Incidental Mutation 'R0090:Ddx60'
ID 20149
Institutional Source Beutler Lab
Gene Symbol Ddx60
Ensembl Gene ENSMUSG00000037921
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Synonyms
MMRRC Submission 038377-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R0090 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 8
Chromosomal Location 61928087-62038244 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 61942293 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 88 (D88G)
Ref Sequence ENSEMBL: ENSMUSP00000122841 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070631] [ENSMUST00000093485] [ENSMUST00000154398] [ENSMUST00000156980]
AlphaFold E9PZQ1
Predicted Effect probably damaging
Transcript: ENSMUST00000070631
AA Change: D88G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070741
Gene: ENSMUSG00000037921
AA Change: D88G

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 758 949 1.05e-15 SMART
Blast:DEXDc 1007 1132 4e-24 BLAST
HELICc 1245 1328 4.35e-13 SMART
low complexity region 1362 1373 N/A INTRINSIC
Blast:DEXDc 1503 1584 1e-20 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000093485
AA Change: D88G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091197
Gene: ENSMUSG00000037921
AA Change: D88G

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
DEXDc 759 950 1.05e-15 SMART
Blast:DEXDc 1008 1133 4e-24 BLAST
HELICc 1246 1329 4.35e-13 SMART
low complexity region 1363 1374 N/A INTRINSIC
Blast:DEXDc 1504 1585 1e-20 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000154398
AA Change: D88G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000122841
Gene: ENSMUSG00000037921
AA Change: D88G

DomainStartEndE-ValueType
low complexity region 99 110 N/A INTRINSIC
low complexity region 364 376 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000156980
Meta Mutation Damage Score 0.4710 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.7%
  • 20x: 91.4%
Validation Efficiency 99% (90/91)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal immunity to several viruses (IAV, EMCV, SINV) but increased susceptibility to VSV infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,295,159 (GRCm38) probably benign Het
4933427I04Rik A G 4: 123,860,982 (GRCm38) T230A possibly damaging Het
9230110C19Rik T A 9: 8,027,183 (GRCm38) N118I probably benign Het
Acsm1 T C 7: 119,662,189 (GRCm38) probably benign Het
Acta1 T C 8: 123,893,657 (GRCm38) N14S probably damaging Het
Aff4 A G 11: 53,392,782 (GRCm38) T362A probably benign Het
Aggf1 A G 13: 95,364,959 (GRCm38) I305T probably benign Het
Ap4b1 A G 3: 103,820,429 (GRCm38) D325G possibly damaging Het
Ap4e1 C T 2: 127,064,985 (GRCm38) T1055I possibly damaging Het
Arhgef2 A T 3: 88,639,348 (GRCm38) Q496L probably damaging Het
Arhgef28 A G 13: 98,075,110 (GRCm38) F122L probably damaging Het
Baiap3 G A 17: 25,250,070 (GRCm38) probably benign Het
Casp8ap2 T A 4: 32,640,327 (GRCm38) H460Q probably damaging Het
Casz1 A G 4: 148,933,411 (GRCm38) T386A probably benign Het
Cd53 A T 3: 106,767,409 (GRCm38) V114E possibly damaging Het
Celsr2 A G 3: 108,393,327 (GRCm38) probably benign Het
Chaf1b G T 16: 93,887,124 (GRCm38) A88S possibly damaging Het
Cldn10 A T 14: 118,874,200 (GRCm38) Y194F probably damaging Het
Clec2e A C 6: 129,095,218 (GRCm38) probably null Het
Cmpk2 A T 12: 26,478,022 (GRCm38) T413S probably benign Het
Col9a1 T A 1: 24,223,562 (GRCm38) probably null Het
Dchs1 G T 7: 105,755,932 (GRCm38) Q2468K probably benign Het
Dnah8 A G 17: 30,784,090 (GRCm38) R3588G probably benign Het
Ect2 T C 3: 27,115,476 (GRCm38) T774A probably benign Het
Ect2 C T 3: 27,138,502 (GRCm38) E431K probably null Het
Ern1 A G 11: 106,405,823 (GRCm38) V767A probably damaging Het
Fbln1 A C 15: 85,224,288 (GRCm38) E75A possibly damaging Het
Fgf5 C T 5: 98,261,987 (GRCm38) R132* probably null Het
Folh1 T C 7: 86,725,868 (GRCm38) probably benign Het
Gdf15 A T 8: 70,629,684 (GRCm38) H257Q probably damaging Het
Ghitm T C 14: 37,122,219 (GRCm38) T322A probably benign Het
Gm13212 A T 4: 145,622,625 (GRCm38) K211* probably null Het
Gm5709 A G 3: 59,618,771 (GRCm38) noncoding transcript Het
Hbb-y C T 7: 103,852,743 (GRCm38) probably null Het
Hmcn2 A T 2: 31,426,198 (GRCm38) D3771V probably damaging Het
Hspa12a T C 19: 58,799,509 (GRCm38) D627G probably benign Het
Idh2 T C 7: 80,097,914 (GRCm38) E286G probably damaging Het
Idh3b C A 2: 130,280,979 (GRCm38) A297S probably benign Het
Igsf3 A G 3: 101,435,652 (GRCm38) E535G probably damaging Het
Ilf3 T A 9: 21,395,414 (GRCm38) D314E probably damaging Het
Itgb8 A G 12: 119,202,563 (GRCm38) S78P probably benign Het
Itih5 G A 2: 10,164,684 (GRCm38) V31I probably benign Het
Kcnj2 T C 11: 111,073,027 (GRCm38) V415A probably benign Het
Kin A G 2: 10,085,773 (GRCm38) Q53R possibly damaging Het
Krt78 A T 15: 101,947,837 (GRCm38) M513K probably benign Het
Krtap4-8 A T 11: 99,780,486 (GRCm38) probably benign Het
Ltbr T C 6: 125,309,449 (GRCm38) probably benign Het
Mgat4a G A 1: 37,490,333 (GRCm38) T146I probably damaging Het
Mrps2 G C 2: 28,468,256 (GRCm38) W19C probably damaging Het
Mthfs T C 9: 89,211,291 (GRCm38) S33P probably damaging Het
Myh6 T C 14: 54,958,704 (GRCm38) D546G probably damaging Het
Nanos3 C T 8: 84,176,134 (GRCm38) R133Q probably damaging Het
Ndst2 T C 14: 20,727,267 (GRCm38) T553A probably damaging Het
Nlrp12 T C 7: 3,240,034 (GRCm38) E616G probably damaging Het
Nrde2 T C 12: 100,129,286 (GRCm38) probably benign Het
Nup210l G A 3: 90,211,779 (GRCm38) V1832I probably benign Het
Olfr1283 A T 2: 111,369,294 (GRCm38) I221F probably damaging Het
Olfr376 G A 11: 73,375,576 (GRCm38) V276I probably benign Het
Pcm1 A T 8: 41,256,041 (GRCm38) E9D probably damaging Het
Pear1 A T 3: 87,754,342 (GRCm38) D541E possibly damaging Het
Peg10 A G 6: 4,756,063 (GRCm38) probably benign Het
Prss1 G A 6: 41,461,232 (GRCm38) R31Q probably benign Het
Ptpn13 T C 5: 103,569,503 (GRCm38) V1837A probably damaging Het
Rasgrp3 A G 17: 75,498,461 (GRCm38) D149G probably damaging Het
Reg3d A T 6: 78,378,483 (GRCm38) H8Q possibly damaging Het
Rhox4f A C X: 37,607,469 (GRCm38) V15G probably benign Het
Sacs T A 14: 61,205,440 (GRCm38) L1645H probably damaging Het
Slc16a5 A T 11: 115,464,925 (GRCm38) S71C probably damaging Het
Slc9a3 A G 13: 74,158,728 (GRCm38) E324G probably damaging Het
Smgc T C 15: 91,859,762 (GRCm38) V574A possibly damaging Het
Stac3 C T 10: 127,503,930 (GRCm38) probably benign Het
Supv3l1 A G 10: 62,429,706 (GRCm38) L685P probably benign Het
Taar2 G A 10: 23,941,495 (GRCm38) R311H probably benign Het
Tas2r125 G T 6: 132,910,398 (GRCm38) A250S probably benign Het
Tdrd6 C T 17: 43,628,241 (GRCm38) V639I probably benign Het
Thap12 T G 7: 98,715,893 (GRCm38) W423G probably damaging Het
Tmem245 T C 4: 56,899,410 (GRCm38) I217V probably benign Het
Trip12 T A 1: 84,732,136 (GRCm38) probably benign Het
Tshz3 T C 7: 36,768,892 (GRCm38) V102A probably benign Het
Ubap1 T C 4: 41,379,826 (GRCm38) S347P probably damaging Het
Usp10 C T 8: 119,953,196 (GRCm38) Q612* probably null Het
Vmn2r72 T C 7: 85,754,876 (GRCm38) I36V probably benign Het
Vps37a T C 8: 40,526,989 (GRCm38) I63T possibly damaging Het
Whrn C A 4: 63,432,732 (GRCm38) R9L possibly damaging Het
Xrcc1 T C 7: 24,570,217 (GRCm38) Y401H probably damaging Het
Ylpm1 GCCTAAGCAGCAACCTAAG GCCTAAG 12: 85,029,040 (GRCm38) probably benign Het
Zfhx3 G A 8: 108,950,057 (GRCm38) D2580N possibly damaging Het
Zfhx4 A G 3: 5,243,625 (GRCm38) N637S probably damaging Het
Zyg11a A T 4: 108,201,347 (GRCm38) probably benign Het
Other mutations in Ddx60
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Ddx60 APN 8 61,958,646 (GRCm38) missense probably damaging 1.00
IGL00915:Ddx60 APN 8 61,987,431 (GRCm38) missense possibly damaging 0.79
IGL00931:Ddx60 APN 8 61,969,583 (GRCm38) missense probably benign 0.18
IGL01023:Ddx60 APN 8 61,942,514 (GRCm38) missense probably damaging 0.99
IGL01313:Ddx60 APN 8 61,982,526 (GRCm38) missense probably damaging 1.00
IGL01615:Ddx60 APN 8 61,963,740 (GRCm38) missense probably null 0.81
IGL01733:Ddx60 APN 8 61,983,865 (GRCm38) missense probably damaging 0.99
IGL01779:Ddx60 APN 8 62,017,823 (GRCm38) missense possibly damaging 0.94
IGL01900:Ddx60 APN 8 62,000,709 (GRCm38) splice site probably benign
IGL02110:Ddx60 APN 8 62,017,247 (GRCm38) critical splice donor site probably null
IGL02302:Ddx60 APN 8 61,975,832 (GRCm38) missense possibly damaging 0.85
IGL02468:Ddx60 APN 8 61,958,642 (GRCm38) missense probably damaging 1.00
IGL02569:Ddx60 APN 8 62,024,951 (GRCm38) missense possibly damaging 0.93
IGL02622:Ddx60 APN 8 61,942,436 (GRCm38) splice site probably null
IGL02657:Ddx60 APN 8 61,984,115 (GRCm38) missense probably benign 0.01
IGL02677:Ddx60 APN 8 61,988,132 (GRCm38) missense probably damaging 1.00
IGL02701:Ddx60 APN 8 61,979,341 (GRCm38) missense probably damaging 0.96
IGL02806:Ddx60 APN 8 61,956,122 (GRCm38) missense probably benign 0.00
IGL03137:Ddx60 APN 8 61,988,083 (GRCm38) missense possibly damaging 0.61
IGL03295:Ddx60 APN 8 61,956,121 (GRCm38) missense possibly damaging 0.82
IGL03387:Ddx60 APN 8 62,012,449 (GRCm38) missense probably damaging 1.00
IGL03411:Ddx60 APN 8 61,977,882 (GRCm38) critical splice acceptor site probably null
Scatter UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
shotgun UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
splay UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
G1Funyon:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
PIT4504001:Ddx60 UTSW 8 61,958,113 (GRCm38) missense probably benign
PIT4677001:Ddx60 UTSW 8 61,972,254 (GRCm38) missense possibly damaging 0.87
R0266:Ddx60 UTSW 8 62,033,493 (GRCm38) missense possibly damaging 0.92
R0325:Ddx60 UTSW 8 61,983,855 (GRCm38) missense probably benign 0.00
R0367:Ddx60 UTSW 8 62,017,749 (GRCm38) missense possibly damaging 0.78
R0403:Ddx60 UTSW 8 61,994,541 (GRCm38) splice site probably benign
R0479:Ddx60 UTSW 8 61,969,657 (GRCm38) missense probably damaging 1.00
R0561:Ddx60 UTSW 8 62,017,794 (GRCm38) missense possibly damaging 0.93
R0844:Ddx60 UTSW 8 61,987,361 (GRCm38) missense probably benign 0.27
R1119:Ddx60 UTSW 8 61,942,544 (GRCm38) missense probably damaging 1.00
R1428:Ddx60 UTSW 8 61,958,159 (GRCm38) splice site probably benign
R1778:Ddx60 UTSW 8 61,974,176 (GRCm38) missense possibly damaging 0.85
R1840:Ddx60 UTSW 8 61,969,553 (GRCm38) missense probably damaging 0.99
R1964:Ddx60 UTSW 8 61,948,869 (GRCm38) missense probably benign 0.10
R1970:Ddx60 UTSW 8 61,972,206 (GRCm38) missense possibly damaging 0.93
R2101:Ddx60 UTSW 8 61,940,645 (GRCm38) missense probably damaging 1.00
R2174:Ddx60 UTSW 8 62,017,200 (GRCm38) missense probably benign 0.01
R2174:Ddx60 UTSW 8 61,956,141 (GRCm38) missense probably damaging 1.00
R2198:Ddx60 UTSW 8 61,958,063 (GRCm38) missense possibly damaging 0.79
R2332:Ddx60 UTSW 8 62,037,091 (GRCm38) missense probably benign 0.08
R2338:Ddx60 UTSW 8 62,012,436 (GRCm38) missense possibly damaging 0.91
R2379:Ddx60 UTSW 8 62,037,088 (GRCm38) missense probably damaging 1.00
R4010:Ddx60 UTSW 8 61,956,144 (GRCm38) missense probably benign 0.25
R4010:Ddx60 UTSW 8 61,954,535 (GRCm38) missense possibly damaging 0.65
R4133:Ddx60 UTSW 8 61,972,220 (GRCm38) missense probably damaging 0.99
R4282:Ddx60 UTSW 8 61,994,393 (GRCm38) missense probably damaging 0.99
R4382:Ddx60 UTSW 8 61,948,978 (GRCm38) splice site probably null
R4561:Ddx60 UTSW 8 61,942,461 (GRCm38) missense probably damaging 0.96
R4572:Ddx60 UTSW 8 61,987,421 (GRCm38) missense probably damaging 1.00
R4581:Ddx60 UTSW 8 62,023,261 (GRCm38) missense possibly damaging 0.90
R4635:Ddx60 UTSW 8 62,037,067 (GRCm38) missense probably benign 0.28
R4698:Ddx60 UTSW 8 62,012,424 (GRCm38) missense probably benign 0.01
R4807:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R4858:Ddx60 UTSW 8 62,021,314 (GRCm38) missense possibly damaging 0.80
R4964:Ddx60 UTSW 8 61,979,338 (GRCm38) missense probably damaging 1.00
R5120:Ddx60 UTSW 8 61,945,906 (GRCm38) missense probably benign 0.01
R5187:Ddx60 UTSW 8 61,974,188 (GRCm38) missense probably damaging 1.00
R5222:Ddx60 UTSW 8 61,984,158 (GRCm38) missense probably damaging 0.99
R5400:Ddx60 UTSW 8 62,010,002 (GRCm38) missense possibly damaging 0.65
R5500:Ddx60 UTSW 8 61,950,451 (GRCm38) missense probably benign 0.28
R5514:Ddx60 UTSW 8 61,958,057 (GRCm38) missense probably damaging 1.00
R5668:Ddx60 UTSW 8 62,000,578 (GRCm38) missense probably benign 0.38
R5742:Ddx60 UTSW 8 61,948,921 (GRCm38) missense probably benign
R5772:Ddx60 UTSW 8 61,948,897 (GRCm38) missense probably damaging 1.00
R5810:Ddx60 UTSW 8 62,012,388 (GRCm38) nonsense probably null
R5815:Ddx60 UTSW 8 61,963,722 (GRCm38) missense probably damaging 0.98
R5820:Ddx60 UTSW 8 61,956,121 (GRCm38) missense possibly damaging 0.82
R5866:Ddx60 UTSW 8 61,940,740 (GRCm38) missense probably damaging 1.00
R5881:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R5977:Ddx60 UTSW 8 62,021,410 (GRCm38) critical splice donor site probably null
R6048:Ddx60 UTSW 8 62,000,582 (GRCm38) missense probably benign 0.01
R6061:Ddx60 UTSW 8 62,023,241 (GRCm38) missense probably null 0.01
R6153:Ddx60 UTSW 8 61,945,940 (GRCm38) missense possibly damaging 0.47
R6287:Ddx60 UTSW 8 61,950,578 (GRCm38) missense probably damaging 1.00
R6415:Ddx60 UTSW 8 61,983,905 (GRCm38) missense probably benign 0.00
R6416:Ddx60 UTSW 8 61,998,681 (GRCm38) missense probably benign
R6416:Ddx60 UTSW 8 61,977,950 (GRCm38) missense probably benign 0.00
R6660:Ddx60 UTSW 8 61,956,239 (GRCm38) missense probably benign 0.00
R6694:Ddx60 UTSW 8 62,037,070 (GRCm38) missense probably damaging 1.00
R6715:Ddx60 UTSW 8 61,983,890 (GRCm38) missense probably benign 0.03
R6720:Ddx60 UTSW 8 62,000,689 (GRCm38) missense probably benign 0.10
R6937:Ddx60 UTSW 8 62,037,069 (GRCm38) missense probably damaging 1.00
R7153:Ddx60 UTSW 8 61,988,108 (GRCm38) missense possibly damaging 0.71
R7274:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R7409:Ddx60 UTSW 8 61,958,578 (GRCm38) missense probably benign 0.24
R7464:Ddx60 UTSW 8 61,940,674 (GRCm38) missense possibly damaging 0.82
R7670:Ddx60 UTSW 8 61,975,792 (GRCm38) missense probably damaging 1.00
R7904:Ddx60 UTSW 8 61,977,890 (GRCm38) missense possibly damaging 0.81
R7992:Ddx60 UTSW 8 61,954,535 (GRCm38) missense probably benign 0.03
R8124:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8125:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8126:Ddx60 UTSW 8 61,983,911 (GRCm38) missense probably benign
R8155:Ddx60 UTSW 8 62,017,171 (GRCm38) missense possibly damaging 0.61
R8174:Ddx60 UTSW 8 62,017,250 (GRCm38) splice site probably null
R8192:Ddx60 UTSW 8 61,977,968 (GRCm38) missense probably damaging 1.00
R8271:Ddx60 UTSW 8 61,940,108 (GRCm38) critical splice donor site probably null
R8301:Ddx60 UTSW 8 62,000,597 (GRCm38) missense probably benign 0.01
R8304:Ddx60 UTSW 8 61,998,769 (GRCm38) missense possibly damaging 0.67
R8319:Ddx60 UTSW 8 61,942,635 (GRCm38) critical splice donor site probably null
R8374:Ddx60 UTSW 8 61,974,171 (GRCm38) missense probably benign 0.01
R8401:Ddx60 UTSW 8 61,956,243 (GRCm38) missense possibly damaging 0.57
R8487:Ddx60 UTSW 8 61,974,150 (GRCm38) missense probably damaging 1.00
R8804:Ddx60 UTSW 8 61,958,606 (GRCm38) missense probably benign 0.27
R8826:Ddx60 UTSW 8 61,945,956 (GRCm38) missense probably benign 0.02
R8829:Ddx60 UTSW 8 61,940,661 (GRCm38) missense probably damaging 1.00
R8881:Ddx60 UTSW 8 62,021,309 (GRCm38) missense possibly damaging 0.80
R8884:Ddx60 UTSW 8 61,994,519 (GRCm38) missense possibly damaging 0.86
R8990:Ddx60 UTSW 8 61,974,134 (GRCm38) nonsense probably null
R9122:Ddx60 UTSW 8 61,989,864 (GRCm38) missense probably benign 0.16
R9225:Ddx60 UTSW 8 62,017,841 (GRCm38) missense probably benign 0.36
R9278:Ddx60 UTSW 8 61,977,978 (GRCm38) missense possibly damaging 0.83
R9293:Ddx60 UTSW 8 62,009,960 (GRCm38) missense possibly damaging 0.89
R9405:Ddx60 UTSW 8 61,972,214 (GRCm38) missense probably benign 0.03
R9766:Ddx60 UTSW 8 62,012,278 (GRCm38) missense probably damaging 1.00
X0003:Ddx60 UTSW 8 62,033,417 (GRCm38) missense possibly damaging 0.88
X0019:Ddx60 UTSW 8 61,963,692 (GRCm38) missense probably benign 0.01
Z1177:Ddx60 UTSW 8 62,000,588 (GRCm38) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- CATTTGTGAAACAGCACCAGTGCC -3'
(R):5'- ACCTCCTTGAAGAACATCTGCATTCC -3'

Sequencing Primer
(F):5'- GCACCAGTGCCAATTTACTGAC -3'
(R):5'- TGTCTGTCCTGAGAAGAGCAC -3'
Posted On 2013-04-11