Incidental Mutation 'R0087:Or6b6'
ID 19953
Institutional Source Beutler Lab
Gene Symbol Or6b6
Ensembl Gene ENSMUSG00000045013
Gene Name olfactory receptor family 6 subfamily B member 6
Synonyms MOR103-4, Olfr711, GA_x6K02T2PBJ9-9352783-9351839
MMRRC Submission 038374-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R0087 (G1)
Quality Score 194
Status Validated (trace)
Chromosome 7
Chromosomal Location 106570575-106574658 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106571323 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 76 (V76A)
Ref Sequence ENSEMBL: ENSMUSP00000149016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051715] [ENSMUST00000207200] [ENSMUST00000216335]
AlphaFold Q9EPG2
Predicted Effect probably benign
Transcript: ENSMUST00000051715
AA Change: V76A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000055724
Gene: ENSMUSG00000045013
AA Change: V76A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-58 PFAM
Pfam:7tm_1 41 290 1.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207200
AA Change: V76A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000216335
AA Change: V76A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.6%
  • 10x: 93.5%
  • 20x: 82.3%
Validation Efficiency 86% (59/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 T A 19: 53,215,038 (GRCm39) L71Q probably damaging Het
Adgrv1 T A 13: 81,535,070 (GRCm39) I5732F probably damaging Het
Adss2 A T 1: 177,598,788 (GRCm39) V330E probably benign Het
Agps T A 2: 75,739,979 (GRCm39) Y488N probably damaging Het
Ap3s1 A T 18: 46,891,106 (GRCm39) R66S probably damaging Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Atp2a2 C T 5: 122,599,024 (GRCm39) V593I probably benign Het
Chrna6 C T 8: 27,897,014 (GRCm39) V288M probably damaging Het
Col4a2 C T 8: 11,491,296 (GRCm39) L1232F probably benign Het
Dcaf1 A G 9: 106,740,288 (GRCm39) N1225D probably damaging Het
Degs1 A G 1: 182,106,875 (GRCm39) I128T probably benign Het
Dnaaf11 T C 15: 66,341,824 (GRCm39) T91A probably benign Het
Dnah5 A T 15: 28,350,759 (GRCm39) T2594S probably damaging Het
Dnah8 G T 17: 30,974,093 (GRCm39) R2826L probably damaging Het
Elf3 A G 1: 135,184,875 (GRCm39) Y104H probably damaging Het
Fam222b C A 11: 78,044,718 (GRCm39) T93N probably benign Het
Fbxw26 A G 9: 109,554,006 (GRCm39) I211T probably benign Het
Fcho2 T C 13: 98,871,594 (GRCm39) T541A probably benign Het
Flg2 T C 3: 93,109,738 (GRCm39) S589P unknown Het
Foxj3 T A 4: 119,483,597 (GRCm39) V589E unknown Het
Gria1 A G 11: 57,208,538 (GRCm39) Y742C probably damaging Het
Inpp5d T C 1: 87,642,860 (GRCm39) S672P probably damaging Het
Lrrc19 A C 4: 94,529,009 (GRCm39) F91C probably damaging Het
Mppe1 A G 18: 67,358,775 (GRCm39) *398R probably null Het
Mroh3 T C 1: 136,118,541 (GRCm39) I561V probably benign Het
Myh11 C A 16: 14,041,883 (GRCm39) Q720H probably damaging Het
Nbea G T 3: 55,998,444 (GRCm39) T121K possibly damaging Het
Nbr1 A C 11: 101,455,519 (GRCm39) D91A probably benign Het
Ncam2 C A 16: 81,231,789 (GRCm39) N84K probably benign Het
Or4c35 T C 2: 89,808,475 (GRCm39) Y118H probably damaging Het
Or51ac3 A T 7: 103,213,569 (GRCm39) C306S probably benign Het
Or52h9 A G 7: 104,202,869 (GRCm39) I248V possibly damaging Het
Or52z13 A G 7: 103,246,928 (GRCm39) Y135C probably benign Het
Pdgfrb A T 18: 61,194,585 (GRCm39) I121F probably damaging Het
Peak1 A T 9: 56,165,609 (GRCm39) I773N probably damaging Het
Pfkfb4 G T 9: 108,836,769 (GRCm39) V155F probably damaging Het
Pkm C T 9: 59,585,382 (GRCm39) R455* probably null Het
Plbd2 C A 5: 120,632,550 (GRCm39) E151* probably null Het
Pld5 G A 1: 175,812,025 (GRCm39) T353M probably damaging Het
Psme2b A T 11: 48,836,544 (GRCm39) D134E possibly damaging Het
Rida T A 15: 34,488,772 (GRCm39) D40V possibly damaging Het
Rnf126 A T 10: 79,595,068 (GRCm39) H265Q probably damaging Het
Rock2 C A 12: 16,978,967 (GRCm39) Q86K probably benign Het
Serpinb1b A T 13: 33,269,302 (GRCm39) T12S probably benign Het
Slco6c1 T A 1: 97,046,303 (GRCm39) Q277L probably benign Het
Spmap2 A T 10: 79,421,785 (GRCm39) Y144* probably null Het
Sptlc2 T A 12: 87,415,892 (GRCm39) H45L probably benign Het
Srsf4 A G 4: 131,627,641 (GRCm39) probably benign Het
Sspo A G 6: 48,454,719 (GRCm39) S2969G probably damaging Het
Steap1 C T 5: 5,786,664 (GRCm39) G258R probably damaging Het
Stk19 A T 17: 35,055,851 (GRCm39) M1K probably null Het
Stk-ps2 C A 1: 46,069,049 (GRCm39) noncoding transcript Het
Taf1c C T 8: 120,327,726 (GRCm39) R332H probably damaging Het
Thbs4 T A 13: 92,891,743 (GRCm39) T791S probably damaging Het
Tjap1 A G 17: 46,574,652 (GRCm39) L21P probably damaging Het
Tmem145 A G 7: 25,007,268 (GRCm39) Y148C probably damaging Het
Tmem267 T A 13: 120,070,810 (GRCm39) V155E probably benign Het
Tns1 T A 1: 73,956,076 (GRCm39) H549L possibly damaging Het
Tyro3 T G 2: 119,632,182 (GRCm39) I83S probably benign Het
Ubxn4 G A 1: 128,190,641 (GRCm39) E256K probably benign Het
Vmn1r53 A T 6: 90,200,413 (GRCm39) C304S probably benign Het
Vwf G A 6: 125,622,917 (GRCm39) M1761I probably benign Het
Zfp276 T C 8: 123,991,786 (GRCm39) Y445H probably damaging Het
Zfp407 A T 18: 84,578,536 (GRCm39) I859N probably damaging Het
Other mutations in Or6b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02600:Or6b6 APN 7 106,570,756 (GRCm39) missense possibly damaging 0.51
R0580:Or6b6 UTSW 7 106,571,447 (GRCm39) missense probably damaging 1.00
R1375:Or6b6 UTSW 7 106,571,305 (GRCm39) missense probably damaging 1.00
R1538:Or6b6 UTSW 7 106,571,190 (GRCm39) nonsense probably null
R1875:Or6b6 UTSW 7 106,571,389 (GRCm39) missense possibly damaging 0.86
R2156:Or6b6 UTSW 7 106,570,775 (GRCm39) missense probably damaging 1.00
R4290:Or6b6 UTSW 7 106,570,918 (GRCm39) missense probably damaging 0.97
R4332:Or6b6 UTSW 7 106,571,354 (GRCm39) missense probably benign 0.00
R4400:Or6b6 UTSW 7 106,571,209 (GRCm39) missense probably damaging 1.00
R4688:Or6b6 UTSW 7 106,571,068 (GRCm39) missense probably benign 0.02
R4868:Or6b6 UTSW 7 106,570,974 (GRCm39) missense probably benign
R4970:Or6b6 UTSW 7 106,570,778 (GRCm39) missense probably benign 0.35
R5006:Or6b6 UTSW 7 106,570,808 (GRCm39) missense probably damaging 1.00
R5082:Or6b6 UTSW 7 106,570,871 (GRCm39) missense probably benign 0.00
R5121:Or6b6 UTSW 7 106,571,438 (GRCm39) missense probably benign
R6465:Or6b6 UTSW 7 106,571,419 (GRCm39) missense possibly damaging 0.63
R6541:Or6b6 UTSW 7 106,571,410 (GRCm39) missense probably benign 0.20
R7419:Or6b6 UTSW 7 106,571,353 (GRCm39) missense probably benign 0.01
R8048:Or6b6 UTSW 7 106,571,671 (GRCm39) start gained probably benign
R9310:Or6b6 UTSW 7 106,570,678 (GRCm39) missense probably damaging 1.00
R9470:Or6b6 UTSW 7 106,571,461 (GRCm39) missense probably benign 0.26
R9603:Or6b6 UTSW 7 106,571,103 (GRCm39) nonsense probably null
Z1177:Or6b6 UTSW 7 106,571,122 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGACATTGGAGCCACAGAAAGCAAC -3'
(R):5'- GGTCTGATGCCATAGACATTGCCC -3'

Sequencing Primer
(F):5'- TGAAATAGACTTTGACAACAGAGACC -3'
(R):5'- GCTGGATATGAACATTACTCTGGTC -3'
Posted On 2013-04-11