Incidental Mutation 'R1734:Vmn1r20'
ID 199560
Institutional Source Beutler Lab
Gene Symbol Vmn1r20
Ensembl Gene ENSMUSG00000115253
Gene Name vomeronasal 1 receptor 20
Synonyms Gm5569
MMRRC Submission 039766-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.459) question?
Stock # R1734 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 57428930-57435261 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57432300 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 204 (R204G)
Ref Sequence ENSEMBL: ENSMUSP00000153815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176085] [ENSMUST00000226808] [ENSMUST00000227909]
AlphaFold K7N778
Predicted Effect probably damaging
Transcript: ENSMUST00000176085
AA Change: R204G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134973
Gene: ENSMUSG00000093679
AA Change: R204G

DomainStartEndE-ValueType
Pfam:V1R 28 293 2.3e-51 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226808
AA Change: R204G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000227909
AA Change: R204G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 97.0%
  • 10x: 95.5%
  • 20x: 92.9%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,585,460 (GRCm38) C4695R probably benign Het
Actr10 T A 12: 70,961,996 (GRCm38) V401E probably benign Het
Adamts16 G A 13: 70,779,518 (GRCm38) probably benign Het
Aimp1 A T 3: 132,674,796 (GRCm38) I59K probably damaging Het
Alms1 T A 6: 85,641,550 (GRCm38) probably null Het
Anln A T 9: 22,350,955 (GRCm38) S947T possibly damaging Het
Atp2c1 T C 9: 105,414,655 (GRCm38) T733A probably damaging Het
BC049715 C T 6: 136,840,308 (GRCm38) P182L probably damaging Het
Cblb T C 16: 52,186,240 (GRCm38) probably benign Het
Cep295 C T 9: 15,340,883 (GRCm38) E397K probably damaging Het
Ces4a G A 8: 105,138,097 (GRCm38) G69S probably damaging Het
Chac1 A T 2: 119,353,458 (GRCm38) L180F probably damaging Het
Cherp A T 8: 72,470,088 (GRCm38) probably null Het
Ckap4 A G 10: 84,527,874 (GRCm38) S442P probably benign Het
Clstn3 G A 6: 124,436,814 (GRCm38) probably benign Het
Crb2 T A 2: 37,793,656 (GRCm38) C1057S probably damaging Het
Dact2 T C 17: 14,196,639 (GRCm38) D433G probably benign Het
Dnah6 G A 6: 73,044,761 (GRCm38) T3526M probably damaging Het
Ethe1 A G 7: 24,608,384 (GRCm38) T210A probably benign Het
Fat2 A G 11: 55,281,371 (GRCm38) S2839P probably benign Het
Fbxl7 T C 15: 26,543,649 (GRCm38) Y304C probably damaging Het
Gad1-ps A T 10: 99,445,775 (GRCm38) noncoding transcript Het
Gm436 A T 4: 144,670,026 (GRCm38) C379S probably benign Het
Grm3 C T 5: 9,589,742 (GRCm38) R101K probably benign Het
Hspa12b A G 2: 131,138,536 (GRCm38) Y125C possibly damaging Het
Il10ra T C 9: 45,255,943 (GRCm38) T437A probably benign Het
Jcad T C 18: 4,674,526 (GRCm38) F763L probably damaging Het
Map3k10 T C 7: 27,658,115 (GRCm38) D746G probably damaging Het
Mettl9 T A 7: 121,047,841 (GRCm38) Y57N probably damaging Het
Nav2 G A 7: 49,575,720 (GRCm38) E1803K probably damaging Het
Nol11 G A 11: 107,175,623 (GRCm38) S447L possibly damaging Het
Olfr294 C T 7: 86,616,217 (GRCm38) V143M probably benign Het
Osbpl1a T C 18: 12,788,316 (GRCm38) probably null Het
Pde6a A G 18: 61,285,965 (GRCm38) N804S probably damaging Het
Pepd A T 7: 35,031,426 (GRCm38) D301V probably benign Het
Piwil2 A T 14: 70,426,505 (GRCm38) probably null Het
Plec C T 15: 76,186,218 (GRCm38) V931M probably damaging Het
Prrc2a A G 17: 35,150,707 (GRCm38) S1877P possibly damaging Het
Retreg2 G T 1: 75,142,986 (GRCm38) probably null Het
Slc7a11 G A 3: 50,372,346 (GRCm38) Q489* probably null Het
Sned1 G A 1: 93,259,768 (GRCm38) D256N probably damaging Het
Sphkap G A 1: 83,277,515 (GRCm38) R838* probably null Het
Ssfa2 G A 2: 79,657,822 (GRCm38) V750M probably damaging Het
Syce2 G A 8: 84,887,147 (GRCm38) E168K probably benign Het
Tex37 T A 6: 70,913,661 (GRCm38) Q49L probably benign Het
Tmem260 G T 14: 48,509,093 (GRCm38) V609L probably benign Het
Trim35 A G 14: 66,309,329 (GRCm38) D515G probably damaging Het
Tspan5 T C 3: 138,898,140 (GRCm38) Y131H probably damaging Het
Ttbk2 T C 2: 120,755,838 (GRCm38) I466V probably benign Het
Ttn T C 2: 76,745,813 (GRCm38) D24912G probably damaging Het
Utp20 A T 10: 88,767,461 (GRCm38) N1843K probably damaging Het
Vps18 A T 2: 119,293,942 (GRCm38) Q450L probably benign Het
Zbtb4 A G 11: 69,776,463 (GRCm38) E198G probably benign Het
Other mutations in Vmn1r20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01761:Vmn1r20 APN 6 57,431,740 (GRCm38) missense probably damaging 1.00
IGL02622:Vmn1r20 APN 6 57,432,598 (GRCm38) missense probably damaging 0.99
IGL02636:Vmn1r20 APN 6 57,431,761 (GRCm38) missense probably benign
R0006:Vmn1r20 UTSW 6 57,432,305 (GRCm38) missense probably damaging 0.99
R0079:Vmn1r20 UTSW 6 57,431,792 (GRCm38) missense possibly damaging 0.70
R0200:Vmn1r20 UTSW 6 57,432,099 (GRCm38) missense probably damaging 0.96
R1675:Vmn1r20 UTSW 6 57,431,952 (GRCm38) missense probably benign 0.00
R1883:Vmn1r20 UTSW 6 57,432,321 (GRCm38) missense probably benign 0.14
R2049:Vmn1r20 UTSW 6 57,431,958 (GRCm38) missense probably damaging 1.00
R2307:Vmn1r20 UTSW 6 57,432,136 (GRCm38) missense probably benign 0.03
R2346:Vmn1r20 UTSW 6 57,431,946 (GRCm38) missense possibly damaging 0.83
R4405:Vmn1r20 UTSW 6 57,432,057 (GRCm38) missense probably benign 0.02
R4946:Vmn1r20 UTSW 6 57,432,174 (GRCm38) missense probably damaging 0.98
R5259:Vmn1r20 UTSW 6 57,432,065 (GRCm38) nonsense probably null
R5321:Vmn1r20 UTSW 6 57,432,442 (GRCm38) missense probably benign 0.21
R5911:Vmn1r20 UTSW 6 57,431,789 (GRCm38) missense probably benign 0.16
R6042:Vmn1r20 UTSW 6 57,432,406 (GRCm38) missense possibly damaging 0.90
R6298:Vmn1r20 UTSW 6 57,432,127 (GRCm38) missense probably benign
R6314:Vmn1r20 UTSW 6 57,432,057 (GRCm38) missense probably benign 0.00
R6331:Vmn1r20 UTSW 6 57,431,670 (GRCm38) splice site probably null
R6482:Vmn1r20 UTSW 6 57,432,108 (GRCm38) missense probably benign 0.01
R9161:Vmn1r20 UTSW 6 57,431,774 (GRCm38) missense probably benign 0.00
R9165:Vmn1r20 UTSW 6 57,432,261 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTCCAGGCTGTCACAATCAGTCCC -3'
(R):5'- ACCCTCAGGATGACTGTGTCATACC -3'

Sequencing Primer
(F):5'- CTACAGTAGTAGCCGGATCTTCTATG -3'
(R):5'- GGATGACTGTGTCATACCTCCAC -3'
Posted On 2014-05-23