Incidental Mutation 'R0090:Casp8ap2'
| ID |
20125 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Casp8ap2
|
| Ensembl Gene |
ENSMUSG00000028282 |
| Gene Name |
caspase 8 associated protein 2 |
| Synonyms |
FLASH, D4Ertd659e |
| MMRRC Submission |
038377-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0090 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
4 |
| Chromosomal Location |
32615462-32653271 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 32640327 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 460
(H460Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136016
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029950]
[ENSMUST00000108178]
[ENSMUST00000178925]
|
| AlphaFold |
Q9WUF3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000029950
AA Change: H460Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000029950
Gene: ENSMUSG00000028282
AA Change: H460Q
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
|
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
|
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
|
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108178
|
| SMART Domains |
Protein: ENSMUSP00000103813
Gene: ENSMUSG00000028282
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2LR8|A
|
126 |
190 |
4e-26 |
PDB |
|
Blast:SANT
|
139 |
183 |
4e-19 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127619
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000178925
AA Change: H460Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000136016
Gene: ENSMUSG00000028282
AA Change: H460Q
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
68 |
142 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
303 |
N/A |
INTRINSIC |
|
low complexity region
|
458 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
1124 |
1135 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1377 |
N/A |
INTRINSIC |
|
low complexity region
|
1458 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1477 |
1498 |
N/A |
INTRINSIC |
|
low complexity region
|
1882 |
1895 |
N/A |
INTRINSIC |
|
PDB:2LR8|A
|
1896 |
1962 |
1e-31 |
PDB |
|
Blast:SANT
|
1905 |
1955 |
2e-21 |
BLAST |
|
| Meta Mutation Damage Score |
0.1057 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.7%
- 20x: 91.4%
|
| Validation Efficiency |
99% (90/91) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
PHENOTYPE: Mice homozygous for disruption of this gene die before implantation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010315B03Rik |
T |
C |
9: 124,057,789 (GRCm39) |
|
probably benign |
Het |
| 4933427I04Rik |
A |
G |
4: 123,754,775 (GRCm39) |
T230A |
possibly damaging |
Het |
| Acsm1 |
T |
C |
7: 119,261,412 (GRCm39) |
|
probably benign |
Het |
| Acta1 |
T |
C |
8: 124,620,396 (GRCm39) |
N14S |
probably damaging |
Het |
| Aff4 |
A |
G |
11: 53,283,609 (GRCm39) |
T362A |
probably benign |
Het |
| Aggf1 |
A |
G |
13: 95,501,467 (GRCm39) |
I305T |
probably benign |
Het |
| Ap4b1 |
A |
G |
3: 103,727,745 (GRCm39) |
D325G |
possibly damaging |
Het |
| Ap4e1 |
C |
T |
2: 126,906,905 (GRCm39) |
T1055I |
possibly damaging |
Het |
| Arhgef2 |
A |
T |
3: 88,546,655 (GRCm39) |
Q496L |
probably damaging |
Het |
| Arhgef28 |
A |
G |
13: 98,211,618 (GRCm39) |
F122L |
probably damaging |
Het |
| Baiap3 |
G |
A |
17: 25,469,044 (GRCm39) |
|
probably benign |
Het |
| Casz1 |
A |
G |
4: 149,017,868 (GRCm39) |
T386A |
probably benign |
Het |
| Cd53 |
A |
T |
3: 106,674,725 (GRCm39) |
V114E |
possibly damaging |
Het |
| Celsr2 |
A |
G |
3: 108,300,643 (GRCm39) |
|
probably benign |
Het |
| Cfap300 |
T |
A |
9: 8,027,184 (GRCm39) |
N118I |
probably benign |
Het |
| Chaf1b |
G |
T |
16: 93,684,012 (GRCm39) |
A88S |
possibly damaging |
Het |
| Cldn10 |
A |
T |
14: 119,111,612 (GRCm39) |
Y194F |
probably damaging |
Het |
| Clec2e |
A |
C |
6: 129,072,181 (GRCm39) |
|
probably null |
Het |
| Cmpk2 |
A |
T |
12: 26,528,021 (GRCm39) |
T413S |
probably benign |
Het |
| Col9a1 |
T |
A |
1: 24,262,643 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,405,139 (GRCm39) |
Q2468K |
probably benign |
Het |
| Ddx60 |
A |
G |
8: 62,395,327 (GRCm39) |
D88G |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 31,003,064 (GRCm39) |
R3588G |
probably benign |
Het |
| Ect2 |
T |
C |
3: 27,169,625 (GRCm39) |
T774A |
probably benign |
Het |
| Ect2 |
C |
T |
3: 27,192,651 (GRCm39) |
E431K |
probably null |
Het |
| Ern1 |
A |
G |
11: 106,296,649 (GRCm39) |
V767A |
probably damaging |
Het |
| Fbln1 |
A |
C |
15: 85,108,489 (GRCm39) |
E75A |
possibly damaging |
Het |
| Fgf5 |
C |
T |
5: 98,409,846 (GRCm39) |
R132* |
probably null |
Het |
| Folh1 |
T |
C |
7: 86,375,076 (GRCm39) |
|
probably benign |
Het |
| Gdf15 |
A |
T |
8: 71,082,334 (GRCm39) |
H257Q |
probably damaging |
Het |
| Ghitm |
T |
C |
14: 36,844,176 (GRCm39) |
T322A |
probably benign |
Het |
| Gm5709 |
A |
G |
3: 59,526,192 (GRCm39) |
|
noncoding transcript |
Het |
| Hbb-y |
C |
T |
7: 103,501,950 (GRCm39) |
|
probably null |
Het |
| Hmcn2 |
A |
T |
2: 31,316,210 (GRCm39) |
D3771V |
probably damaging |
Het |
| Hspa12a |
T |
C |
19: 58,787,941 (GRCm39) |
D627G |
probably benign |
Het |
| Idh2 |
T |
C |
7: 79,747,662 (GRCm39) |
E286G |
probably damaging |
Het |
| Idh3b |
C |
A |
2: 130,122,899 (GRCm39) |
A297S |
probably benign |
Het |
| Igsf3 |
A |
G |
3: 101,342,968 (GRCm39) |
E535G |
probably damaging |
Het |
| Ilf3 |
T |
A |
9: 21,306,710 (GRCm39) |
D314E |
probably damaging |
Het |
| Itgb8 |
A |
G |
12: 119,166,298 (GRCm39) |
S78P |
probably benign |
Het |
| Itih5 |
G |
A |
2: 10,169,495 (GRCm39) |
V31I |
probably benign |
Het |
| Kcnj2 |
T |
C |
11: 110,963,853 (GRCm39) |
V415A |
probably benign |
Het |
| Kin |
A |
G |
2: 10,090,584 (GRCm39) |
Q53R |
possibly damaging |
Het |
| Krt78 |
A |
T |
15: 101,856,272 (GRCm39) |
M513K |
probably benign |
Het |
| Krtap4-8 |
A |
T |
11: 99,671,312 (GRCm39) |
|
probably benign |
Het |
| Ltbr |
T |
C |
6: 125,286,412 (GRCm39) |
|
probably benign |
Het |
| Mgat4a |
G |
A |
1: 37,529,414 (GRCm39) |
T146I |
probably damaging |
Het |
| Mrps2 |
G |
C |
2: 28,358,268 (GRCm39) |
W19C |
probably damaging |
Het |
| Mthfs |
T |
C |
9: 89,093,344 (GRCm39) |
S33P |
probably damaging |
Het |
| Myh6 |
T |
C |
14: 55,196,161 (GRCm39) |
D546G |
probably damaging |
Het |
| Nanos3 |
C |
T |
8: 84,902,763 (GRCm39) |
R133Q |
probably damaging |
Het |
| Ndst2 |
T |
C |
14: 20,777,335 (GRCm39) |
T553A |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,288,664 (GRCm39) |
E616G |
probably damaging |
Het |
| Nrde2 |
T |
C |
12: 100,095,545 (GRCm39) |
|
probably benign |
Het |
| Nup210l |
G |
A |
3: 90,119,086 (GRCm39) |
V1832I |
probably benign |
Het |
| Or1e1c |
G |
A |
11: 73,266,402 (GRCm39) |
V276I |
probably benign |
Het |
| Or4k77 |
A |
T |
2: 111,199,639 (GRCm39) |
I221F |
probably damaging |
Het |
| Pcm1 |
A |
T |
8: 41,709,078 (GRCm39) |
E9D |
probably damaging |
Het |
| Pear1 |
A |
T |
3: 87,661,649 (GRCm39) |
D541E |
possibly damaging |
Het |
| Peg10 |
A |
G |
6: 4,756,063 (GRCm39) |
|
probably benign |
Het |
| Prss1 |
G |
A |
6: 41,438,166 (GRCm39) |
R31Q |
probably benign |
Het |
| Ptpn13 |
T |
C |
5: 103,717,369 (GRCm39) |
V1837A |
probably damaging |
Het |
| Rasgrp3 |
A |
G |
17: 75,805,456 (GRCm39) |
D149G |
probably damaging |
Het |
| Reg3d |
A |
T |
6: 78,355,466 (GRCm39) |
H8Q |
possibly damaging |
Het |
| Rhox4f |
A |
C |
X: 36,789,122 (GRCm39) |
V15G |
probably benign |
Het |
| Sacs |
T |
A |
14: 61,442,889 (GRCm39) |
L1645H |
probably damaging |
Het |
| Slc16a5 |
A |
T |
11: 115,355,751 (GRCm39) |
S71C |
probably damaging |
Het |
| Slc9a3 |
A |
G |
13: 74,306,847 (GRCm39) |
E324G |
probably damaging |
Het |
| Smgc |
T |
C |
15: 91,743,960 (GRCm39) |
V574A |
possibly damaging |
Het |
| Stac3 |
C |
T |
10: 127,339,799 (GRCm39) |
|
probably benign |
Het |
| Supv3l1 |
A |
G |
10: 62,265,485 (GRCm39) |
L685P |
probably benign |
Het |
| Taar2 |
G |
A |
10: 23,817,393 (GRCm39) |
R311H |
probably benign |
Het |
| Tas2r125 |
G |
T |
6: 132,887,361 (GRCm39) |
A250S |
probably benign |
Het |
| Tdrd6 |
C |
T |
17: 43,939,132 (GRCm39) |
V639I |
probably benign |
Het |
| Thap12 |
T |
G |
7: 98,365,100 (GRCm39) |
W423G |
probably damaging |
Het |
| Tmem245 |
T |
C |
4: 56,899,410 (GRCm39) |
I217V |
probably benign |
Het |
| Trip12 |
T |
A |
1: 84,709,857 (GRCm39) |
|
probably benign |
Het |
| Tshz3 |
T |
C |
7: 36,468,317 (GRCm39) |
V102A |
probably benign |
Het |
| Ubap1 |
T |
C |
4: 41,379,826 (GRCm39) |
S347P |
probably damaging |
Het |
| Usp10 |
C |
T |
8: 120,679,935 (GRCm39) |
Q612* |
probably null |
Het |
| Vmn2r72 |
T |
C |
7: 85,404,084 (GRCm39) |
I36V |
probably benign |
Het |
| Vps37a |
T |
C |
8: 40,980,030 (GRCm39) |
I63T |
possibly damaging |
Het |
| Whrn |
C |
A |
4: 63,350,969 (GRCm39) |
R9L |
possibly damaging |
Het |
| Xrcc1 |
T |
C |
7: 24,269,642 (GRCm39) |
Y401H |
probably damaging |
Het |
| Ylpm1 |
GCCTAAGCAGCAACCTAAG |
GCCTAAG |
12: 85,075,814 (GRCm39) |
|
probably benign |
Het |
| Zfhx3 |
G |
A |
8: 109,676,689 (GRCm39) |
D2580N |
possibly damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,308,685 (GRCm39) |
N637S |
probably damaging |
Het |
| Zfp268 |
A |
T |
4: 145,349,195 (GRCm39) |
K211* |
probably null |
Het |
| Zyg11a |
A |
T |
4: 108,058,544 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Casp8ap2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00686:Casp8ap2
|
APN |
4 |
32,641,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00714:Casp8ap2
|
APN |
4 |
32,649,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00754:Casp8ap2
|
APN |
4 |
32,641,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00954:Casp8ap2
|
APN |
4 |
32,645,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00970:Casp8ap2
|
APN |
4 |
32,646,182 (GRCm39) |
missense |
probably benign |
|
|
IGL01534:Casp8ap2
|
APN |
4 |
32,648,134 (GRCm39) |
splice site |
probably benign |
|
|
IGL01596:Casp8ap2
|
APN |
4 |
32,646,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01686:Casp8ap2
|
APN |
4 |
32,641,294 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02002:Casp8ap2
|
APN |
4 |
32,639,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02273:Casp8ap2
|
APN |
4 |
32,643,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02510:Casp8ap2
|
APN |
4 |
32,639,704 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02600:Casp8ap2
|
APN |
4 |
32,630,246 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL02929:Casp8ap2
|
APN |
4 |
32,624,105 (GRCm39) |
utr 5 prime |
probably benign |
|
|
F5770:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02988:Casp8ap2
|
UTSW |
4 |
32,644,590 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0023:Casp8ap2
|
UTSW |
4 |
32,640,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0027:Casp8ap2
|
UTSW |
4 |
32,643,810 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0117:Casp8ap2
|
UTSW |
4 |
32,640,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0144:Casp8ap2
|
UTSW |
4 |
32,643,797 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0268:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0344:Casp8ap2
|
UTSW |
4 |
32,644,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0555:Casp8ap2
|
UTSW |
4 |
32,640,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1051:Casp8ap2
|
UTSW |
4 |
32,640,790 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1165:Casp8ap2
|
UTSW |
4 |
32,640,563 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1243:Casp8ap2
|
UTSW |
4 |
32,645,687 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1311:Casp8ap2
|
UTSW |
4 |
32,648,111 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1337:Casp8ap2
|
UTSW |
4 |
32,645,721 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1471:Casp8ap2
|
UTSW |
4 |
32,639,386 (GRCm39) |
nonsense |
probably null |
|
|
R1497:Casp8ap2
|
UTSW |
4 |
32,639,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1521:Casp8ap2
|
UTSW |
4 |
32,631,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Casp8ap2
|
UTSW |
4 |
32,640,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1625:Casp8ap2
|
UTSW |
4 |
32,648,068 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1731:Casp8ap2
|
UTSW |
4 |
32,641,442 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1899:Casp8ap2
|
UTSW |
4 |
32,643,647 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2000:Casp8ap2
|
UTSW |
4 |
32,634,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2022:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2023:Casp8ap2
|
UTSW |
4 |
32,644,560 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2088:Casp8ap2
|
UTSW |
4 |
32,631,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2104:Casp8ap2
|
UTSW |
4 |
32,644,727 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2128:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2129:Casp8ap2
|
UTSW |
4 |
32,640,142 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2305:Casp8ap2
|
UTSW |
4 |
32,646,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2316:Casp8ap2
|
UTSW |
4 |
32,643,781 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2919:Casp8ap2
|
UTSW |
4 |
32,645,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4091:Casp8ap2
|
UTSW |
4 |
32,643,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4357:Casp8ap2
|
UTSW |
4 |
32,646,150 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4807:Casp8ap2
|
UTSW |
4 |
32,644,505 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4828:Casp8ap2
|
UTSW |
4 |
32,639,807 (GRCm39) |
missense |
probably benign |
|
|
R4908:Casp8ap2
|
UTSW |
4 |
32,639,905 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4945:Casp8ap2
|
UTSW |
4 |
32,631,163 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4962:Casp8ap2
|
UTSW |
4 |
32,640,554 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6014:Casp8ap2
|
UTSW |
4 |
32,641,400 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6092:Casp8ap2
|
UTSW |
4 |
32,639,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6257:Casp8ap2
|
UTSW |
4 |
32,641,364 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6289:Casp8ap2
|
UTSW |
4 |
32,639,590 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6482:Casp8ap2
|
UTSW |
4 |
32,634,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6496:Casp8ap2
|
UTSW |
4 |
32,641,553 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6515:Casp8ap2
|
UTSW |
4 |
32,646,423 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7015:Casp8ap2
|
UTSW |
4 |
32,644,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Casp8ap2
|
UTSW |
4 |
32,639,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Casp8ap2
|
UTSW |
4 |
32,644,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7448:Casp8ap2
|
UTSW |
4 |
32,643,974 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7944:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7945:Casp8ap2
|
UTSW |
4 |
32,645,909 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8170:Casp8ap2
|
UTSW |
4 |
32,615,490 (GRCm39) |
splice site |
probably benign |
|
|
R8179:Casp8ap2
|
UTSW |
4 |
32,643,939 (GRCm39) |
nonsense |
probably null |
|
|
R8207:Casp8ap2
|
UTSW |
4 |
32,646,446 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8263:Casp8ap2
|
UTSW |
4 |
32,644,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8298:Casp8ap2
|
UTSW |
4 |
32,640,429 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9441:Casp8ap2
|
UTSW |
4 |
32,645,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9455:Casp8ap2
|
UTSW |
4 |
32,643,924 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9729:Casp8ap2
|
UTSW |
4 |
32,643,807 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
V7580:Casp8ap2
|
UTSW |
4 |
32,639,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0018:Casp8ap2
|
UTSW |
4 |
32,643,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCGTTACCTCCTCATCCCAAGAATG -3'
(R):5'- AAAGCTCACTGTTAGAGACTGCACC -3'
Sequencing Primer
(F):5'- GACGTGAAACATTACGGCTTC -3'
(R):5'- ACTGTTAGAGACTGCACCTTTAC -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation