Incidental Mutation 'R1737:Cdh10'
ID 199814
Institutional Source Beutler Lab
Gene Symbol Cdh10
Ensembl Gene ENSMUSG00000022321
Gene Name cadherin 10
Synonyms C030011H18Rik, A830016G23Rik, C030003B10Rik, T2-cadherin
MMRRC Submission 039769-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R1737 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 18819033-19014322 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18964149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 104 (I104F)
Ref Sequence ENSEMBL: ENSMUSP00000135546 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040562] [ENSMUST00000166873] [ENSMUST00000176146]
AlphaFold P70408
Predicted Effect probably damaging
Transcript: ENSMUST00000040562
AA Change: I104F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000042199
Gene: ENSMUSG00000022321
AA Change: I104F

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 77 158 2.8e-14 SMART
CA 182 267 1.03e-30 SMART
CA 291 383 6.04e-19 SMART
CA 406 487 6.23e-21 SMART
CA 510 594 3.56e-7 SMART
transmembrane domain 612 634 N/A INTRINSIC
Pfam:Cadherin_C 635 782 9.2e-58 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000166873
AA Change: I104F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128782
Gene: ENSMUSG00000022321
AA Change: I104F

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 77 158 2.8e-14 SMART
CA 182 267 1.03e-30 SMART
CA 291 383 6.04e-19 SMART
CA 406 487 6.23e-21 SMART
CA 510 594 3.56e-7 SMART
transmembrane domain 612 634 N/A INTRINSIC
Pfam:Cadherin_C 637 783 1.1e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176146
AA Change: I104F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000135546
Gene: ENSMUSG00000022321
AA Change: I104F

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 77 158 2.8e-14 SMART
CA 182 267 1.03e-30 SMART
CA 291 383 6.04e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176593
Meta Mutation Damage Score 0.7814 question?
Coding Region Coverage
  • 1x: 97.6%
  • 3x: 96.9%
  • 10x: 95.1%
  • 20x: 91.4%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is expressed in the blood-brain barrier and retinal endothelia suggesting a role in the development and maintenance of brain barrier. Alternative splicing results in multiple transcript variants. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 15. [provided by RefSeq, Oct 2015]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Ak7 G A 12: 105,708,591 (GRCm39) V349M probably damaging Het
Aldh1a2 A T 9: 71,192,453 (GRCm39) E436V possibly damaging Het
Apc C A 18: 34,450,075 (GRCm39) P2290T probably damaging Het
Atp10a T C 7: 58,476,986 (GRCm39) probably benign Het
Bahd1 T C 2: 118,746,404 (GRCm39) S8P probably damaging Het
BC049715 C T 6: 136,817,306 (GRCm39) P182L probably damaging Het
Capn10 T C 1: 92,862,677 (GRCm39) Y28H probably benign Het
Cep170b A G 12: 112,703,061 (GRCm39) D508G possibly damaging Het
Ces2a G T 8: 105,467,456 (GRCm39) A494S probably damaging Het
Ces4a G A 8: 105,864,729 (GRCm39) G69S probably damaging Het
Cltc G A 11: 86,624,553 (GRCm39) T123M probably damaging Het
Cnot1 A G 8: 96,474,904 (GRCm39) S1102P probably damaging Het
Col12a1 C A 9: 79,610,733 (GRCm39) D224Y probably damaging Het
Col14a1 T A 15: 55,208,357 (GRCm39) probably benign Het
Cyp7a1 T A 4: 6,272,848 (GRCm39) T122S probably benign Het
Dock4 A G 12: 40,857,000 (GRCm39) probably null Het
Eid2 T C 7: 27,967,924 (GRCm39) V182A possibly damaging Het
Eloa A T 4: 135,738,081 (GRCm39) V293D probably benign Het
Enkur G A 2: 21,199,106 (GRCm39) P143S probably damaging Het
Ep300 T C 15: 81,510,548 (GRCm39) Y99H probably damaging Het
Fbxw5 C A 2: 25,393,596 (GRCm39) L66I probably benign Het
Flg2 A T 3: 93,110,928 (GRCm39) R985S unknown Het
Fscb A T 12: 64,521,355 (GRCm39) I37K possibly damaging Het
H2-M10.3 T C 17: 36,679,296 (GRCm39) N3S probably benign Het
H2-Q7 A C 17: 35,658,602 (GRCm39) Y80S probably damaging Het
H60c A T 10: 3,209,914 (GRCm39) D124E possibly damaging Het
Hsd3b2 A T 3: 98,618,862 (GRCm39) V361E probably damaging Het
Ice1 A C 13: 70,754,444 (GRCm39) C547W probably damaging Het
Itprid1 A T 6: 55,945,289 (GRCm39) D670V probably damaging Het
Jmy A G 13: 93,635,303 (GRCm39) V171A probably damaging Het
Klf7 C A 1: 64,118,372 (GRCm39) R75L possibly damaging Het
Klk1b1 A T 7: 43,619,783 (GRCm39) Q114L probably benign Het
Krt10 A G 11: 99,278,213 (GRCm39) M280T possibly damaging Het
Lama1 G A 17: 68,109,916 (GRCm39) R2179Q probably benign Het
Mbd3l1 C T 9: 18,396,225 (GRCm39) P117S possibly damaging Het
Med18 A T 4: 132,187,420 (GRCm39) S71R probably damaging Het
Mov10l1 T A 15: 88,895,607 (GRCm39) I643N possibly damaging Het
Nfib T C 4: 82,416,826 (GRCm39) K70E probably damaging Het
Nr3c2 A C 8: 77,634,958 (GRCm39) S20R probably benign Het
Nr6a1 A T 2: 38,628,955 (GRCm39) F356L probably benign Het
Oca2 G A 7: 55,978,533 (GRCm39) R567H probably damaging Het
Or10k2 A G 8: 84,268,045 (GRCm39) S91G probably benign Het
Or1e35 T A 11: 73,797,911 (GRCm39) M136L possibly damaging Het
Or1p1 T C 11: 74,179,637 (GRCm39) L55P probably damaging Het
Or6c88 T A 10: 129,406,697 (GRCm39) Y58N probably damaging Het
Or8g33 T C 9: 39,338,254 (GRCm39) T38A probably damaging Het
Pcdhb10 A G 18: 37,546,009 (GRCm39) T362A probably benign Het
Pip5k1b A T 19: 24,374,404 (GRCm39) V59E probably damaging Het
Pkhd1l1 G A 15: 44,410,905 (GRCm39) probably null Het
Prr36 T C 8: 4,264,370 (GRCm39) probably benign Het
Ptger2 A G 14: 45,239,228 (GRCm39) T289A probably benign Het
Rad18 A G 6: 112,658,498 (GRCm39) F136L probably damaging Het
Rhbg T A 3: 88,153,181 (GRCm39) S258C probably damaging Het
Scgb2b27 T C 7: 33,712,739 (GRCm39) I34M possibly damaging Het
Senp7 C A 16: 55,944,162 (GRCm39) T135K probably damaging Het
Slc20a2 A G 8: 23,035,582 (GRCm39) I193M probably damaging Het
Slc27a1 G A 8: 72,023,504 (GRCm39) V47I probably benign Het
Slc9a5 G A 8: 106,094,766 (GRCm39) V786M probably damaging Het
Smyd1 A G 6: 71,193,875 (GRCm39) L350P probably damaging Het
Ston2 A T 12: 91,614,681 (GRCm39) F576I probably damaging Het
Sulf2 A T 2: 165,924,598 (GRCm39) V496E probably benign Het
Tcl1b3 C A 12: 105,157,481 (GRCm39) S41Y probably damaging Het
Tulp2 A T 7: 45,169,201 (GRCm39) N256I probably damaging Het
Uspl1 T A 5: 149,138,668 (GRCm39) C349S probably damaging Het
Vcl T C 14: 21,070,604 (GRCm39) I730T probably damaging Het
Vmn1r61 A T 7: 5,614,060 (GRCm39) F85I probably benign Het
Zfp318 A G 17: 46,710,403 (GRCm39) T709A probably benign Het
Zfr2 T C 10: 81,077,919 (GRCm39) S249P probably damaging Het
Other mutations in Cdh10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00475:Cdh10 APN 15 19,013,349 (GRCm39) missense probably damaging 1.00
IGL00540:Cdh10 APN 15 18,964,081 (GRCm39) missense probably damaging 1.00
IGL00769:Cdh10 APN 15 18,985,185 (GRCm39) missense possibly damaging 0.63
IGL00837:Cdh10 APN 15 19,013,490 (GRCm39) missense probably benign
IGL01307:Cdh10 APN 15 18,899,886 (GRCm39) missense probably benign 0.34
IGL01509:Cdh10 APN 15 18,986,884 (GRCm39) missense possibly damaging 0.70
IGL01561:Cdh10 APN 15 19,000,012 (GRCm39) missense possibly damaging 0.52
IGL01743:Cdh10 APN 15 18,986,855 (GRCm39) missense probably benign 0.06
IGL02065:Cdh10 APN 15 19,013,342 (GRCm39) missense probably damaging 1.00
IGL02083:Cdh10 APN 15 18,986,975 (GRCm39) missense possibly damaging 0.79
IGL02238:Cdh10 APN 15 19,013,605 (GRCm39) missense probably damaging 1.00
IGL02838:Cdh10 APN 15 18,899,849 (GRCm39) missense probably damaging 1.00
IGL03397:Cdh10 APN 15 18,964,114 (GRCm39) missense probably damaging 1.00
R0423:Cdh10 UTSW 15 18,986,965 (GRCm39) missense probably benign 0.00
R0828:Cdh10 UTSW 15 18,986,837 (GRCm39) missense possibly damaging 0.52
R1488:Cdh10 UTSW 15 19,013,349 (GRCm39) missense probably damaging 1.00
R1563:Cdh10 UTSW 15 18,986,853 (GRCm39) nonsense probably null
R1674:Cdh10 UTSW 15 19,013,416 (GRCm39) missense probably damaging 1.00
R1674:Cdh10 UTSW 15 18,985,152 (GRCm39) missense probably benign 0.11
R1819:Cdh10 UTSW 15 18,992,051 (GRCm39) nonsense probably null
R1865:Cdh10 UTSW 15 18,899,690 (GRCm39) missense probably benign 0.01
R1953:Cdh10 UTSW 15 18,966,997 (GRCm39) critical splice donor site probably null
R2439:Cdh10 UTSW 15 19,013,484 (GRCm39) missense probably damaging 1.00
R3944:Cdh10 UTSW 15 18,964,335 (GRCm39) missense probably benign
R4320:Cdh10 UTSW 15 18,985,251 (GRCm39) missense probably benign 0.03
R4330:Cdh10 UTSW 15 19,000,045 (GRCm39) missense probably damaging 1.00
R4765:Cdh10 UTSW 15 19,013,364 (GRCm39) missense probably damaging 0.98
R4831:Cdh10 UTSW 15 19,013,664 (GRCm39) missense probably benign 0.10
R5102:Cdh10 UTSW 15 18,986,971 (GRCm39) missense probably benign 0.05
R5166:Cdh10 UTSW 15 19,013,446 (GRCm39) missense probably damaging 0.99
R5217:Cdh10 UTSW 15 18,966,108 (GRCm39) missense probably damaging 0.98
R5843:Cdh10 UTSW 15 18,985,286 (GRCm39) missense possibly damaging 0.68
R5902:Cdh10 UTSW 15 18,985,341 (GRCm39) critical splice donor site probably null
R6263:Cdh10 UTSW 15 18,964,154 (GRCm39) missense possibly damaging 0.86
R6636:Cdh10 UTSW 15 18,985,259 (GRCm39) missense probably damaging 0.99
R6770:Cdh10 UTSW 15 18,985,308 (GRCm39) missense probably benign 0.09
R7046:Cdh10 UTSW 15 19,013,287 (GRCm39) missense probably damaging 0.98
R7362:Cdh10 UTSW 15 18,899,780 (GRCm39) missense probably benign
R7491:Cdh10 UTSW 15 19,013,445 (GRCm39) missense probably damaging 0.99
R7921:Cdh10 UTSW 15 18,992,042 (GRCm39) missense probably damaging 1.00
R7937:Cdh10 UTSW 15 18,964,335 (GRCm39) missense probably benign
R8685:Cdh10 UTSW 15 18,899,851 (GRCm39) missense possibly damaging 0.89
R8843:Cdh10 UTSW 15 19,013,487 (GRCm39) missense possibly damaging 0.83
R8907:Cdh10 UTSW 15 19,013,521 (GRCm39) missense probably damaging 1.00
R9121:Cdh10 UTSW 15 19,011,074 (GRCm39) missense probably damaging 1.00
R9264:Cdh10 UTSW 15 18,964,081 (GRCm39) missense probably damaging 1.00
R9449:Cdh10 UTSW 15 19,013,521 (GRCm39) missense possibly damaging 0.89
R9497:Cdh10 UTSW 15 18,964,267 (GRCm39) missense probably damaging 0.98
R9584:Cdh10 UTSW 15 18,992,095 (GRCm39) missense probably benign 0.07
R9638:Cdh10 UTSW 15 18,964,301 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACAGCCCTGAGATTACTGACCC -3'
(R):5'- CAGTATCTGGTCCATCGTGGAAAGC -3'

Sequencing Primer
(F):5'- CTGAGATTACTGACCCTGTTATTTG -3'
(R):5'- GTGCTGTGAAATCTGCAAATCC -3'
Posted On 2014-05-23