Incidental Mutation 'R0005:Trappc14'
ID 201302
Institutional Source Beutler Lab
Gene Symbol Trappc14
Ensembl Gene ENSMUSG00000036948
Gene Name trafficking protein particle complex 14
Synonyms Map11, BC037034
MMRRC Submission 038301-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0005 (G1)
Quality Score 80
Status Validated
Chromosome 5
Chromosomal Location 138257918-138262295 bp(-) (GRCm39)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to C at 138260916 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000048421] [ENSMUST00000048421] [ENSMUST00000062067] [ENSMUST00000100530] [ENSMUST00000159123] [ENSMUST00000159123] [ENSMUST00000159649] [ENSMUST00000159649] [ENSMUST00000159146] [ENSMUST00000161647] [ENSMUST00000159067] [ENSMUST00000161279]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000048421
SMART Domains Protein: ENSMUSP00000046898
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
low complexity region 215 225 N/A INTRINSIC
low complexity region 488 502 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000048421
SMART Domains Protein: ENSMUSP00000046898
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
low complexity region 215 225 N/A INTRINSIC
low complexity region 488 502 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000062067
Predicted Effect probably benign
Transcript: ENSMUST00000100530
SMART Domains Protein: ENSMUSP00000098099
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 2 231 1.1e-57 PFAM
Pfam:Gal-3-0_sulfotr 270 463 1e-54 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124298
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125662
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138911
Predicted Effect probably benign
Transcript: ENSMUST00000159123
SMART Domains Protein: ENSMUSP00000137679
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159123
SMART Domains Protein: ENSMUSP00000137679
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159534
Predicted Effect probably null
Transcript: ENSMUST00000159649
SMART Domains Protein: ENSMUSP00000125208
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000159649
SMART Domains Protein: ENSMUSP00000125208
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159872
Predicted Effect probably null
Transcript: ENSMUST00000161604
SMART Domains Protein: ENSMUSP00000125441
Gene: ENSMUSG00000036948

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141454
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160157
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144460
Predicted Effect probably benign
Transcript: ENSMUST00000159146
Predicted Effect probably benign
Transcript: ENSMUST00000161647
SMART Domains Protein: ENSMUSP00000125084
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 4 226 5.3e-58 PFAM
Pfam:Gal-3-0_sulfotr 265 458 3.8e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159067
SMART Domains Protein: ENSMUSP00000125178
Gene: ENSMUSG00000106247

DomainStartEndE-ValueType
Pfam:Glypican 7 250 1e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161279
SMART Domains Protein: ENSMUSP00000124841
Gene: ENSMUSG00000075593

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 2 231 1.1e-57 PFAM
Pfam:Gal-3-0_sulfotr 270 463 1e-54 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000164203
SMART Domains Protein: ENSMUSP00000127440
Gene: ENSMUSG00000091964

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Pfam:DUF4707 139 579 4.7e-252 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000163268
SMART Domains Protein: ENSMUSP00000127072
Gene: ENSMUSG00000091964

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000167840
SMART Domains Protein: ENSMUSP00000132756
Gene: ENSMUSG00000091964

DomainStartEndE-ValueType
low complexity region 219 233 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000170479
AA Change: *396W
Predicted Effect probably null
Transcript: ENSMUST00000171557
SMART Domains Protein: ENSMUSP00000128031
Gene: ENSMUSG00000091964

DomainStartEndE-ValueType
low complexity region 53 71 N/A INTRINSIC
low complexity region 75 93 N/A INTRINSIC
low complexity region 95 114 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162557
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162632
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.3%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn2l A G 7: 126,097,446 (GRCm39) F201L probably damaging Het
Camsap3 T A 8: 3,654,288 (GRCm39) F653I probably damaging Het
Cemip2 A G 19: 21,789,584 (GRCm39) T595A probably damaging Het
Col11a2 C T 17: 34,281,853 (GRCm39) probably benign Het
Col27a1 A G 4: 63,143,637 (GRCm39) T442A probably benign Het
Cpsf1 A G 15: 76,484,880 (GRCm39) probably null Het
Enpp4 T C 17: 44,413,066 (GRCm39) N156S probably benign Het
Fat3 T A 9: 15,874,162 (GRCm39) N3485I probably damaging Het
Gabra2 C T 5: 71,130,779 (GRCm39) V350I probably benign Het
H2-T5 G T 17: 36,473,084 (GRCm39) probably benign Het
Hivep2 A G 10: 14,004,493 (GRCm39) T364A probably damaging Het
Kif1b A T 4: 149,266,384 (GRCm39) V402E probably damaging Het
Lamc3 A G 2: 31,812,440 (GRCm39) D959G probably benign Het
Mag T A 7: 30,607,779 (GRCm39) probably benign Het
Map3k1 A G 13: 111,892,238 (GRCm39) F1006L probably benign Het
Mapre2 G A 18: 23,986,750 (GRCm39) G54D probably damaging Het
Muc6 G T 7: 141,218,685 (GRCm39) T1996N possibly damaging Het
Myadm C T 7: 3,346,080 (GRCm39) Q281* probably null Het
Mylk3 A T 8: 86,053,832 (GRCm39) V625D possibly damaging Het
Nlrp9a T C 7: 26,273,213 (GRCm39) probably benign Het
Or8d6 A G 9: 39,854,252 (GRCm39) D232G probably benign Het
Plcz1 T A 6: 139,986,290 (GRCm39) probably benign Het
Plekhg5 TCCCCC TCC 4: 152,197,108 (GRCm39) probably benign Het
Plekhh2 A C 17: 84,893,861 (GRCm39) D892A probably benign Het
Ppih A G 4: 119,175,798 (GRCm39) probably benign Het
Pramel13 G T 4: 144,122,423 (GRCm39) F40L probably damaging Het
Rtn4ip1 A T 10: 43,808,474 (GRCm39) M84L probably benign Het
Slc35f4 G A 14: 49,559,943 (GRCm39) probably benign Het
Spocd1 G T 4: 129,850,571 (GRCm39) D866Y possibly damaging Het
Stxbp4 C T 11: 90,439,743 (GRCm39) R365Q possibly damaging Het
Tmed4 C T 11: 6,221,781 (GRCm39) R185H probably damaging Het
Tnfsf9 T C 17: 57,414,236 (GRCm39) V221A possibly damaging Het
Vsx2 C A 12: 84,617,015 (GRCm39) P100Q possibly damaging Het
Wdr48 T A 9: 119,738,500 (GRCm39) D53E probably benign Het
Zfp335 T A 2: 164,751,222 (GRCm39) S115C possibly damaging Het
Zfp608 G A 18: 55,028,592 (GRCm39) P1274S possibly damaging Het
Other mutations in Trappc14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00517:Trappc14 APN 5 138,259,967 (GRCm39) missense possibly damaging 0.46
IGL01617:Trappc14 APN 5 138,260,478 (GRCm39) missense probably damaging 1.00
IGL02256:Trappc14 APN 5 138,258,577 (GRCm39) missense probably damaging 0.99
IGL02493:Trappc14 APN 5 138,261,432 (GRCm39) splice site probably null
IGL02904:Trappc14 APN 5 138,258,864 (GRCm39) missense probably benign 0.04
IGL03151:Trappc14 APN 5 138,260,934 (GRCm39) missense possibly damaging 0.95
R0010:Trappc14 UTSW 5 138,258,555 (GRCm39) splice site probably null
R0010:Trappc14 UTSW 5 138,258,555 (GRCm39) splice site probably null
R0619:Trappc14 UTSW 5 138,262,088 (GRCm39) unclassified probably benign
R0630:Trappc14 UTSW 5 138,260,551 (GRCm39) missense probably damaging 0.98
R1579:Trappc14 UTSW 5 138,260,128 (GRCm39) missense probably benign 0.00
R1778:Trappc14 UTSW 5 138,260,739 (GRCm39) splice site probably null
R1816:Trappc14 UTSW 5 138,258,603 (GRCm39) missense possibly damaging 0.91
R2009:Trappc14 UTSW 5 138,259,191 (GRCm39) missense probably damaging 1.00
R4711:Trappc14 UTSW 5 138,261,167 (GRCm39) unclassified probably benign
R4923:Trappc14 UTSW 5 138,260,641 (GRCm39) unclassified probably benign
R4999:Trappc14 UTSW 5 138,259,884 (GRCm39) missense probably damaging 1.00
R5103:Trappc14 UTSW 5 138,260,562 (GRCm39) missense probably benign 0.15
R5221:Trappc14 UTSW 5 138,260,502 (GRCm39) missense probably benign 0.14
R5444:Trappc14 UTSW 5 138,259,260 (GRCm39) splice site probably null
R5720:Trappc14 UTSW 5 138,261,964 (GRCm39) missense probably benign 0.00
R6519:Trappc14 UTSW 5 138,260,110 (GRCm39) missense probably damaging 0.99
R6599:Trappc14 UTSW 5 138,261,720 (GRCm39) splice site probably null
R6918:Trappc14 UTSW 5 138,258,926 (GRCm39) missense probably benign 0.03
R7275:Trappc14 UTSW 5 138,261,839 (GRCm39) missense probably benign 0.18
R7460:Trappc14 UTSW 5 138,260,991 (GRCm39) missense probably benign 0.32
R7564:Trappc14 UTSW 5 138,261,104 (GRCm39) splice site probably null
R8745:Trappc14 UTSW 5 138,261,327 (GRCm39) critical splice donor site probably null
R9043:Trappc14 UTSW 5 138,259,889 (GRCm39) missense possibly damaging 0.84
R9057:Trappc14 UTSW 5 138,260,949 (GRCm39) missense probably damaging 1.00
R9540:Trappc14 UTSW 5 138,260,127 (GRCm39) missense probably benign 0.28
R9607:Trappc14 UTSW 5 138,259,862 (GRCm39) missense probably damaging 1.00
R9798:Trappc14 UTSW 5 138,259,940 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ATTGTCCACCAGCAGCACAGAG -3'
(R):5'- AGTCAGAGATCAAGGCTACCTGCG -3'

Sequencing Primer
(F):5'- CCATCAGGCATGACAGGTAG -3'
(R):5'- GCTACAGACTCGATCTCCTGG -3'
Posted On 2014-05-28