Mutagenetix > Incidental Mutation

Incidental Mutation 'R1739:Hivep3'

200168

Institutional Source

Beutler Lab

Gene Symbol

Hivep3

Ensembl Gene

ENSMUSG00000028634

Gene Name

human immunodeficiency virus type I enhancer binding protein 3

Synonyms

E030045D18Rik, Schnurri-3, Shn3, 2900056N03Rik, Krc

MMRRC Submission

039771-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1739 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

119733784-120138045 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 120095174 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 229 (Y229C)

Ref Sequence

ENSEMBL: ENSMUSP00000130249 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106307] [ENSMUST00000166542] [ENSMUST00000226560]

AlphaFold

A2A884

Predicted Effect

probably benign
Transcript: ENSMUST00000106307
AA Change: Y229C

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000101914
Gene: ENSMUSG00000028634
AA Change: Y229C

Domain	Start	End	E-Value	Type
ZnF_C2H2	185	207	1.67e-2	SMART
ZnF_C2H2	213	235	8.34e-3	SMART
low complexity region	257	285	N/A	INTRINSIC
low complexity region	292	323	N/A	INTRINSIC
low complexity region	425	438	N/A	INTRINSIC
low complexity region	513	527	N/A	INTRINSIC
low complexity region	589	612	N/A	INTRINSIC
low complexity region	622	633	N/A	INTRINSIC
ZnF_C2H2	636	656	2.06e1	SMART
low complexity region	736	749	N/A	INTRINSIC
low complexity region	806	817	N/A	INTRINSIC
low complexity region	844	865	N/A	INTRINSIC
low complexity region	878	894	N/A	INTRINSIC
low complexity region	896	931	N/A	INTRINSIC
low complexity region	1010	1020	N/A	INTRINSIC
low complexity region	1050	1061	N/A	INTRINSIC
low complexity region	1110	1136	N/A	INTRINSIC
low complexity region	1143	1167	N/A	INTRINSIC
low complexity region	1170	1183	N/A	INTRINSIC
low complexity region	1259	1284	N/A	INTRINSIC
low complexity region	1376	1390	N/A	INTRINSIC
low complexity region	1529	1547	N/A	INTRINSIC
low complexity region	1673	1684	N/A	INTRINSIC
ZnF_C2H2	1720	1742	1.82e-3	SMART
ZnF_C2H2	1748	1772	1.69e-3	SMART
low complexity region	1778	1791	N/A	INTRINSIC
low complexity region	1814	1843	N/A	INTRINSIC
low complexity region	2203	2216	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000166542
AA Change: Y229C

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000130249
Gene: ENSMUSG00000028634
AA Change: Y229C

Domain	Start	End	E-Value	Type
ZnF_C2H2	185	207	1.67e-2	SMART
ZnF_C2H2	213	235	8.34e-3	SMART
low complexity region	257	285	N/A	INTRINSIC
low complexity region	292	323	N/A	INTRINSIC
low complexity region	425	438	N/A	INTRINSIC
low complexity region	513	527	N/A	INTRINSIC
low complexity region	589	612	N/A	INTRINSIC
low complexity region	622	633	N/A	INTRINSIC
ZnF_C2H2	636	656	2.06e1	SMART
low complexity region	736	749	N/A	INTRINSIC
low complexity region	806	817	N/A	INTRINSIC
low complexity region	844	865	N/A	INTRINSIC
low complexity region	878	894	N/A	INTRINSIC
low complexity region	896	931	N/A	INTRINSIC
low complexity region	1010	1020	N/A	INTRINSIC
low complexity region	1050	1061	N/A	INTRINSIC
low complexity region	1110	1136	N/A	INTRINSIC
low complexity region	1143	1167	N/A	INTRINSIC
low complexity region	1170	1183	N/A	INTRINSIC
low complexity region	1259	1284	N/A	INTRINSIC
low complexity region	1376	1390	N/A	INTRINSIC
low complexity region	1529	1547	N/A	INTRINSIC
low complexity region	1673	1684	N/A	INTRINSIC
ZnF_C2H2	1720	1742	1.82e-3	SMART
ZnF_C2H2	1748	1772	1.69e-3	SMART
low complexity region	1778	1791	N/A	INTRINSIC
low complexity region	1814	1843	N/A	INTRINSIC
low complexity region	2203	2216	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000226560

Coding Region Coverage

1x: 97.5%
3x: 96.8%
10x: 94.9%
20x: 91.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 231 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	C	T	7: 120,278,306 (GRCm38)	T1059I	probably benign	Het
Abcb11	C	T	2: 69,261,566 (GRCm38)	A871T	probably damaging	Het
Acot7	T	C	4: 152,260,912 (GRCm38)	L313P	probably damaging	Het
Adam20	T	A	8: 40,796,558 (GRCm38)	H568Q	probably benign	Het
Adam26b	T	A	8: 43,521,677 (GRCm38)	D96V	probably damaging	Het
Adgrf4	C	T	17: 42,666,898 (GRCm38)	R518Q	possibly damaging	Het
Apbb1	A	G	7: 105,574,227 (GRCm38)	V59A	probably benign	Het
Apc	A	G	18: 34,312,318 (GRCm38)	K722E	probably damaging	Het
Aspm	A	G	1: 139,473,574 (GRCm38)	I1111V	probably benign	Het
Aspscr1	A	G	11: 120,678,516 (GRCm38)	T47A	probably damaging	Het
Atr	G	A	9: 95,897,581 (GRCm38)	V1331I	probably benign	Het
Baz1a	G	A	12: 54,898,788 (GRCm38)	R1261*	probably null	Het
C2cd2l	C	A	9: 44,319,743 (GRCm38)	R49L	probably benign	Het
C4bp	C	G	1: 130,642,988 (GRCm38)	V284L	probably benign	Het
Cacna1c	A	C	6: 118,610,544 (GRCm38)	M1287R	probably damaging	Het
Cacna1s	T	C	1: 136,118,716 (GRCm38)	F1761S	probably benign	Het
Camsap2	C	T	1: 136,281,315 (GRCm38)	R802Q	probably benign	Het
Capn9	G	A	8: 124,605,711 (GRCm38)	G430R	possibly damaging	Het
Ccdc177	A	G	12: 80,759,239 (GRCm38)	V87A	probably damaging	Het
Ccdc178	T	A	18: 22,097,723 (GRCm38)	I364F	possibly damaging	Het
Ccdc93	T	C	1: 121,461,939 (GRCm38)	V237A	probably benign	Het
Ccdc93	C	T	1: 121,456,126 (GRCm38)	P192L	probably benign	Het
Cd55	C	A	1: 130,459,633 (GRCm38)	A143S	probably benign	Het
Cd55	C	T	1: 130,449,423 (GRCm38)	V333I	probably benign	Het
Cdh19	C	A	1: 110,893,384 (GRCm38)	E541D	probably damaging	Het
Cdh7	C	G	1: 110,065,735 (GRCm38)	L307V	possibly damaging	Het
Cep120	A	G	18: 53,719,214 (GRCm38)		probably null	Het
Cep128	G	T	12: 91,022,491 (GRCm38)		probably null	Het
Cep131	T	C	11: 120,083,906 (GRCm38)	I23V	probably benign	Het
Cfc1	A	G	1: 34,537,234 (GRCm38)	D125G	probably damaging	Het
Cfh	C	T	1: 140,147,697 (GRCm38)	V268I	possibly damaging	Het
Cfh	T	C	1: 140,136,788 (GRCm38)	K374R	probably benign	Het
Cfhr2	A	C	1: 139,813,459 (GRCm38)	N259K	probably benign	Het
Cfhr2	A	G	1: 139,813,442 (GRCm38)	M265T	probably benign	Het
Chil1	C	T	1: 134,188,529 (GRCm38)	A250V	probably damaging	Het
Clca1	C	A	3: 145,007,778 (GRCm38)	M697I	probably benign	Het
Clec4a3	C	T	6: 122,954,041 (GRCm38)	Q30*	probably null	Het
Cntnap3	T	A	13: 64,740,592 (GRCm38)	R1232S	probably benign	Het
Cntnap5a	C	T	1: 116,455,143 (GRCm38)	T1047I	probably benign	Het
Cntnap5a	T	C	1: 116,455,101 (GRCm38)	L1033S	probably benign	Het
Cntnap5a	C	A	1: 116,455,004 (GRCm38)	L1001I	probably benign	Het
Col12a1	T	A	9: 79,633,468 (GRCm38)	I2412F	probably damaging	Het
Crb1	C	T	1: 139,243,417 (GRCm38)	R684H	probably benign	Het
Crb1	C	T	1: 139,242,995 (GRCm38)	G825R	probably damaging	Het
Crb1	G	A	1: 139,241,138 (GRCm38)	P881S	probably damaging	Het
Crb1	A	T	1: 139,237,622 (GRCm38)	H921Q	probably benign	Het
Crb1	T	C	1: 139,234,779 (GRCm38)	M1214V	probably benign	Het
Cxcl2	C	T	5: 90,904,158 (GRCm38)	T41I	probably damaging	Het
Cxcr4	C	T	1: 128,589,277 (GRCm38)	V216I	probably benign	Het
Cyb5r1	C	T	1: 134,407,667 (GRCm38)	R147W	probably damaging	Het
Ddx59	T	C	1: 136,417,053 (GRCm38)	V154A	probably benign	Het
Disp2	T	C	2: 118,791,550 (GRCm38)	V921A	probably damaging	Het
Dnajc10	C	G	2: 80,347,662 (GRCm38)	A671G	probably benign	Het
Dner	T	C	1: 84,370,784 (GRCm38)	I732V	probably damaging	Het
Dsel	T	C	1: 111,859,457 (GRCm38)	N1116S	probably benign	Het
Dsel	G	C	1: 111,859,994 (GRCm38)	T937S	probably benign	Het
Dstyk	C	T	1: 132,456,984 (GRCm38)	L739F	probably damaging	Het
Dysf	T	C	6: 84,112,235 (GRCm38)		probably null	Het
Eefsec	T	A	6: 88,376,205 (GRCm38)	K161*	probably null	Het
Ehhadh	G	C	16: 21,762,253 (GRCm38)	A663G	probably benign	Het
En1	A	G	1: 120,603,621 (GRCm38)	S197G	unknown	Het
Etnk2	T	A	1: 133,376,915 (GRCm38)	V292E	probably benign	Het
Etnk2	G	A	1: 133,365,817 (GRCm38)	R166Q	probably benign	Het
Etnk2	C	T	1: 133,365,816 (GRCm38)	R166*	probably null	Het
Etnk2	G	T	1: 133,365,765 (GRCm38)	G149W	probably damaging	Het
Etnk2	A	G	1: 133,363,923 (GRCm38)	S54G	probably benign	Het
Etnk2	C	A	1: 133,365,587 (GRCm38)	D89E	probably benign	Het
Exph5	T	C	9: 53,375,588 (GRCm38)	V1323A	possibly damaging	Het
Eya2	G	T	2: 165,687,663 (GRCm38)	G109W	probably damaging	Het
Fam72a	T	C	1: 131,530,668 (GRCm38)	I56T	probably benign	Het
Fam72a	C	T	1: 131,538,895 (GRCm38)	T139M	probably benign	Het
Fcamr	A	G	1: 130,812,809 (GRCm38)	M322V	probably benign	Het
Fcamr	A	C	1: 130,804,627 (GRCm38)	N117T	probably benign	Het
Fcamr	A	G	1: 130,811,580 (GRCm38)	I206V	probably benign	Het
Fcamr	C	T	1: 130,812,816 (GRCm38)	P324L	probably benign	Het
Fcamr	A	G	1: 130,814,597 (GRCm38)	N574D	probably benign	Het
Fcamr	G	A	1: 130,812,629 (GRCm38)	G262S	probably benign	Het
Fcamr	A	G	1: 130,812,692 (GRCm38)	I283V	probably benign	Het
Fcamr	T	C	1: 130,812,738 (GRCm38)	V298A	probably benign	Het
Fcmr	T	C	1: 130,878,269 (GRCm38)	S321P	probably benign	Het
Fcmr	A	G	1: 130,875,974 (GRCm38)	T172A	probably benign	Het
Focad	T	C	4: 88,397,891 (GRCm38)	M1560T	probably benign	Het
Gadd45gip1	T	A	8: 84,832,292 (GRCm38)	M1K	probably null	Het
Gbgt1	T	C	2: 28,505,052 (GRCm38)	V234A	possibly damaging	Het
Gin1	T	A	1: 97,786,104 (GRCm38)	D376E	probably damaging	Het
Git1	A	T	11: 77,498,982 (GRCm38)	I24F	probably damaging	Het
Gli2	G	T	1: 119,002,044 (GRCm38)	H44Q	probably benign	Het
Gli2	C	T	1: 118,868,087 (GRCm38)	A113T	possibly damaging	Het
Gm5152	T	C	5: 10,245,204 (GRCm38)	I90V	possibly damaging	Het
Gnptab	T	C	10: 88,436,095 (GRCm38)	Y916H	probably benign	Het
Gpr25	G	A	1: 136,260,710 (GRCm38)	P55L	probably benign	Het
Heg1	T	G	16: 33,738,583 (GRCm38)	I1058S	possibly damaging	Het
Idi1	T	C	13: 8,890,411 (GRCm38)	F210L	probably benign	Het
Igfn1	T	C	1: 135,998,683 (GRCm38)	I10V	unknown	Het
Igfn1	T	C	1: 135,998,625 (GRCm38)	E29G	probably benign	Het
Igfn1	G	A	1: 135,982,475 (GRCm38)	R124W	probably benign	Het
Igfn1	C	T	1: 135,979,915 (GRCm38)	A231T	probably benign	Het
Igfn1	C	T	1: 135,972,127 (GRCm38)	R482Q	probably benign	Het
Igfn1	T	C	1: 135,970,411 (GRCm38)	S806G	probably benign	Het
Igfn1	G	A	1: 135,968,199 (GRCm38)	A1543V	probably benign	Het
Igfn1	G	A	1: 135,959,928 (GRCm38)	P2466L	probably damaging	Het
Ikbke	C	A	1: 131,265,937 (GRCm38)	A459S	probably benign	Het
Ikbke	T	C	1: 131,269,823 (GRCm38)	S447G	probably benign	Het
Ipo9	A	G	1: 135,402,250 (GRCm38)	V484A	probably benign	Het
Ipo9	ATCCTCCTCCTCCTCCTC	ATCCTCCTCCTCCTCCTCCTC	1: 135,386,268 (GRCm38)		probably benign	Het
Jarid2	T	A	13: 44,906,276 (GRCm38)	N661K	probably damaging	Het
Kat7	T	G	11: 95,276,547 (GRCm38)	I455L	possibly damaging	Het
Kcnh5	G	T	12: 75,114,229 (GRCm38)	P302T	probably damaging	Het
Kcnt2	G	A	1: 140,354,547 (GRCm38)	S90N	probably benign	Het
Kif14	A	G	1: 136,468,279 (GRCm38)	N108D	probably benign	Het
Kif14	A	G	1: 136,468,975 (GRCm38)	K340E	probably damaging	Het
Kif14	G	A	1: 136,478,365 (GRCm38)	A556T	probably benign	Het
Kif14	A	G	1: 136,490,332 (GRCm38)	S868G	probably benign	Het
Kif14	C	T	1: 136,503,431 (GRCm38)	L1189F	probably benign	Het
Kif14	T	C	1: 136,515,961 (GRCm38)	F1291L	probably benign	Het
Kif14	T	C	1: 136,525,783 (GRCm38)	V1433A	probably benign	Het
Krtap12-1	C	T	10: 77,720,992 (GRCm38)	T123I	possibly damaging	Het
Ksr1	G	A	11: 79,047,305 (GRCm38)	T49I	probably damaging	Het
Lad1	C	T	1: 135,828,023 (GRCm38)	R346C	probably damaging	Het
Lad1	C	T	1: 135,827,381 (GRCm38)	P132S	possibly damaging	Het
Lat2	T	C	5: 134,606,369 (GRCm38)	H89R	possibly damaging	Het
Lax1	G	A	1: 133,683,634 (GRCm38)	P67S	probably damaging	Het
Lax1	T	C	1: 133,680,569 (GRCm38)	N145D	probably benign	Het
Lax1	T	C	1: 133,679,978 (GRCm38)	R342G	probably benign	Het
Lgr6	C	T	1: 135,003,476 (GRCm38)	S3N	probably benign	Het
Lgr6	G	T	1: 134,990,635 (GRCm38)	H263N	probably benign	Het
Lgr6	A	T	1: 134,988,009 (GRCm38)	S334T	probably benign	Het
Lgr6	C	T	1: 134,987,088 (GRCm38)	V641I	probably benign	Het
Lmod1	C	T	1: 135,364,073 (GRCm38)	T222I	probably benign	Het
Man2a2	T	C	7: 80,362,438 (GRCm38)	E657G	probably benign	Het
Mfsd4a	C	T	1: 132,067,883 (GRCm38)	D4N	possibly damaging	Het
Mn1	G	T	5: 111,420,014 (GRCm38)	A617S	possibly damaging	Het
Mov10	T	C	3: 104,800,282 (GRCm38)	D592G	probably damaging	Het
Mroh3	G	C	1: 136,192,144 (GRCm38)	Q440E	possibly damaging	Het
Mtmr12	A	T	15: 12,245,019 (GRCm38)	T207S	probably benign	Het
Musk	G	A	4: 58,293,563 (GRCm38)	V51M	probably damaging	Het
Mybph	C	T	1: 134,197,480 (GRCm38)	R249C	probably benign	Het
Naglu	C	T	11: 101,076,403 (GRCm38)	A393V	possibly damaging	Het
Nav1	A	T	1: 135,584,727 (GRCm38)	D198E	possibly damaging	Het
Ncan	T	A	8: 70,108,086 (GRCm38)	T744S	probably benign	Het
Nlrp4c	T	A	7: 6,073,222 (GRCm38)	V707E	probably damaging	Het
Nr5a2	C	A	1: 136,952,125 (GRCm38)	R35L	probably benign	Het
Nrcam	A	T	12: 44,571,675 (GRCm38)	Q822L	probably damaging	Het
Obsl1	G	A	1: 75,486,756 (GRCm38)	T1764M	probably benign	Het
Olfr1232	T	A	2: 89,325,566 (GRCm38)	I205F	probably benign	Het
Olfr1240	C	T	2: 89,439,583 (GRCm38)	R232H	probably benign	Het
Olfr453	C	A	6: 42,744,135 (GRCm38)	L33M	possibly damaging	Het
Optc	A	T	1: 133,903,796 (GRCm38)		probably null	Het
Optc	C	G	1: 133,905,170 (GRCm38)	S64T	probably benign	Het
Pak1	T	A	7: 97,904,695 (GRCm38)	V424E	probably damaging	Het
Pdcd6	G	A	13: 74,304,041 (GRCm38)	T160I	probably damaging	Het
Phf21a	C	T	2: 92,360,299 (GRCm38)	T535M	possibly damaging	Het
Pigr	C	T	1: 130,844,522 (GRCm38)	A159V	possibly damaging	Het
Pik3c2b	C	T	1: 133,066,627 (GRCm38)	P110S	probably benign	Het
Pkdrej	G	A	15: 85,820,427 (GRCm38)	T436I	probably benign	Het
Plekha6	C	G	1: 133,287,846 (GRCm38)	T792S	probably benign	Het
Ppil2	C	G	16: 17,089,419 (GRCm38)		probably benign	Het
Ppip5k2	A	T	1: 97,728,957 (GRCm38)	H830Q	probably damaging	Het
Prelp	C	T	1: 133,915,131 (GRCm38)	R92K	probably benign	Het
Ptpn7	A	G	1: 135,134,475 (GRCm38)	Q53R	probably benign	Het
Ptprc	C	A	1: 138,107,824 (GRCm38)	E402D	probably benign	Het
Ptprc	A	G	1: 138,107,837 (GRCm38)	V400A	probably benign	Het
Ptprc	T	C	1: 138,112,254 (GRCm38)	K212E	possibly damaging	Het
Ptprc	A	G	1: 138,107,823 (GRCm38)	S405P	probably benign	Het
Ptprc	T	G	1: 138,099,676 (GRCm38)	N478T	probably benign	Het
Rab29	A	G	1: 131,872,110 (GRCm38)	Q141R	probably benign	Het
Ren1	T	A	1: 133,354,206 (GRCm38)	W22R	probably damaging	Het
Ren1	C	T	1: 133,354,237 (GRCm38)	T32I	probably benign	Het
Ren1	A	C	1: 133,356,457 (GRCm38)	K187Q	probably benign	Het
Ren1	A	T	1: 133,359,079 (GRCm38)	E315D	probably benign	Het
Ren1	A	T	1: 133,359,983 (GRCm38)	N352Y	probably benign	Het
Ren1	C	G	1: 133,360,007 (GRCm38)	L360V	probably benign	Het
Rnpep	C	T	1: 135,263,096 (GRCm38)	A571T	possibly damaging	Het
Rnpep	C	G	1: 135,283,629 (GRCm38)	R127P	probably benign	Het
Sctr	T	C	1: 120,031,656 (GRCm38)	F110L	probably benign	Het
Sctr	G	T	1: 120,063,246 (GRCm38)	E453D	probably benign	Het
Sctr	G	A	1: 120,063,257 (GRCm38)	S440N	possibly damaging	Het
Sema4a	A	G	3: 88,436,838 (GRCm38)	L702P	possibly damaging	Het
Sept4	A	T	11: 87,583,436 (GRCm38)	Q60L	probably benign	Het
Serpinb10	C	T	1: 107,538,473 (GRCm38)	S63F	probably damaging	Het
Serpinb2	A	C	1: 107,524,543 (GRCm38)	S284R	probably benign	Het
Serpinb2	G	A	1: 107,515,635 (GRCm38)	A55T	probably damaging	Het
Serpinb2	C	T	1: 107,523,894 (GRCm38)	T259I	probably benign	Het
Serpinb2	C	A	1: 107,523,834 (GRCm38)	A239E	probably benign	Het
Serpinb2	C	T	1: 107,523,890 (GRCm38)	H258Y	probably benign	Het
Serpinb8	A	G	1: 107,597,527 (GRCm38)	S20G	probably benign	Het
Serpinb8	G	A	1: 107,598,954 (GRCm38)	A75T	probably benign	Het
Serpinb8	A	C	1: 107,607,004 (GRCm38)	L268F	probably benign	Het
Shank2	A	T	7: 144,179,853 (GRCm38)	N482Y	probably damaging	Het
Shc3	A	T	13: 51,482,916 (GRCm38)	V72E	probably damaging	Het
Slc26a9	C	T	1: 131,763,870 (GRCm38)	A617V	probably benign	Het
Slc45a4	A	G	15: 73,586,038 (GRCm38)	I562T	probably damaging	Het
Smc6	T	G	12: 11,317,853 (GRCm38)	V1088G	probably benign	Het
Snx32	C	A	19: 5,496,111 (GRCm38)	R341L	probably benign	Het
Specc1	C	T	11: 62,118,818 (GRCm38)	Q467*	probably null	Het
Spock3	A	T	8: 63,348,947 (GRCm38)	N323I	probably damaging	Het
Stac3	A	G	10: 127,507,766 (GRCm38)	K259R	probably benign	Het
Steap3	T	C	1: 120,227,750 (GRCm38)	N493S	probably benign	Het
Steap3	G	A	1: 120,234,378 (GRCm38)	A350V	probably benign	Het
Stx3	A	G	19: 11,785,523 (GRCm38)	I163T	probably damaging	Het
Suco	A	G	1: 161,827,655 (GRCm38)		probably null	Het
Syngr4	A	G	7: 45,888,722 (GRCm38)	F74S	possibly damaging	Het
Synpo2l	G	A	14: 20,665,819 (GRCm38)	P233S	probably damaging	Het
Tcf4	A	T	18: 69,642,970 (GRCm38)	T163S	probably damaging	Het
Thsd7b	C	T	1: 129,628,891 (GRCm38)	T328I	probably damaging	Het
Thsd7b	T	A	1: 129,667,937 (GRCm38)	F498Y	probably benign	Het
Thsd7b	G	C	1: 129,678,183 (GRCm38)	A554P	probably benign	Het
Thsd7b	A	C	1: 130,116,631 (GRCm38)	Q1116P	probably benign	Het
Tlk1	T	C	2: 70,721,077 (GRCm38)	Y634C	probably damaging	Het
Tnnt2	C	T	1: 135,845,506 (GRCm38)		probably benign	Het
Tox2	T	C	2: 163,247,785 (GRCm38)	Y66H	probably damaging	Het
Trove2	T	C	1: 143,760,034 (GRCm38)	D458G	probably benign	Het
Trove2	C	T	1: 143,760,014 (GRCm38)	V465I	probably benign	Het
Ttn	C	T	2: 76,813,339 (GRCm38)	G11436R	probably damaging	Het
Ttyh1	G	A	7: 4,129,349 (GRCm38)	M261I	probably benign	Het
Ubap2	A	G	4: 41,206,849 (GRCm38)	V509A	probably benign	Het
Ube2t	C	T	1: 134,972,167 (GRCm38)	A149V	probably benign	Het
Ucp3	G	C	7: 100,482,720 (GRCm38)	M259I	probably benign	Het
Unc80	A	T	1: 66,527,892 (GRCm38)	N886Y	probably damaging	Het
Vmn1r197	T	A	13: 22,328,371 (GRCm38)	L154Q	possibly damaging	Het
Vmn1r40	T	A	6: 89,714,315 (GRCm38)	M38K	probably benign	Het
Vmn2r78	C	A	7: 86,920,789 (GRCm38)	Q172K	probably benign	Het
Zc3h11a	G	A	1: 133,622,154 (GRCm38)	P695S	probably benign	Het
Zc3h11a	C	T	1: 133,624,621 (GRCm38)	V583I	probably benign	Het
Zfhx4	A	T	3: 5,401,730 (GRCm38)	D2316V	probably damaging	Het
Zfp108	T	C	7: 24,261,310 (GRCm38)	V442A	probably damaging	Het
Zfp260	A	T	7: 30,104,806 (GRCm38)	T44S	probably benign	Het
Zfp873	C	A	10: 82,060,707 (GRCm38)	T424N	probably damaging	Het
Zp3r	A	G	1: 130,596,814 (GRCm38)	L164P	probably benign	Het
Zp3r	C	A	1: 130,619,414 (GRCm38)	E8D	possibly damaging	Het
Zswim2	T	A	2: 83,915,340 (GRCm38)	K585*	probably null	Het

Other mutations in Hivep3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00953:Hivep3	APN	4	120,098,374 (GRCm38)	missense	probably damaging	1.00
IGL01017:Hivep3	APN	4	120,099,246 (GRCm38)	missense	probably damaging	0.98
IGL01837:Hivep3	APN	4	120,094,562 (GRCm38)	missense	possibly damaging	0.72
IGL01878:Hivep3	APN	4	120,095,227 (GRCm38)	missense	possibly damaging	0.84
IGL02134:Hivep3	APN	4	120,133,574 (GRCm38)	splice site	probably benign
IGL02183:Hivep3	APN	4	120,132,024 (GRCm38)	missense	probably benign	0.04
IGL02350:Hivep3	APN	4	120,123,025 (GRCm38)	missense	probably damaging	1.00
IGL02451:Hivep3	APN	4	120,133,965 (GRCm38)	missense	probably damaging	1.00
IGL02567:Hivep3	APN	4	120,133,956 (GRCm38)	missense	probably damaging	0.99
IGL02617:Hivep3	APN	4	120,095,444 (GRCm38)	missense	probably benign	0.04
IGL02725:Hivep3	APN	4	120,095,822 (GRCm38)	missense	possibly damaging	0.48
IGL02828:Hivep3	APN	4	120,097,732 (GRCm38)	nonsense	probably null
IGL02954:Hivep3	APN	4	120,133,641 (GRCm38)	missense	probably damaging	1.00
IGL02966:Hivep3	APN	4	120,132,186 (GRCm38)	missense	probably benign	0.04
Branchial	UTSW	4	120,096,575 (GRCm38)	missense	possibly damaging	0.92
Deceit	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
Mandible	UTSW	4	120,097,121 (GRCm38)	missense	probably damaging	0.99
Sclerotic	UTSW	4	120,095,099 (GRCm38)	missense	possibly damaging	0.82
Stealth	UTSW	4	120,122,876 (GRCm38)	nonsense	probably null
Yellowjacket	UTSW	4	120,132,357 (GRCm38)	missense	probably benign	0.01
PIT4260001:Hivep3	UTSW	4	120,099,182 (GRCm38)	missense	probably damaging	1.00
R0321:Hivep3	UTSW	4	120,095,591 (GRCm38)	missense	possibly damaging	0.84
R0336:Hivep3	UTSW	4	120,103,847 (GRCm38)	missense	probably damaging	1.00
R0558:Hivep3	UTSW	4	120,096,566 (GRCm38)	missense	probably damaging	0.98
R0562:Hivep3	UTSW	4	120,096,554 (GRCm38)	missense	probably benign	0.00
R0637:Hivep3	UTSW	4	120,132,541 (GRCm38)	nonsense	probably null
R0645:Hivep3	UTSW	4	120,097,334 (GRCm38)	missense	possibly damaging	0.95
R1186:Hivep3	UTSW	4	119,814,723 (GRCm38)	start gained	probably benign
R1254:Hivep3	UTSW	4	120,099,293 (GRCm38)	missense	probably damaging	1.00
R1428:Hivep3	UTSW	4	120,096,575 (GRCm38)	missense	possibly damaging	0.92
R1623:Hivep3	UTSW	4	120,095,704 (GRCm38)	missense	possibly damaging	0.84
R1766:Hivep3	UTSW	4	120,096,671 (GRCm38)	missense	probably benign
R1769:Hivep3	UTSW	4	120,097,571 (GRCm38)	missense	possibly damaging	0.68
R1773:Hivep3	UTSW	4	120,098,837 (GRCm38)	missense	probably damaging	1.00
R1968:Hivep3	UTSW	4	120,096,238 (GRCm38)	missense	possibly damaging	0.83
R2220:Hivep3	UTSW	4	119,734,038 (GRCm38)	missense	possibly damaging	0.92
R2428:Hivep3	UTSW	4	120,098,508 (GRCm38)	nonsense	probably null
R3789:Hivep3	UTSW	4	120,098,416 (GRCm38)	missense	probably damaging	1.00
R3917:Hivep3	UTSW	4	120,099,427 (GRCm38)	missense	probably benign	0.27
R4366:Hivep3	UTSW	4	120,096,089 (GRCm38)	missense	possibly damaging	0.84
R4436:Hivep3	UTSW	4	120,095,923 (GRCm38)	missense	probably benign	0.11
R4504:Hivep3	UTSW	4	119,733,793 (GRCm38)	unclassified	probably benign
R4705:Hivep3	UTSW	4	119,872,050 (GRCm38)	intron	probably benign
R4713:Hivep3	UTSW	4	120,131,803 (GRCm38)	missense	probably damaging	1.00
R4756:Hivep3	UTSW	4	120,097,823 (GRCm38)	missense	probably damaging	0.98
R4887:Hivep3	UTSW	4	120,122,934 (GRCm38)	missense	probably damaging	1.00
R4888:Hivep3	UTSW	4	120,122,934 (GRCm38)	missense	probably damaging	1.00
R5008:Hivep3	UTSW	4	120,098,917 (GRCm38)	missense	probably benign	0.22
R5204:Hivep3	UTSW	4	120,103,856 (GRCm38)	critical splice donor site	probably null
R5594:Hivep3	UTSW	4	120,123,048 (GRCm38)	critical splice donor site	probably null
R5697:Hivep3	UTSW	4	120,096,955 (GRCm38)	missense	possibly damaging	0.68
R5715:Hivep3	UTSW	4	120,096,373 (GRCm38)	missense	probably benign
R5740:Hivep3	UTSW	4	120,096,023 (GRCm38)	missense	possibly damaging	0.83
R5760:Hivep3	UTSW	4	120,095,011 (GRCm38)	missense	possibly damaging	0.83
R5923:Hivep3	UTSW	4	120,096,293 (GRCm38)	missense	possibly damaging	0.92
R5927:Hivep3	UTSW	4	120,097,108 (GRCm38)	missense	possibly damaging	0.68
R6042:Hivep3	UTSW	4	120,097,864 (GRCm38)	missense	possibly damaging	0.85
R6074:Hivep3	UTSW	4	120,097,694 (GRCm38)	missense	possibly damaging	0.68
R6150:Hivep3	UTSW	4	119,734,077 (GRCm38)	nonsense	probably null
R6211:Hivep3	UTSW	4	120,098,405 (GRCm38)	missense	probably damaging	1.00
R6251:Hivep3	UTSW	4	120,094,940 (GRCm38)	missense	probably damaging	0.98
R6451:Hivep3	UTSW	4	120,098,908 (GRCm38)	missense	probably benign	0.22
R6531:Hivep3	UTSW	4	120,122,876 (GRCm38)	nonsense	probably null
R6651:Hivep3	UTSW	4	120,122,949 (GRCm38)	missense	probably damaging	1.00
R6701:Hivep3	UTSW	4	120,094,540 (GRCm38)	missense	probably damaging	0.97
R6721:Hivep3	UTSW	4	120,095,099 (GRCm38)	missense	possibly damaging	0.82
R6796:Hivep3	UTSW	4	120,096,361 (GRCm38)	missense	possibly damaging	0.68
R6864:Hivep3	UTSW	4	120,094,888 (GRCm38)	missense	possibly damaging	0.48
R6902:Hivep3	UTSW	4	120,095,995 (GRCm38)	missense	possibly damaging	0.48
R7111:Hivep3	UTSW	4	120,095,234 (GRCm38)	missense	possibly damaging	0.68
R7113:Hivep3	UTSW	4	120,098,369 (GRCm38)	missense	probably damaging	1.00
R7140:Hivep3	UTSW	4	120,097,121 (GRCm38)	missense	probably damaging	0.99
R7189:Hivep3	UTSW	4	120,132,219 (GRCm38)	missense	probably damaging	0.99
R7218:Hivep3	UTSW	4	120,095,452 (GRCm38)	missense	possibly damaging	0.92
R7366:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7368:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7491:Hivep3	UTSW	4	120,098,830 (GRCm38)	missense	probably benign	0.09
R7496:Hivep3	UTSW	4	120,132,402 (GRCm38)	missense	probably benign	0.00
R7514:Hivep3	UTSW	4	120,096,855 (GRCm38)	missense	possibly damaging	0.48
R7604:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7605:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7607:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7610:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7611:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7613:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7626:Hivep3	UTSW	4	120,097,911 (GRCm38)	frame shift	probably null
R7707:Hivep3	UTSW	4	119,733,959 (GRCm38)	missense
R7736:Hivep3	UTSW	4	120,095,543 (GRCm38)	missense	possibly damaging	0.92
R7915:Hivep3	UTSW	4	120,097,765 (GRCm38)	missense	possibly damaging	0.83
R7943:Hivep3	UTSW	4	120,132,357 (GRCm38)	missense	probably benign	0.01
R7972:Hivep3	UTSW	4	120,097,514 (GRCm38)	missense	possibly damaging	0.48
R8093:Hivep3	UTSW	4	120,095,435 (GRCm38)	missense	possibly damaging	0.68
R8111:Hivep3	UTSW	4	120,098,386 (GRCm38)	missense	probably damaging	0.99
R8215:Hivep3	UTSW	4	120,122,901 (GRCm38)	missense	probably damaging	1.00
R8364:Hivep3	UTSW	4	120,099,442 (GRCm38)	missense	probably benign	0.10
R8467:Hivep3	UTSW	4	120,095,041 (GRCm38)	missense	probably damaging	0.98
R8768:Hivep3	UTSW	4	120,132,324 (GRCm38)	missense	probably damaging	0.99
R8890:Hivep3	UTSW	4	120,096,460 (GRCm38)	missense	possibly damaging	0.95
R8902:Hivep3	UTSW	4	120,096,740 (GRCm38)	missense	possibly damaging	0.83
R9022:Hivep3	UTSW	4	120,098,107 (GRCm38)	missense	probably benign	0.09
R9336:Hivep3	UTSW	4	120,095,203 (GRCm38)	missense	possibly damaging	0.84
R9606:Hivep3	UTSW	4	120,132,589 (GRCm38)	missense	probably damaging	0.98
RF019:Hivep3	UTSW	4	120,098,270 (GRCm38)	missense	probably benign	0.12
X0062:Hivep3	UTSW	4	120,098,698 (GRCm38)	missense	probably damaging	1.00
X0067:Hivep3	UTSW	4	120,131,787 (GRCm38)	missense	probably damaging	0.96
Z1176:Hivep3	UTSW	4	120,133,782 (GRCm38)	missense	probably damaging	1.00
Z1177:Hivep3	UTSW	4	120,131,778 (GRCm38)	nonsense	probably null
Z1177:Hivep3	UTSW	4	120,095,946 (GRCm38)	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- TGAGGAGCTGCCTGGCATCCCTAAG -3'
(R):5'- GCGTGAGAAGTACCCGGACTCTGTG -3'

Sequencing Primer
(F):5'- AGGTCTCCCTGAAACCTGC -3'
(R):5'- CCGGAGCTGTACAAACTACTTG -3'

Posted On

2014-05-23