Mutagenetix > Incidental Mutation

Incidental Mutation 'R1464:Inpp5d'

200904

Institutional Source

Beutler Lab

Gene Symbol

Inpp5d

Ensembl Gene

ENSMUSG00000026288

Gene Name

inositol polyphosphate-5-phosphatase D

Synonyms

SHIP1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP, SHIP-1

MMRRC Submission

039518-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.914) question?

Stock #

R1464 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

87548034-87648229 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 87625827 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132384 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042275] [ENSMUST00000072999] [ENSMUST00000167032] [ENSMUST00000168783] [ENSMUST00000169754] [ENSMUST00000170300]

AlphaFold

Q9ES52

Predicted Effect

probably benign
Transcript: ENSMUST00000042275

SMART Domains

Protein: ENSMUSP00000044647
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
SH2	6	95	7.15e-29	SMART
low complexity region	107	120	N/A	INTRINSIC
IPPc	404	720	4.5e-104	SMART
low complexity region	767	777	N/A	INTRINSIC
low complexity region	954	979	N/A	INTRINSIC
low complexity region	1045	1057	N/A	INTRINSIC
low complexity region	1119	1131	N/A	INTRINSIC
low complexity region	1139	1148	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000072999

SMART Domains

Protein: ENSMUSP00000072763
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
SH2	6	95	7.15e-29	SMART
low complexity region	107	120	N/A	INTRINSIC
IPPc	404	720	4.5e-104	SMART
low complexity region	767	777	N/A	INTRINSIC
low complexity region	932	953	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167032

SMART Domains

Protein: ENSMUSP00000126569
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
IPPc	142	458	4.5e-104	SMART
low complexity region	505	515	N/A	INTRINSIC
low complexity region	692	717	N/A	INTRINSIC
low complexity region	783	795	N/A	INTRINSIC
low complexity region	857	869	N/A	INTRINSIC
low complexity region	877	886	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000168783

SMART Domains

Protein: ENSMUSP00000131244
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
SH2	6	95	7.15e-29	SMART
low complexity region	107	118	N/A	INTRINSIC
IPPc	405	721	4.5e-104	SMART
low complexity region	768	778	N/A	INTRINSIC
low complexity region	985	997	N/A	INTRINSIC
low complexity region	1059	1071	N/A	INTRINSIC
low complexity region	1079	1088	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000169754

SMART Domains

Protein: ENSMUSP00000127941
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
SH2	6	95	4.6e-31	SMART
low complexity region	107	118	N/A	INTRINSIC
IPPc	405	721	2.2e-106	SMART
low complexity region	768	778	N/A	INTRINSIC
low complexity region	955	980	N/A	INTRINSIC
low complexity region	1046	1058	N/A	INTRINSIC
low complexity region	1120	1132	N/A	INTRINSIC
low complexity region	1140	1149	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000170300

SMART Domains

Protein: ENSMUSP00000132384
Gene: ENSMUSG00000026288

Domain	Start	End	E-Value	Type
IPPc	142	458	4.5e-104	SMART
low complexity region	505	515	N/A	INTRINSIC
low complexity region	722	734	N/A	INTRINSIC
low complexity region	796	808	N/A	INTRINSIC
low complexity region	816	825	N/A	INTRINSIC

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 95.0%
20x: 91.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration anddefective cytolysis by NK cells and CTLs. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 113 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6030469F06Rik	A	G	12: 31,234,914 (GRCm39)		noncoding transcript	Het
Abca2	T	G	2: 25,337,846 (GRCm39)		probably benign	Het
Adamts8	T	A	9: 30,862,673 (GRCm39)	W86R	probably benign	Het
Adh1	A	G	3: 137,994,508 (GRCm39)		probably null	Het
Adipor2	A	T	6: 119,338,804 (GRCm39)	W150R	probably damaging	Het
Aff4	T	A	11: 53,263,351 (GRCm39)	S124T	probably damaging	Het
Ahnak	G	T	19: 8,982,260 (GRCm39)	K1181N	probably damaging	Het
Ak2	C	A	4: 128,896,152 (GRCm39)		probably benign	Het
Alkbh5	A	G	11: 60,429,873 (GRCm39)	I209V	probably benign	Het
Ankrd11	T	C	8: 123,619,463 (GRCm39)	E1442G	probably damaging	Het
Apba2	T	A	7: 64,345,297 (GRCm39)	D162E	probably benign	Het
Asic3	G	A	5: 24,618,819 (GRCm39)	G37E	probably damaging	Het
AU040320	A	T	4: 126,685,824 (GRCm39)	K133N	possibly damaging	Het
C1qtnf7	A	G	5: 43,766,481 (GRCm39)	S34G	probably benign	Het
Carf	A	G	1: 60,165,065 (GRCm39)		probably benign	Het
Ccdc148	T	A	2: 58,796,374 (GRCm39)	R463*	probably null	Het
Ccdc148	T	C	2: 58,824,455 (GRCm39)	R329G	probably damaging	Het
Ccdc185	A	G	1: 182,576,263 (GRCm39)	I142T	probably benign	Het
Cd274	T	C	19: 29,359,992 (GRCm39)		probably benign	Het
Chrna10	G	A	7: 101,763,454 (GRCm39)	P114S	probably damaging	Het
Chst10	A	G	1: 38,904,772 (GRCm39)	I311T	probably damaging	Het
Cpne9	T	C	6: 113,271,698 (GRCm39)	Y353H	probably damaging	Het
Cubn	G	T	2: 13,330,099 (GRCm39)	A2594E	possibly damaging	Het
Cyp3a13	T	C	5: 137,903,827 (GRCm39)	N277S	possibly damaging	Het
Dctn4	A	G	18: 60,671,478 (GRCm39)	T117A	probably damaging	Het
Ddah1	A	T	3: 145,559,029 (GRCm39)	K96*	probably null	Het
Ddx5	A	C	11: 106,675,711 (GRCm39)	D326E	probably benign	Het
Dlg2	T	C	7: 91,617,406 (GRCm39)	S323P	probably damaging	Het
Dnaaf1	C	T	8: 120,306,049 (GRCm39)	H109Y	probably damaging	Het
Dnah8	C	A	17: 30,914,147 (GRCm39)	R1098S	possibly damaging	Het
Dnajc13	T	C	9: 104,091,366 (GRCm39)	T642A	probably benign	Het
Dnajc18	A	G	18: 35,813,900 (GRCm39)	S290P	possibly damaging	Het
Dscam	T	A	16: 96,602,453 (GRCm39)	H663L	possibly damaging	Het
Eefsec	C	T	6: 88,353,182 (GRCm39)		probably benign	Het
Emc1	A	G	4: 139,098,248 (GRCm39)	N740S	probably damaging	Het
Enpp2	C	T	15: 54,727,208 (GRCm39)	G541D	probably damaging	Het
Fam234b	C	T	6: 135,205,490 (GRCm39)	T485I	probably benign	Het
Fbxl13	A	T	5: 21,688,989 (GRCm39)	I773K	probably benign	Het
Fmo4	A	G	1: 162,621,924 (GRCm39)	F429S	possibly damaging	Het
Fndc3b	A	G	3: 27,494,334 (GRCm39)		probably benign	Het
Frem1	T	C	4: 82,930,116 (GRCm39)	S277G	probably damaging	Het
Gaa	A	G	11: 119,163,810 (GRCm39)	I221V	probably benign	Het
Gnptab	A	G	10: 88,281,616 (GRCm39)		probably benign	Het
Gphn	T	A	12: 78,659,738 (GRCm39)		probably benign	Het
Helz2	T	C	2: 180,881,447 (GRCm39)	E345G	probably damaging	Het
Ifna4	G	T	4: 88,760,237 (GRCm39)	R47I	probably damaging	Het
Igsf21	C	A	4: 139,761,836 (GRCm39)	A281S	probably benign	Het
Ikzf3	T	A	11: 98,407,731 (GRCm39)	I37L	probably benign	Het
Jag1	T	C	2: 136,957,568 (GRCm39)	E48G	probably damaging	Het
Jarid2	G	T	13: 45,001,857 (GRCm39)	V57F	probably damaging	Het
Kcnj4	A	G	15: 79,369,605 (GRCm39)	L125P	probably damaging	Het
Kif21b	A	G	1: 136,083,891 (GRCm39)	K713E	possibly damaging	Het
Layn	T	A	9: 50,968,886 (GRCm39)	S286C	probably damaging	Het
Lepr	T	A	4: 101,592,878 (GRCm39)	D164E	probably benign	Het
Macroh2a1	A	T	13: 56,230,949 (GRCm39)	S310T	probably damaging	Het
Map3k1	T	C	13: 111,892,405 (GRCm39)	H950R	possibly damaging	Het
Map4k5	C	A	12: 69,852,124 (GRCm39)	V801L	possibly damaging	Het
Mapkbp1	T	A	2: 119,851,742 (GRCm39)	S895T	probably benign	Het
Mthfr	T	A	4: 148,138,029 (GRCm39)		probably benign	Het
Naca	T	A	10: 127,884,157 (GRCm39)	M2157K	probably damaging	Het
Nav2	T	C	7: 49,011,952 (GRCm39)	I61T	probably damaging	Het
Nkx2-5	C	A	17: 27,058,253 (GRCm39)	A234S	probably benign	Het
Nol8	G	A	13: 49,830,264 (GRCm39)	S1116N	probably benign	Het
Nphp3	T	C	9: 103,909,078 (GRCm39)		probably benign	Het
Nppa	T	C	4: 148,085,304 (GRCm39)	S5P	probably benign	Het
Nup210	A	G	6: 91,030,551 (GRCm39)	V123A	possibly damaging	Het
Or13a21	G	T	7: 139,999,286 (GRCm39)	N133K	probably benign	Het
Osbpl11	A	G	16: 33,049,455 (GRCm39)	K604R	probably damaging	Het
Osbpl1a	C	T	18: 13,047,615 (GRCm39)	S113N	probably benign	Het
P2rx4	C	A	5: 122,852,602 (GRCm39)	P92Q	probably damaging	Het
Pde9a	A	T	17: 31,692,136 (GRCm39)	Q148L	probably benign	Het
Phf21b	T	A	15: 84,689,160 (GRCm39)	H122L	probably damaging	Het
Pik3ca	T	A	3: 32,515,990 (GRCm39)	F977I	probably damaging	Het
Pkd1l3	A	G	8: 110,363,059 (GRCm39)		probably benign	Het
Potefam1	A	G	2: 111,055,748 (GRCm39)		probably null	Het
Pp2d1	T	G	17: 53,823,015 (GRCm39)	K17T	possibly damaging	Het
Ppp4r2	A	G	6: 100,843,527 (GRCm39)	E415G	probably damaging	Het
Pramel19	T	A	4: 101,798,503 (GRCm39)	L158Q	probably damaging	Het
Prkg1	A	G	19: 30,556,270 (GRCm39)	S559P	probably damaging	Het
Prss45	A	T	9: 110,670,019 (GRCm39)	Y276F	possibly damaging	Het
Ptk7	G	T	17: 46,883,517 (GRCm39)	N849K	probably damaging	Het
Rnf121	A	G	7: 101,680,782 (GRCm39)	I125T	possibly damaging	Het
Rnf17	A	G	14: 56,699,368 (GRCm39)	N502S	probably damaging	Het
Sap25	T	A	5: 137,640,622 (GRCm39)	Y167*	probably null	Het
Sdk2	G	A	11: 113,720,906 (GRCm39)	T1341I	possibly damaging	Het
Sgcb	A	G	5: 73,792,896 (GRCm39)	V302A	probably benign	Het
Skor1	T	A	9: 63,047,393 (GRCm39)	M865L	possibly damaging	Het
Slc25a45	T	C	19: 5,929,928 (GRCm39)		probably benign	Het
Slc2a3	A	G	6: 122,714,269 (GRCm39)		probably benign	Het
Slc35g1	C	A	19: 38,391,665 (GRCm39)	L316I	probably benign	Het
Slco1a8	C	T	6: 141,938,243 (GRCm39)	W225*	probably null	Het
Spint4	T	A	2: 164,540,568 (GRCm39)	L33H	probably damaging	Het
Sptlc3	A	T	2: 139,389,154 (GRCm39)	D178V	probably benign	Het
Stoml1	A	G	9: 58,167,709 (GRCm39)		probably benign	Het
Tbc1d2	T	A	4: 46,606,491 (GRCm39)	Y818F	possibly damaging	Het
Tbc1d24	A	T	17: 24,400,197 (GRCm39)		probably null	Het
Teddm2	C	T	1: 153,726,277 (GRCm39)	W146*	probably null	Het
Ttn	T	A	2: 76,589,338 (GRCm39)	D12948V	probably damaging	Het
Txndc8	T	C	4: 58,000,274 (GRCm39)	T102A	probably damaging	Het
Uxs1	G	A	1: 43,804,076 (GRCm39)	Q280*	probably null	Het
Vmn1r167	T	C	7: 23,204,681 (GRCm39)	T112A	possibly damaging	Het
Vmn1r195	A	T	13: 22,463,348 (GRCm39)	I273L	probably benign	Het
Vmn1r28	T	A	6: 58,242,217 (GRCm39)	M20K	probably benign	Het
Vmn1r53	G	A	6: 90,200,914 (GRCm39)	L137F	probably benign	Het
Vmn2r105	G	A	17: 20,449,004 (GRCm39)		probably benign	Het
Vps13b	C	T	15: 35,709,630 (GRCm39)	A1859V	probably benign	Het
Vwa5b2	A	G	16: 20,415,019 (GRCm39)	H347R	probably benign	Het
Wnk2	G	A	13: 49,235,451 (GRCm39)	P655S	probably damaging	Het
Zan	T	G	5: 137,418,191 (GRCm39)	D2969A	unknown	Het
Zbtb24	A	G	10: 41,331,075 (GRCm39)	H334R	probably damaging	Het
Zfp108	A	G	7: 23,959,973 (GRCm39)	D188G	probably benign	Het
Zfp784	A	T	7: 5,038,800 (GRCm39)	C253S	possibly damaging	Het
Zfr	T	G	15: 12,146,458 (GRCm39)	C336W	probably damaging	Het

Other mutations in Inpp5d

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00323:Inpp5d	APN	1	87,611,537 (GRCm39)	missense	probably benign	0.00
IGL00329:Inpp5d	APN	1	87,595,725 (GRCm39)	missense	probably benign	0.00
IGL00897:Inpp5d	APN	1	87,639,836 (GRCm39)	missense	probably benign	0.14
IGL01314:Inpp5d	APN	1	87,611,472 (GRCm39)	nonsense	probably null
IGL02145:Inpp5d	APN	1	87,642,777 (GRCm39)	missense	probably damaging	1.00
IGL02422:Inpp5d	APN	1	87,635,854 (GRCm39)	missense	probably damaging	1.00
IGL02538:Inpp5d	APN	1	87,623,088 (GRCm39)	missense	probably null	0.92
IGL02680:Inpp5d	APN	1	87,629,205 (GRCm39)	missense	possibly damaging	0.87
IGL03083:Inpp5d	APN	1	87,638,863 (GRCm39)	missense	probably damaging	1.00
IGL03308:Inpp5d	APN	1	87,630,919 (GRCm39)	missense	probably damaging	1.00
americas	UTSW	1	87,642,864 (GRCm39)	missense	probably damaging	1.00
Apfelsine	UTSW	1	87,611,567 (GRCm39)	nonsense	probably null
Auburn	UTSW	1	87,609,402 (GRCm39)	splice site	probably null
Autumnal	UTSW	1	87,619,433 (GRCm39)	missense	probably damaging	0.97
Gourd	UTSW	1	87,625,337 (GRCm39)	intron	probably benign
lyda	UTSW	1	87,611,484 (GRCm39)	missense	probably damaging	1.00
Mandarin	UTSW	1	87,637,348 (GRCm39)	missense	probably damaging	0.99
naranjo	UTSW	1	87,635,933 (GRCm39)	critical splice donor site	probably null
New_black	UTSW	1	87,637,397 (GRCm39)	missense	probably damaging	1.00
Orange	UTSW	1	87,625,268 (GRCm39)	critical splice donor site	probably null
pantone	UTSW	1	87,627,397 (GRCm39)	missense	probably damaging	1.00
sailing	UTSW	1	87,633,686 (GRCm39)	missense	probably damaging	1.00
Salamander	UTSW	1	87,623,102 (GRCm39)	missense	probably damaging	0.99
Sandstone	UTSW	1	87,623,122 (GRCm39)	missense	probably damaging	1.00
styx	UTSW	1	87,597,506 (GRCm39)	critical splice donor site	probably benign
tangerine	UTSW	1	87,633,671 (GRCm39)	missense	probably damaging	1.00
ulster	UTSW	1	87,629,198 (GRCm39)	nonsense	probably null
R0010:Inpp5d	UTSW	1	87,625,268 (GRCm39)	critical splice donor site	probably null
R0037:Inpp5d	UTSW	1	87,635,851 (GRCm39)	missense	probably damaging	0.99
R0087:Inpp5d	UTSW	1	87,642,860 (GRCm39)	missense	probably damaging	1.00
R0492:Inpp5d	UTSW	1	87,625,872 (GRCm39)	missense	possibly damaging	0.94
R0520:Inpp5d	UTSW	1	87,633,642 (GRCm39)	splice site	probably benign
R0733:Inpp5d	UTSW	1	87,595,799 (GRCm39)	splice site	probably benign
R1576:Inpp5d	UTSW	1	87,609,280 (GRCm39)	missense	probably damaging	0.96
R1576:Inpp5d	UTSW	1	87,597,407 (GRCm39)	missense	probably benign	0.16
R1592:Inpp5d	UTSW	1	87,593,254 (GRCm39)	missense	possibly damaging	0.90
R1750:Inpp5d	UTSW	1	87,626,803 (GRCm39)	missense	probably damaging	1.00
R1774:Inpp5d	UTSW	1	87,595,611 (GRCm39)	missense	probably benign	0.30
R1972:Inpp5d	UTSW	1	87,604,036 (GRCm39)	missense	probably benign	0.00
R2024:Inpp5d	UTSW	1	87,623,072 (GRCm39)	nonsense	probably null
R2405:Inpp5d	UTSW	1	87,627,451 (GRCm39)	missense	possibly damaging	0.94
R3412:Inpp5d	UTSW	1	87,595,779 (GRCm39)	missense	possibly damaging	0.93
R3414:Inpp5d	UTSW	1	87,595,779 (GRCm39)	missense	possibly damaging	0.93
R3756:Inpp5d	UTSW	1	87,629,130 (GRCm39)	splice site	probably benign
R4652:Inpp5d	UTSW	1	87,593,173 (GRCm39)	missense	probably benign	0.03
R4676:Inpp5d	UTSW	1	87,642,864 (GRCm39)	missense	probably damaging	1.00
R4834:Inpp5d	UTSW	1	87,625,245 (GRCm39)	missense	possibly damaging	0.52
R5086:Inpp5d	UTSW	1	87,633,686 (GRCm39)	missense	probably damaging	1.00
R5159:Inpp5d	UTSW	1	87,604,064 (GRCm39)	missense	probably damaging	1.00
R5250:Inpp5d	UTSW	1	87,637,397 (GRCm39)	missense	probably damaging	1.00
R5442:Inpp5d	UTSW	1	87,645,788 (GRCm39)	missense	probably benign	0.02
R5875:Inpp5d	UTSW	1	87,645,696 (GRCm39)	missense	possibly damaging	0.47
R6135:Inpp5d	UTSW	1	87,548,119 (GRCm39)	splice site	probably null
R6371:Inpp5d	UTSW	1	87,627,397 (GRCm39)	missense	probably damaging	1.00
R6385:Inpp5d	UTSW	1	87,627,397 (GRCm39)	missense	probably damaging	1.00
R6386:Inpp5d	UTSW	1	87,627,397 (GRCm39)	missense	probably damaging	1.00
R6526:Inpp5d	UTSW	1	87,603,972 (GRCm39)	start gained	probably benign
R6572:Inpp5d	UTSW	1	87,623,118 (GRCm39)	missense	probably damaging	0.99
R6831:Inpp5d	UTSW	1	87,629,198 (GRCm39)	nonsense	probably null
R6853:Inpp5d	UTSW	1	87,609,402 (GRCm39)	splice site	probably null
R6883:Inpp5d	UTSW	1	87,627,412 (GRCm39)	missense	probably damaging	0.98
R7082:Inpp5d	UTSW	1	87,623,102 (GRCm39)	missense	probably damaging	0.99
R7215:Inpp5d	UTSW	1	87,628,940 (GRCm39)	missense	probably benign	0.30
R7418:Inpp5d	UTSW	1	87,635,933 (GRCm39)	critical splice donor site	probably null
R7471:Inpp5d	UTSW	1	87,623,122 (GRCm39)	missense	probably damaging	1.00
R7593:Inpp5d	UTSW	1	87,645,500 (GRCm39)	missense	possibly damaging	0.82
R7716:Inpp5d	UTSW	1	87,593,121 (GRCm39)	missense	probably damaging	0.97
R7781:Inpp5d	UTSW	1	87,627,394 (GRCm39)	missense	probably damaging	1.00
R7808:Inpp5d	UTSW	1	87,611,567 (GRCm39)	nonsense	probably null
R7920:Inpp5d	UTSW	1	87,633,671 (GRCm39)	missense	probably damaging	1.00
R8788:Inpp5d	UTSW	1	87,611,484 (GRCm39)	missense	probably damaging	1.00
R8839:Inpp5d	UTSW	1	87,619,433 (GRCm39)	missense	probably damaging	0.97
R8905:Inpp5d	UTSW	1	87,637,348 (GRCm39)	missense	probably damaging	0.99
R8906:Inpp5d	UTSW	1	87,625,337 (GRCm39)	intron	probably benign
R9517:Inpp5d	UTSW	1	87,638,853 (GRCm39)	missense	probably benign	0.01
R9667:Inpp5d	UTSW	1	87,623,128 (GRCm39)	missense	probably damaging	1.00
R9716:Inpp5d	UTSW	1	87,625,191 (GRCm39)	missense	possibly damaging	0.90
Z1176:Inpp5d	UTSW	1	87,630,853 (GRCm39)	missense	probably damaging	1.00
Z1176:Inpp5d	UTSW	1	87,597,431 (GRCm39)	missense	probably benign	0.16
Z1191:Inpp5d	UTSW	1	87,611,492 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TACTCAGGCACTCCCTGCAAGAAG -3'
(R):5'- GGAATGGCTTTCCCTCTATGCTCAC -3'

Sequencing Primer
(F):5'- ctgagtccgccatcttcc -3'
(R):5'- CTATGCTCACCCAGGGTGTTG -3'

Posted On

2014-05-23