Incidental Mutation 'R1789:Acad10'
ID 201604
Institutional Source Beutler Lab
Gene Symbol Acad10
Ensembl Gene ENSMUSG00000029456
Gene Name acyl-Coenzyme A dehydrogenase family, member 10
Synonyms 2410021P16Rik
MMRRC Submission 039820-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1789 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 121621026-121660514 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 121631393 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 667 (Y667N)
Ref Sequence ENSEMBL: ENSMUSP00000107400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031412] [ENSMUST00000111770]
AlphaFold Q8K370
Predicted Effect possibly damaging
Transcript: ENSMUST00000031412
AA Change: Y667N

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000031412
Gene: ENSMUSG00000029456
AA Change: Y667N

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 1.6e-14 PFAM
Pfam:Hydrolase 88 225 5e-8 PFAM
Pfam:APH 287 531 1.8e-52 PFAM
Pfam:Acyl-CoA_dh_N 660 787 1.7e-15 PFAM
Pfam:Acyl-CoA_dh_M 791 892 2.7e-20 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 1.1e-35 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 6.4e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000111770
AA Change: Y667N

PolyPhen 2 Score 0.671 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000107400
Gene: ENSMUSG00000029456
AA Change: Y667N

DomainStartEndE-ValueType
Pfam:HAD_2 45 231 2.3e-14 PFAM
Pfam:APH 287 523 3.2e-50 PFAM
Pfam:EcKinase 390 504 5.2e-8 PFAM
Pfam:Acyl-CoA_dh_N 660 787 3.4e-14 PFAM
Pfam:Acyl-CoA_dh_M 791 845 2.7e-13 PFAM
Pfam:Acyl-CoA_dh_1 904 1055 9.4e-36 PFAM
Pfam:Acyl-CoA_dh_2 919 1037 1.6e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133775
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137789
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143187
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.2%
  • 20x: 92.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 G A 16: 20,365,951 (GRCm38) P986L probably damaging Het
Ahi1 G A 10: 20,963,115 (GRCm38) G121D probably benign Het
Ampd1 T A 3: 103,099,126 (GRCm38) I690N possibly damaging Het
Amy1 C A 3: 113,558,165 (GRCm38) W425L possibly damaging Het
Arhgap27 A T 11: 103,333,005 (GRCm38) V823E probably damaging Het
Arhgef17 A G 7: 100,929,870 (GRCm38) S624P probably damaging Het
Arid5b T C 10: 68,186,067 (GRCm38) H231R probably damaging Het
Aspscr1 C A 11: 120,688,560 (GRCm38) T78N probably damaging Het
Auts2 T A 5: 131,472,450 (GRCm38) T42S probably damaging Het
Ccdc171 A G 4: 83,554,808 (GRCm38) D158G probably damaging Het
Ces4a G A 8: 105,138,097 (GRCm38) G69S probably damaging Het
Cfap61 T C 2: 145,939,993 (GRCm38) probably null Het
Chrna5 T C 9: 55,004,651 (GRCm38) V245A possibly damaging Het
Cntnap5c G A 17: 58,013,921 (GRCm38) G163R probably damaging Het
Col5a2 A G 1: 45,378,305 (GRCm38) probably null Het
Col5a2 T C 1: 45,394,776 (GRCm38) Q759R probably damaging Het
Comp A G 8: 70,377,146 (GRCm38) D340G probably benign Het
Cyfip1 T A 7: 55,926,395 (GRCm38) D1104E probably damaging Het
Dnah11 A T 12: 118,038,780 (GRCm38) S308T probably damaging Het
Dnah5 A G 15: 28,270,426 (GRCm38) H958R probably benign Het
Elp3 A G 14: 65,547,919 (GRCm38) Y478H probably damaging Het
Fam237b A T 5: 5,575,652 (GRCm38) Q116L possibly damaging Het
Fat3 T C 9: 16,376,985 (GRCm38) Y414C probably benign Het
Fbxo10 C A 4: 45,046,389 (GRCm38) A574S probably damaging Het
Fsip2 G T 2: 82,977,562 (GRCm38) L1408F probably benign Het
Fubp3 T C 2: 31,611,735 (GRCm38) V425A possibly damaging Het
Gm7168 A T 17: 13,949,584 (GRCm38) R404S probably benign Het
Gpd1 T G 15: 99,723,202 (GRCm38) F299C probably damaging Het
Gpr137 C T 19: 6,942,057 (GRCm38) probably benign Het
Grin3b T C 10: 79,973,408 (GRCm38) S331P probably benign Het
Grk3 T A 5: 112,941,718 (GRCm38) I281F probably damaging Het
Hoxb7 T A 11: 96,286,781 (GRCm38) S18R probably damaging Het
Igf1r C T 7: 68,214,933 (GRCm38) R1160* probably null Het
Itfg1 A G 8: 85,725,512 (GRCm38) probably null Het
Itgb8 T C 12: 119,202,455 (GRCm38) I114V probably benign Het
Kcnk1 A G 8: 126,025,384 (GRCm38) E243G possibly damaging Het
Kif27 A G 13: 58,344,008 (GRCm38) L439P probably damaging Het
Kif2c T A 4: 117,167,361 (GRCm38) Q279L probably benign Het
Kmt2d A T 15: 98,852,074 (GRCm38) probably benign Het
L3mbtl1 A G 2: 162,974,502 (GRCm38) T821A probably benign Het
Lrrc24 A T 15: 76,722,578 (GRCm38) M206K probably benign Het
Mamdc4 T G 2: 25,567,622 (GRCm38) K460Q possibly damaging Het
Maml2 C G 9: 13,697,345 (GRCm38) L30V probably damaging Het
Mc5r C G 18: 68,338,670 (GRCm38) probably null Het
Myo10 T G 15: 25,726,525 (GRCm38) probably null Het
Myo1e T A 9: 70,338,784 (GRCm38) L419Q probably damaging Het
Myo6 C A 9: 80,300,572 (GRCm38) H1115Q probably damaging Het
Myo7a A G 7: 98,107,095 (GRCm38) V10A probably damaging Het
Myoz2 C T 3: 123,026,127 (GRCm38) R61H probably damaging Het
Ncdn G A 4: 126,752,003 (GRCm38) R38C probably damaging Het
Nckap1 T A 2: 80,520,556 (GRCm38) T736S probably benign Het
Ncor2 G A 5: 125,019,890 (GRCm38) A2325V probably damaging Het
Nid2 T A 14: 19,752,431 (GRCm38) V140E possibly damaging Het
Nlrp9c C A 7: 26,380,490 (GRCm38) D704Y probably benign Het
Notch3 T A 17: 32,158,725 (GRCm38) S126C probably damaging Het
Or2g7 T C 17: 38,067,948 (GRCm38) I259T probably damaging Het
Or5p60 A G 7: 108,124,915 (GRCm38) F116S probably benign Het
Or5w10 A T 2: 87,544,983 (GRCm38) L187H probably damaging Het
Or6c219 A T 10: 129,945,582 (GRCm38) L160* probably null Het
Or6c6c T C 10: 129,705,607 (GRCm38) M243T possibly damaging Het
Or6d15 A C 6: 116,582,697 (GRCm38) F83C probably damaging Het
Pdzd7 A G 19: 45,039,228 (GRCm38) I269T probably damaging Het
Phf3 A T 1: 30,806,206 (GRCm38) D1299E probably damaging Het
Pitx2 T A 3: 129,218,754 (GRCm38) Y271N probably damaging Het
Polk T C 13: 96,496,632 (GRCm38) E301G probably damaging Het
Prkdc C A 16: 15,739,524 (GRCm38) N2230K probably damaging Het
Prlr A G 15: 10,322,536 (GRCm38) E170G probably benign Het
Prss55 A G 14: 64,075,730 (GRCm38) I235T probably damaging Het
Psd3 T C 8: 67,960,565 (GRCm38) I724V probably benign Het
Rabep2 A G 7: 126,438,799 (GRCm38) T248A possibly damaging Het
Rbm26 T A 14: 105,117,073 (GRCm38) K949N probably benign Het
Rnf213 T A 11: 119,440,221 (GRCm38) D2085E probably damaging Het
Serpinb7 A T 1: 107,450,273 (GRCm38) H232L possibly damaging Het
Slu7 A G 11: 43,445,242 (GRCm38) Q484R probably benign Het
Smg1 A G 7: 118,145,798 (GRCm38) S3044P possibly damaging Het
Snrnp48 A G 13: 38,221,360 (GRCm38) D248G possibly damaging Het
Snrpc C A 17: 27,845,219 (GRCm38) P66Q unknown Het
Snrpn T A 7: 59,983,459 (GRCm38) probably benign Het
Spag17 T A 3: 99,939,356 (GRCm38) S65R possibly damaging Het
Srsf6 C A 2: 162,934,488 (GRCm38) probably benign Het
Stil T A 4: 115,041,782 (GRCm38) M1203K probably benign Het
Syt17 T C 7: 118,436,838 (GRCm38) T106A probably benign Het
Tbx15 C T 3: 99,352,246 (GRCm38) Q478* probably null Het
Tg A T 15: 66,737,548 (GRCm38) Q319L probably benign Het
Thada A G 17: 84,448,033 (GRCm38) L243P probably damaging Het
Thada G T 17: 84,448,034 (GRCm38) L243I probably damaging Het
Tnnt3 A G 7: 142,512,364 (GRCm38) R211G probably damaging Het
Togaram1 A T 12: 65,002,635 (GRCm38) Q1282L possibly damaging Het
Tpm3-rs7 T G 14: 113,314,947 (GRCm38) M91R probably damaging Het
Trappc9 G A 15: 73,025,967 (GRCm38) R377W probably damaging Het
Ttll7 T G 3: 146,915,780 (GRCm38) L378R probably damaging Het
Tyw1 T G 5: 130,258,993 (GRCm38) I22R probably damaging Het
Ubr3 T C 2: 70,016,367 (GRCm38) S1645P possibly damaging Het
Ubr4 T C 4: 139,393,053 (GRCm38) L263P probably damaging Het
Unc13c T C 9: 73,756,339 (GRCm38) E1071G possibly damaging Het
Vmn2r44 G T 7: 8,380,123 (GRCm38) D157E possibly damaging Het
Vps16 C T 2: 130,443,600 (GRCm38) T821I probably benign Het
Washc4 T C 10: 83,579,525 (GRCm38) V793A possibly damaging Het
Wdr35 G T 12: 8,977,435 (GRCm38) probably null Het
Zfp277 A G 12: 40,364,085 (GRCm38) F254L probably benign Het
Other mutations in Acad10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02379:Acad10 APN 5 121,622,043 (GRCm38) missense probably damaging 1.00
IGL02469:Acad10 APN 5 121,645,459 (GRCm38) missense probably damaging 1.00
IGL02526:Acad10 APN 5 121,646,860 (GRCm38) missense probably damaging 0.99
IGL02623:Acad10 APN 5 121,629,930 (GRCm38) missense possibly damaging 0.94
IGL02643:Acad10 APN 5 121,631,570 (GRCm38) missense probably benign
IGL02685:Acad10 APN 5 121,632,609 (GRCm38) missense probably benign
IGL03139:Acad10 APN 5 121,626,082 (GRCm38) missense probably benign
IGL03267:Acad10 APN 5 121,637,349 (GRCm38) missense probably benign 0.34
P0026:Acad10 UTSW 5 121,637,352 (GRCm38) missense probably damaging 1.00
R0099:Acad10 UTSW 5 121,621,290 (GRCm38) missense probably damaging 1.00
R0453:Acad10 UTSW 5 121,627,382 (GRCm38) nonsense probably null
R1051:Acad10 UTSW 5 121,626,080 (GRCm38) missense probably damaging 0.97
R1052:Acad10 UTSW 5 121,649,541 (GRCm38) missense possibly damaging 0.65
R1116:Acad10 UTSW 5 121,630,751 (GRCm38) missense probably damaging 1.00
R1548:Acad10 UTSW 5 121,626,041 (GRCm38) splice site probably benign
R1548:Acad10 UTSW 5 121,626,040 (GRCm38) splice site probably benign
R1571:Acad10 UTSW 5 121,621,348 (GRCm38) missense probably damaging 0.99
R1592:Acad10 UTSW 5 121,645,381 (GRCm38) missense probably damaging 0.99
R1741:Acad10 UTSW 5 121,647,836 (GRCm38) missense probably damaging 1.00
R1974:Acad10 UTSW 5 121,626,185 (GRCm38) missense possibly damaging 0.95
R2007:Acad10 UTSW 5 121,634,751 (GRCm38) missense probably damaging 1.00
R2085:Acad10 UTSW 5 121,649,460 (GRCm38) missense possibly damaging 0.79
R2351:Acad10 UTSW 5 121,629,927 (GRCm38) missense probably benign 0.23
R2511:Acad10 UTSW 5 121,631,567 (GRCm38) missense probably benign 0.02
R2570:Acad10 UTSW 5 121,630,204 (GRCm38) missense probably damaging 1.00
R3824:Acad10 UTSW 5 121,622,818 (GRCm38) missense probably benign
R3846:Acad10 UTSW 5 121,634,686 (GRCm38) missense probably benign 0.19
R4106:Acad10 UTSW 5 121,631,464 (GRCm38) missense probably damaging 0.98
R4107:Acad10 UTSW 5 121,631,464 (GRCm38) missense probably damaging 0.98
R4108:Acad10 UTSW 5 121,631,464 (GRCm38) missense probably damaging 0.98
R5569:Acad10 UTSW 5 121,626,080 (GRCm38) missense probably damaging 0.97
R5704:Acad10 UTSW 5 121,631,543 (GRCm38) missense probably benign 0.03
R5845:Acad10 UTSW 5 121,626,083 (GRCm38) missense probably benign
R5990:Acad10 UTSW 5 121,645,405 (GRCm38) missense probably damaging 1.00
R6019:Acad10 UTSW 5 121,634,801 (GRCm38) missense possibly damaging 0.88
R6145:Acad10 UTSW 5 121,622,033 (GRCm38) missense probably damaging 0.97
R6384:Acad10 UTSW 5 121,652,003 (GRCm38) missense probably benign 0.43
R6491:Acad10 UTSW 5 121,630,157 (GRCm38) missense probably damaging 1.00
R6608:Acad10 UTSW 5 121,632,492 (GRCm38) missense probably benign 0.02
R6941:Acad10 UTSW 5 121,649,357 (GRCm38) missense probably damaging 1.00
R7221:Acad10 UTSW 5 121,630,210 (GRCm38) missense probably damaging 1.00
R7283:Acad10 UTSW 5 121,649,475 (GRCm38) missense possibly damaging 0.79
R7355:Acad10 UTSW 5 121,630,717 (GRCm38) nonsense probably null
R7483:Acad10 UTSW 5 121,656,012 (GRCm38) critical splice donor site probably null
R7553:Acad10 UTSW 5 121,639,255 (GRCm38) missense probably damaging 1.00
R7721:Acad10 UTSW 5 121,646,866 (GRCm38) splice site probably null
R8075:Acad10 UTSW 5 121,652,085 (GRCm38) missense probably benign 0.00
R8400:Acad10 UTSW 5 121,626,205 (GRCm38) missense possibly damaging 0.82
R9171:Acad10 UTSW 5 121,629,918 (GRCm38) missense probably benign 0.14
X0061:Acad10 UTSW 5 121,622,813 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCCTGTCAGGGAAAAGGGAAATC -3'
(R):5'- TTCAAAGAGATGCCAGCCAC -3'

Sequencing Primer
(F):5'- GCCAACCTAGTCTACAAAGTGAGTTG -3'
(R):5'- GATGCCAGCCACCAAAACACTG -3'
Posted On 2014-06-23