Incidental Mutation 'R0085:Or8b1b'
ID 19861
Institutional Source Beutler Lab
Gene Symbol Or8b1b
Ensembl Gene ENSMUSG00000094380
Gene Name olfactory receptor family 8 subfamily B member 1B
Synonyms Olfr904, MOR167-3, GA_x6K02T2PVTD-32156773-32157705
MMRRC Submission 038372-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R0085 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38375330-38378952 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38375958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 207 (I207T)
Ref Sequence ENSEMBL: ENSMUSP00000150057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058153] [ENSMUST00000216724]
AlphaFold Q7TRC9
Predicted Effect probably benign
Transcript: ENSMUST00000058153
AA Change: I207T

PolyPhen 2 Score 0.373 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000057148
Gene: ENSMUSG00000094380
AA Change: I207T

Pfam:7tm_4 31 308 5.7e-51 PFAM
Pfam:7tm_1 41 291 1.5e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216724
AA Change: I207T

PolyPhen 2 Score 0.373 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.4%
Validation Efficiency 95% (71/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad12 A G 5: 121,742,357 (GRCm39) I417T possibly damaging Het
Adcy9 T C 16: 4,106,088 (GRCm39) T1009A probably benign Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Baat T C 4: 49,490,425 (GRCm39) probably benign Het
Bpi T A 2: 158,115,072 (GRCm39) L311* probably null Het
Brd2 A C 17: 34,332,233 (GRCm39) F294L probably damaging Het
Carmil1 T A 13: 24,209,850 (GRCm39) E804D probably benign Het
Cd209g A T 8: 4,184,785 (GRCm39) probably benign Het
Cfi A G 3: 129,668,635 (GRCm39) I554V probably benign Het
Clvs2 G C 10: 33,498,542 (GRCm39) S129R possibly damaging Het
Dst T C 1: 34,268,268 (GRCm39) S2897P probably damaging Het
Efcab7 T C 4: 99,761,877 (GRCm39) probably benign Het
Fbxo2 T C 4: 148,249,367 (GRCm39) probably null Het
Fgfr2 C A 7: 129,797,993 (GRCm39) R400L probably damaging Het
Hsd17b14 T C 7: 45,205,834 (GRCm39) probably benign Het
Il23r T C 6: 67,463,206 (GRCm39) N96D probably damaging Het
Ints13 T A 6: 146,476,285 (GRCm39) probably benign Het
Khdc4 T A 3: 88,619,046 (GRCm39) S583R probably damaging Het
Lig1 A G 7: 13,041,495 (GRCm39) I776V possibly damaging Het
Madd T C 2: 90,993,083 (GRCm39) I997V probably benign Het
Mgat4b C T 11: 50,121,826 (GRCm39) H116Y possibly damaging Het
Myh11 C A 16: 14,041,883 (GRCm39) Q720H probably damaging Het
Myo5b A C 18: 74,834,751 (GRCm39) D937A probably benign Het
Nox3 T C 17: 3,685,556 (GRCm39) N584S probably benign Het
Ogfr A G 2: 180,232,830 (GRCm39) probably null Het
Or11g25 T A 14: 50,723,791 (GRCm39) M292K probably benign Het
Or13p3 T C 4: 118,567,078 (GRCm39) V158A probably benign Het
Osbpl6 G T 2: 76,423,758 (GRCm39) V728F probably benign Het
Picalm T A 7: 89,831,525 (GRCm39) S453T probably benign Het
Piezo1 A G 8: 123,228,354 (GRCm39) L310P probably damaging Het
Pitrm1 C T 13: 6,599,604 (GRCm39) probably benign Het
Pkd1 T C 17: 24,805,197 (GRCm39) F3250L probably damaging Het
Plekha4 C T 7: 45,193,373 (GRCm39) R376* probably null Het
Pnma8b A T 7: 16,679,474 (GRCm39) S153C unknown Het
Rp1l1 C T 14: 64,259,744 (GRCm39) R129W probably damaging Het
Ryr3 A G 2: 112,690,108 (GRCm39) V1147A probably damaging Het
Sema3d G A 5: 12,620,953 (GRCm39) V520I probably benign Het
Sgsm1 A G 5: 113,427,136 (GRCm39) probably benign Het
Slc13a2 A G 11: 78,297,694 (GRCm39) V58A probably damaging Het
Slc1a4 A G 11: 20,254,510 (GRCm39) probably benign Het
Slc4a10 G A 2: 62,074,690 (GRCm39) probably benign Het
Tab1 G T 15: 80,040,094 (GRCm39) A305S probably benign Het
Tmem30a T A 9: 79,678,576 (GRCm39) T327S probably benign Het
Tpr A C 1: 150,293,164 (GRCm39) E863A possibly damaging Het
Upk3bl A G 5: 136,088,969 (GRCm39) N161D probably benign Het
Ush1c T A 7: 45,874,979 (GRCm39) I131F probably benign Het
Wdfy4 C A 14: 32,800,200 (GRCm39) R1975S possibly damaging Het
Zbtb18 C T 1: 177,275,501 (GRCm39) A287V probably benign Het
Zfp712 T C 13: 67,189,256 (GRCm39) T424A probably benign Het
Zfp791 G T 8: 85,838,862 (GRCm39) Y56* probably null Het
Other mutations in Or8b1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Or8b1b APN 9 38,376,030 (GRCm39) missense probably benign
IGL01966:Or8b1b APN 9 38,376,225 (GRCm39) missense possibly damaging 0.82
IGL02328:Or8b1b APN 9 38,375,972 (GRCm39) missense probably benign
IGL03394:Or8b1b APN 9 38,375,517 (GRCm39) missense probably damaging 1.00
R0125:Or8b1b UTSW 9 38,375,757 (GRCm39) nonsense probably null
R1506:Or8b1b UTSW 9 38,375,439 (GRCm39) missense probably benign 0.02
R1545:Or8b1b UTSW 9 38,375,815 (GRCm39) missense probably benign 0.37
R1610:Or8b1b UTSW 9 38,375,927 (GRCm39) missense probably damaging 0.97
R2008:Or8b1b UTSW 9 38,375,537 (GRCm39) missense probably damaging 1.00
R2424:Or8b1b UTSW 9 38,376,128 (GRCm39) missense probably damaging 0.99
R3824:Or8b1b UTSW 9 38,375,822 (GRCm39) missense probably benign 0.13
R3964:Or8b1b UTSW 9 38,375,979 (GRCm39) missense probably benign 0.25
R4093:Or8b1b UTSW 9 38,375,379 (GRCm39) missense probably null 1.00
R4454:Or8b1b UTSW 9 38,375,938 (GRCm39) missense probably benign 0.03
R5650:Or8b1b UTSW 9 38,376,023 (GRCm39) nonsense probably null
R6921:Or8b1b UTSW 9 38,375,543 (GRCm39) missense probably benign 0.01
R7406:Or8b1b UTSW 9 38,375,439 (GRCm39) missense possibly damaging 0.88
R7597:Or8b1b UTSW 9 38,375,802 (GRCm39) missense probably benign 0.01
R7959:Or8b1b UTSW 9 38,376,211 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-04-11