Mutagenetix > Incidental Mutation

Incidental Mutation 'R1466:Corin'

201165

Institutional Source

Beutler Lab

Gene Symbol

Corin

Ensembl Gene

ENSMUSG00000005220

Gene Name

corin, serine peptidase

Synonyms

Lrp4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.237) question?

Stock #

R1466 (G1)

Quality Score

173

Status

Not validated

Chromosome

Chromosomal Location

72457368-72661816 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 72460133 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000135511 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000005352] [ENSMUST00000094710] [ENSMUST00000126664] [ENSMUST00000167460] [ENSMUST00000175766] [ENSMUST00000176974] [ENSMUST00000177290]

AlphaFold

Q9Z319

Predicted Effect

probably null
Transcript: ENSMUST00000005352

SMART Domains

Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220

Domain	Start	End	E-Value	Type
low complexity region	3	15	N/A	INTRINSIC
transmembrane domain	113	135	N/A	INTRINSIC
FRI	205	318	6.15e-11	SMART
LDLa	336	372	1.31e-8	SMART
LDLa	373	408	1.5e-8	SMART
LDLa	409	447	5.47e-11	SMART
LDLa	448	484	1.22e-8	SMART
low complexity region	508	521	N/A	INTRINSIC
FRI	522	643	2.75e-31	SMART
LDLa	647	684	2.19e-10	SMART
LDLa	685	722	1.76e-5	SMART
LDLa	723	759	4.18e-7	SMART
SR	758	853	3.99e-10	SMART
Tryp_SPc	868	1097	5.45e-76	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000094710

SMART Domains

Protein: ENSMUSP00000142749
Gene: ENSMUSG00000046808

Domain	Start	End	E-Value	Type
SCOP:d1eula_	5	180	9e-15	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126664

SMART Domains

Protein: ENSMUSP00000143594
Gene: ENSMUSG00000046808

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:PhoLip_ATPase_N	111	176	1.2e-21	PFAM
Pfam:E1-E2_ATPase	181	450	3e-10	PFAM
low complexity region	523	534	N/A	INTRINSIC
low complexity region	684	696	N/A	INTRINSIC
Pfam:Cation_ATPase	739	859	3.4e-7	PFAM
Pfam:HAD	754	1114	1.3e-12	PFAM
Pfam:PhoLip_ATPase_C	1131	1376	4.3e-77	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000136350

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146393

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158570

Predicted Effect

probably null
Transcript: ENSMUST00000167460

SMART Domains

Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220

Domain	Start	End	E-Value	Type
transmembrane domain	47	69	N/A	INTRINSIC
FRI	139	252	6.15e-11	SMART
LDLa	270	306	1.31e-8	SMART
LDLa	307	342	1.5e-8	SMART
LDLa	343	381	5.47e-11	SMART
LDLa	382	418	1.22e-8	SMART
low complexity region	442	455	N/A	INTRINSIC
FRI	456	577	2.75e-31	SMART
LDLa	581	618	2.19e-10	SMART
LDLa	619	656	1.76e-5	SMART
LDLa	657	693	4.18e-7	SMART
SR	692	787	3.99e-10	SMART
Tryp_SPc	802	1031	5.45e-76	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000175766

SMART Domains

Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220

Domain	Start	End	E-Value	Type
transmembrane domain	45	67	N/A	INTRINSIC
FRI	137	250	6.15e-11	SMART
LDLa	268	304	1.31e-8	SMART
LDLa	305	343	2.07e-11	SMART
low complexity region	367	380	N/A	INTRINSIC
FRI	381	502	2.75e-31	SMART
LDLa	506	543	2.19e-10	SMART
LDLa	544	581	1.76e-5	SMART
LDLa	582	618	4.18e-7	SMART
SR	617	712	3.99e-10	SMART
Tryp_SPc	727	956	5.45e-76	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000176974

SMART Domains

Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220

Domain	Start	End	E-Value	Type
transmembrane domain	47	69	N/A	INTRINSIC
FRI	139	252	6.15e-11	SMART
LDLa	270	306	1.31e-8	SMART
LDLa	307	344	3.86e-11	SMART
LDLa	345	381	1.22e-8	SMART
low complexity region	405	418	N/A	INTRINSIC
FRI	419	540	2.75e-31	SMART
LDLa	544	581	2.19e-10	SMART
LDLa	582	619	1.76e-5	SMART
LDLa	620	656	4.18e-7	SMART
SR	655	750	3.99e-10	SMART
Tryp_SPc	765	994	5.45e-76	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000177290

SMART Domains

Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220

Domain	Start	End	E-Value	Type
transmembrane domain	47	69	N/A	INTRINSIC
FRI	72	185	6.15e-11	SMART
LDLa	203	239	1.31e-8	SMART
LDLa	240	275	1.5e-8	SMART
LDLa	276	314	5.47e-11	SMART
LDLa	315	351	1.22e-8	SMART
low complexity region	375	388	N/A	INTRINSIC
FRI	389	510	2.75e-31	SMART
LDLa	514	551	2.19e-10	SMART
LDLa	552	589	1.76e-5	SMART
LDLa	590	626	4.18e-7	SMART
SR	625	720	3.99e-10	SMART
Tryp_SPc	735	964	5.45e-76	SMART

Meta Mutation Damage Score

0.9470

Coding Region Coverage

1x: 97.4%
3x: 96.7%
10x: 94.7%
20x: 90.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 134 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,520,536 (GRCm39)		probably benign	Het
Abcg8	G	C	17: 84,994,155 (GRCm39)		probably benign	Het
Abhd15	C	T	11: 77,406,236 (GRCm39)	A71V	probably damaging	Het
AC167973.1	A	T	9: 43,176,649 (GRCm39)		noncoding transcript	Het
Adamts12	T	C	15: 11,311,445 (GRCm39)	F1234S	probably benign	Het
Ahnak	A	G	19: 8,993,239 (GRCm39)	D4841G	probably damaging	Het
Akap13	T	C	7: 75,378,797 (GRCm39)	S2095P	possibly damaging	Het
Ampd2	T	C	3: 107,987,653 (GRCm39)		probably null	Het
Arhgef17	G	T	7: 100,578,866 (GRCm39)	P694Q	possibly damaging	Het
Arrdc1	T	C	2: 24,815,807 (GRCm39)	I398V	probably benign	Het
Ash1l	T	C	3: 88,959,372 (GRCm39)	Y2250H	probably damaging	Het
Aspg	A	G	12: 112,088,286 (GRCm39)	N385D	probably benign	Het
Atxn3	G	A	12: 101,892,758 (GRCm39)	R319C	possibly damaging	Het
Brca2	G	A	5: 150,475,723 (GRCm39)	A2478T	probably damaging	Het
Btrc	T	A	19: 45,501,821 (GRCm39)		probably benign	Het
C1s1	C	T	6: 124,508,090 (GRCm39)	C633Y	probably damaging	Het
C8g	C	T	2: 25,390,228 (GRCm39)	A6T	probably benign	Het
Capza2	T	C	6: 17,657,158 (GRCm39)		probably benign	Het
Cbl	A	T	9: 44,065,541 (GRCm39)	V706E	probably benign	Het
Ccdc121rt3	C	T	5: 112,502,630 (GRCm39)	G358D	probably benign	Het
Cenatac	A	T	9: 44,324,977 (GRCm39)		probably benign	Het
Cfhr1	C	T	1: 139,485,312 (GRCm39)	E45K	probably benign	Het
Chd7	G	A	4: 8,840,561 (GRCm39)		probably null	Het
Chek1	G	T	9: 36,637,153 (GRCm39)	A2E	probably damaging	Het
Clcn2	G	A	16: 20,531,302 (GRCm39)		probably benign	Het
Cndp2	G	A	18: 84,695,440 (GRCm39)		probably benign	Het
Cntnap1	C	A	11: 101,071,186 (GRCm39)	F366L	probably damaging	Het
Col5a1	G	T	2: 27,893,858 (GRCm39)		probably benign	Het
Crb2	T	C	2: 37,673,400 (GRCm39)	Y99H	probably damaging	Het
Csf3r	T	A	4: 125,925,725 (GRCm39)		probably benign	Het
Ctdspl2	G	A	2: 121,834,410 (GRCm39)	R332K	probably benign	Het
Ctnnbl1	C	T	2: 157,641,337 (GRCm39)		probably benign	Het
Cym	G	A	3: 107,120,774 (GRCm39)	T277I	probably damaging	Het
Cyp2d11	C	T	15: 82,275,936 (GRCm39)	C215Y	probably benign	Het
Dido1	G	A	2: 180,304,121 (GRCm39)	P1261L	probably damaging	Het
Dnah10	T	A	5: 124,840,160 (GRCm39)	Y1265N	probably benign	Het
Dtx3l	G	A	16: 35,753,098 (GRCm39)	L503F	probably damaging	Het
Eda	T	A	X: 99,435,998 (GRCm39)		probably benign	Homo
Efhb	A	G	17: 53,744,206 (GRCm39)	F462L	probably damaging	Het
Enpep	T	A	3: 129,113,097 (GRCm39)	T203S	probably damaging	Het
Exd1	G	A	2: 119,351,215 (GRCm39)		probably benign	Het
Fam184b	G	A	5: 45,737,851 (GRCm39)		probably benign	Het
Fam20b	T	C	1: 156,513,758 (GRCm39)		probably benign	Het
Fat3	A	C	9: 16,286,778 (GRCm39)	V915G	probably damaging	Het
Fbln7	A	G	2: 128,719,349 (GRCm39)	T49A	probably benign	Het
Fcho1	C	T	8: 72,165,204 (GRCm39)	A418T	probably benign	Het
Fgf14	T	A	14: 124,913,951 (GRCm39)	K60M	probably benign	Het
Galnt4	A	G	10: 98,944,571 (GRCm39)	R99G	probably benign	Het
Gimap4	C	A	6: 48,668,216 (GRCm39)	Q196K	probably benign	Het
Glcci1	C	T	6: 8,537,964 (GRCm39)	T6I	probably damaging	Het
Gm10110	A	T	14: 90,135,511 (GRCm39)		noncoding transcript	Het
Gm4884	A	G	7: 40,692,552 (GRCm39)	K174E	probably damaging	Het
Grip2	A	T	6: 91,765,424 (GRCm39)	D19E	probably damaging	Het
Grk4	T	C	5: 34,852,094 (GRCm39)	S113P	probably benign	Het
Hectd3	G	A	4: 116,853,763 (GRCm39)	E220K	probably damaging	Het
Helz2	G	A	2: 180,878,090 (GRCm39)	P903S	probably damaging	Het
Hydin	T	A	8: 111,259,585 (GRCm39)	V2519E	possibly damaging	Het
Igf2r	A	T	17: 12,936,156 (GRCm39)		probably benign	Het
Ints11	G	A	4: 155,972,567 (GRCm39)		probably null	Het
Kif1a	A	G	1: 92,982,651 (GRCm39)	W718R	possibly damaging	Het
Kif1b	A	T	4: 149,307,709 (GRCm39)	Y839N	probably damaging	Het
Kif20b	T	A	19: 34,927,999 (GRCm39)	V1047D	probably benign	Het
Klhl23	T	C	2: 69,664,232 (GRCm39)	I527T	probably damaging	Het
Klra10	T	A	6: 130,256,278 (GRCm39)	R125S	probably damaging	Het
Klra10	T	C	6: 130,256,394 (GRCm39)	N87D	probably damaging	Het
Lars1	G	A	18: 42,343,115 (GRCm39)	R1101C	probably damaging	Het
Lcn4	G	A	2: 26,558,588 (GRCm39)	P166L	probably damaging	Het
Letmd1	T	A	15: 100,370,423 (GRCm39)		probably null	Het
Lrrc27	A	G	7: 138,810,224 (GRCm39)		probably benign	Het
Map4k2	G	T	19: 6,391,947 (GRCm39)	W87L	probably damaging	Het
Mccc1	A	G	3: 36,028,435 (GRCm39)	V457A	probably benign	Het
Mdn1	T	A	4: 32,730,788 (GRCm39)	S2886T	probably benign	Het
Mgat4a	A	T	1: 37,503,487 (GRCm39)		probably benign	Het
Mmp1b	A	T	9: 7,384,779 (GRCm39)		probably benign	Het
Mroh2b	G	T	15: 4,955,166 (GRCm39)	D720Y	probably damaging	Het
Mrpl24	T	A	3: 87,829,235 (GRCm39)	Y21*	probably null	Het
Mrps35	C	T	6: 146,957,482 (GRCm39)	T169M	probably damaging	Het
Mtcl1	T	A	17: 66,687,430 (GRCm39)	D492V	probably damaging	Het
Muc2	A	G	7: 141,302,711 (GRCm39)	Y457C	probably damaging	Het
Muc4	G	A	16: 32,574,886 (GRCm39)	G1157D	probably benign	Het
Myg1	T	A	15: 102,245,825 (GRCm39)	L275Q	probably damaging	Het
Naga	T	A	15: 82,218,989 (GRCm39)	M237L	probably null	Het
Nek1	C	T	8: 61,578,170 (GRCm39)		probably benign	Het
Oc90	T	A	15: 65,769,569 (GRCm39)	Y96F	probably damaging	Het
Or12d13	A	T	17: 37,647,847 (GRCm39)	L92H	probably benign	Het
Or13a18	A	G	7: 140,190,882 (GRCm39)	I268V	probably benign	Het
Or4a80	C	T	2: 89,582,611 (GRCm39)	C187Y	probably damaging	Het
Or5m11b	T	A	2: 85,806,339 (GRCm39)	F251I	probably damaging	Het
Or6ae1	A	G	7: 139,742,116 (GRCm39)	V249A	probably damaging	Het
Orc4	A	T	2: 48,799,506 (GRCm39)	C324S	possibly damaging	Het
Pald1	T	C	10: 61,184,304 (GRCm39)		probably benign	Het
Paox	A	G	7: 139,709,194 (GRCm39)		probably benign	Het
Pcdh10	T	G	3: 45,334,409 (GRCm39)	L241R	probably damaging	Het
Pdzrn4	T	C	15: 92,668,418 (GRCm39)	S857P	probably benign	Het
Plec	C	T	15: 76,070,108 (GRCm39)	E1000K	possibly damaging	Het
Plvap	A	T	8: 71,961,125 (GRCm39)	V149D	probably benign	Het
Ppef1	C	A	X: 159,408,670 (GRCm39)		probably null	Homo
Prkaa1	C	A	15: 5,208,279 (GRCm39)	P507T	probably benign	Het
Psmd2	A	G	16: 20,476,715 (GRCm39)		probably benign	Het
Ptch1	A	G	13: 63,672,783 (GRCm39)	Y804H	probably benign	Het
R3hdm2	A	G	10: 127,312,559 (GRCm39)	I434V	probably benign	Het
Rbm28	G	A	6: 29,155,016 (GRCm39)		probably benign	Het
Rfx5	T	A	3: 94,863,614 (GRCm39)	Y88N	probably damaging	Het
Rnase2b	A	T	14: 51,400,296 (GRCm39)	K126*	probably null	Het
Rpl3l	A	G	17: 24,949,845 (GRCm39)	I15V	probably benign	Het
Saal1	G	T	7: 46,351,969 (GRCm39)		probably null	Het
Sbpl	A	C	17: 24,172,228 (GRCm39)	D230E	unknown	Het
Scn10a	T	C	9: 119,495,556 (GRCm39)	Y322C	probably damaging	Het
Sec16a	A	T	2: 26,321,169 (GRCm39)	Y1308N	probably damaging	Het
Sis	A	T	3: 72,839,393 (GRCm39)	D824E	possibly damaging	Het
Slc25a36	A	G	9: 96,962,408 (GRCm39)	F194L	probably damaging	Het
Slc27a4	T	A	2: 29,701,202 (GRCm39)	V331E	probably damaging	Het
Slc7a11	G	T	3: 50,335,522 (GRCm39)		probably null	Het
Slco4c1	A	T	1: 96,768,897 (GRCm39)	S322T	probably damaging	Het
Smarcc2	A	T	10: 128,310,114 (GRCm39)	T376S	probably damaging	Het
Srebf1	C	T	11: 60,091,528 (GRCm39)	R999H	probably benign	Het
St3gal3	A	C	4: 117,964,859 (GRCm39)	M1R	probably null	Het
Syp	A	T	X: 7,514,944 (GRCm39)		probably benign	Homo
Tas1r2	A	G	4: 139,396,722 (GRCm39)	D687G	probably damaging	Het
Tekt4	A	T	17: 25,691,048 (GRCm39)	Q118L	probably benign	Het
Thoc2l	T	A	5: 104,666,123 (GRCm39)	I215N	probably damaging	Het
Tph2	T	C	10: 114,915,600 (GRCm39)	N480S	probably benign	Het
Tsc2	A	T	17: 24,827,947 (GRCm39)	M839K	probably damaging	Het
Ttc22	T	C	4: 106,479,977 (GRCm39)	F77S	probably damaging	Het
Uaca	C	T	9: 60,761,603 (GRCm39)	A205V	possibly damaging	Het
Ubp1	T	G	9: 113,773,903 (GRCm39)		probably benign	Het
Uhmk1	A	T	1: 170,036,222 (GRCm39)		probably null	Het
Usp17lc	A	G	7: 103,068,148 (GRCm39)	H481R	possibly damaging	Het
Vwa3a	A	G	7: 120,367,388 (GRCm39)	Y181C	probably damaging	Het
Wdr26	C	T	1: 181,013,499 (GRCm39)		probably benign	Het
Wfikkn2	G	A	11: 94,129,721 (GRCm39)	T140I	probably damaging	Het
Zfp704	G	T	3: 9,512,408 (GRCm39)	T288N	possibly damaging	Het
Zfp93	T	C	7: 23,975,521 (GRCm39)	V502A	probably damaging	Het
Zzef1	C	T	11: 72,815,505 (GRCm39)	P2942S	probably damaging	Het

Other mutations in Corin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00557:Corin	APN	5	72,462,231 (GRCm39)	missense	probably damaging	1.00
IGL01114:Corin	APN	5	72,462,354 (GRCm39)	missense	probably damaging	1.00
IGL01351:Corin	APN	5	72,496,334 (GRCm39)	missense	probably damaging	1.00
IGL01516:Corin	APN	5	72,611,830 (GRCm39)	nonsense	probably null
IGL01785:Corin	APN	5	72,497,219 (GRCm39)	missense	probably damaging	1.00
IGL01786:Corin	APN	5	72,497,219 (GRCm39)	missense	probably damaging	1.00
IGL01845:Corin	APN	5	72,511,282 (GRCm39)	missense	probably damaging	1.00
IGL02097:Corin	APN	5	72,529,489 (GRCm39)	missense	probably damaging	1.00
IGL02629:Corin	APN	5	72,490,016 (GRCm39)	missense	probably damaging	1.00
IGL03085:Corin	APN	5	72,511,273 (GRCm39)	missense	probably damaging	1.00
IGL03120:Corin	APN	5	72,518,032 (GRCm39)	missense	probably damaging	1.00
IGL03150:Corin	APN	5	72,460,201 (GRCm39)	missense	probably damaging	1.00
IGL03183:Corin	APN	5	72,458,929 (GRCm39)	missense	probably damaging	0.99
IGL03185:Corin	APN	5	72,490,124 (GRCm39)	missense	probably damaging	1.00
IGL03408:Corin	APN	5	72,500,304 (GRCm39)	missense	probably benign	0.40
alpaca	UTSW	5	72,661,295 (GRCm39)	missense	possibly damaging	0.85
R0078:Corin	UTSW	5	72,611,816 (GRCm39)	missense	possibly damaging	0.77
R0724:Corin	UTSW	5	72,490,138 (GRCm39)	splice site	probably benign
R1065:Corin	UTSW	5	72,458,993 (GRCm39)	nonsense	probably null
R1301:Corin	UTSW	5	72,462,276 (GRCm39)	missense	possibly damaging	0.81
R1466:Corin	UTSW	5	72,460,133 (GRCm39)	critical splice donor site	probably null
R1520:Corin	UTSW	5	72,488,238 (GRCm39)	missense	probably damaging	1.00
R1584:Corin	UTSW	5	72,460,133 (GRCm39)	critical splice donor site	probably null
R1617:Corin	UTSW	5	72,661,295 (GRCm39)	missense	possibly damaging	0.85
R1912:Corin	UTSW	5	72,515,746 (GRCm39)	missense	probably damaging	1.00
R2059:Corin	UTSW	5	72,473,394 (GRCm39)	missense	possibly damaging	0.76
R2173:Corin	UTSW	5	72,661,422 (GRCm39)	missense	probably benign	0.01
R2242:Corin	UTSW	5	72,490,054 (GRCm39)	missense	probably damaging	1.00
R2373:Corin	UTSW	5	72,496,381 (GRCm39)	missense	probably damaging	1.00
R2850:Corin	UTSW	5	72,462,298 (GRCm39)	missense	probably damaging	1.00
R3683:Corin	UTSW	5	72,488,198 (GRCm39)	missense	probably damaging	1.00
R3684:Corin	UTSW	5	72,488,198 (GRCm39)	missense	probably damaging	1.00
R3790:Corin	UTSW	5	72,592,641 (GRCm39)	missense	probably benign	0.38
R3847:Corin	UTSW	5	72,579,508 (GRCm39)	missense	probably benign	0.13
R3926:Corin	UTSW	5	72,529,473 (GRCm39)	missense	probably damaging	1.00
R3939:Corin	UTSW	5	72,497,222 (GRCm39)	missense	possibly damaging	0.80
R3945:Corin	UTSW	5	72,515,767 (GRCm39)	missense	probably damaging	1.00
R4079:Corin	UTSW	5	72,661,226 (GRCm39)	missense	probably benign	0.03
R4224:Corin	UTSW	5	72,500,451 (GRCm39)	missense	probably damaging	1.00
R4473:Corin	UTSW	5	72,496,400 (GRCm39)	missense	probably damaging	1.00
R4585:Corin	UTSW	5	72,487,042 (GRCm39)	missense	probably damaging	1.00
R4586:Corin	UTSW	5	72,487,042 (GRCm39)	missense	probably damaging	1.00
R4849:Corin	UTSW	5	72,460,178 (GRCm39)	missense	probably damaging	1.00
R4926:Corin	UTSW	5	72,529,525 (GRCm39)	missense	probably damaging	1.00
R5080:Corin	UTSW	5	72,511,194 (GRCm39)	intron	probably benign
R5138:Corin	UTSW	5	72,496,402 (GRCm39)	missense	probably damaging	1.00
R5262:Corin	UTSW	5	72,462,298 (GRCm39)	missense	probably damaging	1.00
R5268:Corin	UTSW	5	72,500,362 (GRCm39)	missense	probably damaging	1.00
R5302:Corin	UTSW	5	72,473,441 (GRCm39)	missense	probably benign	0.07
R5307:Corin	UTSW	5	72,514,321 (GRCm39)	missense	probably damaging	1.00
R5324:Corin	UTSW	5	72,592,600 (GRCm39)	missense	probably damaging	1.00
R5352:Corin	UTSW	5	72,462,376 (GRCm39)	missense	probably benign	0.04
R5373:Corin	UTSW	5	72,462,296 (GRCm39)	missense	probably damaging	1.00
R5374:Corin	UTSW	5	72,462,296 (GRCm39)	missense	probably damaging	1.00
R5484:Corin	UTSW	5	72,515,827 (GRCm39)	missense	probably benign	0.15
R5502:Corin	UTSW	5	72,473,449 (GRCm39)	nonsense	probably null
R5544:Corin	UTSW	5	72,462,357 (GRCm39)	nonsense	probably null
R5682:Corin	UTSW	5	72,579,497 (GRCm39)	missense	possibly damaging	0.85
R5818:Corin	UTSW	5	72,592,738 (GRCm39)	missense	probably benign	0.00
R5992:Corin	UTSW	5	72,473,732 (GRCm39)	missense	probably benign	0.01
R6115:Corin	UTSW	5	72,518,072 (GRCm39)	missense	probably damaging	1.00
R6181:Corin	UTSW	5	72,529,439 (GRCm39)	critical splice donor site	probably null
R6317:Corin	UTSW	5	72,496,388 (GRCm39)	missense	probably damaging	1.00
R7053:Corin	UTSW	5	72,458,870 (GRCm39)	missense	probably benign	0.28
R7242:Corin	UTSW	5	72,462,398 (GRCm39)	missense	probably benign	0.14
R7452:Corin	UTSW	5	72,592,590 (GRCm39)	missense	possibly damaging	0.94
R7783:Corin	UTSW	5	72,458,967 (GRCm39)	missense	probably benign	0.26
R7903:Corin	UTSW	5	72,458,843 (GRCm39)	missense	probably benign	0.00
R7956:Corin	UTSW	5	72,579,530 (GRCm39)	missense	probably damaging	0.99
R8007:Corin	UTSW	5	72,473,446 (GRCm39)	missense	probably damaging	0.96
R8125:Corin	UTSW	5	72,515,806 (GRCm39)	missense	probably damaging	0.96
R8215:Corin	UTSW	5	72,462,361 (GRCm39)	missense	probably damaging	1.00
R8251:Corin	UTSW	5	72,514,269 (GRCm39)	missense	probably damaging	1.00
R8364:Corin	UTSW	5	72,462,274 (GRCm39)	missense	probably benign
R8505:Corin	UTSW	5	72,592,750 (GRCm39)	missense	probably benign	0.21
R8746:Corin	UTSW	5	72,592,695 (GRCm39)	missense	probably benign	0.31
R8887:Corin	UTSW	5	72,486,953 (GRCm39)	critical splice donor site	probably null
R9484:Corin	UTSW	5	72,497,280 (GRCm39)	missense	probably damaging	1.00
R9640:Corin	UTSW	5	72,592,597 (GRCm39)	missense	probably benign
Z1177:Corin	UTSW	5	72,611,836 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGGTTATACATGGCAATGCCCTCTG -3'
(R):5'- CTTTGAACGCAGTGCCCTTTAAGC -3'

Sequencing Primer
(F):5'- CTGCTTAAGACAGTGGATTTGAAG -3'
(R):5'- GATCTGTGCTGGCTATGAGT -3'

Posted On

2014-05-23