Incidental Mutation 'R0086:Or1j14'
ID 19877
Institutional Source Beutler Lab
Gene Symbol Or1j14
Ensembl Gene ENSMUSG00000111869
Gene Name olfactory receptor family 1 subfamily J member 14
Synonyms GA_x6K02T2NLDC-33222024-33222962, MOR136-4, Olfr342
MMRRC Submission 038373-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.290) question?
Stock # R0086 (G1)
Quality Score 218
Status Validated
Chromosome 2
Chromosomal Location 36415010-36420802 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36417462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 13 (I13F)
Ref Sequence ENSEMBL: ENSMUSP00000149751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074192] [ENSMUST00000216275]
AlphaFold Q8VGK7
Predicted Effect possibly damaging
Transcript: ENSMUST00000074192
AA Change: I13F

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000073818
Gene: ENSMUSG00000111869
AA Change: I13F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.7e-56 PFAM
Pfam:7tm_1 41 290 2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213794
Predicted Effect possibly damaging
Transcript: ENSMUST00000216275
AA Change: I13F

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.0%
  • 10x: 94.6%
  • 20x: 86.6%
Validation Efficiency 96% (91/95)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T A 15: 81,946,802 (GRCm39) V233D probably benign Het
Abcg8 T C 17: 85,000,199 (GRCm39) V252A probably damaging Het
Adam39 C T 8: 41,279,397 (GRCm39) T596I possibly damaging Het
Agap2 C A 10: 126,923,751 (GRCm39) probably null Het
Ap4b1 T G 3: 103,722,176 (GRCm39) V50G probably damaging Het
Atp13a1 T A 8: 70,250,424 (GRCm39) I381N possibly damaging Het
Bcl2 G A 1: 106,640,292 (GRCm39) R107C probably damaging Het
Birc6 T C 17: 74,900,161 (GRCm39) V1113A possibly damaging Het
C1galt1 T A 6: 7,867,051 (GRCm39) probably benign Het
Capza2 A G 6: 17,660,773 (GRCm39) K158E probably damaging Het
Cenpe C T 3: 134,970,185 (GRCm39) probably benign Het
Cercam T C 2: 29,761,076 (GRCm39) L42P probably damaging Het
Cfap54 T C 10: 92,864,456 (GRCm39) E807G possibly damaging Het
Cog6 A G 3: 52,900,991 (GRCm39) V157A probably damaging Het
Cts6 A T 13: 61,344,271 (GRCm39) probably benign Het
Cyp2c39 A T 19: 39,499,357 (GRCm39) I15F unknown Het
Dock7 A T 4: 98,833,381 (GRCm39) V1970D probably damaging Het
Exph5 A G 9: 53,249,230 (GRCm39) D73G possibly damaging Het
Gjc2 A T 11: 59,067,672 (GRCm39) M270K probably benign Het
Gns G A 10: 121,227,378 (GRCm39) D463N probably damaging Het
Hoxd8 G T 2: 74,536,276 (GRCm39) G129W probably damaging Het
Ina A G 19: 47,012,030 (GRCm39) T483A possibly damaging Het
Lmod3 T A 6: 97,224,306 (GRCm39) Q505L probably damaging Het
Map3k13 A G 16: 21,732,975 (GRCm39) N526D probably damaging Het
Map3k2 A T 18: 32,351,521 (GRCm39) I435F probably damaging Het
Mfsd6l A G 11: 68,447,391 (GRCm39) T81A probably benign Het
Micall1 T C 15: 79,009,689 (GRCm39) probably benign Het
Mkrn2 G T 6: 115,590,296 (GRCm39) M217I possibly damaging Het
Mtrex G T 13: 113,063,862 (GRCm39) F10L probably benign Het
Myh11 C A 16: 14,041,883 (GRCm39) Q720H probably damaging Het
Ncapg A G 5: 45,834,086 (GRCm39) probably null Het
Nlrp9a G A 7: 26,257,972 (GRCm39) C530Y probably damaging Het
Numb T C 12: 83,842,704 (GRCm39) T442A probably damaging Het
Oip5 C T 2: 119,448,410 (GRCm39) probably benign Het
Or4c119 C T 2: 88,986,820 (GRCm39) R233H probably benign Het
Or51k1 A G 7: 103,661,261 (GRCm39) I216T probably benign Het
Or8g22 T C 9: 38,958,191 (GRCm39) T175A probably benign Het
Pcnx1 T C 12: 82,038,832 (GRCm39) probably benign Het
Pkhd1l1 T A 15: 44,419,404 (GRCm39) N2956K possibly damaging Het
Plcl1 T A 1: 55,754,742 (GRCm39) W1030R probably damaging Het
Polr2i G A 7: 29,932,511 (GRCm39) V73M probably damaging Het
Prr14l T A 5: 32,988,903 (GRCm39) probably benign Het
Pxdn G T 12: 30,052,418 (GRCm39) R865L possibly damaging Het
Scnn1a T C 6: 125,319,550 (GRCm39) probably benign Het
Shkbp1 G T 7: 27,051,451 (GRCm39) H203N probably benign Het
Slc22a14 C T 9: 119,051,804 (GRCm39) probably benign Het
Snap29 C A 16: 17,246,100 (GRCm39) T240K probably damaging Het
Sp2 C A 11: 96,848,253 (GRCm39) G457C probably damaging Het
Ssr2 C T 3: 88,484,187 (GRCm39) probably benign Het
Synpo2 A T 3: 122,910,753 (GRCm39) C297* probably null Het
Tpm3 T A 3: 89,997,399 (GRCm39) probably benign Het
Trmt6 CTG C 2: 132,650,937 (GRCm39) probably benign Het
Trp63 T C 16: 25,689,837 (GRCm39) Y431H probably damaging Het
Tuba3b T A 6: 145,566,886 (GRCm39) C376S probably damaging Het
Ubxn4 G A 1: 128,190,641 (GRCm39) E256K probably benign Het
Ulk1 G A 5: 110,935,573 (GRCm39) probably benign Het
Usp24 T C 4: 106,249,557 (GRCm39) S1425P probably damaging Het
Xdh T C 17: 74,191,433 (GRCm39) I1335V probably benign Het
Zmynd15 T C 11: 70,355,058 (GRCm39) Y352H probably damaging Het
Other mutations in Or1j14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Or1j14 APN 2 36,418,005 (GRCm39) missense probably benign 0.22
IGL01372:Or1j14 APN 2 36,417,463 (GRCm39) missense probably benign 0.00
IGL01747:Or1j14 APN 2 36,417,844 (GRCm39) missense probably damaging 1.00
IGL01836:Or1j14 APN 2 36,417,837 (GRCm39) nonsense probably null
IGL02409:Or1j14 APN 2 36,418,165 (GRCm39) missense probably damaging 1.00
IGL02578:Or1j14 APN 2 36,418,156 (GRCm39) missense probably damaging 1.00
IGL03344:Or1j14 APN 2 36,418,140 (GRCm39) missense probably damaging 1.00
IGL03396:Or1j14 APN 2 36,417,692 (GRCm39) missense probably benign 0.00
R0427:Or1j14 UTSW 2 36,417,994 (GRCm39) missense probably damaging 1.00
R0973:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R0973:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R0974:Or1j14 UTSW 2 36,418,020 (GRCm39) missense probably benign 0.13
R2183:Or1j14 UTSW 2 36,417,723 (GRCm39) nonsense probably null
R2437:Or1j14 UTSW 2 36,418,258 (GRCm39) missense probably damaging 1.00
R4060:Or1j14 UTSW 2 36,417,426 (GRCm39) start codon destroyed probably null 0.01
R4982:Or1j14 UTSW 2 36,417,409 (GRCm39) critical splice acceptor site probably null
R5070:Or1j14 UTSW 2 36,417,778 (GRCm39) missense probably damaging 1.00
R6244:Or1j14 UTSW 2 36,418,353 (GRCm39) missense probably benign 0.00
R8350:Or1j14 UTSW 2 36,418,176 (GRCm39) missense probably damaging 1.00
R8690:Or1j14 UTSW 2 36,418,207 (GRCm39) missense probably benign 0.22
R9105:Or1j14 UTSW 2 36,418,294 (GRCm39) missense probably damaging 1.00
R9224:Or1j14 UTSW 2 36,417,838 (GRCm39) missense probably benign 0.00
R9249:Or1j14 UTSW 2 36,417,559 (GRCm39) missense probably damaging 1.00
R9274:Or1j14 UTSW 2 36,417,559 (GRCm39) missense probably damaging 1.00
R9465:Or1j14 UTSW 2 36,417,898 (GRCm39) missense probably benign 0.02
R9644:Or1j14 UTSW 2 36,417,777 (GRCm39) missense probably damaging 1.00
R9700:Or1j14 UTSW 2 36,418,313 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- ACCAACCATCACTAGCCCATTATTGTG -3'
(R):5'- ATTGCCTGAAGATAAGGCCCAAGAC -3'

Sequencing Primer
(F):5'- GCCCATTATTGTGACAAAAAGCTC -3'
(R):5'- GATGGCTACATACCTGTCATAGGC -3'
Posted On 2013-04-11