Incidental Mutation 'R1465:Inpp4b'
| ID |
201070 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Inpp4b
|
| Ensembl Gene |
ENSMUSG00000037940 |
| Gene Name |
inositol polyphosphate-4-phosphatase, type II |
| Synonyms |
E130107I17Rik |
| MMRRC Submission |
039519-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R1465 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
82069185-82854543 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 82494786 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 67
(V67E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150541
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042529]
[ENSMUST00000109852]
[ENSMUST00000169116]
[ENSMUST00000169387]
[ENSMUST00000170160]
[ENSMUST00000172031]
[ENSMUST00000213285]
[ENSMUST00000217122]
[ENSMUST00000215332]
|
| AlphaFold |
Q6P1Y8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000042529
AA Change: V67E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000044466
Gene: ENSMUSG00000037940
AA Change: V67E
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
147 |
1.72e0 |
SMART |
|
low complexity region
|
302 |
319 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
434 |
N/A |
INTRINSIC |
|
transmembrane domain
|
898 |
920 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109852
AA Change: V67E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000105478
Gene: ENSMUSG00000037940
AA Change: V67E
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
transmembrane domain
|
915 |
937 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164870
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169116
AA Change: V67E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000131947
Gene: ENSMUSG00000037940
AA Change: V67E
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169387
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170160
|
| SMART Domains |
Protein: ENSMUSP00000132156
Gene: ENSMUSG00000037940
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
257 |
266 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172031
AA Change: V67E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000131324
Gene: ENSMUSG00000037940
AA Change: V67E
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
40 |
164 |
5.29e0 |
SMART |
|
low complexity region
|
319 |
336 |
N/A |
INTRINSIC |
|
low complexity region
|
442 |
451 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000213285
AA Change: V67E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000217122
AA Change: V67E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000215332
AA Change: V67E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000216036
|
| Coding Region Coverage |
- 1x: 97.3%
- 3x: 96.5%
- 10x: 93.6%
- 20x: 86.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit osteoporosis, reduced long bone length, increased osteoclast numbers and size, increased osteoblast numbers, and increased bone resorption and resorption. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310030G06Rik |
A |
G |
9: 50,651,866 (GRCm39) |
Y121H |
probably damaging |
Het |
| Abca13 |
G |
T |
11: 9,349,303 (GRCm39) |
G3626W |
probably damaging |
Het |
| Acvr1c |
A |
G |
2: 58,174,973 (GRCm39) |
Y192H |
probably damaging |
Het |
| Afm |
A |
T |
5: 90,698,200 (GRCm39) |
D534V |
probably damaging |
Het |
| Agl |
T |
C |
3: 116,565,021 (GRCm39) |
E1076G |
probably benign |
Het |
| Ahcyl |
T |
C |
16: 45,974,211 (GRCm39) |
K389E |
probably benign |
Het |
| Angptl3 |
A |
T |
4: 98,925,757 (GRCm39) |
H361L |
probably benign |
Het |
| Apob |
T |
C |
12: 8,061,421 (GRCm39) |
F3301S |
possibly damaging |
Het |
| Arhgef33 |
T |
A |
17: 80,674,730 (GRCm39) |
C376S |
possibly damaging |
Het |
| Ass1 |
A |
G |
2: 31,410,428 (GRCm39) |
*413W |
probably null |
Het |
| Atp6v1h |
T |
A |
1: 5,165,911 (GRCm39) |
L127Q |
probably damaging |
Het |
| Bcl2l1 |
G |
A |
2: 152,671,870 (GRCm39) |
S14F |
probably damaging |
Het |
| Bhmt1b |
T |
G |
18: 87,775,382 (GRCm39) |
F302V |
probably damaging |
Het |
| Birc6 |
G |
A |
17: 74,930,853 (GRCm39) |
A2477T |
probably benign |
Het |
| Bpifb9a |
G |
A |
2: 154,112,941 (GRCm39) |
A589T |
possibly damaging |
Het |
| Casp9 |
C |
A |
4: 141,533,151 (GRCm39) |
T252K |
probably benign |
Het |
| Cct4 |
G |
A |
11: 22,952,922 (GRCm39) |
D533N |
probably damaging |
Het |
| Clcn6 |
A |
C |
4: 148,098,358 (GRCm39) |
I555S |
probably damaging |
Het |
| Col4a4 |
A |
T |
1: 82,475,543 (GRCm39) |
|
probably null |
Het |
| Cyp2d10 |
A |
T |
15: 82,288,129 (GRCm39) |
|
probably null |
Het |
| D930048N14Rik |
A |
G |
11: 51,545,740 (GRCm39) |
|
probably benign |
Het |
| Dhfr |
A |
G |
13: 92,504,815 (GRCm39) |
|
probably benign |
Het |
| Dlg5 |
T |
C |
14: 24,204,764 (GRCm39) |
|
probably null |
Het |
| Dnah11 |
T |
C |
12: 118,002,430 (GRCm39) |
E2240G |
probably damaging |
Het |
| Dnmt3a |
A |
G |
12: 3,916,088 (GRCm39) |
E17G |
probably damaging |
Het |
| Dock1 |
A |
G |
7: 134,384,138 (GRCm39) |
T670A |
probably benign |
Het |
| Dpy19l2 |
A |
G |
9: 24,580,618 (GRCm39) |
M241T |
probably benign |
Het |
| Dpy19l4 |
A |
G |
4: 11,296,034 (GRCm39) |
S212P |
probably damaging |
Het |
| Ephb6 |
T |
C |
6: 41,593,040 (GRCm39) |
F426S |
probably damaging |
Het |
| F5 |
A |
T |
1: 164,026,402 (GRCm39) |
D1658V |
probably benign |
Het |
| Faah |
A |
T |
4: 115,856,755 (GRCm39) |
V469E |
probably damaging |
Het |
| Fas |
T |
C |
19: 34,294,013 (GRCm39) |
C123R |
probably damaging |
Het |
| Fhod1 |
T |
C |
8: 106,065,546 (GRCm39) |
|
probably benign |
Het |
| Filip1 |
A |
G |
9: 79,805,589 (GRCm39) |
V55A |
probably benign |
Het |
| Frmpd1 |
G |
A |
4: 45,273,197 (GRCm39) |
R372Q |
probably damaging |
Het |
| Glyctk |
C |
T |
9: 106,034,806 (GRCm39) |
G87S |
probably damaging |
Het |
| Golga3 |
T |
C |
5: 110,357,744 (GRCm39) |
L1080P |
probably damaging |
Het |
| Gpr137 |
T |
C |
19: 6,915,812 (GRCm39) |
T281A |
probably benign |
Het |
| Grap2 |
T |
A |
15: 80,532,612 (GRCm39) |
|
probably null |
Het |
| Hlcs |
T |
C |
16: 94,069,151 (GRCm39) |
D170G |
probably damaging |
Het |
| Hook1 |
A |
G |
4: 95,901,493 (GRCm39) |
T484A |
probably benign |
Het |
| Hoxa5 |
T |
A |
6: 52,180,771 (GRCm39) |
H187L |
probably benign |
Het |
| Inpp1 |
G |
T |
1: 52,829,253 (GRCm39) |
S255R |
probably benign |
Het |
| Iqgap3 |
A |
G |
3: 87,994,616 (GRCm39) |
N105S |
probably damaging |
Het |
| Kcnq5 |
A |
G |
1: 21,539,692 (GRCm39) |
|
probably null |
Het |
| Klhl1 |
T |
C |
14: 96,477,649 (GRCm39) |
N473S |
probably benign |
Het |
| Klk1b24 |
C |
A |
7: 43,840,785 (GRCm39) |
T71N |
probably benign |
Het |
| Loxhd1 |
A |
G |
18: 77,468,269 (GRCm39) |
|
probably null |
Het |
| Lrp1b |
C |
T |
2: 41,001,071 (GRCm39) |
R2165Q |
probably benign |
Het |
| Lrp2bp |
A |
T |
8: 46,478,272 (GRCm39) |
Q328L |
possibly damaging |
Het |
| Lrrc63 |
T |
A |
14: 75,344,829 (GRCm39) |
K419N |
possibly damaging |
Het |
| Lrrc9 |
A |
G |
12: 72,547,533 (GRCm39) |
N150S |
probably benign |
Het |
| Lrrn4 |
C |
A |
2: 132,713,995 (GRCm39) |
C317F |
probably damaging |
Het |
| Ltbp2 |
T |
C |
12: 84,860,074 (GRCm39) |
S627G |
probably damaging |
Het |
| Macf1 |
A |
T |
4: 123,386,947 (GRCm39) |
S1224T |
probably damaging |
Het |
| Meis2 |
A |
C |
2: 115,889,151 (GRCm39) |
H200Q |
probably benign |
Het |
| Mesd |
C |
A |
7: 83,544,790 (GRCm39) |
A80E |
probably benign |
Het |
| Mtor |
G |
T |
4: 148,610,450 (GRCm39) |
|
probably benign |
Het |
| Myo3a |
T |
C |
2: 22,467,939 (GRCm39) |
F398L |
probably benign |
Het |
| Nagpa |
G |
T |
16: 5,019,392 (GRCm39) |
|
probably benign |
Het |
| Nanp |
A |
G |
2: 150,872,749 (GRCm39) |
C60R |
probably benign |
Het |
| Nectin2 |
T |
G |
7: 19,464,041 (GRCm39) |
M313L |
probably benign |
Het |
| Nek4 |
C |
T |
14: 30,678,844 (GRCm39) |
H123Y |
probably damaging |
Het |
| Nploc4 |
A |
G |
11: 120,299,607 (GRCm39) |
V371A |
probably damaging |
Het |
| Ntrk3 |
T |
C |
7: 78,005,762 (GRCm39) |
|
probably benign |
Het |
| Or11g7 |
A |
G |
14: 50,690,634 (GRCm39) |
T42A |
possibly damaging |
Het |
| Or13c7b |
A |
G |
4: 43,820,723 (GRCm39) |
F213L |
probably benign |
Het |
| Or52n4 |
T |
C |
7: 104,294,153 (GRCm39) |
N140S |
probably benign |
Het |
| Or5b109 |
T |
A |
19: 13,212,265 (GRCm39) |
V217E |
possibly damaging |
Het |
| Pcdh20 |
T |
A |
14: 88,706,673 (GRCm39) |
Q209L |
probably benign |
Het |
| Pcdhb20 |
G |
A |
18: 37,637,750 (GRCm39) |
R92H |
probably damaging |
Het |
| Pgap1 |
T |
C |
1: 54,567,714 (GRCm39) |
H377R |
probably benign |
Het |
| Phyhipl |
G |
T |
10: 70,406,798 (GRCm39) |
P52Q |
probably damaging |
Het |
| Plekhg4 |
T |
C |
8: 106,107,672 (GRCm39) |
|
probably benign |
Het |
| Pwwp2a |
T |
A |
11: 43,596,383 (GRCm39) |
V516E |
possibly damaging |
Het |
| Rack1 |
T |
C |
11: 48,692,586 (GRCm39) |
V69A |
probably damaging |
Het |
| Rexo5 |
T |
A |
7: 119,400,581 (GRCm39) |
|
probably null |
Het |
| Rnf123 |
T |
C |
9: 107,948,665 (GRCm39) |
|
probably benign |
Het |
| Rock1 |
G |
T |
18: 10,072,863 (GRCm39) |
Q1161K |
possibly damaging |
Het |
| Rps6ka2 |
T |
C |
17: 7,560,266 (GRCm39) |
L568P |
probably damaging |
Het |
| Seh1l |
T |
C |
18: 67,917,054 (GRCm39) |
S78P |
probably damaging |
Het |
| Serpinb3b |
A |
T |
1: 107,083,573 (GRCm39) |
|
probably null |
Het |
| Setd1a |
T |
C |
7: 127,387,512 (GRCm39) |
|
probably benign |
Het |
| Setx |
G |
T |
2: 29,030,401 (GRCm39) |
|
probably null |
Het |
| Sh3bp1 |
T |
C |
15: 78,791,545 (GRCm39) |
|
probably benign |
Het |
| Shc2 |
G |
T |
10: 79,467,136 (GRCm39) |
R146S |
probably damaging |
Het |
| Skap2 |
T |
C |
6: 51,886,348 (GRCm39) |
T5A |
probably benign |
Het |
| Skor2 |
A |
T |
18: 76,964,340 (GRCm39) |
|
probably benign |
Het |
| Slc35a3 |
T |
C |
3: 116,480,983 (GRCm39) |
I93M |
probably benign |
Het |
| Sohlh1 |
C |
T |
2: 25,733,359 (GRCm39) |
G295D |
probably damaging |
Het |
| Speg |
A |
G |
1: 75,405,128 (GRCm39) |
|
probably benign |
Het |
| Sult2a8 |
A |
C |
7: 14,150,208 (GRCm39) |
C168G |
probably benign |
Het |
| Tax1bp1 |
T |
C |
6: 52,704,179 (GRCm39) |
|
probably benign |
Het |
| Tbc1d4 |
T |
C |
14: 101,685,124 (GRCm39) |
I1176V |
possibly damaging |
Het |
| Tcof1 |
A |
G |
18: 60,952,026 (GRCm39) |
|
probably benign |
Het |
| Thada |
A |
T |
17: 84,744,104 (GRCm39) |
F735I |
possibly damaging |
Het |
| Tle1 |
A |
C |
4: 72,058,068 (GRCm39) |
H52Q |
probably damaging |
Het |
| Tmem101 |
A |
T |
11: 102,044,155 (GRCm39) |
V244E |
probably damaging |
Het |
| Tnfrsf26 |
C |
A |
7: 143,171,668 (GRCm39) |
C95F |
probably damaging |
Het |
| Uspl1 |
T |
C |
5: 149,150,842 (GRCm39) |
S482P |
probably benign |
Het |
| Vmn2r118 |
G |
T |
17: 55,917,935 (GRCm39) |
N192K |
probably benign |
Het |
| Vmn2r14 |
C |
T |
5: 109,368,195 (GRCm39) |
V266I |
possibly damaging |
Het |
| Vmn2r51 |
A |
G |
7: 9,834,249 (GRCm39) |
I263T |
probably damaging |
Het |
| Zfp937 |
T |
A |
2: 150,080,967 (GRCm39) |
C332* |
probably null |
Het |
| Zscan21 |
T |
A |
5: 138,123,470 (GRCm39) |
S50T |
probably benign |
Het |
|
| Other mutations in Inpp4b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00850:Inpp4b
|
APN |
8 |
82,583,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01481:Inpp4b
|
APN |
8 |
82,724,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01509:Inpp4b
|
APN |
8 |
82,617,332 (GRCm39) |
splice site |
probably benign |
|
|
IGL01515:Inpp4b
|
APN |
8 |
82,679,340 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL01607:Inpp4b
|
APN |
8 |
82,737,292 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01643:Inpp4b
|
APN |
8 |
82,798,400 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01736:Inpp4b
|
APN |
8 |
82,723,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02154:Inpp4b
|
APN |
8 |
82,696,130 (GRCm39) |
splice site |
probably benign |
|
|
IGL02327:Inpp4b
|
APN |
8 |
82,768,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02413:Inpp4b
|
APN |
8 |
82,759,800 (GRCm39) |
missense |
probably benign |
|
|
IGL02652:Inpp4b
|
APN |
8 |
82,497,429 (GRCm39) |
splice site |
probably benign |
|
|
IGL02678:Inpp4b
|
APN |
8 |
82,583,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03146:Inpp4b
|
APN |
8 |
82,470,410 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
LCD18:Inpp4b
|
UTSW |
8 |
82,419,639 (GRCm39) |
intron |
probably benign |
|
|
PIT4280001:Inpp4b
|
UTSW |
8 |
82,761,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4480001:Inpp4b
|
UTSW |
8 |
82,772,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4504001:Inpp4b
|
UTSW |
8 |
82,768,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Inpp4b
|
UTSW |
8 |
82,468,091 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0212:Inpp4b
|
UTSW |
8 |
82,497,546 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0285:Inpp4b
|
UTSW |
8 |
82,761,145 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Inpp4b
|
UTSW |
8 |
82,610,886 (GRCm39) |
splice site |
probably benign |
|
|
R0364:Inpp4b
|
UTSW |
8 |
82,723,943 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0471:Inpp4b
|
UTSW |
8 |
82,768,528 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0550:Inpp4b
|
UTSW |
8 |
82,723,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0562:Inpp4b
|
UTSW |
8 |
82,494,780 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0661:Inpp4b
|
UTSW |
8 |
82,468,091 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0693:Inpp4b
|
UTSW |
8 |
82,723,943 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1081:Inpp4b
|
UTSW |
8 |
82,795,653 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1251:Inpp4b
|
UTSW |
8 |
82,617,382 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1374:Inpp4b
|
UTSW |
8 |
82,470,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1445:Inpp4b
|
UTSW |
8 |
82,679,463 (GRCm39) |
splice site |
probably null |
|
|
R1465:Inpp4b
|
UTSW |
8 |
82,494,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1647:Inpp4b
|
UTSW |
8 |
82,583,403 (GRCm39) |
splice site |
probably benign |
|
|
R1754:Inpp4b
|
UTSW |
8 |
82,497,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1759:Inpp4b
|
UTSW |
8 |
82,494,732 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2085:Inpp4b
|
UTSW |
8 |
82,678,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2156:Inpp4b
|
UTSW |
8 |
82,775,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2160:Inpp4b
|
UTSW |
8 |
82,848,004 (GRCm39) |
nonsense |
probably null |
|
|
R2175:Inpp4b
|
UTSW |
8 |
82,583,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2191:Inpp4b
|
UTSW |
8 |
82,723,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2401:Inpp4b
|
UTSW |
8 |
82,723,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2475:Inpp4b
|
UTSW |
8 |
82,768,607 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2512:Inpp4b
|
UTSW |
8 |
82,737,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Inpp4b
|
UTSW |
8 |
82,711,958 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3021:Inpp4b
|
UTSW |
8 |
82,629,467 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3423:Inpp4b
|
UTSW |
8 |
82,678,890 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3777:Inpp4b
|
UTSW |
8 |
82,768,621 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3778:Inpp4b
|
UTSW |
8 |
82,768,621 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3794:Inpp4b
|
UTSW |
8 |
82,759,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3795:Inpp4b
|
UTSW |
8 |
82,759,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4590:Inpp4b
|
UTSW |
8 |
82,468,040 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R4602:Inpp4b
|
UTSW |
8 |
82,696,164 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4691:Inpp4b
|
UTSW |
8 |
82,849,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4924:Inpp4b
|
UTSW |
8 |
82,849,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Inpp4b
|
UTSW |
8 |
82,759,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5219:Inpp4b
|
UTSW |
8 |
82,610,785 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5228:Inpp4b
|
UTSW |
8 |
82,494,744 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5557:Inpp4b
|
UTSW |
8 |
82,678,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5627:Inpp4b
|
UTSW |
8 |
82,470,445 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R5691:Inpp4b
|
UTSW |
8 |
82,617,323 (GRCm39) |
intron |
probably benign |
|
|
R6186:Inpp4b
|
UTSW |
8 |
82,772,863 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6213:Inpp4b
|
UTSW |
8 |
82,724,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6232:Inpp4b
|
UTSW |
8 |
82,678,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6283:Inpp4b
|
UTSW |
8 |
82,497,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6302:Inpp4b
|
UTSW |
8 |
82,494,806 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6309:Inpp4b
|
UTSW |
8 |
82,768,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6360:Inpp4b
|
UTSW |
8 |
82,629,481 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6477:Inpp4b
|
UTSW |
8 |
82,571,343 (GRCm39) |
splice site |
probably null |
|
|
R6773:Inpp4b
|
UTSW |
8 |
82,583,249 (GRCm39) |
intron |
probably benign |
|
|
R6968:Inpp4b
|
UTSW |
8 |
82,571,086 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7147:Inpp4b
|
UTSW |
8 |
82,629,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7318:Inpp4b
|
UTSW |
8 |
82,798,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7409:Inpp4b
|
UTSW |
8 |
82,679,314 (GRCm39) |
splice site |
probably null |
|
|
R7455:Inpp4b
|
UTSW |
8 |
82,798,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7632:Inpp4b
|
UTSW |
8 |
82,772,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7844:Inpp4b
|
UTSW |
8 |
82,467,949 (GRCm39) |
start gained |
probably benign |
|
|
R7958:Inpp4b
|
UTSW |
8 |
82,696,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8440:Inpp4b
|
UTSW |
8 |
82,768,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9160:Inpp4b
|
UTSW |
8 |
82,610,782 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9303:Inpp4b
|
UTSW |
8 |
82,759,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9390:Inpp4b
|
UTSW |
8 |
82,497,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9583:Inpp4b
|
UTSW |
8 |
82,497,555 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9705:Inpp4b
|
UTSW |
8 |
82,772,890 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9778:Inpp4b
|
UTSW |
8 |
82,775,160 (GRCm39) |
missense |
probably benign |
|
|
RF003:Inpp4b
|
UTSW |
8 |
82,696,150 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Inpp4b
|
UTSW |
8 |
82,795,560 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1176:Inpp4b
|
UTSW |
8 |
82,795,630 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCATCCCGGAGCACTCAA -3'
(R):5'- CAGCCAGCAAGAGACCACAAGTT -3'
Sequencing Primer
(F):5'- GAACTCTCAATTCAGCTTGGCAG -3'
(R):5'- ggggggagggagagagag -3'
|
| Posted On |
2014-05-23 |
Incidental Mutation