,498,248 (GRCm39) L99P probably damaging Het
Anxa8 T A 14: 33,811,547 (GRCm39) M34K probably damaging Het
Axl T G 7: 25,460,191 (GRCm39) D767A possibly damaging Het
B430305J03Rik A G 3: 61,271,299 (GRCm39) probably benign Het
Cdh24 A T 14: 54,876,095 (GRCm39) Y182* probably null Het
Cdk5rap2 T C 4: 70,190,916 (GRCm39) D1043G probably benign Het
Cdk5rap2 A T 4: 70,208,209 (GRCm39) S746T possibly damaging Het
Cep120 T C 18: 53,860,801 (GRCm39) M210V probably benign Het
Chga C T 12: 102,527,696 (GRCm39) H117Y possibly damaging Het
Cnga4 T C 7: 105,054,961 (GRCm39) W79R probably damaging Het
Cntnap5b C T 1: 100,141,469 (GRCm39) T575I possibly damaging Het
Col6a3 T A 1: 90,724,296 (GRCm39) probably null Het
Copz2 T C 11: 96,744,301 (GRCm39) V71A probably benign Het
Dennd3 G T 15: 73,436,977 (GRCm39) R1068L possibly damaging Het
Dhrs7 T C 12: 72,706,238 (GRCm39) T56A probably damaging Het
Dnah17 G A 11: 117,961,315 (GRCm39) T2557I probably damaging Het
Dnah17 A T 11: 117,987,362 (GRCm39) L1320* probably null Het
Dynlt2b T A 16: 32,241,751 (GRCm39) M78K probably benign Het
Eif3b T C 5: 140,411,077 (GRCm39) I176T probably damaging Het
Eif4b T A 15: 101,998,497 (GRCm39) D392E possibly damaging Het
Eif4h T C 5: 134,668,134 (GRCm39) Y7C probably damaging Het
Enam A T 5: 88,651,853 (GRCm39) S1046C probably damaging Het
Epg5 T A 18: 78,059,030 (GRCm39) V1928E possibly damaging Het
Erbin T A 13: 103,964,476 (GRCm39) E1222V probably benign Het
Fhdc1 T A 3: 84,353,483 (GRCm39) I581F possibly damaging Het
Fhip2b C A 14: 70,831,438 (GRCm39) G32V probably damaging Het
Fstl4 A C 11: 52,959,478 (GRCm39) Q173P probably damaging Het
Gm266 A G 12: 111,451,913 (GRCm39) F98L possibly damaging Het
Gsdmc2 T C 15: 63,721,628 (GRCm39) probably benign Het
Gtf2h3 A G 5: 124,728,419 (GRCm39) Q156R probably benign Het
H2-T23 T C 17: 36,342,545 (GRCm39) T198A possibly damaging Het
Il1r1 C A 1: 40,332,424 (GRCm39) A68E probably benign Het
Kcna7 A T 7: 45,058,930 (GRCm39) I406F possibly damaging Het
Lbr A G 1: 181,647,481 (GRCm39) I432T probably benign Het
Lnx1 A T 5: 74,768,577 (GRCm39) probably null Het
Lrrcc1 T A 3: 14,602,423 (GRCm39) I50N probably damaging Het
Lss T C 10: 76,375,678 (GRCm39) V237A possibly damaging Het
Mcm10 A G 2: 5,011,336 (GRCm39) F212L probably benign Het
Methig1 A C 15: 100,251,130 (GRCm39) I14L probably benign Het
Mrpl41 A T 2: 24,864,636 (GRCm39) V55E probably damaging Het
Mtfp1 C A 11: 4,043,982 (GRCm39) D83Y probably damaging Het
Myh1 T A 11: 67,101,292 (GRCm39) probably benign Het
Myo1e T C 9: 70,283,806 (GRCm39) F834S possibly damaging Het
Ndufs7 A T 10: 80,091,853 (GRCm39) probably benign Het
Nlrp4e T A 7: 23,020,420 (GRCm39) N302K probably benign Het
Nt5e T A 9: 88,210,082 (GRCm39) M115K possibly damaging Het
Nup153 A T 13: 46,847,261 (GRCm39) C723S probably damaging Het
Obox6 G A 7: 15,568,502 (GRCm39) P125S probably benign Het
Or1n2 G A 2: 36,797,405 (GRCm39) C149Y probably benign Het
Or2t48 A T 11: 58,420,342 (GRCm39) S157T possibly damaging Het
Or52n3 C T 7: 104,530,721 (GRCm39) T269I probably benign Het
Or5an11 T G 19: 12,246,365 (GRCm39) I257S possibly damaging Het
Or8i2 A G 2: 86,852,607 (GRCm39) F94L probably damaging Het
Pcdh1 A C 18: 38,336,085 (GRCm39) Y44* probably null Het
Pcdhb6 A T 18: 37,467,640 (GRCm39) D187V probably damaging Het
Pclo A G 5: 14,727,001 (GRCm39) probably benign Het
Pdcl3 T A 1: 39,034,836 (GRCm39) I80K possibly damaging Het
Pde12 A T 14: 26,390,022 (GRCm39) V229E probably benign Het
Plcg1 A G 2: 160,590,008 (GRCm39) E142G probably benign Het
Plxnb1 A G 9: 108,930,125 (GRCm39) probably null Het
Pnpla1 A G 17: 29,097,508 (GRCm39) I225V probably benign Het
Polr2f A G 15: 79,028,805 (GRCm39) probably benign Het
Prob1 A G 18: 35,787,364 (GRCm39) S297P possibly damaging Het
Qsox2 A C 2: 26,110,970 (GRCm39) S132A probably benign Het
Rab19 T A 6: 39,365,095 (GRCm39) Y118* probably null Het
Rfwd3 C T 8: 112,014,874 (GRCm39) R326Q probably damaging Het
Rptn T C 3: 93,304,445 (GRCm39) S593P possibly damaging Het
Septin11 T C 5: 93,304,783 (GRCm39) I200T probably damaging Het
Slc10a4 T A 5: 73,173,491 (GRCm39) probably benign Het
Slc9c1 A T 16: 45,422,324 (GRCm39) I1130F probably benign Het
Slit3 C T 11: 35,520,659 (GRCm39) R599C probably damaging Het
Snx19 C T 9: 30,344,662 (GRCm39) P622L probably damaging Het
Sspo T C 6: 48,471,782 (GRCm39) L50P probably damaging Het
St8sia1 A T 6: 142,822,453 (GRCm39) C137S probably damaging Het
Syt11 G C 3: 88,669,259 (GRCm39) T211S possibly damaging Het
Tanc1 A C 2: 59,621,153 (GRCm39) Y324S probably damaging Het
Tas2r136 T C 6: 132,754,753 (GRCm39) I125V possibly damaging Het
Tbc1d15 A T 10: 115,046,130 (GRCm39) W458R probably damaging Het
Tecta G T 9: 42,270,597 (GRCm39) T1237N probably damaging Het
Tet2 T A 3: 133,193,051 (GRCm39) D461V probably damaging Het
Tmco3 G A 8: 13,368,866 (GRCm39) V573M possibly damaging Het
Tmem212 A T 3: 27,938,961 (GRCm39) M175K probably benign Het
Traf6 A G 2: 101,527,084 (GRCm39) H278R probably benign Het
Trerf1 T A 17: 47,652,092 (GRCm39) noncoding transcript Het
Ttn A C 2: 76,576,988 (GRCm39) V24635G probably damaging Het
Ush1c A T 7: 45,858,655 (GRCm39) D544E probably damaging Het
Usp47 C T 7: 111,685,307 (GRCm39) T586M probably damaging Het
Vmn2r1 T A 3: 63,989,163 (GRCm39) M34K probably benign Het
Vmn2r102 T A 17: 19,897,770 (GRCm39) W262R probably damaging Het
Wasf3 C T 5: 146,403,769 (GRCm39) A293V probably benign Het
Xrn2 A G 2: 146,903,436 (GRCm39) Q812R probably benign Het
Zc3h7b T C 15: 81,652,230 (GRCm39) I10T probably damaging Het
Zfp747 A T 7: 126,973,249 (GRCm39) L307Q probably damaging Het
Other mutations in Zfp777
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01530:Zfp777 APN 6 48,020,918 (GRCm39) missense probably damaging 1.00
IGL01916:Zfp777 APN 6 48,002,276 (GRCm39) missense probably damaging 1.00
IGL01959:Zfp777 APN 6 48,021,275 (GRCm39) missense probably benign
IGL02167:Zfp777 APN 6 48,021,460 (GRCm39) missense probably damaging 0.98
IGL03150:Zfp777 APN 6 48,021,059 (GRCm39) missense probably damaging 1.00
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0238:Zfp777 UTSW 6 48,001,903 (GRCm39) missense probably damaging 0.99
R0372:Zfp777 UTSW 6 48,021,410 (GRCm39) missense possibly damaging 0.62
R0762:Zfp777 UTSW 6 48,006,294 (GRCm39) missense probably damaging 1.00
R1300:Zfp777 UTSW 6 48,002,704 (GRCm39) missense probably benign 0.43
R1906:Zfp777 UTSW 6 48,018,995 (GRCm39) missense probably damaging 0.99
R2047:Zfp777 UTSW 6 48,021,280 (GRCm39) missense probably benign
R2097:Zfp777 UTSW 6 48,021,176 (GRCm39) missense probably benign 0.08
R2211:Zfp777 UTSW 6 48,020,819 (GRCm39) missense possibly damaging 0.79
R2898:Zfp777 UTSW 6 48,002,594 (GRCm39) missense probably damaging 0.97
R3123:Zfp777 UTSW 6 48,006,050 (GRCm39) unclassified probably benign
R3832:Zfp777 UTSW 6 48,021,149 (GRCm39) missense probably benign 0.00
R4019:Zfp777 UTSW 6 48,019,046 (GRCm39) missense probably damaging 1.00
R4077:Zfp777 UTSW 6 48,002,456 (GRCm39) missense probably benign
R4471:Zfp777 UTSW 6 48,019,041 (GRCm39) missense probably damaging 1.00
R5021:Zfp777 UTSW 6 48,019,061 (GRCm39) missense probably damaging 0.99
R5030:Zfp777 UTSW 6 48,014,601 (GRCm39) missense probably damaging 0.99
R5819:Zfp777 UTSW 6 48,014,522 (GRCm39) missense probably damaging 0.99
R6544:Zfp777 UTSW 6 48,021,419 (GRCm39) missense probably damaging 0.98
R6736:Zfp777 UTSW 6 48,001,790 (GRCm39) missense probably damaging 0.99
R6971:Zfp777 UTSW 6 48,001,625 (GRCm39) missense probably damaging 1.00
R7240:Zfp777 UTSW 6 48,021,383 (GRCm39) missense probably benign 0.00
R7258:Zfp777 UTSW 6 48,002,731 (GRCm39) missense probably damaging 0.99
R7586:Zfp777 UTSW 6 48,006,152 (GRCm39) missense probably benign 0.33
R7833:Zfp777 UTSW 6 48,002,072 (GRCm39) missense probably damaging 0.99
R7947:Zfp777 UTSW 6 48,001,645 (GRCm39) missense probably damaging 1.00
R8136:Zfp777 UTSW 6 48,021,559 (GRCm39) missense probably benign 0.25
R8151:Zfp777 UTSW 6 48,006,075 (GRCm39) nonsense probably null
R8348:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8448:Zfp777 UTSW 6 48,006,101 (GRCm39) missense probably damaging 0.99
R8942:Zfp777 UTSW 6 48,006,125 (GRCm39) missense probably benign 0.25
R8983:Zfp777 UTSW 6 48,006,158 (GRCm39) missense probably damaging 1.00
R9205:Zfp777 UTSW 6 48,002,521 (GRCm39) missense probably benign 0.07
R9397:Zfp777 UTSW 6 48,021,190 (GRCm39) missense probably benign 0.00
R9562:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
R9565:Zfp777 UTSW 6 48,021,580 (GRCm39) missense possibly damaging 0.84
RF008:Zfp777 UTSW 6 48,018,982 (GRCm39) nonsense probably null
Z1177:Zfp777 UTSW 6 48,002,168 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCCTGATCTCGGTGAAGCAATAC -3'
(R):5'- TCTTCTGCCGCCCAGAAAGAAC -3'

Sequencing Primer
(F):5'- TCTCGGTGAAGCAATACTGGAAG -3'
(R):5'- TGCAGAGATCACTCGATTGGC -3'
Posted On 2014-05-23