Mutagenetix > Incidental Mutation

Incidental Mutation 'R1466:Kif1b'

201161

Institutional Source

Beutler Lab

Gene Symbol

Kif1b

Ensembl Gene

ENSMUSG00000063077

Gene Name

kinesin family member 1B

Synonyms

Kif1b beta, KIF1Bp130, A530096N05Rik, D4Mil1e, Kif1b alpha, N-3 kinesin, KIF1Bp204

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1466 (G1)

Quality Score

214

Status

Not validated

Chromosome

Chromosomal Location

149176319-149307693 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 149223252 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 839 (Y839N)

Ref Sequence

ENSEMBL: ENSMUSP00000056754 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055647] [ENSMUST00000060537]

AlphaFold

Q60575

Predicted Effect

probably damaging
Transcript: ENSMUST00000055647
AA Change: Y793N

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000061472
Gene: ENSMUSG00000063077
AA Change: Y793N

Domain	Start	End	E-Value	Type
KISc	3	356	5.85e-176	SMART
low complexity region	389	404	N/A	INTRINSIC
FHA	509	566	1.61e-4	SMART
coiled coil region	626	685	N/A	INTRINSIC
Pfam:KIF1B	799	846	9.7e-13	PFAM
internal_repeat_1	901	933	7.01e-7	PROSPERO
low complexity region	1165	1179	N/A	INTRINSIC
Pfam:DUF3694	1220	1368	1.1e-46	PFAM
low complexity region	1444	1461	N/A	INTRINSIC
low complexity region	1479	1507	N/A	INTRINSIC
low complexity region	1573	1591	N/A	INTRINSIC
PH	1656	1755	1.02e-14	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000060537
AA Change: Y839N

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000056754
Gene: ENSMUSG00000063077
AA Change: Y839N

Domain	Start	End	E-Value	Type
KISc	3	362	7.61e-175	SMART
low complexity region	390	400	N/A	INTRINSIC
low complexity region	432	450	N/A	INTRINSIC
FHA	555	612	1.61e-4	SMART
coiled coil region	672	731	N/A	INTRINSIC
Pfam:KIF1B	845	892	7.1e-15	PFAM
internal_repeat_1	947	979	4.76e-7	PROSPERO
low complexity region	1211	1225	N/A	INTRINSIC
Pfam:DUF3694	1266	1413	1.1e-40	PFAM
low complexity region	1490	1507	N/A	INTRINSIC
low complexity region	1525	1553	N/A	INTRINSIC
low complexity region	1619	1637	N/A	INTRINSIC
PH	1702	1801	1.02e-14	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133526

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.7%
20x: 90.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 134 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110012J17Rik	T	A	17: 66,380,435 (GRCm38)	D492V	probably damaging	Het
Abca13	T	C	11: 9,570,536 (GRCm38)		probably benign	Het
Abcg8	G	C	17: 84,686,727 (GRCm38)		probably benign	Het
Abhd15	C	T	11: 77,515,410 (GRCm38)	A71V	probably damaging	Het
AC167973.1	A	T	9: 43,265,352 (GRCm38)		noncoding transcript	Het
Adamts12	T	C	15: 11,311,359 (GRCm38)	F1234S	probably benign	Het
Ahnak	A	G	19: 9,015,875 (GRCm38)	D4841G	probably damaging	Het
Akap13	T	C	7: 75,729,049 (GRCm38)	S2095P	possibly damaging	Het
Ampd2	T	C	3: 108,080,337 (GRCm38)		probably null	Het
Arhgef17	G	T	7: 100,929,659 (GRCm38)	P694Q	possibly damaging	Het
Arrdc1	T	C	2: 24,925,795 (GRCm38)	I398V	probably benign	Het
Ash1l	T	C	3: 89,052,065 (GRCm38)	Y2250H	probably damaging	Het
Aspg	A	G	12: 112,121,852 (GRCm38)	N385D	probably benign	Het
Atxn3	G	A	12: 101,926,499 (GRCm38)	R319C	possibly damaging	Het
BC005561	T	A	5: 104,518,257 (GRCm38)	I215N	probably damaging	Het
Brca2	G	A	5: 150,552,258 (GRCm38)	A2478T	probably damaging	Het
Btrc	T	A	19: 45,513,382 (GRCm38)		probably benign	Het
C1s1	C	T	6: 124,531,131 (GRCm38)	C633Y	probably damaging	Het
C8g	C	T	2: 25,500,216 (GRCm38)	A6T	probably benign	Het
Capza2	T	C	6: 17,657,159 (GRCm38)		probably benign	Het
Cbl	A	T	9: 44,154,244 (GRCm38)	V706E	probably benign	Het
Ccdc84	A	T	9: 44,413,680 (GRCm38)		probably benign	Het
Cfhr1	C	T	1: 139,557,574 (GRCm38)	E45K	probably benign	Het
Chd7	G	A	4: 8,840,561 (GRCm38)		probably null	Het
Chek1	G	T	9: 36,725,857 (GRCm38)	A2E	probably damaging	Het
Clcn2	G	A	16: 20,712,552 (GRCm38)		probably benign	Het
Cndp2	G	A	18: 84,677,315 (GRCm38)		probably benign	Het
Cntnap1	C	A	11: 101,180,360 (GRCm38)	F366L	probably damaging	Het
Col5a1	G	T	2: 28,003,846 (GRCm38)		probably benign	Het
Corin	C	T	5: 72,302,790 (GRCm38)		probably null	Het
Crb2	T	C	2: 37,783,388 (GRCm38)	Y99H	probably damaging	Het
Csf3r	T	A	4: 126,031,932 (GRCm38)		probably benign	Het
Ctdspl2	G	A	2: 122,003,929 (GRCm38)	R332K	probably benign	Het
Ctnnbl1	C	T	2: 157,799,417 (GRCm38)		probably benign	Het
Cym	G	A	3: 107,213,458 (GRCm38)	T277I	probably damaging	Het
Cyp2d11	C	T	15: 82,391,735 (GRCm38)	C215Y	probably benign	Het
Dido1	G	A	2: 180,662,328 (GRCm38)	P1261L	probably damaging	Het
Dnah10	T	A	5: 124,763,096 (GRCm38)	Y1265N	probably benign	Het
Dtx3l	G	A	16: 35,932,728 (GRCm38)	L503F	probably damaging	Het
Eda	T	A	X: 100,392,392 (GRCm38)		probably benign	Homo
Efhb	A	G	17: 53,437,178 (GRCm38)	F462L	probably damaging	Het
Enpep	T	A	3: 129,319,448 (GRCm38)	T203S	probably damaging	Het
Exd1	G	A	2: 119,520,734 (GRCm38)		probably benign	Het
Fam184b	G	A	5: 45,580,509 (GRCm38)		probably benign	Het
Fam20b	T	C	1: 156,686,188 (GRCm38)		probably benign	Het
Fat3	A	C	9: 16,375,482 (GRCm38)	V915G	probably damaging	Het
Fbln7	A	G	2: 128,877,429 (GRCm38)	T49A	probably benign	Het
Fcho1	C	T	8: 71,712,560 (GRCm38)	A418T	probably benign	Het
Fgf14	T	A	14: 124,676,539 (GRCm38)	K60M	probably benign	Het
Galnt4	A	G	10: 99,108,709 (GRCm38)	R99G	probably benign	Het
Gimap4	C	A	6: 48,691,282 (GRCm38)	Q196K	probably benign	Het
Glcci1	C	T	6: 8,537,964 (GRCm38)	T6I	probably damaging	Het
Gm10110	A	T	14: 89,898,075 (GRCm38)		noncoding transcript	Het
Gm4884	A	G	7: 41,043,128 (GRCm38)	K174E	probably damaging	Het
Gm6583	C	T	5: 112,354,764 (GRCm38)	G358D	probably benign	Het
Grip2	A	T	6: 91,788,443 (GRCm38)	D19E	probably damaging	Het
Grk4	T	C	5: 34,694,750 (GRCm38)	S113P	probably benign	Het
Hectd3	G	A	4: 116,996,566 (GRCm38)	E220K	probably damaging	Het
Helz2	G	A	2: 181,236,297 (GRCm38)	P903S	probably damaging	Het
Hydin	T	A	8: 110,532,953 (GRCm38)	V2519E	possibly damaging	Het
Igf2r	A	T	17: 12,717,269 (GRCm38)		probably benign	Het
Ints11	G	A	4: 155,888,110 (GRCm38)		probably null	Het
Kif1a	A	G	1: 93,054,929 (GRCm38)	W718R	possibly damaging	Het
Kif20b	T	A	19: 34,950,599 (GRCm38)	V1047D	probably benign	Het
Klhl23	T	C	2: 69,833,888 (GRCm38)	I527T	probably damaging	Het
Klra10	T	A	6: 130,279,315 (GRCm38)	R125S	probably damaging	Het
Klra10	T	C	6: 130,279,431 (GRCm38)	N87D	probably damaging	Het
Lars	G	A	18: 42,210,050 (GRCm38)	R1101C	probably damaging	Het
Lcn4	G	A	2: 26,668,576 (GRCm38)	P166L	probably damaging	Het
Letmd1	T	A	15: 100,472,542 (GRCm38)		probably null	Het
Lrrc27	A	G	7: 139,230,308 (GRCm38)		probably benign	Het
Map4k2	G	T	19: 6,341,917 (GRCm38)	W87L	probably damaging	Het
Mccc1	A	G	3: 35,974,286 (GRCm38)	V457A	probably benign	Het
Mdn1	T	A	4: 32,730,788 (GRCm38)	S2886T	probably benign	Het
Mgat4a	A	T	1: 37,464,406 (GRCm38)		probably benign	Het
Mmp1b	A	T	9: 7,384,779 (GRCm38)		probably benign	Het
Mroh2b	G	T	15: 4,925,684 (GRCm38)	D720Y	probably damaging	Het
Mrpl24	T	A	3: 87,921,928 (GRCm38)	Y21*	probably null	Het
Mrps35	C	T	6: 147,055,984 (GRCm38)	T169M	probably damaging	Het
Muc2	A	G	7: 141,748,974 (GRCm38)	Y457C	probably damaging	Het
Muc4	G	A	16: 32,753,595 (GRCm38)	G1157D	probably benign	Het
Myg1	T	A	15: 102,337,390 (GRCm38)	L275Q	probably damaging	Het
Naga	T	A	15: 82,334,788 (GRCm38)	M237L	probably null	Het
Nek1	C	T	8: 61,125,136 (GRCm38)		probably benign	Het
Oc90	T	A	15: 65,897,720 (GRCm38)	Y96F	probably damaging	Het
Olfr1029	T	A	2: 85,975,995 (GRCm38)	F251I	probably damaging	Het
Olfr103	A	T	17: 37,336,956 (GRCm38)	L92H	probably benign	Het
Olfr1253	C	T	2: 89,752,267 (GRCm38)	C187Y	probably damaging	Het
Olfr46	A	G	7: 140,610,969 (GRCm38)	I268V	probably benign	Het
Olfr522	A	G	7: 140,162,203 (GRCm38)	V249A	probably damaging	Het
Orc4	A	T	2: 48,909,494 (GRCm38)	C324S	possibly damaging	Het
Pald1	T	C	10: 61,348,525 (GRCm38)		probably benign	Het
Paox	A	G	7: 140,129,281 (GRCm38)		probably benign	Het
Pcdh10	T	G	3: 45,379,974 (GRCm38)	L241R	probably damaging	Het
Pdzrn4	T	C	15: 92,770,537 (GRCm38)	S857P	probably benign	Het
Plec	C	T	15: 76,185,908 (GRCm38)	E1000K	possibly damaging	Het
Plvap	A	T	8: 71,508,481 (GRCm38)	V149D	probably benign	Het
Ppef1	C	A	X: 160,625,674 (GRCm38)		probably null	Homo
Prkaa1	C	A	15: 5,178,798 (GRCm38)	P507T	probably benign	Het
Psmd2	A	G	16: 20,657,965 (GRCm38)		probably benign	Het
Ptch1	A	G	13: 63,524,969 (GRCm38)	Y804H	probably benign	Het
R3hdm2	A	G	10: 127,476,690 (GRCm38)	I434V	probably benign	Het
Rbm28	G	A	6: 29,155,017 (GRCm38)		probably benign	Het
Rfx5	T	A	3: 94,956,303 (GRCm38)	Y88N	probably damaging	Het
Rnase2b	A	T	14: 51,162,839 (GRCm38)	K126*	probably null	Het
Rpl3l	A	G	17: 24,730,871 (GRCm38)	I15V	probably benign	Het
Saal1	G	T	7: 46,702,545 (GRCm38)		probably null	Het
Sbpl	A	C	17: 23,953,254 (GRCm38)	D230E	unknown	Het
Scn10a	T	C	9: 119,666,490 (GRCm38)	Y322C	probably damaging	Het
Sec16a	A	T	2: 26,431,157 (GRCm38)	Y1308N	probably damaging	Het
Sis	A	T	3: 72,932,060 (GRCm38)	D824E	possibly damaging	Het
Slc25a36	A	G	9: 97,080,355 (GRCm38)	F194L	probably damaging	Het
Slc27a4	T	A	2: 29,811,190 (GRCm38)	V331E	probably damaging	Het
Slc7a11	G	T	3: 50,381,073 (GRCm38)		probably null	Het
Slco4c1	A	T	1: 96,841,172 (GRCm38)	S322T	probably damaging	Het
Smarcc2	A	T	10: 128,474,245 (GRCm38)	T376S	probably damaging	Het
Srebf1	C	T	11: 60,200,702 (GRCm38)	R999H	probably benign	Het
St3gal3	A	C	4: 118,107,662 (GRCm38)	M1R	probably null	Het
Syp	A	T	X: 7,648,705 (GRCm38)		probably benign	Homo
Tas1r2	A	G	4: 139,669,411 (GRCm38)	D687G	probably damaging	Het
Tekt4	A	T	17: 25,472,074 (GRCm38)	Q118L	probably benign	Het
Tph2	T	C	10: 115,079,695 (GRCm38)	N480S	probably benign	Het
Tsc2	A	T	17: 24,608,973 (GRCm38)	M839K	probably damaging	Het
Ttc22	T	C	4: 106,622,780 (GRCm38)	F77S	probably damaging	Het
Uaca	C	T	9: 60,854,321 (GRCm38)	A205V	possibly damaging	Het
Ubp1	T	G	9: 113,944,835 (GRCm38)		probably benign	Het
Uhmk1	A	T	1: 170,208,653 (GRCm38)		probably null	Het
Usp17lc	A	G	7: 103,418,941 (GRCm38)	H481R	possibly damaging	Het
Vwa3a	A	G	7: 120,768,165 (GRCm38)	Y181C	probably damaging	Het
Wdr26	C	T	1: 181,185,934 (GRCm38)		probably benign	Het
Wfikkn2	G	A	11: 94,238,895 (GRCm38)	T140I	probably damaging	Het
Zfp704	G	T	3: 9,447,348 (GRCm38)	T288N	possibly damaging	Het
Zfp93	T	C	7: 24,276,096 (GRCm38)	V502A	probably damaging	Het
Zzef1	C	T	11: 72,924,679 (GRCm38)	P2942S	probably damaging	Het

Other mutations in Kif1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01311:Kif1b	APN	4	149,220,602 (GRCm38)	missense	probably damaging	1.00
IGL01943:Kif1b	APN	4	149,214,905 (GRCm38)	critical splice donor site	probably null
IGL02240:Kif1b	APN	4	149,246,414 (GRCm38)	missense	probably damaging	1.00
IGL02414:Kif1b	APN	4	149,199,314 (GRCm38)	missense	probably damaging	0.96
IGL02490:Kif1b	APN	4	149,204,208 (GRCm38)	missense	probably benign
IGL02501:Kif1b	APN	4	149,214,976 (GRCm38)	missense	probably damaging	1.00
IGL02833:Kif1b	APN	4	149,246,364 (GRCm38)	missense	probably damaging	1.00
IGL02852:Kif1b	APN	4	149,291,328 (GRCm38)	missense	probably damaging	1.00
IGL02900:Kif1b	APN	4	149,180,809 (GRCm38)	missense	possibly damaging	0.81
IGL03287:Kif1b	APN	4	149,214,981 (GRCm38)	missense	possibly damaging	0.67
IGL03412:Kif1b	APN	4	149,274,939 (GRCm38)	missense	probably benign	0.00
PIT4305001:Kif1b	UTSW	4	149,220,792 (GRCm38)	critical splice acceptor site	probably null
R0005:Kif1b	UTSW	4	149,181,927 (GRCm38)	missense	probably damaging	1.00
R0044:Kif1b	UTSW	4	149,263,601 (GRCm38)	splice site	probably benign
R0044:Kif1b	UTSW	4	149,263,601 (GRCm38)	splice site	probably benign
R0129:Kif1b	UTSW	4	149,261,201 (GRCm38)	missense	probably benign
R0180:Kif1b	UTSW	4	149,213,659 (GRCm38)	missense	probably damaging	1.00
R0288:Kif1b	UTSW	4	149,199,338 (GRCm38)	missense	probably damaging	1.00
R0360:Kif1b	UTSW	4	149,262,729 (GRCm38)	missense	probably damaging	1.00
R0383:Kif1b	UTSW	4	149,202,512 (GRCm38)	missense	probably damaging	1.00
R0398:Kif1b	UTSW	4	149,204,231 (GRCm38)	missense	possibly damaging	0.89
R0403:Kif1b	UTSW	4	149,181,967 (GRCm38)	nonsense	probably null
R0445:Kif1b	UTSW	4	149,188,009 (GRCm38)	missense	probably benign	0.01
R1466:Kif1b	UTSW	4	149,223,252 (GRCm38)	missense	probably damaging	0.99
R1681:Kif1b	UTSW	4	149,195,501 (GRCm38)	critical splice acceptor site	probably null
R1728:Kif1b	UTSW	4	149,187,722 (GRCm38)	missense	probably damaging	0.99
R1840:Kif1b	UTSW	4	149,188,132 (GRCm38)	missense	probably damaging	1.00
R1874:Kif1b	UTSW	4	149,187,632 (GRCm38)	missense	probably benign
R1915:Kif1b	UTSW	4	149,267,216 (GRCm38)	missense	probably damaging	1.00
R2106:Kif1b	UTSW	4	149,187,640 (GRCm38)	missense	possibly damaging	0.92
R2124:Kif1b	UTSW	4	149,222,296 (GRCm38)	missense	probably benign	0.08
R2126:Kif1b	UTSW	4	149,187,640 (GRCm38)	missense	possibly damaging	0.92
R2127:Kif1b	UTSW	4	149,187,640 (GRCm38)	missense	possibly damaging	0.92
R2128:Kif1b	UTSW	4	149,187,640 (GRCm38)	missense	possibly damaging	0.92
R2129:Kif1b	UTSW	4	149,187,640 (GRCm38)	missense	possibly damaging	0.92
R2146:Kif1b	UTSW	4	149,184,309 (GRCm38)	missense	probably damaging	0.99
R2255:Kif1b	UTSW	4	149,274,997 (GRCm38)	missense	probably damaging	1.00
R2392:Kif1b	UTSW	4	149,220,620 (GRCm38)	missense	possibly damaging	0.93
R2883:Kif1b	UTSW	4	149,237,648 (GRCm38)	missense	possibly damaging	0.78
R2981:Kif1b	UTSW	4	149,220,541 (GRCm38)	critical splice donor site	probably null
R3038:Kif1b	UTSW	4	149,213,333 (GRCm38)	missense	probably benign	0.02
R3616:Kif1b	UTSW	4	149,262,283 (GRCm38)	splice site	probably benign
R3935:Kif1b	UTSW	4	149,237,160 (GRCm38)	missense	probably benign	0.00
R4347:Kif1b	UTSW	4	149,247,234 (GRCm38)	missense	probably damaging	1.00
R4423:Kif1b	UTSW	4	149,214,105 (GRCm38)	missense	probably damaging	0.99
R4637:Kif1b	UTSW	4	149,199,311 (GRCm38)	missense	probably damaging	0.97
R4745:Kif1b	UTSW	4	149,237,882 (GRCm38)	nonsense	probably null
R4807:Kif1b	UTSW	4	149,247,921 (GRCm38)	intron	probably benign
R5618:Kif1b	UTSW	4	149,269,889 (GRCm38)	missense	possibly damaging	0.94
R5644:Kif1b	UTSW	4	149,238,482 (GRCm38)	missense	probably damaging	0.96
R5683:Kif1b	UTSW	4	149,222,261 (GRCm38)	missense	probably damaging	1.00
R5696:Kif1b	UTSW	4	149,273,849 (GRCm38)	splice site	probably null
R6022:Kif1b	UTSW	4	149,198,532 (GRCm38)	missense	probably benign	0.01
R6048:Kif1b	UTSW	4	149,263,629 (GRCm38)	missense	probably damaging	1.00
R6137:Kif1b	UTSW	4	149,238,426 (GRCm38)	missense	possibly damaging	0.47
R6139:Kif1b	UTSW	4	149,237,532 (GRCm38)	missense	possibly damaging	0.88
R6171:Kif1b	UTSW	4	149,258,048 (GRCm38)	missense	probably damaging	1.00
R6250:Kif1b	UTSW	4	149,213,643 (GRCm38)	missense	probably benign	0.00
R6423:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6424:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6425:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6443:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6460:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6462:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6463:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6469:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6470:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6471:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6472:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6504:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6536:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6537:Kif1b	UTSW	4	149,192,596 (GRCm38)	missense	probably benign	0.16
R6668:Kif1b	UTSW	4	149,213,407 (GRCm38)	missense	probably benign	0.09
R6698:Kif1b	UTSW	4	149,274,956 (GRCm38)	missense	probably damaging	0.99
R7065:Kif1b	UTSW	4	149,202,525 (GRCm38)	missense	possibly damaging	0.46
R7222:Kif1b	UTSW	4	149,225,157 (GRCm38)	missense	probably damaging	1.00
R7342:Kif1b	UTSW	4	149,214,090 (GRCm38)	missense	possibly damaging	0.94
R7720:Kif1b	UTSW	4	149,182,355 (GRCm38)	missense	probably benign	0.01
R7744:Kif1b	UTSW	4	149,237,075 (GRCm38)	missense	possibly damaging	0.83
R7797:Kif1b	UTSW	4	149,237,387 (GRCm38)	missense	probably benign
R7829:Kif1b	UTSW	4	149,220,990 (GRCm38)	splice site	probably null
R7869:Kif1b	UTSW	4	149,184,376 (GRCm38)	missense	probably benign	0.01
R7878:Kif1b	UTSW	4	149,214,997 (GRCm38)	missense	probably damaging	0.98
R7980:Kif1b	UTSW	4	149,269,921 (GRCm38)	missense	probably damaging	1.00
R8047:Kif1b	UTSW	4	149,214,922 (GRCm38)	missense	probably damaging	1.00
R8237:Kif1b	UTSW	4	149,191,185 (GRCm38)	missense	probably benign	0.10
R8243:Kif1b	UTSW	4	149,204,267 (GRCm38)	missense	probably benign
R8252:Kif1b	UTSW	4	149,273,805 (GRCm38)	missense	probably damaging	1.00
R8342:Kif1b	UTSW	4	149,222,348 (GRCm38)	missense	probably damaging	0.96
R8460:Kif1b	UTSW	4	149,187,620 (GRCm38)	missense	possibly damaging	0.93
R8462:Kif1b	UTSW	4	149,182,340 (GRCm38)	missense	probably benign	0.05
R8496:Kif1b	UTSW	4	149,192,611 (GRCm38)	nonsense	probably null
R8687:Kif1b	UTSW	4	149,261,163 (GRCm38)	nonsense	probably null
R8694:Kif1b	UTSW	4	149,220,567 (GRCm38)	missense	probably damaging	0.98
R8842:Kif1b	UTSW	4	149,253,739 (GRCm38)	missense	probably damaging	0.98
R8883:Kif1b	UTSW	4	149,276,885 (GRCm38)	missense	probably benign
R8971:Kif1b	UTSW	4	149,247,816 (GRCm38)	missense	probably damaging	1.00
R8994:Kif1b	UTSW	4	149,195,482 (GRCm38)	missense
R9002:Kif1b	UTSW	4	149,191,255 (GRCm38)	missense	probably damaging	0.96
R9227:Kif1b	UTSW	4	149,237,900 (GRCm38)	missense	probably damaging	1.00
R9231:Kif1b	UTSW	4	149,191,195 (GRCm38)	missense	possibly damaging	0.94
R9450:Kif1b	UTSW	4	149,238,010 (GRCm38)	missense	probably benign	0.01
R9478:Kif1b	UTSW	4	149,261,159 (GRCm38)	critical splice donor site	probably null
R9571:Kif1b	UTSW	4	149,220,641 (GRCm38)	missense	probably damaging	1.00
R9644:Kif1b	UTSW	4	149,291,379 (GRCm38)	missense	probably damaging	1.00
RF008:Kif1b	UTSW	4	149,251,738 (GRCm38)	splice site	probably null
X0009:Kif1b	UTSW	4	149,247,264 (GRCm38)	missense	probably damaging	1.00
X0062:Kif1b	UTSW	4	149,275,005 (GRCm38)	missense	probably damaging	1.00
Z1176:Kif1b	UTSW	4	149,266,298 (GRCm38)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- GCTGACATCTCAGACATAGCTCCAC -3'
(R):5'- AGTTTGTTCTGCTGACTGACACGC -3'

Sequencing Primer
(F):5'- tttctgtgtagccctagctatc -3'
(R):5'- GACTGACACGCTGTACTCC -3'

Posted On

2014-05-23