Mutagenetix > Incidental Mutation

Incidental Mutation 'R1729:Sctr'

198653

Institutional Source

Beutler Lab

Gene Symbol

Sctr

Ensembl Gene

ENSMUSG00000026387

Gene Name

secretin receptor

Synonyms

6530402O03Rik

MMRRC Submission

039761-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R1729 (G1)

Quality Score

183

Status

Not validated

Chromosome

Chromosomal Location

119934710-119991269 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 119990987 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Asparagine at position 440 (S440N)

Ref Sequence

ENSEMBL: ENSMUSP00000139932 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056089] [ENSMUST00000072886] [ENSMUST00000189037]

AlphaFold

Q5FWI2

Predicted Effect

probably benign
Transcript: ENSMUST00000056089

SMART Domains

Protein: ENSMUSP00000050862
Gene: ENSMUSG00000050777

Domain	Start	End	E-Value	Type
Pfam:TMEM37	7	189	4.1e-97	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000072886
AA Change: S457N

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000072660
Gene: ENSMUSG00000026387
AA Change: S457N

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
low complexity region	36	53	N/A	INTRINSIC
HormR	76	146	5.18e-21	SMART
Pfam:7tm_2	153	398	3.8e-88	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000189037
AA Change: S440N

PolyPhen 2 Score 0.665 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000139932
Gene: ENSMUSG00000026387
AA Change: S440N

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
low complexity region	36	53	N/A	INTRINSIC
HormR	61	131	2.59e-21	SMART
Pfam:7tm_2	138	383	1.9e-89	PFAM

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show polydipsia, polyuria, decreased urine osmolality, higher serum glucose levels, kidney glomerular and tubular pathology, and impaired renal water reabsorption. Homozygotes for a different null allele show impaired synaptic plasticity and social behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 223 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447A16Rik	G	A	15: 37,439,844 (GRCm39)		probably benign	Het
4930453N24Rik	T	C	16: 64,589,385 (GRCm39)	I90V	probably damaging	Het
Aadat	A	G	8: 60,979,746 (GRCm39)	T203A	probably damaging	Het
Adam34l	T	C	8: 44,078,620 (GRCm39)	N535D	probably damaging	Het
Adamts17	C	T	7: 66,799,704 (GRCm39)	R1060*	probably null	Het
Adamts5	T	A	16: 85,674,803 (GRCm39)	K454*	probably null	Het
Adgrg6	T	C	10: 14,315,526 (GRCm39)	T593A	probably damaging	Het
Aldh1l2	T	A	10: 83,343,946 (GRCm39)	K377*	probably null	Het
Aldh4a1	A	G	4: 139,371,472 (GRCm39)	Y462C	probably damaging	Het
Ankrd12	G	T	17: 66,291,071 (GRCm39)	P1454Q	probably benign	Het
Ap2m1	T	A	16: 20,358,088 (GRCm39)	N35K	probably damaging	Het
Aspm	A	G	1: 139,401,312 (GRCm39)	I1111V	probably benign	Het
Atr	G	A	9: 95,779,634 (GRCm39)	V1331I	probably benign	Het
Boc	T	C	16: 44,316,782 (GRCm39)	T454A	probably benign	Het
C4bp	C	G	1: 130,570,725 (GRCm39)	V284L	probably benign	Het
Cacna1s	T	C	1: 136,046,454 (GRCm39)	F1761S	probably benign	Het
Camsap2	C	T	1: 136,209,053 (GRCm39)	R802Q	probably benign	Het
Capn9	G	A	8: 125,332,450 (GRCm39)	G430R	possibly damaging	Het
Car14	G	A	3: 95,808,560 (GRCm39)	P18L	possibly damaging	Het
Cbs	G	T	17: 31,839,923 (GRCm39)	A337E	probably benign	Het
Ccdc186	A	C	19: 56,797,652 (GRCm39)	H306Q	probably benign	Het
Ccdc93	T	C	1: 121,389,668 (GRCm39)	V237A	probably benign	Het
Ccdc93	C	T	1: 121,383,855 (GRCm39)	P192L	probably benign	Het
Cd55	C	T	1: 130,377,160 (GRCm39)	V333I	probably benign	Het
Cd55	C	A	1: 130,387,370 (GRCm39)	A143S	probably benign	Het
Cdh19	C	A	1: 110,821,114 (GRCm39)	E541D	probably damaging	Het
Cdh20	C	G	1: 109,993,465 (GRCm39)	L307V	possibly damaging	Het
Cdk12	T	C	11: 98,140,796 (GRCm39)		probably benign	Het
Cep350	A	T	1: 155,787,727 (GRCm39)	H1370Q	probably benign	Het
Cfh	T	C	1: 140,064,526 (GRCm39)	K374R	probably benign	Het
Cfh	C	T	1: 140,075,435 (GRCm39)	V268I	possibly damaging	Het
Cfhr2	A	G	1: 139,741,180 (GRCm39)	M265T	probably benign	Het
Cfhr2	A	C	1: 139,741,197 (GRCm39)	N259K	probably benign	Het
Chat	A	T	14: 32,168,752 (GRCm39)	L261H	probably damaging	Het
Chi3l1	C	T	1: 134,116,267 (GRCm39)	A250V	probably damaging	Het
Clcn1	T	A	6: 42,276,448 (GRCm39)	F360Y	possibly damaging	Het
Clgn	A	G	8: 84,149,659 (GRCm39)	S387G	probably damaging	Het
Clk1	C	T	1: 58,460,420 (GRCm39)	R70Q	probably damaging	Het
Cntnap5a	C	T	1: 116,382,873 (GRCm39)	T1047I	probably benign	Het
Cntnap5a	C	A	1: 116,382,734 (GRCm39)	L1001I	probably benign	Het
Cntnap5a	T	C	1: 116,382,831 (GRCm39)	L1033S	probably benign	Het
Crb1	A	T	1: 139,165,360 (GRCm39)	H921Q	probably benign	Het
Crb1	G	A	1: 139,168,876 (GRCm39)	P881S	probably damaging	Het
Crb1	C	T	1: 139,170,733 (GRCm39)	G825R	probably damaging	Het
Crb1	C	T	1: 139,171,155 (GRCm39)	R684H	probably benign	Het
Crb1	T	C	1: 139,162,517 (GRCm39)	M1214V	probably benign	Het
Cspg4	G	T	9: 56,805,821 (GRCm39)	V2211L	probably benign	Het
Cwh43	T	C	5: 73,565,561 (GRCm39)	L42P	probably damaging	Het
Cxcr4	C	T	1: 128,517,014 (GRCm39)	V216I	probably benign	Het
Cyb5r1	C	T	1: 134,335,405 (GRCm39)	R147W	probably damaging	Het
D830039M14Rik	C	T	10: 61,311,506 (GRCm39)		probably benign	Het
Ddx59	T	C	1: 136,344,791 (GRCm39)	V154A	probably benign	Het
Dhx30	T	C	9: 109,927,819 (GRCm39)	H101R	probably damaging	Het
Dnah11	T	A	12: 117,880,666 (GRCm39)	D3818V	probably damaging	Het
Dnah9	G	A	11: 65,975,846 (GRCm39)	T1401I	possibly damaging	Het
Dsel	G	C	1: 111,787,724 (GRCm39)	T937S	probably benign	Het
Dsel	T	C	1: 111,787,187 (GRCm39)	N1116S	probably benign	Het
Dstyk	C	T	1: 132,384,722 (GRCm39)	L739F	probably damaging	Het
Ehf	T	G	2: 103,104,251 (GRCm39)	T186P	possibly damaging	Het
Elf2	A	T	3: 51,164,993 (GRCm39)	V277D	probably damaging	Het
Etnk2	A	G	1: 133,291,661 (GRCm39)	S54G	probably benign	Het
Etnk2	C	A	1: 133,293,325 (GRCm39)	D89E	probably benign	Het
Etnk2	G	T	1: 133,293,503 (GRCm39)	G149W	probably damaging	Het
Etnk2	C	T	1: 133,293,554 (GRCm39)	R166*	probably null	Het
Etnk2	G	A	1: 133,293,555 (GRCm39)	R166Q	probably benign	Het
Etnk2	T	A	1: 133,304,653 (GRCm39)	V292E	probably benign	Het
Eya2	G	T	2: 165,529,583 (GRCm39)	G109W	probably damaging	Het
Fam72a	C	T	1: 131,466,633 (GRCm39)	T139M	probably benign	Het
Fam72a	T	C	1: 131,458,406 (GRCm39)	I56T	probably benign	Het
Fam78b	A	G	1: 166,829,199 (GRCm39)	D22G	possibly damaging	Het
Fastkd2	T	A	1: 63,790,459 (GRCm39)	C628*	probably null	Het
Fat3	A	C	9: 15,907,611 (GRCm39)	V2797G	possibly damaging	Het
Fcamr	A	G	1: 130,739,317 (GRCm39)	I206V	probably benign	Het
Fcamr	G	A	1: 130,740,366 (GRCm39)	G262S	probably benign	Het
Fcamr	A	G	1: 130,740,429 (GRCm39)	I283V	probably benign	Het
Fcamr	T	C	1: 130,740,475 (GRCm39)	V298A	probably benign	Het
Fcamr	A	G	1: 130,740,546 (GRCm39)	M322V	probably benign	Het
Fcamr	C	T	1: 130,740,553 (GRCm39)	P324L	probably benign	Het
Fcamr	A	G	1: 130,742,334 (GRCm39)	N574D	probably benign	Het
Fcamr	A	C	1: 130,732,364 (GRCm39)	N117T	probably benign	Het
Fcmr	T	C	1: 130,806,006 (GRCm39)	S321P	probably benign	Het
Fcmr	A	G	1: 130,803,711 (GRCm39)	T172A	probably benign	Het
Fut10	T	A	8: 31,691,418 (GRCm39)	S88T	probably benign	Het
Gabarap	C	T	11: 69,882,515 (GRCm39)		probably benign	Het
Gli2	G	T	1: 118,929,774 (GRCm39)	H44Q	probably benign	Het
Gli2	C	T	1: 118,795,817 (GRCm39)	A113T	possibly damaging	Het
Gon4l	T	A	3: 88,810,405 (GRCm39)	D1844E	probably damaging	Het
Gpr25	G	A	1: 136,188,448 (GRCm39)	P55L	probably benign	Het
Guk1	A	T	11: 59,076,138 (GRCm39)	V100E	probably damaging	Het
Ifi44l	T	C	3: 151,468,456 (GRCm39)	I25V	unknown	Het
Igfn1	T	C	1: 135,926,421 (GRCm39)	I10V	unknown	Het
Igfn1	T	C	1: 135,926,363 (GRCm39)	E29G	probably benign	Het
Igfn1	G	A	1: 135,910,213 (GRCm39)	R124W	probably benign	Het
Igfn1	C	T	1: 135,907,653 (GRCm39)	A231T	probably benign	Het
Igfn1	C	T	1: 135,899,865 (GRCm39)	R482Q	probably benign	Het
Igfn1	T	C	1: 135,898,149 (GRCm39)	S806G	probably benign	Het
Igfn1	G	A	1: 135,895,937 (GRCm39)	A1543V	probably benign	Het
Igfn1	G	A	1: 135,887,666 (GRCm39)	P2466L	probably damaging	Het
Ikbke	C	A	1: 131,193,674 (GRCm39)	A459S	probably benign	Het
Ikbke	T	C	1: 131,197,560 (GRCm39)	S447G	probably benign	Het
Ipo9	A	G	1: 135,329,988 (GRCm39)	V484A	probably benign	Het
Ipo9	ATCCTCCTCCTCCTCCTC	ATCCTCCTCCTCCTCCTCCTC	1: 135,314,006 (GRCm39)		probably benign	Het
Itprid1	T	C	6: 55,945,526 (GRCm39)	F749S	probably benign	Het
Jarid2	T	A	13: 45,059,752 (GRCm39)	N661K	probably damaging	Het
Kcnt2	G	A	1: 140,282,285 (GRCm39)	S90N	probably benign	Het
Kif14	A	G	1: 136,396,017 (GRCm39)	N108D	probably benign	Het
Kif14	T	C	1: 136,453,521 (GRCm39)	V1433A	probably benign	Het
Kif14	T	C	1: 136,443,699 (GRCm39)	F1291L	probably benign	Het
Kif14	C	T	1: 136,431,169 (GRCm39)	L1189F	probably benign	Het
Kif14	A	G	1: 136,418,070 (GRCm39)	S868G	probably benign	Het
Kif14	G	A	1: 136,406,103 (GRCm39)	A556T	probably benign	Het
Kif14	A	G	1: 136,396,713 (GRCm39)	K340E	probably damaging	Het
Kif18b	A	G	11: 102,806,367 (GRCm39)		probably null	Het
Kif26a	T	C	12: 112,143,219 (GRCm39)	S1158P	possibly damaging	Het
Kmt2d	A	G	15: 98,763,013 (GRCm39)	C279R	probably damaging	Het
Kremen1	CGGG	CGGGGGG	11: 5,151,791 (GRCm39)		probably benign	Het
Krt23	A	T	11: 99,383,790 (GRCm39)	V34D	probably damaging	Het
Lad1	C	T	1: 135,755,119 (GRCm39)	P132S	possibly damaging	Het
Lad1	C	T	1: 135,755,761 (GRCm39)	R346C	probably damaging	Het
Lax1	G	A	1: 133,611,372 (GRCm39)	P67S	probably damaging	Het
Lax1	T	C	1: 133,607,716 (GRCm39)	R342G	probably benign	Het
Lax1	T	C	1: 133,608,307 (GRCm39)	N145D	probably benign	Het
Lgr6	A	T	1: 134,915,747 (GRCm39)	S334T	probably benign	Het
Lgr6	G	T	1: 134,918,373 (GRCm39)	H263N	probably benign	Het
Lgr6	C	T	1: 134,931,214 (GRCm39)	S3N	probably benign	Het
Lgr6	C	T	1: 134,914,826 (GRCm39)	V641I	probably benign	Het
Lmod1	C	T	1: 135,291,811 (GRCm39)	T222I	probably benign	Het
Mb21d2	A	G	16: 28,647,173 (GRCm39)	V267A	probably benign	Het
Megf10	T	C	18: 57,373,864 (GRCm39)		probably null	Het
Mfrp	A	G	9: 44,015,884 (GRCm39)	T334A	possibly damaging	Het
Miga2	A	G	2: 30,258,980 (GRCm39)	H63R	probably damaging	Het
Mrgbp	T	A	2: 180,227,242 (GRCm39)	N192K	probably damaging	Het
Mrgpra2b	A	G	7: 47,114,627 (GRCm39)	I35T	probably benign	Het
Mroh3	G	C	1: 136,119,882 (GRCm39)	Q440E	possibly damaging	Het
Mybph	C	T	1: 134,125,218 (GRCm39)	R249C	probably benign	Het
Nav1	A	T	1: 135,512,465 (GRCm39)	D198E	possibly damaging	Het
Ndufaf7	A	T	17: 79,245,058 (GRCm39)	K59M	probably damaging	Het
Necab3	T	C	2: 154,388,795 (GRCm39)	S208G	probably benign	Het
Nfrkb	C	T	9: 31,325,932 (GRCm39)	T1125M	probably benign	Het
Npnt	G	A	3: 132,620,158 (GRCm39)	Q112*	probably null	Het
Nr5a2	C	A	1: 136,879,863 (GRCm39)	R35L	probably benign	Het
Nrcam	A	G	12: 44,620,633 (GRCm39)	K893E	probably benign	Het
Obsl1	G	A	1: 75,486,756 (GRCm38)	T1764M	probably benign	Het
Optc	C	G	1: 133,832,908 (GRCm39)	S64T	probably benign	Het
Optc	A	T	1: 133,831,534 (GRCm39)		probably null	Het
Or2f1	C	A	6: 42,721,069 (GRCm39)	L33M	possibly damaging	Het
Or4a68	C	T	2: 89,269,927 (GRCm39)	R232H	probably benign	Het
Or8b12i	A	T	9: 20,082,209 (GRCm39)	Y219*	probably null	Het
Otoa	T	C	7: 120,724,662 (GRCm39)	V447A	probably benign	Het
Patj	G	A	4: 98,320,017 (GRCm39)	G428D	possibly damaging	Het
Pigr	C	T	1: 130,772,259 (GRCm39)	A159V	possibly damaging	Het
Pik3c2b	C	T	1: 132,994,365 (GRCm39)	P110S	probably benign	Het
Pkn2	G	A	3: 142,516,462 (GRCm39)	P555S	probably benign	Het
Pla2g12a	A	G	3: 129,688,589 (GRCm39)	E149G	probably benign	Het
Plec	C	A	15: 76,061,892 (GRCm39)	E2547*	probably null	Het
Plekha6	C	G	1: 133,215,584 (GRCm39)	T792S	probably benign	Het
Ppfia4	G	A	1: 134,227,059 (GRCm39)	P1159S	probably benign	Het
Prelp	C	T	1: 133,842,869 (GRCm39)	R92K	probably benign	Het
Ptpn7	A	G	1: 135,062,213 (GRCm39)	Q53R	probably benign	Het
Ptprc	T	G	1: 138,027,414 (GRCm39)	N478T	probably benign	Het
Ptprc	T	C	1: 138,039,992 (GRCm39)	K212E	possibly damaging	Het
Ptprc	A	G	1: 138,035,575 (GRCm39)	V400A	probably benign	Het
Ptprc	C	A	1: 138,035,562 (GRCm39)	E402D	probably benign	Het
Ptprc	A	G	1: 138,035,561 (GRCm39)	S405P	probably benign	Het
Rab29	A	G	1: 131,799,848 (GRCm39)	Q141R	probably benign	Het
Rab3gap1	T	G	1: 127,870,223 (GRCm39)	L948R	probably damaging	Het
Rbsn	A	T	6: 92,167,000 (GRCm39)	L548Q	possibly damaging	Het
Ren1	T	A	1: 133,281,944 (GRCm39)	W22R	probably damaging	Het
Ren1	C	G	1: 133,287,745 (GRCm39)	L360V	probably benign	Het
Ren1	A	T	1: 133,286,817 (GRCm39)	E315D	probably benign	Het
Ren1	C	T	1: 133,281,975 (GRCm39)	T32I	probably benign	Het
Rint1	T	A	5: 24,014,841 (GRCm39)	D352E	probably benign	Het
Rnpep	C	T	1: 135,190,834 (GRCm39)	A571T	possibly damaging	Het
Rnpep	G	C	1: 135,211,715 (GRCm39)	A11G	probably benign	Het
Ro60	T	C	1: 143,635,772 (GRCm39)	D458G	probably benign	Het
Ro60	C	T	1: 143,635,752 (GRCm39)	V465I	probably benign	Het
Septin4	A	T	11: 87,474,262 (GRCm39)	Q60L	probably benign	Het
Serpinb10	C	T	1: 107,466,203 (GRCm39)	S63F	probably damaging	Het
Serpinb2	G	A	1: 107,443,365 (GRCm39)	A55T	probably damaging	Het
Serpinb2	A	C	1: 107,452,273 (GRCm39)	S284R	probably benign	Het
Serpinb2	C	T	1: 107,451,624 (GRCm39)	T259I	probably benign	Het
Serpinb2	C	T	1: 107,451,620 (GRCm39)	H258Y	probably benign	Het
Serpinb2	C	A	1: 107,451,564 (GRCm39)	A239E	probably benign	Het
Serpinb8	A	G	1: 107,525,257 (GRCm39)	S20G	probably benign	Het
Serpinb8	A	C	1: 107,534,734 (GRCm39)	L268F	probably benign	Het
Serpinb8	G	A	1: 107,526,684 (GRCm39)	A75T	probably benign	Het
Slain2	A	G	5: 73,114,957 (GRCm39)	H396R	probably damaging	Het
Slc22a5	G	A	11: 53,757,177 (GRCm39)	P491L	probably damaging	Het
Slc26a4	A	G	12: 31,594,493 (GRCm39)	V285A	possibly damaging	Het
Slc26a9	C	A	1: 131,693,750 (GRCm39)	R747S	probably benign	Het
Slc26a9	C	T	1: 131,691,608 (GRCm39)	A617V	probably benign	Het
Slc9a8	T	C	2: 167,266,065 (GRCm39)	F14S	probably benign	Het
Spock3	T	C	8: 63,802,011 (GRCm39)	L330P	probably damaging	Het
Steap3	G	A	1: 120,162,108 (GRCm39)	A350V	probably benign	Het
Steap3	T	C	1: 120,155,480 (GRCm39)	N493S	probably benign	Het
Synpo2l	G	A	14: 20,715,887 (GRCm39)	P233S	probably damaging	Het
Tasor	A	T	14: 27,201,590 (GRCm39)	N1367Y	probably damaging	Het
Tbc1d19	T	G	5: 53,986,714 (GRCm39)	I41S	probably damaging	Het
Tecta	G	A	9: 42,303,218 (GRCm39)	T138I	probably benign	Het
Thsd7b	G	C	1: 129,605,920 (GRCm39)	A554P	probably benign	Het
Thsd7b	A	C	1: 130,044,368 (GRCm39)	Q1116P	probably benign	Het
Thsd7b	C	T	1: 129,556,628 (GRCm39)	T328I	probably damaging	Het
Thsd7b	T	A	1: 129,595,674 (GRCm39)	F498Y	probably benign	Het
Tmem241	T	A	18: 12,201,369 (GRCm39)	H157L	probably damaging	Het
Tnfrsf25	T	A	4: 152,202,761 (GRCm39)		probably null	Het
Tnnt2	C	T	1: 135,773,244 (GRCm39)		probably benign	Het
Traf3ip3	T	A	1: 192,864,201 (GRCm39)	Q394L	probably benign	Het
Traf7	A	G	17: 24,731,353 (GRCm39)	F228L	probably damaging	Het
Trhr	A	G	15: 44,060,549 (GRCm39)	E23G	probably damaging	Het
Trim59	T	C	3: 68,944,186 (GRCm39)	T385A	probably benign	Het
Ttn	C	T	2: 76,643,683 (GRCm39)	G11436R	probably damaging	Het
Tubgcp2	T	C	7: 139,577,968 (GRCm39)	T779A	probably benign	Het
Tusc2	A	T	9: 107,441,830 (GRCm39)	I68F	probably damaging	Het
Ube2t	C	T	1: 134,899,905 (GRCm39)	A149V	probably benign	Het
Usp24	A	G	4: 106,217,618 (GRCm39)	N447S	possibly damaging	Het
Usp42	T	C	5: 143,700,381 (GRCm39)	D1214G	probably damaging	Het
Vmn2r73	T	C	7: 85,507,086 (GRCm39)	Y742C	probably damaging	Het
Wdfy4	A	T	14: 32,817,962 (GRCm39)	S1473T	possibly damaging	Het
Zan	C	A	5: 137,413,280 (GRCm39)		probably benign	Het
Zc3h11a	G	A	1: 133,549,892 (GRCm39)	P695S	probably benign	Het
Zfyve9	A	C	4: 108,575,698 (GRCm39)	V461G	possibly damaging	Het
Zp3r	A	G	1: 130,524,551 (GRCm39)	L164P	probably benign	Het
Zp3r	C	A	1: 130,547,151 (GRCm39)	E8D	possibly damaging	Het

Other mutations in Sctr

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00468:Sctr	APN	1	119,972,450 (GRCm39)	missense	probably damaging	1.00
IGL01542:Sctr	APN	1	119,972,499 (GRCm39)	splice site	probably benign
IGL02798:Sctr	APN	1	119,949,910 (GRCm39)	missense	probably damaging	1.00
IGL02850:Sctr	APN	1	119,949,909 (GRCm39)	missense	probably damaging	1.00
IGL02850:Sctr	APN	1	119,972,393 (GRCm39)	missense	possibly damaging	0.95
IGL03256:Sctr	APN	1	119,959,289 (GRCm39)	splice site	probably benign
PIT4677001:Sctr	UTSW	1	119,989,634 (GRCm39)	missense	probably damaging	1.00
R0018:Sctr	UTSW	1	119,971,286 (GRCm39)	splice site	probably benign
R0166:Sctr	UTSW	1	119,983,124 (GRCm39)	missense	probably damaging	0.97
R1678:Sctr	UTSW	1	119,964,169 (GRCm39)	critical splice donor site	probably null
R1728:Sctr	UTSW	1	119,990,987 (GRCm39)	missense	possibly damaging	0.67
R1728:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1729:Sctr	UTSW	1	119,990,976 (GRCm39)	missense	probably benign	0.16
R1729:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1730:Sctr	UTSW	1	119,990,987 (GRCm39)	missense	possibly damaging	0.67
R1730:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1739:Sctr	UTSW	1	119,990,987 (GRCm39)	missense	possibly damaging	0.67
R1739:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1739:Sctr	UTSW	1	119,990,976 (GRCm39)	missense	probably benign	0.16
R1762:Sctr	UTSW	1	119,990,987 (GRCm39)	missense	possibly damaging	0.67
R1762:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1762:Sctr	UTSW	1	119,990,976 (GRCm39)	missense	probably benign	0.16
R1783:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1785:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R1785:Sctr	UTSW	1	119,990,976 (GRCm39)	missense	probably benign	0.16
R1785:Sctr	UTSW	1	119,990,987 (GRCm39)	missense	possibly damaging	0.67
R2116:Sctr	UTSW	1	119,959,312 (GRCm39)	missense	probably damaging	1.00
R5522:Sctr	UTSW	1	119,964,146 (GRCm39)	missense	probably benign	0.10
R5776:Sctr	UTSW	1	119,984,137 (GRCm39)	missense	probably damaging	1.00
R5781:Sctr	UTSW	1	119,959,350 (GRCm39)	missense	probably damaging	0.99
R6333:Sctr	UTSW	1	119,984,182 (GRCm39)	missense	probably damaging	1.00
R7084:Sctr	UTSW	1	119,991,001 (GRCm39)	missense	possibly damaging	0.77
R7263:Sctr	UTSW	1	119,949,955 (GRCm39)	missense	probably benign
R7265:Sctr	UTSW	1	119,949,955 (GRCm39)	missense	probably benign
R7266:Sctr	UTSW	1	119,949,955 (GRCm39)	missense	probably benign
R7304:Sctr	UTSW	1	119,949,970 (GRCm39)	missense	probably damaging	1.00
R7343:Sctr	UTSW	1	119,949,955 (GRCm39)	missense	probably benign
R8063:Sctr	UTSW	1	119,991,005 (GRCm39)	missense	probably benign	0.09
R8914:Sctr	UTSW	1	119,959,386 (GRCm39)	missense	probably benign	0.00
R9146:Sctr	UTSW	1	119,982,010 (GRCm39)	missense	probably damaging	1.00
R9391:Sctr	UTSW	1	119,983,178 (GRCm39)	missense	probably benign	0.00
R9495:Sctr	UTSW	1	119,959,403 (GRCm39)	critical splice donor site	probably null
X0067:Sctr	UTSW	1	119,935,029 (GRCm39)	missense	probably benign
Z1088:Sctr	UTSW	1	119,964,136 (GRCm39)	frame shift	probably null
Z1176:Sctr	UTSW	1	119,949,979 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCTACACAGGGGACAGGAAATGGTC -3'
(R):5'- AGAACACACTCCTTCTCCAGGTAGC -3'

Sequencing Primer
(F):5'- CAACCAGTGAGTTGGGTTCC -3'
(R):5'- GACACACAGGCTAGGCTTTTC -3'

Posted On

2014-05-23