Incidental Mutation 'R1789:Myo10'
ID 201665
Institutional Source Beutler Lab
Gene Symbol Myo10
Ensembl Gene ENSMUSG00000022272
Gene Name myosin X
Synonyms D15Ertd600e, myosin-X
MMRRC Submission 039820-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1789 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 25622525-25813673 bp(+) (GRCm38)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to G at 25726525 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110457] [ENSMUST00000137601]
AlphaFold F8VQB6
Predicted Effect probably null
Transcript: ENSMUST00000110457
SMART Domains Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272

DomainStartEndE-ValueType
MYSc 57 740 N/A SMART
IQ 741 763 1.27e-3 SMART
IQ 764 786 1.06e0 SMART
IQ 787 809 7.07e-2 SMART
Pfam:MYO10_CC 881 932 4.2e-22 PFAM
low complexity region 959 981 N/A INTRINSIC
low complexity region 1090 1102 N/A INTRINSIC
low complexity region 1147 1165 N/A INTRINSIC
PH 1217 1316 1.39e-21 SMART
PH 1397 1503 6.76e-11 SMART
MyTH4 1551 1699 4.12e-37 SMART
B41 1700 1962 1.72e-44 SMART
low complexity region 2050 2062 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126076
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130517
Predicted Effect probably null
Transcript: ENSMUST00000137601
SMART Domains Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272

DomainStartEndE-ValueType
MYSc 24 707 N/A SMART
IQ 708 730 1.27e-3 SMART
IQ 731 753 1.06e0 SMART
IQ 754 776 7.07e-2 SMART
Coding Region Coverage
  • 1x: 97.4%
  • 3x: 96.8%
  • 10x: 95.2%
  • 20x: 92.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 100 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 G A 16: 20,365,951 P986L probably damaging Het
Acad10 A T 5: 121,631,393 Y667N possibly damaging Het
Ahi1 G A 10: 20,963,115 G121D probably benign Het
Ampd1 T A 3: 103,099,126 I690N possibly damaging Het
Amy1 C A 3: 113,558,165 W425L possibly damaging Het
Arhgap27 A T 11: 103,333,005 V823E probably damaging Het
Arhgef17 A G 7: 100,929,870 S624P probably damaging Het
Arid5b T C 10: 68,186,067 H231R probably damaging Het
Aspscr1 C A 11: 120,688,560 T78N probably damaging Het
Auts2 T A 5: 131,472,450 T42S probably damaging Het
Ccdc171 A G 4: 83,554,808 D158G probably damaging Het
Ces4a G A 8: 105,138,097 G69S probably damaging Het
Cfap61 T C 2: 145,939,993 probably null Het
Chrna5 T C 9: 55,004,651 V245A possibly damaging Het
Cntnap5c G A 17: 58,013,921 G163R probably damaging Het
Col5a2 A G 1: 45,378,305 probably null Het
Col5a2 T C 1: 45,394,776 Q759R probably damaging Het
Comp A G 8: 70,377,146 D340G probably benign Het
Cyfip1 T A 7: 55,926,395 D1104E probably damaging Het
Dnah11 A T 12: 118,038,780 S308T probably damaging Het
Dnah5 A G 15: 28,270,426 H958R probably benign Het
Elp3 A G 14: 65,547,919 Y478H probably damaging Het
Fat3 T C 9: 16,376,985 Y414C probably benign Het
Fbxo10 C A 4: 45,046,389 A574S probably damaging Het
Fsip2 G T 2: 82,977,562 L1408F probably benign Het
Fubp3 T C 2: 31,611,735 V425A possibly damaging Het
Gm7168 A T 17: 13,949,584 R404S probably benign Het
Gm8773 A T 5: 5,575,652 Q116L possibly damaging Het
Gpd1 T G 15: 99,723,202 F299C probably damaging Het
Gpr137 C T 19: 6,942,057 probably benign Het
Grin3b T C 10: 79,973,408 S331P probably benign Het
Grk3 T A 5: 112,941,718 I281F probably damaging Het
Hoxb7 T A 11: 96,286,781 S18R probably damaging Het
Igf1r C T 7: 68,214,933 R1160* probably null Het
Itfg1 A G 8: 85,725,512 probably null Het
Itgb8 T C 12: 119,202,455 I114V probably benign Het
Kcnk1 A G 8: 126,025,384 E243G possibly damaging Het
Kif27 A G 13: 58,344,008 L439P probably damaging Het
Kif2c T A 4: 117,167,361 Q279L probably benign Het
Kmt2d A T 15: 98,852,074 probably benign Het
L3mbtl1 A G 2: 162,974,502 T821A probably benign Het
Lrrc24 A T 15: 76,722,578 M206K probably benign Het
Mamdc4 T G 2: 25,567,622 K460Q possibly damaging Het
Maml2 C G 9: 13,697,345 L30V probably damaging Het
Mc5r C G 18: 68,338,670 probably null Het
Myo1e T A 9: 70,338,784 L419Q probably damaging Het
Myo6 C A 9: 80,300,572 H1115Q probably damaging Het
Myo7a A G 7: 98,107,095 V10A probably damaging Het
Myoz2 C T 3: 123,026,127 R61H probably damaging Het
Ncdn G A 4: 126,752,003 R38C probably damaging Het
Nckap1 T A 2: 80,520,556 T736S probably benign Het
Ncor2 G A 5: 125,019,890 A2325V probably damaging Het
Nid2 T A 14: 19,752,431 V140E possibly damaging Het
Nlrp9c C A 7: 26,380,490 D704Y probably benign Het
Notch3 T A 17: 32,158,725 S126C probably damaging Het
Olfr1128 A T 2: 87,544,983 L187H probably damaging Het
Olfr130 T C 17: 38,067,948 I259T probably damaging Het
Olfr215 A C 6: 116,582,697 F83C probably damaging Het
Olfr484 A G 7: 108,124,915 F116S probably benign Het
Olfr804 T C 10: 129,705,607 M243T possibly damaging Het
Olfr818 A T 10: 129,945,582 L160* probably null Het
Pdzd7 A G 19: 45,039,228 I269T probably damaging Het
Phf3 A T 1: 30,806,206 D1299E probably damaging Het
Pitx2 T A 3: 129,218,754 Y271N probably damaging Het
Polk T C 13: 96,496,632 E301G probably damaging Het
Prkdc C A 16: 15,739,524 N2230K probably damaging Het
Prlr A G 15: 10,322,536 E170G probably benign Het
Prss55 A G 14: 64,075,730 I235T probably damaging Het
Psd3 T C 8: 67,960,565 I724V probably benign Het
Rabep2 A G 7: 126,438,799 T248A possibly damaging Het
Rbm26 T A 14: 105,117,073 K949N probably benign Het
Rnf213 T A 11: 119,440,221 D2085E probably damaging Het
Serpinb7 A T 1: 107,450,273 H232L possibly damaging Het
Slu7 A G 11: 43,445,242 Q484R probably benign Het
Smg1 A G 7: 118,145,798 S3044P possibly damaging Het
Snrnp48 A G 13: 38,221,360 D248G possibly damaging Het
Snrpc C A 17: 27,845,219 P66Q unknown Het
Snrpn T A 7: 59,983,459 probably benign Het
Spag17 T A 3: 99,939,356 S65R possibly damaging Het
Srsf6 C A 2: 162,934,488 probably benign Het
Stil T A 4: 115,041,782 M1203K probably benign Het
Syt17 T C 7: 118,436,838 T106A probably benign Het
Tbx15 C T 3: 99,352,246 Q478* probably null Het
Tg A T 15: 66,737,548 Q319L probably benign Het
Thada G T 17: 84,448,034 L243I probably damaging Het
Thada A G 17: 84,448,033 L243P probably damaging Het
Tnnt3 A G 7: 142,512,364 R211G probably damaging Het
Togaram1 A T 12: 65,002,635 Q1282L possibly damaging Het
Tpm3-rs7 T G 14: 113,314,947 M91R probably damaging Het
Trappc9 G A 15: 73,025,967 R377W probably damaging Het
Ttll7 T G 3: 146,915,780 L378R probably damaging Het
Tyw1 T G 5: 130,258,993 I22R probably damaging Het
Ubr3 T C 2: 70,016,367 S1645P possibly damaging Het
Ubr4 T C 4: 139,393,053 L263P probably damaging Het
Unc13c T C 9: 73,756,339 E1071G possibly damaging Het
Vmn2r44 G T 7: 8,380,123 D157E possibly damaging Het
Vps16 C T 2: 130,443,600 T821I probably benign Het
Washc4 T C 10: 83,579,525 V793A possibly damaging Het
Wdr35 G T 12: 8,977,435 probably null Het
Zfp277 A G 12: 40,364,085 F254L probably benign Het
Other mutations in Myo10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Myo10 APN 15 25,776,380 (GRCm38) missense probably damaging 1.00
IGL01068:Myo10 APN 15 25,739,309 (GRCm38) missense possibly damaging 0.93
IGL01352:Myo10 APN 15 25,701,697 (GRCm38) missense probably damaging 1.00
IGL01388:Myo10 APN 15 25,736,617 (GRCm38) missense possibly damaging 0.55
IGL01460:Myo10 APN 15 25,714,108 (GRCm38) missense probably benign 0.00
IGL01553:Myo10 APN 15 25,776,329 (GRCm38) missense probably damaging 1.00
IGL01732:Myo10 APN 15 25,732,063 (GRCm38) missense probably benign 0.10
IGL01992:Myo10 APN 15 25,799,548 (GRCm38) missense possibly damaging 0.92
IGL02000:Myo10 APN 15 25,808,066 (GRCm38) missense probably damaging 1.00
IGL02045:Myo10 APN 15 25,726,488 (GRCm38) missense probably benign 0.03
IGL02307:Myo10 APN 15 25,776,315 (GRCm38) splice site probably benign
IGL02511:Myo10 APN 15 25,723,889 (GRCm38) missense probably damaging 0.97
IGL03240:Myo10 APN 15 25,701,602 (GRCm38) missense probably damaging 1.00
least UTSW 15 25,726,475 (GRCm38) nonsense probably null
R0037:Myo10 UTSW 15 25,666,532 (GRCm38) intron probably benign
R0153:Myo10 UTSW 15 25,781,238 (GRCm38) missense possibly damaging 0.84
R0282:Myo10 UTSW 15 25,793,167 (GRCm38) missense probably damaging 1.00
R0360:Myo10 UTSW 15 25,804,368 (GRCm38) missense probably damaging 1.00
R0585:Myo10 UTSW 15 25,736,455 (GRCm38) missense probably damaging 1.00
R0617:Myo10 UTSW 15 25,738,005 (GRCm38) missense probably damaging 1.00
R0729:Myo10 UTSW 15 25,722,157 (GRCm38) splice site probably benign
R0771:Myo10 UTSW 15 25,778,178 (GRCm38) missense probably damaging 1.00
R0960:Myo10 UTSW 15 25,801,189 (GRCm38) missense probably damaging 1.00
R1562:Myo10 UTSW 15 25,780,411 (GRCm38) missense possibly damaging 0.81
R1651:Myo10 UTSW 15 25,742,369 (GRCm38) missense probably damaging 1.00
R1816:Myo10 UTSW 15 25,800,200 (GRCm38) missense probably damaging 1.00
R1835:Myo10 UTSW 15 25,805,587 (GRCm38) missense possibly damaging 0.53
R1908:Myo10 UTSW 15 25,801,222 (GRCm38) missense probably damaging 1.00
R2082:Myo10 UTSW 15 25,785,993 (GRCm38) missense probably damaging 1.00
R2101:Myo10 UTSW 15 25,722,259 (GRCm38) missense probably benign 0.26
R2129:Myo10 UTSW 15 25,781,799 (GRCm38) missense probably benign 0.09
R2141:Myo10 UTSW 15 25,714,108 (GRCm38) missense probably benign
R2142:Myo10 UTSW 15 25,714,108 (GRCm38) missense probably benign
R2920:Myo10 UTSW 15 25,801,140 (GRCm38) missense probably damaging 1.00
R2938:Myo10 UTSW 15 25,795,717 (GRCm38) missense probably damaging 0.99
R3723:Myo10 UTSW 15 25,803,288 (GRCm38) missense probably damaging 1.00
R3852:Myo10 UTSW 15 25,779,626 (GRCm38) missense probably damaging 1.00
R4162:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4163:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4164:Myo10 UTSW 15 25,726,415 (GRCm38) splice site probably null
R4177:Myo10 UTSW 15 25,734,051 (GRCm38) missense possibly damaging 0.81
R4409:Myo10 UTSW 15 25,807,869 (GRCm38) missense probably damaging 1.00
R4667:Myo10 UTSW 15 25,793,153 (GRCm38) missense possibly damaging 0.91
R4905:Myo10 UTSW 15 25,800,212 (GRCm38) missense probably damaging 0.99
R4933:Myo10 UTSW 15 25,781,118 (GRCm38) missense probably damaging 0.96
R4968:Myo10 UTSW 15 25,808,184 (GRCm38) missense probably damaging 1.00
R5081:Myo10 UTSW 15 25,785,940 (GRCm38) missense probably damaging 1.00
R5123:Myo10 UTSW 15 25,726,483 (GRCm38) missense possibly damaging 0.94
R5310:Myo10 UTSW 15 25,778,078 (GRCm38) splice site probably null
R6073:Myo10 UTSW 15 25,736,642 (GRCm38) missense probably damaging 1.00
R6117:Myo10 UTSW 15 25,805,659 (GRCm38) missense probably benign 0.00
R6185:Myo10 UTSW 15 25,726,510 (GRCm38) missense probably damaging 0.99
R6749:Myo10 UTSW 15 25,714,110 (GRCm38) missense probably damaging 1.00
R6819:Myo10 UTSW 15 25,781,410 (GRCm38) missense possibly damaging 0.80
R6875:Myo10 UTSW 15 25,805,659 (GRCm38) missense probably benign 0.00
R6908:Myo10 UTSW 15 25,804,383 (GRCm38) missense probably damaging 1.00
R6963:Myo10 UTSW 15 25,734,063 (GRCm38) missense probably benign 0.31
R7144:Myo10 UTSW 15 25,723,925 (GRCm38) missense probably damaging 1.00
R7266:Myo10 UTSW 15 25,782,981 (GRCm38) missense probably damaging 1.00
R7380:Myo10 UTSW 15 25,779,620 (GRCm38) missense probably benign 0.01
R7460:Myo10 UTSW 15 25,807,827 (GRCm38) missense probably damaging 1.00
R7614:Myo10 UTSW 15 25,701,623 (GRCm38) missense probably benign 0.00
R7618:Myo10 UTSW 15 25,726,475 (GRCm38) nonsense probably null
R7717:Myo10 UTSW 15 25,731,970 (GRCm38) missense probably benign 0.01
R7811:Myo10 UTSW 15 25,804,524 (GRCm38) missense probably damaging 1.00
R7830:Myo10 UTSW 15 25,737,971 (GRCm38) nonsense probably null
R7862:Myo10 UTSW 15 25,666,436 (GRCm38) missense probably damaging 1.00
R8232:Myo10 UTSW 15 25,804,314 (GRCm38) missense possibly damaging 0.89
R8264:Myo10 UTSW 15 25,800,109 (GRCm38) missense probably damaging 0.99
R8377:Myo10 UTSW 15 25,804,395 (GRCm38) missense possibly damaging 0.94
R8385:Myo10 UTSW 15 25,804,398 (GRCm38) missense probably damaging 1.00
R8426:Myo10 UTSW 15 25,799,490 (GRCm38) missense probably damaging 0.99
R8439:Myo10 UTSW 15 25,725,072 (GRCm38) missense probably benign 0.00
R8696:Myo10 UTSW 15 25,799,486 (GRCm38) missense probably damaging 1.00
R8775:Myo10 UTSW 15 25,800,059 (GRCm38) missense probably damaging 0.97
R8775-TAIL:Myo10 UTSW 15 25,800,059 (GRCm38) missense probably damaging 0.97
R8970:Myo10 UTSW 15 25,803,381 (GRCm38) missense possibly damaging 0.82
R9024:Myo10 UTSW 15 25,793,209 (GRCm38) missense possibly damaging 0.53
R9196:Myo10 UTSW 15 25,805,630 (GRCm38) missense probably damaging 0.96
R9224:Myo10 UTSW 15 25,807,995 (GRCm38) missense probably benign 0.33
R9308:Myo10 UTSW 15 25,781,776 (GRCm38) missense probably damaging 0.99
R9358:Myo10 UTSW 15 25,781,434 (GRCm38) missense possibly damaging 0.69
R9606:Myo10 UTSW 15 25,776,315 (GRCm38) frame shift probably null
R9722:Myo10 UTSW 15 25,801,141 (GRCm38) missense probably damaging 1.00
RF013:Myo10 UTSW 15 25,799,479 (GRCm38) missense probably damaging 0.99
Z1177:Myo10 UTSW 15 25,799,554 (GRCm38) critical splice donor site probably null
Z1177:Myo10 UTSW 15 25,781,401 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCAGAATAGAGTCTTCAGTGTACTC -3'
(R):5'- CAGGCTTCCCTCTGACTTACAG -3'

Sequencing Primer
(F):5'- CAGTGTACTCAGGTAAATTACAGTG -3'
(R):5'- GCTTCCCTCTGACTTACAGGAAAAG -3'
Posted On 2014-06-23