Incidental Mutation 'R0088:Or10d5'
ID 20013
Institutional Source Beutler Lab
Gene Symbol Or10d5
Ensembl Gene ENSMUSG00000043331
Gene Name olfactory receptor family 10 subfamily D member 5
Synonyms MOR224-2, GA_x6K02T2PVTD-33651220-33650288, Olfr975
MMRRC Submission 038375-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R0088 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 9
Chromosomal Location 39861133-39862065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39861671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 132 (V132A)
Ref Sequence ENSEMBL: ENSMUSP00000150664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054067] [ENSMUST00000169307] [ENSMUST00000213171] [ENSMUST00000216647] [ENSMUST00000217630]
AlphaFold Q8VG91
Predicted Effect probably benign
Transcript: ENSMUST00000054067
AA Change: V132A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000059776
Gene: ENSMUSG00000043331
AA Change: V132A

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 1.9e-51 PFAM
Pfam:7TM_GPCR_Srsx 33 249 1.8e-7 PFAM
Pfam:7tm_1 39 286 3.6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169307
SMART Domains Protein: ENSMUSP00000133083
Gene: ENSMUSG00000047352

DomainStartEndE-ValueType
Pfam:7tm_4 43 318 1.5e-48 PFAM
Pfam:7TM_GPCR_Srsx 47 271 1.1e-5 PFAM
Pfam:7tm_1 53 300 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213171
Predicted Effect probably benign
Transcript: ENSMUST00000216647
AA Change: V132A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000217630
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.8%
Validation Efficiency 82% (32/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam32 T C 8: 25,404,083 (GRCm39) K243R probably damaging Het
Akap9 C A 5: 4,011,946 (GRCm39) T883K probably benign Het
Arhgap5 G T 12: 52,563,331 (GRCm39) D101Y probably damaging Het
Bnc1 T G 7: 81,628,246 (GRCm39) N39T possibly damaging Het
Carnmt1 T A 19: 18,655,217 (GRCm39) H123Q probably benign Het
Cdh24 T C 14: 54,871,171 (GRCm39) D92G probably damaging Het
Eomes A G 9: 118,307,741 (GRCm39) E5G probably damaging Het
Eqtn T C 4: 94,808,227 (GRCm39) T192A probably damaging Het
Fam110c T C 12: 31,125,217 (GRCm39) V393A probably damaging Het
Fbll1 C A 11: 35,688,967 (GRCm39) A99S possibly damaging Het
Il1rl2 A T 1: 40,404,213 (GRCm39) I445F possibly damaging Het
Ipo8 T C 6: 148,703,434 (GRCm39) T400A probably benign Het
Iqsec3 T C 6: 121,450,248 (GRCm39) E92G probably damaging Het
Itpr2 C T 6: 146,142,683 (GRCm39) V1679M probably benign Het
Kif2a G A 13: 107,111,940 (GRCm39) A478V probably damaging Het
Lingo4 A G 3: 94,309,340 (GRCm39) S93G probably benign Het
Mrpl37 A G 4: 106,921,621 (GRCm39) S203P possibly damaging Het
Ndel1 A C 11: 68,724,246 (GRCm39) S242R probably damaging Het
Nfatc3 T A 8: 106,854,574 (GRCm39) M1036K possibly damaging Het
Ngrn T C 7: 79,914,203 (GRCm39) I118T probably damaging Het
Pex10 A T 4: 155,154,955 (GRCm39) S236C probably damaging Het
Phkb T G 8: 86,669,020 (GRCm39) probably null Het
Pklr A G 3: 89,049,215 (GRCm39) Y187C probably damaging Het
Plekhh1 A C 12: 79,102,140 (GRCm39) E403D probably benign Het
Pls1 T C 9: 95,677,821 (GRCm39) K22E possibly damaging Het
Prdm2 G A 4: 142,861,524 (GRCm39) H589Y possibly damaging Het
Rabggtb C A 3: 153,614,467 (GRCm39) R230L probably damaging Het
Rsph4a A G 10: 33,785,349 (GRCm39) E420G probably benign Het
Sdk2 T C 11: 113,717,912 (GRCm39) N1484S possibly damaging Het
St8sia3 T A 18: 64,400,056 (GRCm39) V17E possibly damaging Het
Sult6b2 T A 6: 142,743,675 (GRCm39) N117I probably damaging Het
Thbs2 T C 17: 14,901,963 (GRCm39) T422A possibly damaging Het
Tmem266 A G 9: 55,344,613 (GRCm39) D415G probably damaging Het
Tnfrsf21 C T 17: 43,349,104 (GRCm39) H239Y probably benign Het
Ttyh2 G T 11: 114,581,081 (GRCm39) G107C probably damaging Het
Ubr4 A G 4: 139,168,125 (GRCm39) D2835G probably damaging Het
Zranb3 T C 1: 127,904,199 (GRCm39) D540G probably benign Het
Other mutations in Or10d5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01480:Or10d5 APN 9 39,861,284 (GRCm39) missense probably benign 0.01
IGL01537:Or10d5 APN 9 39,861,921 (GRCm39) missense probably benign 0.00
IGL01963:Or10d5 APN 9 39,861,536 (GRCm39) missense probably damaging 1.00
IGL02400:Or10d5 APN 9 39,861,635 (GRCm39) missense probably benign
IGL03115:Or10d5 APN 9 39,862,040 (GRCm39) missense probably damaging 0.98
IGL03226:Or10d5 APN 9 39,861,719 (GRCm39) splice site probably null
R0212:Or10d5 UTSW 9 39,861,236 (GRCm39) missense probably benign 0.44
R1668:Or10d5 UTSW 9 39,861,465 (GRCm39) missense possibly damaging 0.94
R1878:Or10d5 UTSW 9 39,862,053 (GRCm39) missense probably benign 0.35
R2225:Or10d5 UTSW 9 39,861,833 (GRCm39) missense possibly damaging 0.84
R2291:Or10d5 UTSW 9 39,861,630 (GRCm39) missense probably benign 0.19
R2420:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2421:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2422:Or10d5 UTSW 9 39,861,824 (GRCm39) missense possibly damaging 0.47
R2425:Or10d5 UTSW 9 39,861,137 (GRCm39) missense probably null 0.25
R2918:Or10d5 UTSW 9 39,861,660 (GRCm39) missense probably benign
R4536:Or10d5 UTSW 9 39,861,731 (GRCm39) missense probably damaging 1.00
R4709:Or10d5 UTSW 9 39,861,165 (GRCm39) missense probably damaging 0.97
R4831:Or10d5 UTSW 9 39,861,408 (GRCm39) missense probably benign 0.01
R4921:Or10d5 UTSW 9 39,861,521 (GRCm39) missense probably damaging 0.98
R5113:Or10d5 UTSW 9 39,861,221 (GRCm39) missense probably damaging 0.99
R5141:Or10d5 UTSW 9 39,861,170 (GRCm39) missense probably benign 0.07
R5195:Or10d5 UTSW 9 39,861,975 (GRCm39) missense probably benign
R5213:Or10d5 UTSW 9 39,861,389 (GRCm39) missense probably damaging 0.99
R5568:Or10d5 UTSW 9 39,861,983 (GRCm39) missense probably benign 0.05
R6993:Or10d5 UTSW 9 39,861,933 (GRCm39) missense probably benign
R7080:Or10d5 UTSW 9 39,861,444 (GRCm39) missense probably damaging 1.00
R7436:Or10d5 UTSW 9 39,861,349 (GRCm39) nonsense probably null
R8178:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8179:Or10d5 UTSW 9 39,861,708 (GRCm39) missense probably benign 0.05
R8382:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8402:Or10d5 UTSW 9 39,861,713 (GRCm39) missense probably benign 0.39
R8511:Or10d5 UTSW 9 39,861,455 (GRCm39) missense probably benign 0.21
R8798:Or10d5 UTSW 9 39,862,013 (GRCm39) missense probably benign 0.40
R9068:Or10d5 UTSW 9 39,862,087 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TTGAACCACTGAATCCAGCCAAGG -3'
(R):5'- GTTCCCCAAAGATGATGCTCTCCC -3'

Sequencing Primer
(F):5'- ACTTACAGCTTGTGCCAGAG -3'
(R):5'- AAAGATGATGCTCTCCCTCACTG -3'
Posted On 2013-04-11