Mutagenetix > Incidental Mutation

Incidental Mutation 'R0676:Slc22a26'

201538

Institutional Source

Beutler Lab

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

MMRRC Submission

038861-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R0676 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

7781041-7802667 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 7796144 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably benign
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.8%
10x: 97.4%
20x: 95.2%

Validation Efficiency

100% (52/52)

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310003L06Rik	A	G	5: 87,964,657		probably benign	Het
Arhgef25	A	G	10: 127,184,010		probably null	Het
B3galnt2	T	C	13: 13,995,793	S243P	probably benign	Het
Col11a2	A	G	17: 34,057,275	N799D	probably damaging	Het
Cpb1	T	C	3: 20,266,533		probably null	Het
Crot	A	C	5: 8,993,622		probably benign	Het
Ctnna3	A	C	10: 64,409,261	H451P	probably benign	Het
Cts6	C	T	13: 61,197,484		probably benign	Het
Dock2	T	C	11: 34,695,236	T540A	probably damaging	Het
Dysf	C	A	6: 84,113,336	F956L	probably benign	Het
Gabrg3	A	T	7: 56,724,421	Y466N	probably damaging	Het
Gm10845	T	A	14: 79,863,204		noncoding transcript	Het
H2-M5	A	G	17: 36,989,142	F47L	possibly damaging	Het
Hist1h4i	T	C	13: 22,041,106		probably null	Het
Il1rl1	CTTGTTGTTGTTGTTGTTG	CTTGTTGTTGTTGTTGTTGTTG	1: 40,442,574		probably benign	Het
Immt	A	G	6: 71,851,844	S128G	probably benign	Het
Klb	A	T	5: 65,379,055	D576V	probably damaging	Het
Lpin1	A	T	12: 16,540,979	N817K	possibly damaging	Het
Lrrk1	C	T	7: 66,294,981	R627H	probably damaging	Het
Luzp1	A	G	4: 136,542,685	K740E	probably damaging	Het
Mapk9	T	C	11: 49,883,156	*382Q	probably null	Het
Mn1	A	G	5: 111,421,034	S957G	possibly damaging	Het
Mrgprb8	A	T	7: 48,388,664	M28L	probably benign	Het
Myo1a	A	G	10: 127,719,880	I913V	probably benign	Het
Nolc1	T	A	19: 46,080,089		probably benign	Het
Pde4dip	A	C	3: 97,717,097		probably benign	Het
Rbpj	C	T	5: 53,646,048		probably benign	Het
Ric1	T	C	19: 29,577,647	I387T	probably benign	Het
Ruvbl1	A	G	6: 88,473,200	R58G	probably damaging	Het
Scarb1	C	A	5: 125,297,214		probably benign	Het
Sh3tc1	A	T	5: 35,719,114		probably benign	Het
Slc22a23	G	A	13: 34,195,479	T435I	probably damaging	Het
Taf6l	T	C	19: 8,773,369	I114V	probably benign	Het
Tbc1d8b	A	G	X: 139,712,276	S284G	possibly damaging	Het
Tmem131l	C	T	3: 83,934,815		probably benign	Het
Vmn2r115	C	T	17: 23,346,264	S375F	probably benign	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7782836	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7782975	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7790162	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7790099	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7802184	missense	probably benign	0.15
IGL02502:Slc22a26	APN	19	7790760	critical splice donor site	probably null
IGL02658:Slc22a26	APN	19	7788248	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7791105	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7802101	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7802253	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7788210	critical splice donor site	probably null
R2156:Slc22a26	UTSW	19	7802115	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7788329	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7790135	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7791054	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7802181	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7786447	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7802286	missense	probably damaging	1.00
R6512:Slc22a26	UTSW	19	7802500	start gained	probably benign
R6724:Slc22a26	UTSW	19	7802361	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7790894	missense	probably damaging	0.97
R7375:Slc22a26	UTSW	19	7783144	splice site	probably null
R7558:Slc22a26	UTSW	19	7785286	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7802587	splice site	probably null
R8772:Slc22a26	UTSW	19	7790112	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7782966	missense	probably damaging	0.97
R8937:Slc22a26	UTSW	19	7791025	splice site	probably benign
R9059:Slc22a26	UTSW	19	7785194	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02

Predicted Primers

Posted On

2014-06-19