Incidental Mutation 'R1741:Trappc11'
ID 200357
Institutional Source Beutler Lab
Gene Symbol Trappc11
Ensembl Gene ENSMUSG00000038102
Gene Name trafficking protein particle complex 11
Synonyms D030016E14Rik
MMRRC Submission 039773-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1741 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 47943163-47986505 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 47982362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000047562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033973] [ENSMUST00000039061] [ENSMUST00000175692] [ENSMUST00000176379]
AlphaFold B2RXC1
Predicted Effect probably benign
Transcript: ENSMUST00000033973
SMART Domains Protein: ENSMUSP00000033973
Gene: ENSMUSG00000031568

DomainStartEndE-ValueType
RWD 9 111 1.07e-12 SMART
low complexity region 131 153 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000039061
SMART Domains Protein: ENSMUSP00000047562
Gene: ENSMUSG00000038102

DomainStartEndE-ValueType
Pfam:Foie-gras_1 263 522 3e-78 PFAM
Pfam:Gryzun 978 1114 3.9e-10 PFAM
Pfam:Gryzun-like 1036 1095 2.4e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123958
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125065
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131551
Predicted Effect probably benign
Transcript: ENSMUST00000175692
Predicted Effect probably benign
Transcript: ENSMUST00000176379
SMART Domains Protein: ENSMUSP00000135059
Gene: ENSMUSG00000031568

DomainStartEndE-ValueType
RWD 9 111 1.07e-12 SMART
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.5%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034E13Rik A G 18: 52,793,578 (GRCm39) N37S probably damaging Het
Acad10 T C 5: 121,785,899 (GRCm39) K230R probably damaging Het
Actl7a A G 4: 56,744,252 (GRCm39) N260D probably benign Het
Adam24 T C 8: 41,132,642 (GRCm39) Y37H probably benign Het
Ahcy G A 2: 154,906,154 (GRCm39) A229V probably benign Het
Ap3b2 A G 7: 81,117,347 (GRCm39) V563A possibly damaging Het
Bcl9l T A 9: 44,420,986 (GRCm39) M1427K probably damaging Het
Btf3 C T 13: 98,452,804 (GRCm39) M1I probably null Het
Btg4 A T 9: 51,027,910 (GRCm39) I27L probably benign Het
Ccdc171 A G 4: 83,539,076 (GRCm39) Y366C probably damaging Het
Chd3 A G 11: 69,246,480 (GRCm39) Y1085H probably damaging Het
Cnot10 T C 9: 114,426,892 (GRCm39) D616G possibly damaging Het
Crlf1 C A 8: 70,953,556 (GRCm39) D243E probably damaging Het
Cyp2b23 A G 7: 26,372,502 (GRCm39) V371A possibly damaging Het
Dennd2a A G 6: 39,470,091 (GRCm39) S534P probably damaging Het
Eln A G 5: 134,758,038 (GRCm39) V185A unknown Het
Epor C T 9: 21,871,067 (GRCm39) G301D probably damaging Het
Fam83f T G 15: 80,576,468 (GRCm39) V373G possibly damaging Het
Fbxl21 A T 13: 56,684,915 (GRCm39) T340S probably benign Het
Fcgbpl1 G T 7: 27,857,279 (GRCm39) C2209F probably damaging Het
Fez1 T A 9: 36,755,029 (GRCm39) D9E probably damaging Het
Fsip2 T C 2: 82,820,256 (GRCm39) F5330L probably benign Het
Glis1 G A 4: 107,425,544 (GRCm39) R197Q probably damaging Het
Gm10277 TC T 11: 77,676,828 (GRCm39) probably null Het
Gpr158 A G 2: 21,832,359 (GRCm39) N1153S probably benign Het
Gramd4 T C 15: 85,975,730 (GRCm39) probably null Het
Hhatl T A 9: 121,618,125 (GRCm39) Y210F possibly damaging Het
Hltf T C 3: 20,140,352 (GRCm39) W422R probably damaging Het
Hspa5 T C 2: 34,662,704 (GRCm39) S87P possibly damaging Het
Il21 T C 3: 37,281,811 (GRCm39) H111R probably benign Het
Ip6k1 G A 9: 107,918,183 (GRCm39) G73S probably benign Het
Kdm5b A G 1: 134,545,755 (GRCm39) D972G possibly damaging Het
Kif21b C T 1: 136,083,880 (GRCm39) A709V probably damaging Het
Kmt2d T C 15: 98,743,115 (GRCm39) probably benign Het
Lrrc14b A G 13: 74,511,705 (GRCm39) L125P probably damaging Het
Mapk8ip3 A G 17: 25,118,828 (GRCm39) S1169P probably damaging Het
Me3 A T 7: 89,501,041 (GRCm39) Y584F probably damaging Het
Mxra7 T G 11: 116,707,070 (GRCm39) probably null Het
Nf1 T C 11: 79,334,757 (GRCm39) S870P probably benign Het
Npr2 G A 4: 43,643,350 (GRCm39) G525S probably damaging Het
Nyap1 A T 5: 137,731,387 (GRCm39) S726T probably damaging Het
Padi4 A G 4: 140,473,481 (GRCm39) V652A probably damaging Het
Pclo A G 5: 14,726,524 (GRCm39) probably benign Het
Pgm1 G A 4: 99,822,062 (GRCm39) probably null Het
Piezo2 A G 18: 63,154,244 (GRCm39) S2512P probably damaging Het
Ptbp3 A T 4: 59,482,624 (GRCm39) D386E probably damaging Het
Ptk2 A G 15: 73,114,255 (GRCm39) V701A possibly damaging Het
Ptpn3 A G 4: 57,254,922 (GRCm39) V154A probably damaging Het
Rassf4 T C 6: 116,616,450 (GRCm39) E287G probably damaging Het
Rnh1 C T 7: 140,743,936 (GRCm39) R174H probably benign Het
Scn9a T A 2: 66,317,938 (GRCm39) I1517F probably damaging Het
Sftpb C A 6: 72,282,797 (GRCm39) A90E probably benign Het
Slc39a14 T C 14: 70,556,193 (GRCm39) K61R probably damaging Het
Tmem132d A C 5: 127,861,922 (GRCm39) M733R probably benign Het
Tmem248 A G 5: 130,265,664 (GRCm39) I156V probably benign Het
Traf2 T C 2: 25,414,495 (GRCm39) D339G probably damaging Het
Tuba8 T A 6: 121,199,727 (GRCm39) I137N possibly damaging Het
Txlnb A G 10: 17,714,695 (GRCm39) T376A probably damaging Het
Usp34 A G 11: 23,314,103 (GRCm39) T663A probably benign Het
Vmn2r26 T A 6: 124,038,431 (GRCm39) F669I probably damaging Het
Wdr95 G A 5: 149,518,861 (GRCm39) probably null Het
Wfdc8 T G 2: 164,450,789 (GRCm39) probably benign Het
Zfp64 A C 2: 168,768,238 (GRCm39) V458G probably benign Het
Zfp868 C T 8: 70,064,519 (GRCm39) G272D probably damaging Het
Other mutations in Trappc11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Trappc11 APN 8 47,956,337 (GRCm39) unclassified probably benign
IGL01300:Trappc11 APN 8 47,954,903 (GRCm39) missense probably benign
IGL01312:Trappc11 APN 8 47,958,712 (GRCm39) missense possibly damaging 0.95
IGL01344:Trappc11 APN 8 47,972,739 (GRCm39) missense probably damaging 1.00
IGL01518:Trappc11 APN 8 47,954,904 (GRCm39) splice site probably null
IGL01747:Trappc11 APN 8 47,972,656 (GRCm39) missense probably benign 0.41
IGL01781:Trappc11 APN 8 47,967,163 (GRCm39) missense possibly damaging 0.95
IGL01908:Trappc11 APN 8 47,957,029 (GRCm39) missense probably damaging 1.00
IGL01956:Trappc11 APN 8 47,981,036 (GRCm39) missense possibly damaging 0.86
IGL02266:Trappc11 APN 8 47,958,766 (GRCm39) missense probably damaging 1.00
IGL02377:Trappc11 APN 8 47,983,685 (GRCm39) critical splice donor site probably null
IGL02530:Trappc11 APN 8 47,960,617 (GRCm39) missense probably damaging 1.00
IGL02676:Trappc11 APN 8 47,946,448 (GRCm39) splice site probably benign
IGL03030:Trappc11 APN 8 47,966,964 (GRCm39) missense probably damaging 0.98
IGL03393:Trappc11 APN 8 47,963,912 (GRCm39) missense possibly damaging 0.95
bantu UTSW 8 47,951,701 (GRCm39) missense probably benign 0.44
bunyoro UTSW 8 47,965,320 (GRCm39) splice site probably null
nyoro UTSW 8 47,980,014 (GRCm39) missense possibly damaging 0.73
serval UTSW 8 47,957,000 (GRCm39) missense probably damaging 1.00
R0009:Trappc11 UTSW 8 47,956,355 (GRCm39) missense possibly damaging 0.70
R0009:Trappc11 UTSW 8 47,956,355 (GRCm39) missense possibly damaging 0.70
R0043:Trappc11 UTSW 8 47,958,610 (GRCm39) splice site probably benign
R0180:Trappc11 UTSW 8 47,981,009 (GRCm39) missense possibly damaging 0.86
R0529:Trappc11 UTSW 8 47,980,014 (GRCm39) missense possibly damaging 0.73
R0538:Trappc11 UTSW 8 47,956,447 (GRCm39) missense probably benign 0.01
R0740:Trappc11 UTSW 8 47,977,623 (GRCm39) missense probably damaging 0.99
R1352:Trappc11 UTSW 8 47,978,081 (GRCm39) missense possibly damaging 0.90
R1469:Trappc11 UTSW 8 47,957,000 (GRCm39) missense probably damaging 1.00
R1469:Trappc11 UTSW 8 47,957,000 (GRCm39) missense probably damaging 1.00
R1502:Trappc11 UTSW 8 47,983,862 (GRCm39) missense possibly damaging 0.94
R1589:Trappc11 UTSW 8 47,954,715 (GRCm39) missense probably damaging 1.00
R2292:Trappc11 UTSW 8 47,958,771 (GRCm39) missense probably damaging 1.00
R2303:Trappc11 UTSW 8 47,956,451 (GRCm39) missense probably damaging 0.99
R2931:Trappc11 UTSW 8 47,956,977 (GRCm39) missense probably damaging 0.99
R3522:Trappc11 UTSW 8 47,951,708 (GRCm39) missense possibly damaging 0.93
R3714:Trappc11 UTSW 8 47,958,351 (GRCm39) intron probably benign
R3739:Trappc11 UTSW 8 47,967,138 (GRCm39) missense probably damaging 0.98
R4165:Trappc11 UTSW 8 47,978,003 (GRCm39) splice site probably benign
R4581:Trappc11 UTSW 8 47,946,380 (GRCm39) missense probably damaging 0.97
R4598:Trappc11 UTSW 8 47,966,801 (GRCm39) missense probably damaging 0.98
R4939:Trappc11 UTSW 8 47,972,700 (GRCm39) missense probably damaging 1.00
R4990:Trappc11 UTSW 8 47,943,930 (GRCm39) missense probably benign 0.41
R4994:Trappc11 UTSW 8 47,975,476 (GRCm39) nonsense probably null
R5091:Trappc11 UTSW 8 47,965,639 (GRCm39) missense probably benign 0.00
R5123:Trappc11 UTSW 8 47,966,437 (GRCm39) missense probably damaging 0.99
R5176:Trappc11 UTSW 8 47,963,998 (GRCm39) missense possibly damaging 0.79
R5279:Trappc11 UTSW 8 47,958,339 (GRCm39) intron probably benign
R5293:Trappc11 UTSW 8 47,946,377 (GRCm39) missense possibly damaging 0.83
R5294:Trappc11 UTSW 8 47,983,766 (GRCm39) missense possibly damaging 0.88
R5661:Trappc11 UTSW 8 47,965,642 (GRCm39) missense probably damaging 0.99
R5838:Trappc11 UTSW 8 47,965,594 (GRCm39) critical splice donor site probably null
R5889:Trappc11 UTSW 8 47,972,613 (GRCm39) missense probably benign 0.40
R5952:Trappc11 UTSW 8 47,949,952 (GRCm39) critical splice donor site probably null
R5959:Trappc11 UTSW 8 47,954,593 (GRCm39) missense probably damaging 0.97
R6239:Trappc11 UTSW 8 47,982,529 (GRCm39) missense possibly damaging 0.73
R6322:Trappc11 UTSW 8 47,983,808 (GRCm39) missense possibly damaging 0.95
R6369:Trappc11 UTSW 8 47,965,320 (GRCm39) splice site probably null
R7541:Trappc11 UTSW 8 47,958,617 (GRCm39) splice site probably null
R7544:Trappc11 UTSW 8 47,975,449 (GRCm39) missense possibly damaging 0.73
R7762:Trappc11 UTSW 8 47,975,411 (GRCm39) missense probably damaging 0.99
R7964:Trappc11 UTSW 8 47,979,979 (GRCm39) missense possibly damaging 0.54
R8183:Trappc11 UTSW 8 47,982,391 (GRCm39) missense possibly damaging 0.93
R8282:Trappc11 UTSW 8 47,969,624 (GRCm39) missense probably damaging 0.97
R8733:Trappc11 UTSW 8 47,954,883 (GRCm39) missense probably damaging 1.00
R8782:Trappc11 UTSW 8 47,951,701 (GRCm39) missense probably benign 0.44
R8853:Trappc11 UTSW 8 47,982,439 (GRCm39) missense probably damaging 0.98
R9544:Trappc11 UTSW 8 47,972,713 (GRCm39) missense possibly damaging 0.94
R9709:Trappc11 UTSW 8 47,946,348 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CTCCAGGCCAACTAGCCTTCTAAATG -3'
(R):5'- TGACCAGCTAACTGTTTCTGTCACG -3'

Sequencing Primer
(F):5'- TTCAAAGGAGGTCAACAATCTCAG -3'
(R):5'- TGTCACGGTTGGCAGAGAAC -3'
Posted On 2014-05-23