Incidental Mutation 'R0090:Tdrd6'
| ID |
20180 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tdrd6
|
| Ensembl Gene |
ENSMUSG00000040140 |
| Gene Name |
tudor domain containing 6 |
| Synonyms |
|
| MMRRC Submission |
038377-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0090 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
(trace)
|
| Chromosome |
17 |
| Chromosomal Location |
43926226-43941190 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 43939132 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 639
(V639I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045717]
[ENSMUST00000168073]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000045717
AA Change: V639I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000035338
Gene: ENSMUSG00000040140
AA Change: V639I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TUDOR
|
14 |
133 |
9.9e-9 |
PFAM |
|
low complexity region
|
166 |
187 |
N/A |
INTRINSIC |
|
TUDOR
|
308 |
366 |
1.14e-2 |
SMART |
|
low complexity region
|
452 |
463 |
N/A |
INTRINSIC |
|
TUDOR
|
541 |
597 |
2.68e-8 |
SMART |
|
TUDOR
|
817 |
877 |
2.56e-5 |
SMART |
|
TUDOR
|
1037 |
1090 |
5.36e-8 |
SMART |
|
TUDOR
|
1357 |
1415 |
2.19e-13 |
SMART |
|
TUDOR
|
1569 |
1628 |
3.1e-13 |
SMART |
|
low complexity region
|
1826 |
1842 |
N/A |
INTRINSIC |
|
low complexity region
|
1866 |
1876 |
N/A |
INTRINSIC |
|
TUDOR
|
2026 |
2083 |
9.45e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168073
AA Change: V639I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000131277
Gene: ENSMUSG00000040140
AA Change: V639I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TUDOR
|
12 |
133 |
7.2e-9 |
PFAM |
|
low complexity region
|
166 |
187 |
N/A |
INTRINSIC |
|
TUDOR
|
308 |
366 |
1.14e-2 |
SMART |
|
low complexity region
|
452 |
463 |
N/A |
INTRINSIC |
|
TUDOR
|
541 |
597 |
2.68e-8 |
SMART |
|
TUDOR
|
817 |
877 |
2.56e-5 |
SMART |
|
TUDOR
|
1037 |
1090 |
5.36e-8 |
SMART |
|
TUDOR
|
1357 |
1415 |
2.19e-13 |
SMART |
|
TUDOR
|
1569 |
1628 |
3.1e-13 |
SMART |
|
low complexity region
|
1826 |
1842 |
N/A |
INTRINSIC |
|
low complexity region
|
1866 |
1876 |
N/A |
INTRINSIC |
|
TUDOR
|
2027 |
2084 |
9.45e-1 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.7%
- 20x: 91.4%
|
| Validation Efficiency |
99% (90/91) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsense mediated decay (NMD) pathway. This protein is a major autoantigen in human patients with autoimmune polyendocrine syndrome type 1 (APS1). [provided by RefSeq, Oct 2016]
PHENOTYPE: Mice homozygous for a null allele exhibit male fertility associated with arrested spermatogenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2010315B03Rik |
T |
C |
9: 124,057,789 (GRCm39) |
|
probably benign |
Het |
| 4933427I04Rik |
A |
G |
4: 123,754,775 (GRCm39) |
T230A |
possibly damaging |
Het |
| Acsm1 |
T |
C |
7: 119,261,412 (GRCm39) |
|
probably benign |
Het |
| Acta1 |
T |
C |
8: 124,620,396 (GRCm39) |
N14S |
probably damaging |
Het |
| Aff4 |
A |
G |
11: 53,283,609 (GRCm39) |
T362A |
probably benign |
Het |
| Aggf1 |
A |
G |
13: 95,501,467 (GRCm39) |
I305T |
probably benign |
Het |
| Ap4b1 |
A |
G |
3: 103,727,745 (GRCm39) |
D325G |
possibly damaging |
Het |
| Ap4e1 |
C |
T |
2: 126,906,905 (GRCm39) |
T1055I |
possibly damaging |
Het |
| Arhgef2 |
A |
T |
3: 88,546,655 (GRCm39) |
Q496L |
probably damaging |
Het |
| Arhgef28 |
A |
G |
13: 98,211,618 (GRCm39) |
F122L |
probably damaging |
Het |
| Baiap3 |
G |
A |
17: 25,469,044 (GRCm39) |
|
probably benign |
Het |
| Casp8ap2 |
T |
A |
4: 32,640,327 (GRCm39) |
H460Q |
probably damaging |
Het |
| Casz1 |
A |
G |
4: 149,017,868 (GRCm39) |
T386A |
probably benign |
Het |
| Cd53 |
A |
T |
3: 106,674,725 (GRCm39) |
V114E |
possibly damaging |
Het |
| Celsr2 |
A |
G |
3: 108,300,643 (GRCm39) |
|
probably benign |
Het |
| Cfap300 |
T |
A |
9: 8,027,184 (GRCm39) |
N118I |
probably benign |
Het |
| Chaf1b |
G |
T |
16: 93,684,012 (GRCm39) |
A88S |
possibly damaging |
Het |
| Cldn10 |
A |
T |
14: 119,111,612 (GRCm39) |
Y194F |
probably damaging |
Het |
| Clec2e |
A |
C |
6: 129,072,181 (GRCm39) |
|
probably null |
Het |
| Cmpk2 |
A |
T |
12: 26,528,021 (GRCm39) |
T413S |
probably benign |
Het |
| Col9a1 |
T |
A |
1: 24,262,643 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,405,139 (GRCm39) |
Q2468K |
probably benign |
Het |
| Ddx60 |
A |
G |
8: 62,395,327 (GRCm39) |
D88G |
probably damaging |
Het |
| Dnah8 |
A |
G |
17: 31,003,064 (GRCm39) |
R3588G |
probably benign |
Het |
| Ect2 |
T |
C |
3: 27,169,625 (GRCm39) |
T774A |
probably benign |
Het |
| Ect2 |
C |
T |
3: 27,192,651 (GRCm39) |
E431K |
probably null |
Het |
| Ern1 |
A |
G |
11: 106,296,649 (GRCm39) |
V767A |
probably damaging |
Het |
| Fbln1 |
A |
C |
15: 85,108,489 (GRCm39) |
E75A |
possibly damaging |
Het |
| Fgf5 |
C |
T |
5: 98,409,846 (GRCm39) |
R132* |
probably null |
Het |
| Folh1 |
T |
C |
7: 86,375,076 (GRCm39) |
|
probably benign |
Het |
| Gdf15 |
A |
T |
8: 71,082,334 (GRCm39) |
H257Q |
probably damaging |
Het |
| Ghitm |
T |
C |
14: 36,844,176 (GRCm39) |
T322A |
probably benign |
Het |
| Gm5709 |
A |
G |
3: 59,526,192 (GRCm39) |
|
noncoding transcript |
Het |
| Hbb-y |
C |
T |
7: 103,501,950 (GRCm39) |
|
probably null |
Het |
| Hmcn2 |
A |
T |
2: 31,316,210 (GRCm39) |
D3771V |
probably damaging |
Het |
| Hspa12a |
T |
C |
19: 58,787,941 (GRCm39) |
D627G |
probably benign |
Het |
| Idh2 |
T |
C |
7: 79,747,662 (GRCm39) |
E286G |
probably damaging |
Het |
| Idh3b |
C |
A |
2: 130,122,899 (GRCm39) |
A297S |
probably benign |
Het |
| Igsf3 |
A |
G |
3: 101,342,968 (GRCm39) |
E535G |
probably damaging |
Het |
| Ilf3 |
T |
A |
9: 21,306,710 (GRCm39) |
D314E |
probably damaging |
Het |
| Itgb8 |
A |
G |
12: 119,166,298 (GRCm39) |
S78P |
probably benign |
Het |
| Itih5 |
G |
A |
2: 10,169,495 (GRCm39) |
V31I |
probably benign |
Het |
| Kcnj2 |
T |
C |
11: 110,963,853 (GRCm39) |
V415A |
probably benign |
Het |
| Kin |
A |
G |
2: 10,090,584 (GRCm39) |
Q53R |
possibly damaging |
Het |
| Krt78 |
A |
T |
15: 101,856,272 (GRCm39) |
M513K |
probably benign |
Het |
| Krtap4-8 |
A |
T |
11: 99,671,312 (GRCm39) |
|
probably benign |
Het |
| Ltbr |
T |
C |
6: 125,286,412 (GRCm39) |
|
probably benign |
Het |
| Mgat4a |
G |
A |
1: 37,529,414 (GRCm39) |
T146I |
probably damaging |
Het |
| Mrps2 |
G |
C |
2: 28,358,268 (GRCm39) |
W19C |
probably damaging |
Het |
| Mthfs |
T |
C |
9: 89,093,344 (GRCm39) |
S33P |
probably damaging |
Het |
| Myh6 |
T |
C |
14: 55,196,161 (GRCm39) |
D546G |
probably damaging |
Het |
| Nanos3 |
C |
T |
8: 84,902,763 (GRCm39) |
R133Q |
probably damaging |
Het |
| Ndst2 |
T |
C |
14: 20,777,335 (GRCm39) |
T553A |
probably damaging |
Het |
| Nlrp12 |
T |
C |
7: 3,288,664 (GRCm39) |
E616G |
probably damaging |
Het |
| Nrde2 |
T |
C |
12: 100,095,545 (GRCm39) |
|
probably benign |
Het |
| Nup210l |
G |
A |
3: 90,119,086 (GRCm39) |
V1832I |
probably benign |
Het |
| Or1e1c |
G |
A |
11: 73,266,402 (GRCm39) |
V276I |
probably benign |
Het |
| Or4k77 |
A |
T |
2: 111,199,639 (GRCm39) |
I221F |
probably damaging |
Het |
| Pcm1 |
A |
T |
8: 41,709,078 (GRCm39) |
E9D |
probably damaging |
Het |
| Pear1 |
A |
T |
3: 87,661,649 (GRCm39) |
D541E |
possibly damaging |
Het |
| Peg10 |
A |
G |
6: 4,756,063 (GRCm39) |
|
probably benign |
Het |
| Prss1 |
G |
A |
6: 41,438,166 (GRCm39) |
R31Q |
probably benign |
Het |
| Ptpn13 |
T |
C |
5: 103,717,369 (GRCm39) |
V1837A |
probably damaging |
Het |
| Rasgrp3 |
A |
G |
17: 75,805,456 (GRCm39) |
D149G |
probably damaging |
Het |
| Reg3d |
A |
T |
6: 78,355,466 (GRCm39) |
H8Q |
possibly damaging |
Het |
| Rhox4f |
A |
C |
X: 36,789,122 (GRCm39) |
V15G |
probably benign |
Het |
| Sacs |
T |
A |
14: 61,442,889 (GRCm39) |
L1645H |
probably damaging |
Het |
| Slc16a5 |
A |
T |
11: 115,355,751 (GRCm39) |
S71C |
probably damaging |
Het |
| Slc9a3 |
A |
G |
13: 74,306,847 (GRCm39) |
E324G |
probably damaging |
Het |
| Smgc |
T |
C |
15: 91,743,960 (GRCm39) |
V574A |
possibly damaging |
Het |
| Stac3 |
C |
T |
10: 127,339,799 (GRCm39) |
|
probably benign |
Het |
| Supv3l1 |
A |
G |
10: 62,265,485 (GRCm39) |
L685P |
probably benign |
Het |
| Taar2 |
G |
A |
10: 23,817,393 (GRCm39) |
R311H |
probably benign |
Het |
| Tas2r125 |
G |
T |
6: 132,887,361 (GRCm39) |
A250S |
probably benign |
Het |
| Thap12 |
T |
G |
7: 98,365,100 (GRCm39) |
W423G |
probably damaging |
Het |
| Tmem245 |
T |
C |
4: 56,899,410 (GRCm39) |
I217V |
probably benign |
Het |
| Trip12 |
T |
A |
1: 84,709,857 (GRCm39) |
|
probably benign |
Het |
| Tshz3 |
T |
C |
7: 36,468,317 (GRCm39) |
V102A |
probably benign |
Het |
| Ubap1 |
T |
C |
4: 41,379,826 (GRCm39) |
S347P |
probably damaging |
Het |
| Usp10 |
C |
T |
8: 120,679,935 (GRCm39) |
Q612* |
probably null |
Het |
| Vmn2r72 |
T |
C |
7: 85,404,084 (GRCm39) |
I36V |
probably benign |
Het |
| Vps37a |
T |
C |
8: 40,980,030 (GRCm39) |
I63T |
possibly damaging |
Het |
| Whrn |
C |
A |
4: 63,350,969 (GRCm39) |
R9L |
possibly damaging |
Het |
| Xrcc1 |
T |
C |
7: 24,269,642 (GRCm39) |
Y401H |
probably damaging |
Het |
| Ylpm1 |
GCCTAAGCAGCAACCTAAG |
GCCTAAG |
12: 85,075,814 (GRCm39) |
|
probably benign |
Het |
| Zfhx3 |
G |
A |
8: 109,676,689 (GRCm39) |
D2580N |
possibly damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,308,685 (GRCm39) |
N637S |
probably damaging |
Het |
| Zfp268 |
A |
T |
4: 145,349,195 (GRCm39) |
K211* |
probably null |
Het |
| Zyg11a |
A |
T |
4: 108,058,544 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Tdrd6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00571:Tdrd6
|
APN |
17 |
43,939,051 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00844:Tdrd6
|
APN |
17 |
43,928,087 (GRCm39) |
missense |
probably benign |
|
|
IGL00845:Tdrd6
|
APN |
17 |
43,937,607 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01558:Tdrd6
|
APN |
17 |
43,936,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Tdrd6
|
APN |
17 |
43,935,657 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01575:Tdrd6
|
APN |
17 |
43,938,871 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01812:Tdrd6
|
APN |
17 |
43,936,065 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02013:Tdrd6
|
APN |
17 |
43,936,837 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02067:Tdrd6
|
APN |
17 |
43,939,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02112:Tdrd6
|
APN |
17 |
43,940,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02159:Tdrd6
|
APN |
17 |
43,939,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02226:Tdrd6
|
APN |
17 |
43,938,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02416:Tdrd6
|
APN |
17 |
43,935,629 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02577:Tdrd6
|
APN |
17 |
43,937,728 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02631:Tdrd6
|
APN |
17 |
43,937,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02738:Tdrd6
|
APN |
17 |
43,931,337 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02792:Tdrd6
|
APN |
17 |
43,935,918 (GRCm39) |
missense |
probably benign |
|
|
IGL02929:Tdrd6
|
APN |
17 |
43,940,604 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL02934:Tdrd6
|
APN |
17 |
43,938,778 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL02954:Tdrd6
|
APN |
17 |
43,938,153 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02969:Tdrd6
|
APN |
17 |
43,938,440 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03006:Tdrd6
|
APN |
17 |
43,936,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03155:Tdrd6
|
APN |
17 |
43,936,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03219:Tdrd6
|
APN |
17 |
43,938,855 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03372:Tdrd6
|
APN |
17 |
43,936,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Edward
|
UTSW |
17 |
43,938,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
eliza
|
UTSW |
17 |
43,939,053 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
Elizabeth
|
UTSW |
17 |
43,935,095 (GRCm39) |
missense |
probably benign |
0.00 |
|
henry
|
UTSW |
17 |
43,939,050 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB001:Tdrd6
|
UTSW |
17 |
43,938,697 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
BB011:Tdrd6
|
UTSW |
17 |
43,938,697 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
G1citation:Tdrd6
|
UTSW |
17 |
43,938,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0030:Tdrd6
|
UTSW |
17 |
43,937,482 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0057:Tdrd6
|
UTSW |
17 |
43,928,052 (GRCm39) |
splice site |
probably benign |
|
|
R0270:Tdrd6
|
UTSW |
17 |
43,935,199 (GRCm39) |
missense |
probably benign |
|
|
R0463:Tdrd6
|
UTSW |
17 |
43,936,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0594:Tdrd6
|
UTSW |
17 |
43,940,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0650:Tdrd6
|
UTSW |
17 |
43,939,050 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1226:Tdrd6
|
UTSW |
17 |
43,937,523 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1309:Tdrd6
|
UTSW |
17 |
43,937,512 (GRCm39) |
missense |
probably benign |
|
|
R1483:Tdrd6
|
UTSW |
17 |
43,938,498 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1561:Tdrd6
|
UTSW |
17 |
43,936,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1574:Tdrd6
|
UTSW |
17 |
43,936,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1647:Tdrd6
|
UTSW |
17 |
43,938,000 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1648:Tdrd6
|
UTSW |
17 |
43,938,000 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1723:Tdrd6
|
UTSW |
17 |
43,939,218 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1786:Tdrd6
|
UTSW |
17 |
43,935,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1819:Tdrd6
|
UTSW |
17 |
43,937,442 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1836:Tdrd6
|
UTSW |
17 |
43,936,480 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1892:Tdrd6
|
UTSW |
17 |
43,935,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1911:Tdrd6
|
UTSW |
17 |
43,937,979 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1936:Tdrd6
|
UTSW |
17 |
43,937,358 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2005:Tdrd6
|
UTSW |
17 |
43,939,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2006:Tdrd6
|
UTSW |
17 |
43,939,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Tdrd6
|
UTSW |
17 |
43,935,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2133:Tdrd6
|
UTSW |
17 |
43,935,724 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3010:Tdrd6
|
UTSW |
17 |
43,938,933 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4225:Tdrd6
|
UTSW |
17 |
43,936,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4448:Tdrd6
|
UTSW |
17 |
43,940,626 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4449:Tdrd6
|
UTSW |
17 |
43,940,626 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4531:Tdrd6
|
UTSW |
17 |
43,939,645 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4624:Tdrd6
|
UTSW |
17 |
43,936,881 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4665:Tdrd6
|
UTSW |
17 |
43,935,007 (GRCm39) |
missense |
probably benign |
|
|
R4676:Tdrd6
|
UTSW |
17 |
43,938,501 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4785:Tdrd6
|
UTSW |
17 |
43,936,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4912:Tdrd6
|
UTSW |
17 |
43,935,218 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5134:Tdrd6
|
UTSW |
17 |
43,937,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5145:Tdrd6
|
UTSW |
17 |
43,936,966 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5623:Tdrd6
|
UTSW |
17 |
43,940,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Tdrd6
|
UTSW |
17 |
43,937,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5897:Tdrd6
|
UTSW |
17 |
43,935,768 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5913:Tdrd6
|
UTSW |
17 |
43,939,302 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6142:Tdrd6
|
UTSW |
17 |
43,940,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6181:Tdrd6
|
UTSW |
17 |
43,939,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6195:Tdrd6
|
UTSW |
17 |
43,940,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6233:Tdrd6
|
UTSW |
17 |
43,940,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6289:Tdrd6
|
UTSW |
17 |
43,935,411 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6315:Tdrd6
|
UTSW |
17 |
43,937,229 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6578:Tdrd6
|
UTSW |
17 |
43,939,852 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6645:Tdrd6
|
UTSW |
17 |
43,935,423 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6822:Tdrd6
|
UTSW |
17 |
43,938,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7000:Tdrd6
|
UTSW |
17 |
43,938,599 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7075:Tdrd6
|
UTSW |
17 |
43,936,065 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7107:Tdrd6
|
UTSW |
17 |
43,935,095 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7381:Tdrd6
|
UTSW |
17 |
43,936,984 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7458:Tdrd6
|
UTSW |
17 |
43,935,937 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7461:Tdrd6
|
UTSW |
17 |
43,938,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7505:Tdrd6
|
UTSW |
17 |
43,938,570 (GRCm39) |
missense |
not run |
|
|
R7583:Tdrd6
|
UTSW |
17 |
43,935,129 (GRCm39) |
missense |
probably benign |
0.29 |
|
R7613:Tdrd6
|
UTSW |
17 |
43,938,817 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7723:Tdrd6
|
UTSW |
17 |
43,936,851 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7759:Tdrd6
|
UTSW |
17 |
43,935,730 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7924:Tdrd6
|
UTSW |
17 |
43,938,697 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8002:Tdrd6
|
UTSW |
17 |
43,940,710 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8134:Tdrd6
|
UTSW |
17 |
43,937,064 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8231:Tdrd6
|
UTSW |
17 |
43,933,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8242:Tdrd6
|
UTSW |
17 |
43,939,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8542:Tdrd6
|
UTSW |
17 |
43,935,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8713:Tdrd6
|
UTSW |
17 |
43,935,910 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9100:Tdrd6
|
UTSW |
17 |
43,936,305 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9201:Tdrd6
|
UTSW |
17 |
43,936,561 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9222:Tdrd6
|
UTSW |
17 |
43,939,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Tdrd6
|
UTSW |
17 |
43,936,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9373:Tdrd6
|
UTSW |
17 |
43,939,053 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9384:Tdrd6
|
UTSW |
17 |
43,937,783 (GRCm39) |
missense |
probably benign |
0.26 |
|
R9448:Tdrd6
|
UTSW |
17 |
43,936,567 (GRCm39) |
missense |
probably benign |
|
|
R9534:Tdrd6
|
UTSW |
17 |
43,936,510 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9613:Tdrd6
|
UTSW |
17 |
43,939,518 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0065:Tdrd6
|
UTSW |
17 |
43,936,884 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0065:Tdrd6
|
UTSW |
17 |
43,936,044 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
Z1088:Tdrd6
|
UTSW |
17 |
43,937,409 (GRCm39) |
missense |
probably benign |
0.23 |
|
Z1177:Tdrd6
|
UTSW |
17 |
43,938,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTAGGCTCCGCCATAAAATGAC -3'
(R):5'- CACCCGATTAGACAGCAAGAGTGTG -3'
Sequencing Primer
(F):5'- TGACCAGAAACATGCCCAGG -3'
(R):5'- CCGGGGCAACTCTGAGAATG -3'
|
| Posted On |
2013-04-11 |
Incidental Mutation