Incidental Mutation 'R1789:Igf1r'
| ID |
201616 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Igf1r
|
| Ensembl Gene |
ENSMUSG00000005533 |
| Gene Name |
insulin-like growth factor I receptor |
| Synonyms |
line 186, A330103N21Rik, CD221, hyft, IGF-1R |
| MMRRC Submission |
039820-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1789 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
67952827-68233668 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 68214933 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 1160
(R1160*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000005671
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005671]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005671
AA Change: R1160*
|
| SMART Domains |
Protein: ENSMUSP00000005671
Gene: ENSMUSG00000005533
AA Change: R1160*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Recep_L_domain
|
51 |
161 |
1.6e-29 |
PFAM |
|
FU
|
227 |
270 |
2.98e-12 |
SMART |
|
Pfam:Recep_L_domain
|
353 |
467 |
3.8e-32 |
PFAM |
|
FN3
|
490 |
593 |
4.67e-2 |
SMART |
|
FN3
|
612 |
815 |
1.95e-4 |
SMART |
|
FN3
|
833 |
915 |
7.4e-5 |
SMART |
|
low complexity region
|
937 |
954 |
N/A |
INTRINSIC |
|
TyrKc
|
1000 |
1268 |
8.51e-141 |
SMART |
|
low complexity region
|
1285 |
1303 |
N/A |
INTRINSIC |
|
low complexity region
|
1306 |
1319 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208731
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000208871
|
| Coding Region Coverage |
- 1x: 97.4%
- 3x: 96.8%
- 10x: 95.2%
- 20x: 92.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
PHENOTYPE: Targeted null mutants die at birth of respiratory failure; fetuses exhibit retarded growth, organ hypoplasia, ossification delay and nervous system and epidermal abnormalities. hyft homozygous fetuses are growth retarded and exhibit hydrops fetalis and focal hepatic ischemia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc5 |
G |
A |
16: 20,365,951 (GRCm38) |
P986L |
probably damaging |
Het |
| Acad10 |
A |
T |
5: 121,631,393 (GRCm38) |
Y667N |
possibly damaging |
Het |
| Ahi1 |
G |
A |
10: 20,963,115 (GRCm38) |
G121D |
probably benign |
Het |
| Ampd1 |
T |
A |
3: 103,099,126 (GRCm38) |
I690N |
possibly damaging |
Het |
| Amy1 |
C |
A |
3: 113,558,165 (GRCm38) |
W425L |
possibly damaging |
Het |
| Arhgap27 |
A |
T |
11: 103,333,005 (GRCm38) |
V823E |
probably damaging |
Het |
| Arhgef17 |
A |
G |
7: 100,929,870 (GRCm38) |
S624P |
probably damaging |
Het |
| Arid5b |
T |
C |
10: 68,186,067 (GRCm38) |
H231R |
probably damaging |
Het |
| Aspscr1 |
C |
A |
11: 120,688,560 (GRCm38) |
T78N |
probably damaging |
Het |
| Auts2 |
T |
A |
5: 131,472,450 (GRCm38) |
T42S |
probably damaging |
Het |
| Ccdc171 |
A |
G |
4: 83,554,808 (GRCm38) |
D158G |
probably damaging |
Het |
| Ces4a |
G |
A |
8: 105,138,097 (GRCm38) |
G69S |
probably damaging |
Het |
| Cfap61 |
T |
C |
2: 145,939,993 (GRCm38) |
|
probably null |
Het |
| Chrna5 |
T |
C |
9: 55,004,651 (GRCm38) |
V245A |
possibly damaging |
Het |
| Cntnap5c |
G |
A |
17: 58,013,921 (GRCm38) |
G163R |
probably damaging |
Het |
| Col5a2 |
A |
G |
1: 45,378,305 (GRCm38) |
|
probably null |
Het |
| Col5a2 |
T |
C |
1: 45,394,776 (GRCm38) |
Q759R |
probably damaging |
Het |
| Comp |
A |
G |
8: 70,377,146 (GRCm38) |
D340G |
probably benign |
Het |
| Cyfip1 |
T |
A |
7: 55,926,395 (GRCm38) |
D1104E |
probably damaging |
Het |
| Dnah11 |
A |
T |
12: 118,038,780 (GRCm38) |
S308T |
probably damaging |
Het |
| Dnah5 |
A |
G |
15: 28,270,426 (GRCm38) |
H958R |
probably benign |
Het |
| Elp3 |
A |
G |
14: 65,547,919 (GRCm38) |
Y478H |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 16,376,985 (GRCm38) |
Y414C |
probably benign |
Het |
| Fbxo10 |
C |
A |
4: 45,046,389 (GRCm38) |
A574S |
probably damaging |
Het |
| Fsip2 |
G |
T |
2: 82,977,562 (GRCm38) |
L1408F |
probably benign |
Het |
| Fubp3 |
T |
C |
2: 31,611,735 (GRCm38) |
V425A |
possibly damaging |
Het |
| Gm7168 |
A |
T |
17: 13,949,584 (GRCm38) |
R404S |
probably benign |
Het |
| Gm8773 |
A |
T |
5: 5,575,652 (GRCm38) |
Q116L |
possibly damaging |
Het |
| Gpd1 |
T |
G |
15: 99,723,202 (GRCm38) |
F299C |
probably damaging |
Het |
| Gpr137 |
C |
T |
19: 6,942,057 (GRCm38) |
|
probably benign |
Het |
| Grin3b |
T |
C |
10: 79,973,408 (GRCm38) |
S331P |
probably benign |
Het |
| Grk3 |
T |
A |
5: 112,941,718 (GRCm38) |
I281F |
probably damaging |
Het |
| Hoxb7 |
T |
A |
11: 96,286,781 (GRCm38) |
S18R |
probably damaging |
Het |
| Itfg1 |
A |
G |
8: 85,725,512 (GRCm38) |
|
probably null |
Het |
| Itgb8 |
T |
C |
12: 119,202,455 (GRCm38) |
I114V |
probably benign |
Het |
| Kcnk1 |
A |
G |
8: 126,025,384 (GRCm38) |
E243G |
possibly damaging |
Het |
| Kif27 |
A |
G |
13: 58,344,008 (GRCm38) |
L439P |
probably damaging |
Het |
| Kif2c |
T |
A |
4: 117,167,361 (GRCm38) |
Q279L |
probably benign |
Het |
| Kmt2d |
A |
T |
15: 98,852,074 (GRCm38) |
|
probably benign |
Het |
| L3mbtl1 |
A |
G |
2: 162,974,502 (GRCm38) |
T821A |
probably benign |
Het |
| Lrrc24 |
A |
T |
15: 76,722,578 (GRCm38) |
M206K |
probably benign |
Het |
| Mamdc4 |
T |
G |
2: 25,567,622 (GRCm38) |
K460Q |
possibly damaging |
Het |
| Maml2 |
C |
G |
9: 13,697,345 (GRCm38) |
L30V |
probably damaging |
Het |
| Mc5r |
C |
G |
18: 68,338,670 (GRCm38) |
|
probably null |
Het |
| Myo10 |
T |
G |
15: 25,726,525 (GRCm38) |
|
probably null |
Het |
| Myo1e |
T |
A |
9: 70,338,784 (GRCm38) |
L419Q |
probably damaging |
Het |
| Myo6 |
C |
A |
9: 80,300,572 (GRCm38) |
H1115Q |
probably damaging |
Het |
| Myo7a |
A |
G |
7: 98,107,095 (GRCm38) |
V10A |
probably damaging |
Het |
| Myoz2 |
C |
T |
3: 123,026,127 (GRCm38) |
R61H |
probably damaging |
Het |
| Ncdn |
G |
A |
4: 126,752,003 (GRCm38) |
R38C |
probably damaging |
Het |
| Nckap1 |
T |
A |
2: 80,520,556 (GRCm38) |
T736S |
probably benign |
Het |
| Ncor2 |
G |
A |
5: 125,019,890 (GRCm38) |
A2325V |
probably damaging |
Het |
| Nid2 |
T |
A |
14: 19,752,431 (GRCm38) |
V140E |
possibly damaging |
Het |
| Nlrp9c |
C |
A |
7: 26,380,490 (GRCm38) |
D704Y |
probably benign |
Het |
| Notch3 |
T |
A |
17: 32,158,725 (GRCm38) |
S126C |
probably damaging |
Het |
| Olfr1128 |
A |
T |
2: 87,544,983 (GRCm38) |
L187H |
probably damaging |
Het |
| Olfr130 |
T |
C |
17: 38,067,948 (GRCm38) |
I259T |
probably damaging |
Het |
| Olfr215 |
A |
C |
6: 116,582,697 (GRCm38) |
F83C |
probably damaging |
Het |
| Olfr484 |
A |
G |
7: 108,124,915 (GRCm38) |
F116S |
probably benign |
Het |
| Olfr804 |
T |
C |
10: 129,705,607 (GRCm38) |
M243T |
possibly damaging |
Het |
| Olfr818 |
A |
T |
10: 129,945,582 (GRCm38) |
L160* |
probably null |
Het |
| Pdzd7 |
A |
G |
19: 45,039,228 (GRCm38) |
I269T |
probably damaging |
Het |
| Phf3 |
A |
T |
1: 30,806,206 (GRCm38) |
D1299E |
probably damaging |
Het |
| Pitx2 |
T |
A |
3: 129,218,754 (GRCm38) |
Y271N |
probably damaging |
Het |
| Polk |
T |
C |
13: 96,496,632 (GRCm38) |
E301G |
probably damaging |
Het |
| Prkdc |
C |
A |
16: 15,739,524 (GRCm38) |
N2230K |
probably damaging |
Het |
| Prlr |
A |
G |
15: 10,322,536 (GRCm38) |
E170G |
probably benign |
Het |
| Prss55 |
A |
G |
14: 64,075,730 (GRCm38) |
I235T |
probably damaging |
Het |
| Psd3 |
T |
C |
8: 67,960,565 (GRCm38) |
I724V |
probably benign |
Het |
| Rabep2 |
A |
G |
7: 126,438,799 (GRCm38) |
T248A |
possibly damaging |
Het |
| Rbm26 |
T |
A |
14: 105,117,073 (GRCm38) |
K949N |
probably benign |
Het |
| Rnf213 |
T |
A |
11: 119,440,221 (GRCm38) |
D2085E |
probably damaging |
Het |
| Serpinb7 |
A |
T |
1: 107,450,273 (GRCm38) |
H232L |
possibly damaging |
Het |
| Slu7 |
A |
G |
11: 43,445,242 (GRCm38) |
Q484R |
probably benign |
Het |
| Smg1 |
A |
G |
7: 118,145,798 (GRCm38) |
S3044P |
possibly damaging |
Het |
| Snrnp48 |
A |
G |
13: 38,221,360 (GRCm38) |
D248G |
possibly damaging |
Het |
| Snrpc |
C |
A |
17: 27,845,219 (GRCm38) |
P66Q |
unknown |
Het |
| Snrpn |
T |
A |
7: 59,983,459 (GRCm38) |
|
probably benign |
Het |
| Spag17 |
T |
A |
3: 99,939,356 (GRCm38) |
S65R |
possibly damaging |
Het |
| Srsf6 |
C |
A |
2: 162,934,488 (GRCm38) |
|
probably benign |
Het |
| Stil |
T |
A |
4: 115,041,782 (GRCm38) |
M1203K |
probably benign |
Het |
| Syt17 |
T |
C |
7: 118,436,838 (GRCm38) |
T106A |
probably benign |
Het |
| Tbx15 |
C |
T |
3: 99,352,246 (GRCm38) |
Q478* |
probably null |
Het |
| Tg |
A |
T |
15: 66,737,548 (GRCm38) |
Q319L |
probably benign |
Het |
| Thada |
A |
G |
17: 84,448,033 (GRCm38) |
L243P |
probably damaging |
Het |
| Thada |
G |
T |
17: 84,448,034 (GRCm38) |
L243I |
probably damaging |
Het |
| Tnnt3 |
A |
G |
7: 142,512,364 (GRCm38) |
R211G |
probably damaging |
Het |
| Togaram1 |
A |
T |
12: 65,002,635 (GRCm38) |
Q1282L |
possibly damaging |
Het |
| Tpm3-rs7 |
T |
G |
14: 113,314,947 (GRCm38) |
M91R |
probably damaging |
Het |
| Trappc9 |
G |
A |
15: 73,025,967 (GRCm38) |
R377W |
probably damaging |
Het |
| Ttll7 |
T |
G |
3: 146,915,780 (GRCm38) |
L378R |
probably damaging |
Het |
| Tyw1 |
T |
G |
5: 130,258,993 (GRCm38) |
I22R |
probably damaging |
Het |
| Ubr3 |
T |
C |
2: 70,016,367 (GRCm38) |
S1645P |
possibly damaging |
Het |
| Ubr4 |
T |
C |
4: 139,393,053 (GRCm38) |
L263P |
probably damaging |
Het |
| Unc13c |
T |
C |
9: 73,756,339 (GRCm38) |
E1071G |
possibly damaging |
Het |
| Vmn2r44 |
G |
T |
7: 8,380,123 (GRCm38) |
D157E |
possibly damaging |
Het |
| Vps16 |
C |
T |
2: 130,443,600 (GRCm38) |
T821I |
probably benign |
Het |
| Washc4 |
T |
C |
10: 83,579,525 (GRCm38) |
V793A |
possibly damaging |
Het |
| Wdr35 |
G |
T |
12: 8,977,435 (GRCm38) |
|
probably null |
Het |
| Zfp277 |
A |
G |
12: 40,364,085 (GRCm38) |
F254L |
probably benign |
Het |
|
| Other mutations in Igf1r |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00742:Igf1r
|
APN |
7 |
68,190,023 (GRCm38) |
missense |
probably benign |
|
|
IGL00837:Igf1r
|
APN |
7 |
68,201,352 (GRCm38) |
splice site |
probably benign |
|
|
IGL01515:Igf1r
|
APN |
7 |
68,207,452 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01572:Igf1r
|
APN |
7 |
68,193,441 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02100:Igf1r
|
APN |
7 |
68,189,958 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02506:Igf1r
|
APN |
7 |
68,193,396 (GRCm38) |
missense |
probably benign |
|
|
IGL02672:Igf1r
|
APN |
7 |
68,190,033 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02701:Igf1r
|
APN |
7 |
68,201,249 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
IGL02742:Igf1r
|
APN |
7 |
68,189,991 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL03073:Igf1r
|
APN |
7 |
68,215,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03257:Igf1r
|
APN |
7 |
68,214,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Frufru
|
UTSW |
7 |
68,004,163 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Hungarian
|
UTSW |
7 |
68,214,997 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Mimi
|
UTSW |
7 |
68,195,026 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Piroshka
|
UTSW |
7 |
68,207,336 (GRCm38) |
nonsense |
probably null |
|
|
Romanian
|
UTSW |
7 |
68,004,137 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
Sublime
|
UTSW |
7 |
68,004,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Toy
|
UTSW |
7 |
68,003,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB009:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
BB019:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
FR4548:Igf1r
|
UTSW |
7 |
68,226,186 (GRCm38) |
small insertion |
probably benign |
|
|
FR4737:Igf1r
|
UTSW |
7 |
68,226,181 (GRCm38) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
68,226,186 (GRCm38) |
small insertion |
probably benign |
|
|
FR4976:Igf1r
|
UTSW |
7 |
68,226,181 (GRCm38) |
small insertion |
probably benign |
|
|
PIT4445001:Igf1r
|
UTSW |
7 |
68,207,463 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0003:Igf1r
|
UTSW |
7 |
68,165,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0184:Igf1r
|
UTSW |
7 |
68,226,193 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R0538:Igf1r
|
UTSW |
7 |
68,207,826 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0632:Igf1r
|
UTSW |
7 |
68,165,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0727:Igf1r
|
UTSW |
7 |
68,212,158 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0750:Igf1r
|
UTSW |
7 |
68,212,091 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1104:Igf1r
|
UTSW |
7 |
68,195,026 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R1169:Igf1r
|
UTSW |
7 |
68,165,127 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1348:Igf1r
|
UTSW |
7 |
68,218,468 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1471:Igf1r
|
UTSW |
7 |
68,003,837 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1580:Igf1r
|
UTSW |
7 |
68,207,869 (GRCm38) |
missense |
probably benign |
|
|
R1745:Igf1r
|
UTSW |
7 |
68,169,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1772:Igf1r
|
UTSW |
7 |
68,195,074 (GRCm38) |
missense |
probably benign |
0.03 |
|
R1823:Igf1r
|
UTSW |
7 |
68,194,981 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1902:Igf1r
|
UTSW |
7 |
68,201,249 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1962:Igf1r
|
UTSW |
7 |
68,207,275 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2179:Igf1r
|
UTSW |
7 |
68,003,950 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2215:Igf1r
|
UTSW |
7 |
68,165,234 (GRCm38) |
missense |
probably benign |
|
|
R2221:Igf1r
|
UTSW |
7 |
68,201,962 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2233:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2234:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2235:Igf1r
|
UTSW |
7 |
68,212,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3023:Igf1r
|
UTSW |
7 |
68,183,399 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4044:Igf1r
|
UTSW |
7 |
68,190,062 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R4226:Igf1r
|
UTSW |
7 |
68,195,078 (GRCm38) |
nonsense |
probably null |
|
|
R4387:Igf1r
|
UTSW |
7 |
68,170,009 (GRCm38) |
missense |
probably benign |
|
|
R4388:Igf1r
|
UTSW |
7 |
68,170,009 (GRCm38) |
missense |
probably benign |
|
|
R4728:Igf1r
|
UTSW |
7 |
68,189,624 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4781:Igf1r
|
UTSW |
7 |
68,165,199 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R5254:Igf1r
|
UTSW |
7 |
68,207,319 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5278:Igf1r
|
UTSW |
7 |
68,193,418 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R5510:Igf1r
|
UTSW |
7 |
68,193,359 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5522:Igf1r
|
UTSW |
7 |
68,183,510 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5527:Igf1r
|
UTSW |
7 |
68,207,821 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5761:Igf1r
|
UTSW |
7 |
68,207,253 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5849:Igf1r
|
UTSW |
7 |
68,190,033 (GRCm38) |
missense |
probably benign |
|
|
R6189:Igf1r
|
UTSW |
7 |
68,207,336 (GRCm38) |
nonsense |
probably null |
|
|
R6262:Igf1r
|
UTSW |
7 |
68,003,972 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6285:Igf1r
|
UTSW |
7 |
68,004,137 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6318:Igf1r
|
UTSW |
7 |
68,165,233 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6365:Igf1r
|
UTSW |
7 |
68,190,050 (GRCm38) |
missense |
probably benign |
0.26 |
|
R6377:Igf1r
|
UTSW |
7 |
68,201,250 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6831:Igf1r
|
UTSW |
7 |
68,207,319 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6848:Igf1r
|
UTSW |
7 |
68,004,179 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6902:Igf1r
|
UTSW |
7 |
68,004,163 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7193:Igf1r
|
UTSW |
7 |
68,187,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7373:Igf1r
|
UTSW |
7 |
68,195,078 (GRCm38) |
nonsense |
probably null |
|
|
R7442:Igf1r
|
UTSW |
7 |
68,173,278 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7903:Igf1r
|
UTSW |
7 |
68,184,752 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7923:Igf1r
|
UTSW |
7 |
68,190,101 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7932:Igf1r
|
UTSW |
7 |
68,212,054 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R8368:Igf1r
|
UTSW |
7 |
68,187,048 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8458:Igf1r
|
UTSW |
7 |
68,195,629 (GRCm38) |
missense |
probably benign |
|
|
R8539:Igf1r
|
UTSW |
7 |
68,003,848 (GRCm38) |
missense |
probably benign |
0.06 |
|
R8704:Igf1r
|
UTSW |
7 |
68,170,054 (GRCm38) |
splice site |
probably benign |
|
|
R8746:Igf1r
|
UTSW |
7 |
68,214,997 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8829:Igf1r
|
UTSW |
7 |
68,226,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8832:Igf1r
|
UTSW |
7 |
68,226,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8859:Igf1r
|
UTSW |
7 |
68,183,463 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R9057:Igf1r
|
UTSW |
7 |
68,183,438 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9243:Igf1r
|
UTSW |
7 |
68,212,027 (GRCm38) |
missense |
probably benign |
0.11 |
|
R9342:Igf1r
|
UTSW |
7 |
68,194,998 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9412:Igf1r
|
UTSW |
7 |
68,207,253 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9525:Igf1r
|
UTSW |
7 |
68,214,934 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9727:Igf1r
|
UTSW |
7 |
68,207,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9730:Igf1r
|
UTSW |
7 |
68,189,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9779:Igf1r
|
UTSW |
7 |
68,004,317 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF025:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
RF032:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
RF034:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF037:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF039:Igf1r
|
UTSW |
7 |
68,226,176 (GRCm38) |
small insertion |
probably benign |
|
|
RF044:Igf1r
|
UTSW |
7 |
68,226,179 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,168 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,182 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,180 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,174 (GRCm38) |
small insertion |
probably benign |
|
|
Z1186:Igf1r
|
UTSW |
7 |
68,226,169 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,170 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,169 (GRCm38) |
small insertion |
probably benign |
|
|
Z1191:Igf1r
|
UTSW |
7 |
68,226,173 (GRCm38) |
small insertion |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTTAAAGGAGCCTGATGAAGACC -3'
(R):5'- AACTCAAGGCTGGCAGTTGG -3'
Sequencing Primer
(F):5'- AGACCAGAGATGTCTTGTATTCTCC -3'
(R):5'- CTGGCAGTTGGTCACAGTGAAC -3'
|
| Posted On |
2014-06-23 |
Incidental Mutation