Mutagenetix > Incidental Mutation

Incidental Mutation 'R1742:Ifi206'

200395

Institutional Source

Beutler Lab

Gene Symbol

Ifi206

Ensembl Gene

ENSMUSG00000037849

Gene Name

interferon activated gene 206

Synonyms

Pyblhin-C, Gm4955

MMRRC Submission

039774-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.159) question?

Stock #

R1742 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

173296051-173318607 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 173309537 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 153 (T153I)

Ref Sequence

ENSEMBL: ENSMUSP00000134646 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000160565]

AlphaFold

G3UZV2

Predicted Effect

probably benign
Transcript: ENSMUST00000160565
AA Change: T153I

PolyPhen 2 Score 0.059 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000134646
Gene: ENSMUSG00000037849
AA Change: T153I

Domain	Start	End	E-Value	Type
PYRIN	6	84	5.7e-21	SMART
low complexity region	97	108	N/A	INTRINSIC
internal_repeat_1	154	349	6.25e-15	PROSPERO
internal_repeat_1	342	575	6.25e-15	PROSPERO

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.4%
20x: 92.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankhd1	C	A	18: 36,758,318 (GRCm39)	A1004E	probably damaging	Het
Arfgef2	A	G	2: 166,708,900 (GRCm39)	S1071G	probably damaging	Het
Arhgef5	T	A	6: 43,257,133 (GRCm39)	I1228N	probably damaging	Het
Auh	G	A	13: 52,989,532 (GRCm39)	P308L	probably benign	Het
Bptf	A	G	11: 107,001,777 (GRCm39)	V445A	probably damaging	Het
Btf3	C	T	13: 98,452,804 (GRCm39)	M1I	probably null	Het
Bves	C	T	10: 45,223,961 (GRCm39)	T207M	probably damaging	Het
Ccdc171	T	A	4: 83,599,521 (GRCm39)	S779T	probably damaging	Het
Ccdc54	T	C	16: 50,410,601 (GRCm39)	K222E	possibly damaging	Het
Cebpe	A	G	14: 54,949,057 (GRCm39)	V120A	probably benign	Het
Clhc1	T	A	11: 29,507,647 (GRCm39)		probably null	Het
Col22a1	C	T	15: 71,673,762 (GRCm39)	G985S	unknown	Het
Col6a3	T	A	1: 90,741,516 (GRCm39)	I639F	probably damaging	Het
Cryga	C	A	1: 65,142,280 (GRCm39)	V38L	probably benign	Het
Dll3	T	C	7: 27,993,848 (GRCm39)	T530A	probably benign	Het
Dnaaf9	A	T	2: 130,582,315 (GRCm39)		probably null	Het
Dnah7a	G	A	1: 53,495,843 (GRCm39)	P3205S	probably benign	Het
Dpp10	T	A	1: 123,372,935 (GRCm39)	Y224F	probably damaging	Het
Eif1ad10	C	T	12: 88,216,453 (GRCm39)	D140N	unknown	Het
Fcrl2	T	C	3: 87,166,350 (GRCm39)	T142A	possibly damaging	Het
Fyttd1	C	T	16: 32,725,923 (GRCm39)	R175*	probably null	Het
Gm10277	TC	T	11: 77,676,828 (GRCm39)		probably null	Het
Gpr33	T	C	12: 52,071,045 (GRCm39)		probably null	Het
Gse1	T	A	8: 121,293,689 (GRCm39)	V205E	probably damaging	Het
Herc4	C	A	10: 63,123,728 (GRCm39)	N461K	probably benign	Het
Iqca1	T	C	1: 90,025,773 (GRCm39)	I341V	probably benign	Het
Itsn1	T	G	16: 91,613,847 (GRCm39)		probably null	Het
Kcnk5	T	A	14: 20,191,925 (GRCm39)	Y412F	probably benign	Het
Lemd1	T	A	1: 132,156,036 (GRCm39)	I26K	probably damaging	Het
Lipc	A	T	9: 70,727,811 (GRCm39)	L12Q	probably damaging	Het
Lrrtm1	C	A	6: 77,221,074 (GRCm39)	P177Q	probably damaging	Het
Mcph1	G	A	8: 18,657,379 (GRCm39)	G73R	probably benign	Het
Msantd5f6	T	C	4: 73,319,447 (GRCm39)	D99G	probably damaging	Het
Myh11	A	T	16: 14,037,908 (GRCm39)	L899Q	probably damaging	Het
Myo18a	G	T	11: 77,732,293 (GRCm39)	R822L	probably damaging	Het
Nav3	T	C	10: 109,605,074 (GRCm39)	T1000A	probably benign	Het
Nox4	T	C	7: 86,945,026 (GRCm39)	V94A	possibly damaging	Het
Or10ag53	T	A	2: 87,083,122 (GRCm39)	N280K	probably benign	Het
Or4c123	G	T	2: 89,126,768 (GRCm39)	P282H	probably damaging	Het
Or7g32	A	G	9: 19,389,337 (GRCm39)	S67P	probably damaging	Het
Oxr1	T	C	15: 41,713,955 (GRCm39)	L679P	probably damaging	Het
Pcdhb17	T	C	18: 37,619,629 (GRCm39)	I473T	probably damaging	Het
Pgbd5	T	A	8: 125,107,046 (GRCm39)	E165D	probably damaging	Het
Pgpep1l	A	T	7: 67,886,802 (GRCm39)	V169D	probably damaging	Het
Phf12	C	T	11: 77,900,312 (GRCm39)	T136I	probably benign	Het
Pif1	T	A	9: 65,495,132 (GRCm39)	M14K	probably benign	Het
Pigr	A	G	1: 130,772,823 (GRCm39)	E347G	probably damaging	Het
Plekha3	G	A	2: 76,513,223 (GRCm39)	E103K	possibly damaging	Het
Ptgs2	A	G	1: 149,980,150 (GRCm39)	I363V	probably damaging	Het
Rasl11a	T	A	5: 146,783,805 (GRCm39)		probably null	Het
Recql	T	C	6: 142,310,298 (GRCm39)	T511A	probably damaging	Het
Rgl2	T	A	17: 34,156,197 (GRCm39)		probably null	Het
Rpp25l	T	C	4: 41,712,763 (GRCm39)	Y4C	probably damaging	Het
Sass6	T	G	3: 116,401,126 (GRCm39)	C156G	probably damaging	Het
Sgta	T	G	10: 80,882,111 (GRCm39)	N288T	probably damaging	Het
Slco1a4	T	A	6: 141,770,771 (GRCm39)	T282S	probably benign	Het
Smad4	T	C	18: 73,808,968 (GRCm39)	R100G	probably damaging	Het
Sox8	C	T	17: 25,786,915 (GRCm39)	V263M	probably damaging	Het
Sp8	A	G	12: 118,813,552 (GRCm39)	H469R	probably benign	Het
Spata1	A	T	3: 146,175,378 (GRCm39)		probably null	Het
Taar7a	G	A	10: 23,869,117 (GRCm39)	S88F	probably damaging	Het
Tnks2	T	C	19: 36,853,661 (GRCm39)	L749S	probably damaging	Het
Tollip	C	A	7: 141,446,592 (GRCm39)	R19L	probably damaging	Het
Tox2	G	A	2: 163,067,446 (GRCm39)	R55H	probably benign	Het
Vmn2r27	T	C	6: 124,177,636 (GRCm39)	E456G	possibly damaging	Het
Vmn2r77	T	A	7: 86,444,543 (GRCm39)	N65K	probably benign	Het
Vwf	T	C	6: 125,644,513 (GRCm39)	M2456T	probably benign	Het
Zfp526	A	G	7: 24,923,939 (GRCm39)	N66S	possibly damaging	Het
Zic1	T	C	9: 91,243,629 (GRCm39)	Y446C	probably damaging	Het

Other mutations in Ifi206

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01509:Ifi206	APN	1	173,313,142 (GRCm39)	missense	probably benign	0.00
IGL02044:Ifi206	APN	1	173,308,557 (GRCm39)	missense	probably benign	0.41
IGL02118:Ifi206	APN	1	173,309,334 (GRCm39)	missense	probably benign	0.05
IGL02476:Ifi206	APN	1	173,309,132 (GRCm39)	missense	probably benign	0.02
IGL02824:Ifi206	APN	1	173,309,438 (GRCm39)	missense	possibly damaging	0.95
IGL03375:Ifi206	APN	1	173,308,344 (GRCm39)	missense	probably benign	0.06
PIT4142001:Ifi206	UTSW	1	173,308,730 (GRCm39)	missense	probably benign	0.02
R0069:Ifi206	UTSW	1	173,314,413 (GRCm39)	missense	probably damaging	1.00
R0741:Ifi206	UTSW	1	173,301,315 (GRCm39)	missense	probably benign	0.41
R1572:Ifi206	UTSW	1	173,314,419 (GRCm39)	missense	probably benign	0.10
R4109:Ifi206	UTSW	1	173,308,554 (GRCm39)	missense	probably benign	0.00
R4707:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4783:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4785:Ifi206	UTSW	1	173,308,432 (GRCm39)	missense	probably benign	0.00
R4805:Ifi206	UTSW	1	173,308,952 (GRCm39)	missense	possibly damaging	0.55
R4918:Ifi206	UTSW	1	173,309,610 (GRCm39)	missense	possibly damaging	0.73
R5043:Ifi206	UTSW	1	173,314,284 (GRCm39)	missense	probably damaging	1.00
R5080:Ifi206	UTSW	1	173,301,414 (GRCm39)	missense	possibly damaging	0.61
R5419:Ifi206	UTSW	1	173,308,797 (GRCm39)	missense	probably benign	0.05
R5420:Ifi206	UTSW	1	173,308,599 (GRCm39)	missense	possibly damaging	0.84
R5777:Ifi206	UTSW	1	173,308,928 (GRCm39)	missense	possibly damaging	0.55
R5988:Ifi206	UTSW	1	173,308,906 (GRCm39)	missense	possibly damaging	0.90
R6772:Ifi206	UTSW	1	173,308,773 (GRCm39)	missense	unknown
R6782:Ifi206	UTSW	1	173,308,923 (GRCm39)	missense	unknown
R6806:Ifi206	UTSW	1	173,309,137 (GRCm39)	missense	probably benign	0.06
R7042:Ifi206	UTSW	1	173,308,808 (GRCm39)	missense
R7091:Ifi206	UTSW	1	173,301,441 (GRCm39)	missense	unknown
R7292:Ifi206	UTSW	1	173,301,428 (GRCm39)	missense	unknown
R7429:Ifi206	UTSW	1	173,308,157 (GRCm39)	missense
R7499:Ifi206	UTSW	1	173,309,607 (GRCm39)	missense
R7772:Ifi206	UTSW	1	173,308,640 (GRCm39)	missense
R7853:Ifi206	UTSW	1	173,299,100 (GRCm39)	nonsense	probably null
R7971:Ifi206	UTSW	1	173,298,976 (GRCm39)	missense	unknown
R8079:Ifi206	UTSW	1	173,308,724 (GRCm39)	missense
R8205:Ifi206	UTSW	1	173,309,450 (GRCm39)	missense
R8289:Ifi206	UTSW	1	173,308,032 (GRCm39)	missense
R8390:Ifi206	UTSW	1	173,308,511 (GRCm39)	missense
R8500:Ifi206	UTSW	1	173,314,311 (GRCm39)	missense
R8712:Ifi206	UTSW	1	173,308,074 (GRCm39)	missense
R8753:Ifi206	UTSW	1	173,301,223 (GRCm39)	missense	unknown
R8875:Ifi206	UTSW	1	173,301,353 (GRCm39)	missense	unknown
R9128:Ifi206	UTSW	1	173,299,022 (GRCm39)	missense	unknown
R9369:Ifi206	UTSW	1	173,301,489 (GRCm39)	missense	unknown
R9569:Ifi206	UTSW	1	173,314,209 (GRCm39)	missense
R9676:Ifi206	UTSW	1	173,308,718 (GRCm39)	missense
R9695:Ifi206	UTSW	1	173,301,249 (GRCm39)	missense	unknown
R9776:Ifi206	UTSW	1	173,308,075 (GRCm39)	missense
X0052:Ifi206	UTSW	1	173,309,535 (GRCm39)	missense	possibly damaging	0.89
Z1088:Ifi206	UTSW	1	173,301,577 (GRCm39)	missense	probably damaging	1.00
Z1176:Ifi206	UTSW	1	173,309,614 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- AGGCACCCGAGAAGATTTGTCAC -3'
(R):5'- CTCTAAAGATGCCTCATGCAGCCC -3'

Sequencing Primer
(F):5'- CCGAGAAGATTTGTCACAGGTG -3'
(R):5'- CCTCATGCAGCCCAGATG -3'

Posted On

2014-05-23