Incidental Mutation 'R0068:Trim67'
ID 201442
Institutional Source Beutler Lab
Gene Symbol Trim67
Ensembl Gene ENSMUSG00000036913
Gene Name tripartite motif-containing 67
Synonyms D130049O21Rik
MMRRC Submission 038359-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R0068 (G1)
Quality Score 65
Status Validated
Chromosome 8
Chromosomal Location 125519831-125561452 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 125521307 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 223 (V223A)
Ref Sequence ENSEMBL: ENSMUSP00000148625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041106] [ENSMUST00000167588] [ENSMUST00000211867]
AlphaFold Q505D9
Predicted Effect probably damaging
Transcript: ENSMUST00000041106
AA Change: V223A

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000040601
Gene: ENSMUSG00000036913
AA Change: V223A

DomainStartEndE-ValueType
RING 7 157 1.41e-4 SMART
BBOX 198 248 4.65e-5 SMART
BBOX 285 327 3.04e-9 SMART
BBC 334 460 1.18e-28 SMART
FN3 498 579 1.75e-6 SMART
Pfam:SPRY 635 755 1.3e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000167588
AA Change: V223A

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000130343
Gene: ENSMUSG00000036913
AA Change: V223A

DomainStartEndE-ValueType
RING 7 157 1.41e-4 SMART
BBOX 198 248 4.65e-5 SMART
BBOX 285 327 3.04e-9 SMART
BBC 334 460 1.18e-28 SMART
FN3 498 579 1.75e-6 SMART
Pfam:SPRY 633 756 3.6e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211867
AA Change: V223A

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
Meta Mutation Damage Score 0.2127 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 92.6%
Validation Efficiency 99% (72/73)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T C 11: 110,073,708 (GRCm39) T1448A probably damaging Het
Aldoart2 G T 12: 55,612,233 (GRCm39) E53* probably null Het
Ankra2 C T 13: 98,409,891 (GRCm39) Q137* probably null Het
Arpc1a C T 5: 145,028,054 (GRCm39) T21I possibly damaging Het
Arvcf T C 16: 18,214,819 (GRCm39) probably benign Het
Ash1l C A 3: 88,914,624 (GRCm39) S1751R probably benign Het
Bltp1 A G 3: 37,006,370 (GRCm39) T1675A probably benign Het
Bsn C A 9: 107,989,336 (GRCm39) G2139C probably damaging Het
Ccdc148 T C 2: 58,717,629 (GRCm39) E530G probably benign Het
Cct3 A G 3: 88,225,772 (GRCm39) D365G probably benign Het
Chd2 A T 7: 73,134,282 (GRCm39) S688R probably damaging Het
Crispld1 A G 1: 17,823,212 (GRCm39) T398A possibly damaging Het
Ctbp2 A C 7: 132,591,788 (GRCm39) V906G possibly damaging Het
Cwf19l1 A T 19: 44,119,938 (GRCm39) Y68N probably damaging Het
Dlc1 T A 8: 37,404,875 (GRCm39) M305L probably benign Het
Dnm1l C A 16: 16,141,883 (GRCm39) G288C probably damaging Het
Efcab3 T C 11: 104,611,648 (GRCm39) S497P probably benign Het
Fignl2 A T 15: 100,952,129 (GRCm39) I51N probably damaging Het
Flnb A G 14: 7,915,290 (GRCm38) N1474D possibly damaging Het
Ghrhr C T 6: 55,357,849 (GRCm39) probably benign Het
Hltf G A 3: 20,113,254 (GRCm39) R9H probably damaging Het
Hps5 A G 7: 46,426,466 (GRCm39) probably benign Het
Itpr3 T C 17: 27,323,034 (GRCm39) probably benign Het
Kansl1l A G 1: 66,760,047 (GRCm39) V911A probably benign Het
Kdm3b C T 18: 34,957,827 (GRCm39) T1064I probably benign Het
Lrriq1 T A 10: 102,899,279 (GRCm39) Q1654L probably benign Het
Ltbp1 A G 17: 75,666,404 (GRCm39) T1366A probably damaging Het
Mroh1 A G 15: 76,330,892 (GRCm39) probably benign Het
Mroh2a GT GTT 1: 88,183,888 (GRCm39) probably null Het
Napb G A 2: 148,540,843 (GRCm39) probably benign Het
Npc1 G C 18: 12,341,424 (GRCm39) P532A probably benign Het
Nrp2 G T 1: 62,784,536 (GRCm39) K228N possibly damaging Het
Or13f5 T A 4: 52,825,503 (GRCm39) Y35* probably null Het
Plekhg1 A T 10: 3,890,504 (GRCm39) K241* probably null Het
Poln T C 5: 34,234,432 (GRCm39) probably benign Het
Ppil1 A T 17: 29,471,230 (GRCm39) F92I probably damaging Het
Ppp1r9b T G 11: 94,892,046 (GRCm39) F154V probably damaging Het
Ptchd3 T G 11: 121,733,798 (GRCm39) L896R probably damaging Het
Rev3l A G 10: 39,700,827 (GRCm39) N1775D possibly damaging Het
Rusc2 T C 4: 43,424,100 (GRCm39) probably benign Het
Selenbp2 T C 3: 94,610,816 (GRCm39) V294A probably benign Het
Slc25a48 T C 13: 56,599,024 (GRCm39) V118A probably damaging Het
Slc38a10 T C 11: 120,025,679 (GRCm39) D219G probably damaging Het
Slc38a2 C T 15: 96,589,173 (GRCm39) probably null Het
Slc39a12 A G 2: 14,440,489 (GRCm39) E480G probably benign Het
Tab2 C A 10: 7,795,441 (GRCm39) R347L probably damaging Het
Tas2r123 T C 6: 132,824,955 (GRCm39) I284T possibly damaging Het
Tnks1bp1 T A 2: 84,892,696 (GRCm39) D212E probably benign Het
Ugcg A G 4: 59,217,130 (GRCm39) D218G probably benign Het
Vmn2r59 A G 7: 41,695,725 (GRCm39) L229S probably damaging Het
Zfp451 A T 1: 33,816,706 (GRCm39) L198I probably damaging Het
Other mutations in Trim67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00817:Trim67 APN 8 125,541,799 (GRCm39) splice site probably benign
IGL01676:Trim67 APN 8 125,541,899 (GRCm39) missense possibly damaging 0.51
IGL01779:Trim67 APN 8 125,554,860 (GRCm39) missense probably damaging 1.00
IGL02057:Trim67 APN 8 125,549,869 (GRCm39) missense probably benign 0.00
IGL02201:Trim67 APN 8 125,520,797 (GRCm39) missense probably benign 0.26
IGL02304:Trim67 APN 8 125,552,691 (GRCm39) missense probably damaging 1.00
R0241:Trim67 UTSW 8 125,549,929 (GRCm39) missense probably damaging 0.99
R0319:Trim67 UTSW 8 125,549,966 (GRCm39) missense probably damaging 0.98
R0471:Trim67 UTSW 8 125,521,397 (GRCm39) missense probably benign 0.01
R1171:Trim67 UTSW 8 125,555,820 (GRCm39) missense probably damaging 0.97
R1175:Trim67 UTSW 8 125,543,774 (GRCm39) missense probably damaging 0.99
R1444:Trim67 UTSW 8 125,549,932 (GRCm39) missense probably benign 0.01
R1596:Trim67 UTSW 8 125,552,878 (GRCm39) missense probably damaging 0.97
R1706:Trim67 UTSW 8 125,521,160 (GRCm39) missense probably damaging 1.00
R4951:Trim67 UTSW 8 125,521,406 (GRCm39) missense probably benign
R5200:Trim67 UTSW 8 125,551,589 (GRCm39) missense probably damaging 0.99
R5787:Trim67 UTSW 8 125,521,051 (GRCm39) nonsense probably null
R6023:Trim67 UTSW 8 125,541,843 (GRCm39) missense probably damaging 0.99
R6290:Trim67 UTSW 8 125,549,918 (GRCm39) missense probably benign 0.00
R6536:Trim67 UTSW 8 125,521,081 (GRCm39) missense possibly damaging 0.51
R7315:Trim67 UTSW 8 125,521,069 (GRCm39) missense probably benign 0.18
R7660:Trim67 UTSW 8 125,547,024 (GRCm39) missense probably damaging 1.00
R8432:Trim67 UTSW 8 125,520,801 (GRCm39) small deletion probably benign
R8446:Trim67 UTSW 8 125,520,730 (GRCm39) missense probably damaging 0.99
R8713:Trim67 UTSW 8 125,547,074 (GRCm39) missense probably null 0.06
R8897:Trim67 UTSW 8 125,552,718 (GRCm39) missense probably benign
R9322:Trim67 UTSW 8 125,549,967 (GRCm39) nonsense probably null
R9430:Trim67 UTSW 8 125,552,956 (GRCm39) missense probably damaging 0.98
R9542:Trim67 UTSW 8 125,521,497 (GRCm39) missense possibly damaging 0.84
Z1088:Trim67 UTSW 8 125,543,780 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AACCGGCTACTGGAGGGCATTG -3'
(R):5'- ATGTAGCACACAGGGCTCCGAC -3'

Sequencing Primer
(F):5'- GGAGGGCATTGTGCAGC -3'
(R):5'- ACGCAGTACATGCTGTAGTTC -3'
Posted On 2014-06-10