Incidental Mutation 'R1411:Cyp2j11'
ID 200793
Institutional Source Beutler Lab
Gene Symbol Cyp2j11
Ensembl Gene ENSMUSG00000066097
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms Cyp2j11-ps
MMRRC Submission 039467-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R1411 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 96182745-96236899 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96233453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 81 (I81T)
Ref Sequence ENSEMBL: ENSMUSP00000132180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015368]
AlphaFold Q3UNV2
Predicted Effect probably benign
Transcript: ENSMUST00000015368
AA Change: I81T

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000132180
Gene: ENSMUSG00000066097
AA Change: I81T

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:p450 44 500 4.3e-133 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 97.5%
  • 3x: 96.9%
  • 10x: 95.3%
  • 20x: 92.5%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 T A 8: 71,914,374 (GRCm39) I85F probably damaging Het
Acp4 A G 7: 43,906,267 (GRCm39) probably benign Het
Baz1b T C 5: 135,259,177 (GRCm39) F1080L possibly damaging Het
Cbx5 A T 15: 103,121,547 (GRCm39) M30K probably benign Het
Cdc73 A G 1: 143,485,252 (GRCm39) probably benign Het
Cdcp1 A T 9: 123,019,177 (GRCm39) L34Q probably damaging Het
Chd8 C T 14: 52,462,103 (GRCm39) V738I probably benign Het
Cpeb2 T G 5: 43,391,113 (GRCm39) probably benign Het
Cyp2c67 T A 19: 39,627,035 (GRCm39) D265V probably damaging Het
Dbx2 T C 15: 95,530,262 (GRCm39) E235G probably damaging Het
Dgkq C A 5: 108,798,228 (GRCm39) V677F probably damaging Het
Ercc5 A G 1: 44,217,441 (GRCm39) N928S probably damaging Het
Flt1 C T 5: 147,517,126 (GRCm39) V1054M probably damaging Het
Flywch1 T C 17: 23,974,798 (GRCm39) D614G probably damaging Het
Frmd3 T C 4: 74,071,858 (GRCm39) F247L probably damaging Het
Gm1527 A G 3: 28,968,632 (GRCm39) N228S probably benign Het
Gpld1 T A 13: 25,146,791 (GRCm39) L251Q probably damaging Het
Gvin-ps3 C T 7: 105,682,686 (GRCm39) A190T probably benign Het
Gzma C T 13: 113,232,742 (GRCm39) V117I probably benign Het
Hydin C A 8: 111,301,663 (GRCm39) T3798K probably benign Het
Il1rapl1 T A X: 85,790,904 (GRCm39) S679C possibly damaging Het
Lrrc8c G A 5: 105,756,045 (GRCm39) A607T probably damaging Het
Ltbp1 A G 17: 75,532,280 (GRCm39) Q118R possibly damaging Het
Mfsd4b4 A T 10: 39,768,136 (GRCm39) M319K probably damaging Het
Mroh2b A C 15: 4,947,799 (GRCm39) H538P probably damaging Het
Nrbp1 T A 5: 31,403,157 (GRCm39) I210N probably damaging Het
Nup188 A G 2: 30,233,807 (GRCm39) T1733A probably benign Het
Nup58 A T 14: 60,482,119 (GRCm39) probably benign Het
Ofcc1 A G 13: 40,296,263 (GRCm39) S524P probably benign Het
Or6x1 C T 9: 40,098,435 (GRCm39) T8I possibly damaging Het
Padi4 C T 4: 140,479,914 (GRCm39) S413N probably damaging Het
Pdzrn4 A G 15: 92,668,894 (GRCm39) *1015W probably null Het
Pkhd1 G A 1: 20,444,120 (GRCm39) P2314L probably damaging Het
Serpinb9c C G 13: 33,335,817 (GRCm39) V212L probably benign Het
Slc25a23 A G 17: 57,366,622 (GRCm39) F18L probably damaging Het
Smarca4 C A 9: 21,570,251 (GRCm39) N751K probably damaging Het
Tfip11 G T 5: 112,480,899 (GRCm39) V292L probably benign Het
Tnrc18 T C 5: 142,751,702 (GRCm39) K1201R unknown Het
Vmn1r199 T C 13: 22,567,671 (GRCm39) F322L probably benign Het
Vmn1r201 T C 13: 22,658,849 (GRCm39) V21A probably benign Het
Vmn2r108 A T 17: 20,683,107 (GRCm39) I699K probably damaging Het
Vmn2r117 T C 17: 23,679,527 (GRCm39) N566D probably damaging Het
Wdr12 A T 1: 60,127,231 (GRCm39) D141E probably benign Het
Zfp974 A G 7: 27,610,634 (GRCm39) S364P probably benign Het
Other mutations in Cyp2j11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Cyp2j11 APN 4 96,227,332 (GRCm39) missense probably benign
IGL01816:Cyp2j11 APN 4 96,183,161 (GRCm39) missense probably damaging 1.00
IGL02406:Cyp2j11 APN 4 96,236,776 (GRCm39) missense possibly damaging 0.56
E7848:Cyp2j11 UTSW 4 96,207,602 (GRCm39) missense probably benign 0.09
R0020:Cyp2j11 UTSW 4 96,195,641 (GRCm39) missense probably benign 0.19
R0020:Cyp2j11 UTSW 4 96,195,641 (GRCm39) missense probably benign 0.19
R1298:Cyp2j11 UTSW 4 96,195,497 (GRCm39) critical splice donor site probably null
R1428:Cyp2j11 UTSW 4 96,183,117 (GRCm39) missense probably benign 0.01
R1740:Cyp2j11 UTSW 4 96,207,613 (GRCm39) missense probably benign 0.00
R1818:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1819:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1917:Cyp2j11 UTSW 4 96,228,211 (GRCm39) missense probably damaging 1.00
R2084:Cyp2j11 UTSW 4 96,227,438 (GRCm39) missense probably damaging 1.00
R2146:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2148:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2150:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R4963:Cyp2j11 UTSW 4 96,204,619 (GRCm39) missense probably damaging 1.00
R5335:Cyp2j11 UTSW 4 96,195,589 (GRCm39) missense probably damaging 1.00
R5450:Cyp2j11 UTSW 4 96,228,113 (GRCm39) missense probably benign 0.44
R5688:Cyp2j11 UTSW 4 96,233,358 (GRCm39) missense probably damaging 1.00
R5978:Cyp2j11 UTSW 4 96,207,589 (GRCm39) missense probably damaging 1.00
R6061:Cyp2j11 UTSW 4 96,236,853 (GRCm39) start gained probably benign
R6075:Cyp2j11 UTSW 4 96,233,322 (GRCm39) missense probably benign 0.04
R6912:Cyp2j11 UTSW 4 96,183,108 (GRCm39) missense probably benign 0.00
R7338:Cyp2j11 UTSW 4 96,195,524 (GRCm39) missense possibly damaging 0.64
R7394:Cyp2j11 UTSW 4 96,204,677 (GRCm39) missense probably benign 0.00
R7464:Cyp2j11 UTSW 4 96,233,357 (GRCm39) missense probably damaging 1.00
R7972:Cyp2j11 UTSW 4 96,185,871 (GRCm39) missense probably damaging 1.00
R8152:Cyp2j11 UTSW 4 96,195,529 (GRCm39) missense probably damaging 1.00
R8328:Cyp2j11 UTSW 4 96,236,605 (GRCm39) missense probably benign 0.03
R8383:Cyp2j11 UTSW 4 96,236,695 (GRCm39) missense probably benign 0.00
R8519:Cyp2j11 UTSW 4 96,207,539 (GRCm39) missense probably benign 0.44
R8789:Cyp2j11 UTSW 4 96,227,405 (GRCm39) missense probably damaging 0.99
R9268:Cyp2j11 UTSW 4 96,207,781 (GRCm39) intron probably benign
R9323:Cyp2j11 UTSW 4 96,195,619 (GRCm39) missense probably benign 0.01
R9457:Cyp2j11 UTSW 4 96,195,596 (GRCm39) missense probably damaging 0.98
R9590:Cyp2j11 UTSW 4 96,195,614 (GRCm39) missense probably benign 0.11
Z1176:Cyp2j11 UTSW 4 96,195,673 (GRCm39) missense probably damaging 0.99
Z1176:Cyp2j11 UTSW 4 96,195,540 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CAATGGAACATTGCCACAGTTTCCC -3'
(R):5'- TGAGTACCTGAGCCTCTGCCTTTG -3'

Sequencing Primer
(F):5'- ACATTGCCACAGTTTCCCATTTTC -3'
(R):5'- GAATTCTTCAGGTAGAGACCCAG -3'
Posted On 2014-05-23