Incidental Mutation 'R0088:Sult6b2'
ID20005
Institutional Source Beutler Lab
Gene Symbol Sult6b2
Ensembl Gene ENSMUSG00000048473
Gene Namesulfotransferase family 6B, member 2
SynonymsLOC330440, Gm766
MMRRC Submission 038375-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #R0088 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location142785204-142804502 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 142797949 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 117 (N117I)
Ref Sequence ENSEMBL: ENSMUSP00000138527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111768] [ENSMUST00000156662]
Predicted Effect probably damaging
Transcript: ENSMUST00000111768
AA Change: N117I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107398
Gene: ENSMUSG00000048473
AA Change: N117I

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 37 276 1.5e-64 PFAM
Pfam:Sulfotransfer_3 38 200 1.6e-10 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000156662
AA Change: N117I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138527
Gene: ENSMUSG00000048473
AA Change: N117I

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 74 157 5.6e-21 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.8%
Validation Efficiency 82% (32/39)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T C 8: 24,914,067 K243R probably damaging Het
Akap9 C A 5: 3,961,946 T883K probably benign Het
Arhgap5 G T 12: 52,516,548 D101Y probably damaging Het
Bnc1 T G 7: 81,978,498 N39T possibly damaging Het
Carnmt1 T A 19: 18,677,853 H123Q probably benign Het
Cdh24 T C 14: 54,633,714 D92G probably damaging Het
Eomes A G 9: 118,478,673 E5G probably damaging Het
Eqtn T C 4: 94,919,990 T192A probably damaging Het
Fam110c T C 12: 31,075,218 V393A probably damaging Het
Fbll1 C A 11: 35,798,140 A99S possibly damaging Het
Il1rl2 A T 1: 40,365,053 I445F possibly damaging Het
Ipo8 T C 6: 148,801,936 T400A probably benign Het
Iqsec3 T C 6: 121,473,289 E92G probably damaging Het
Itpr2 C T 6: 146,241,185 V1679M probably benign Het
Kif2a G A 13: 106,975,432 A478V probably damaging Het
Lingo4 A G 3: 94,402,033 S93G probably benign Het
Mrpl37 A G 4: 107,064,424 S203P possibly damaging Het
Ndel1 A C 11: 68,833,420 S242R probably damaging Het
Nfatc3 T A 8: 106,127,942 M1036K possibly damaging Het
Ngrn T C 7: 80,264,455 I118T probably damaging Het
Olfr975 A G 9: 39,950,375 V132A probably benign Het
Pex10 A T 4: 155,070,498 S236C probably damaging Het
Phkb T G 8: 85,942,391 probably null Het
Pklr A G 3: 89,141,908 Y187C probably damaging Het
Plekhh1 A C 12: 79,055,366 E403D probably benign Het
Pls1 T C 9: 95,795,768 K22E possibly damaging Het
Prdm2 G A 4: 143,134,954 H589Y possibly damaging Het
Rabggtb C A 3: 153,908,830 R230L probably damaging Het
Rsph4a A G 10: 33,909,353 E420G probably benign Het
Sdk2 T C 11: 113,827,086 N1484S possibly damaging Het
St8sia3 T A 18: 64,266,985 V17E possibly damaging Het
Thbs2 T C 17: 14,681,701 T422A possibly damaging Het
Tmem266 A G 9: 55,437,329 D415G probably damaging Het
Tnfrsf21 C T 17: 43,038,213 H239Y probably benign Het
Ttyh2 G T 11: 114,690,255 G107C probably damaging Het
Ubr4 A G 4: 139,440,814 D2835G probably damaging Het
Zranb3 T C 1: 127,976,462 D540G probably benign Het
Other mutations in Sult6b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00436:Sult6b2 APN 6 142797837 splice site probably benign
IGL00694:Sult6b2 APN 6 142790289 missense possibly damaging 0.92
IGL01146:Sult6b2 APN 6 142804308 missense probably benign 0.00
IGL01886:Sult6b2 APN 6 142790126 critical splice donor site probably null
IGL02385:Sult6b2 APN 6 142801772 missense probably benign 0.01
IGL02477:Sult6b2 APN 6 142801721 missense probably damaging 1.00
R2850:Sult6b2 UTSW 6 142797887 missense probably benign 0.18
R4015:Sult6b2 UTSW 6 142790262 missense possibly damaging 0.89
R4667:Sult6b2 UTSW 6 142801695 nonsense probably null
R5172:Sult6b2 UTSW 6 142797931 missense probably damaging 1.00
R5973:Sult6b2 UTSW 6 142790295 missense probably benign 0.01
R6152:Sult6b2 UTSW 6 142804376 missense probably benign 0.00
R6893:Sult6b2 UTSW 6 142804299 missense possibly damaging 0.63
R7667:Sult6b2 UTSW 6 142786359 missense probably benign 0.10
R7853:Sult6b2 UTSW 6 142801798 missense not run
R7936:Sult6b2 UTSW 6 142801798 missense not run
Predicted Primers PCR Primer
(F):5'- CATTTTGGGTGAGAAAGTTCAGCGG -3'
(R):5'- TTTCCAGAGACTGAAGCACAGGGC -3'

Sequencing Primer
(F):5'- gaggtggagacaggaggg -3'
(R):5'- CAGCTAATGCTATTGgggggg -3'
Posted On2013-04-11