Mutagenetix > Incidental Mutation

Incidental Mutation 'R1793:Arhgef10l'

201911

Institutional Source

Beutler Lab

Gene Symbol

Arhgef10l

Ensembl Gene

ENSMUSG00000040964

Gene Name

Rho guanine nucleotide exchange factor 10-like

Synonyms

2810441C07Rik

MMRRC Submission

039823-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R1793 (G1)

Quality Score

217

Status

Validated

Chromosome

Chromosomal Location

140241796-140393318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 140242684 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 862 (V862M)

Ref Sequence

ENSEMBL: ENSMUSP00000101423 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039204] [ENSMUST00000069623] [ENSMUST00000097820] [ENSMUST00000105797] [ENSMUST00000105798] [ENSMUST00000105799]

AlphaFold

A2AWP8

Predicted Effect

probably benign
Transcript: ENSMUST00000039204
AA Change: V1149M

PolyPhen 2 Score 0.425 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000040531
Gene: ENSMUSG00000040964
AA Change: V1149M

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	748	3e-82	BLAST
low complexity region	821	833	N/A	INTRINSIC
low complexity region	864	876	N/A	INTRINSIC
Blast:WD40	1217	1270	8e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000069623
AA Change: V1115M

PolyPhen 2 Score 0.407 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000066249
Gene: ENSMUSG00000040964
AA Change: V1115M

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	714	5e-80	BLAST
low complexity region	787	799	N/A	INTRINSIC
low complexity region	830	842	N/A	INTRINSIC
Blast:WD40	1183	1236	7e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000097820
AA Change: V1110M

PolyPhen 2 Score 0.425 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000095431
Gene: ENSMUSG00000040964
AA Change: V1110M

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	709	3e-82	BLAST
low complexity region	782	794	N/A	INTRINSIC
low complexity region	825	837	N/A	INTRINSIC
Blast:WD40	1178	1231	6e-18	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000105797
AA Change: V862M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000101423
Gene: ENSMUSG00000040964
AA Change: V862M

Domain	Start	End	E-Value	Type
low complexity region	50	62	N/A	INTRINSIC
Pfam:RhoGEF	101	183	7.1e-15	PFAM
low complexity region	195	213	N/A	INTRINSIC
Blast:PH	248	461	7e-83	BLAST
low complexity region	534	546	N/A	INTRINSIC
low complexity region	577	589	N/A	INTRINSIC
Blast:WD40	618	656	6e-15	BLAST
Blast:WD40	930	983	1e-17	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000105798
AA Change: V914M

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000101424
Gene: ENSMUSG00000040964
AA Change: V914M

Domain	Start	End	E-Value	Type
RhoGEF	78	260	1.95e-52	SMART
Blast:PH	295	513	8e-81	BLAST
low complexity region	586	598	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
Blast:WD40	982	1035	6e-18	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105799
AA Change: V1154M

PolyPhen 2 Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000101425
Gene: ENSMUSG00000040964
AA Change: V1154M

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	753	5e-80	BLAST
low complexity region	826	838	N/A	INTRINSIC
low complexity region	869	881	N/A	INTRINSIC
Blast:WD40	1222	1275	8e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000138493

SMART Domains

Protein: ENSMUSP00000119471
Gene: ENSMUSG00000040964

Domain	Start	End	E-Value	Type
Pfam:RhoGEF	1	46	3.1e-11	PFAM
Blast:PH	81	294	3e-86	BLAST
low complexity region	367	379	N/A	INTRINSIC
Blast:WD40	387	446	8e-6	BLAST
Blast:WD40	451	489	3e-15	BLAST

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 97.5%
3x: 96.9%
10x: 95.4%
20x: 92.9%

Validation Efficiency

100% (122/122)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 118 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	A	T	5: 109,884,144 (GRCm39)	H571Q	probably damaging	Het
Abcf2	T	A	5: 24,773,774 (GRCm39)	M372L	probably benign	Het
Acaca	A	C	11: 84,206,795 (GRCm39)	T1552P	probably damaging	Het
Acaca	A	G	11: 84,229,219 (GRCm39)	D1682G	probably damaging	Het
Acvr1b	T	C	15: 101,091,906 (GRCm39)	V62A	probably benign	Het
Aimp1	C	T	3: 132,379,825 (GRCm39)	V97M	probably benign	Het
Aldh1l1	C	T	6: 90,554,813 (GRCm39)	T557I	possibly damaging	Het
Alpk1	T	C	3: 127,471,447 (GRCm39)	T1012A	probably damaging	Het
Amot	G	A	X: 144,233,585 (GRCm39)		probably benign	Het
Arap1	T	A	7: 101,037,829 (GRCm39)	H477Q	probably benign	Het
Arhgap18	T	A	10: 26,736,732 (GRCm39)		probably benign	Het
Arl4d	A	G	11: 101,557,554 (GRCm39)	I27V	probably benign	Het
Asb18	G	A	1: 89,942,277 (GRCm39)	P8L	probably damaging	Het
Ash1l	A	G	3: 88,977,616 (GRCm39)	H2682R	probably damaging	Het
Aspm	T	A	1: 139,385,079 (GRCm39)	V241E	probably benign	Het
Atf7ip	G	T	6: 136,586,217 (GRCm39)		probably benign	Het
AY358078	T	G	14: 52,042,051 (GRCm39)	M142R	unknown	Het
C3	T	A	17: 57,526,592 (GRCm39)	K796N	possibly damaging	Het
Ceacam16	T	C	7: 19,590,041 (GRCm39)	T301A	probably damaging	Het
Ceacam5	T	G	7: 17,481,320 (GRCm39)	Y356D	probably benign	Het
Cep192	C	T	18: 67,984,838 (GRCm39)	A1616V	possibly damaging	Het
Cfap91	T	A	16: 38,141,781 (GRCm39)	N384Y	possibly damaging	Het
Cherp	A	T	8: 73,216,994 (GRCm39)	H645Q	probably benign	Het
CK137956	T	C	4: 127,845,242 (GRCm39)	D167G	probably benign	Het
Clcn1	T	A	6: 42,275,860 (GRCm39)		probably null	Het
Cntn1	C	T	15: 92,189,552 (GRCm39)	T625I	possibly damaging	Het
Cpn2	T	A	16: 30,078,142 (GRCm39)	N520Y	probably damaging	Het
Crocc	G	A	4: 140,746,620 (GRCm39)	R1762W	probably damaging	Het
Cts3	C	A	13: 61,715,967 (GRCm39)	V100F	probably benign	Het
Ddx56	A	T	11: 6,216,934 (GRCm39)	V87D	probably damaging	Het
Dnah9	C	T	11: 66,010,420 (GRCm39)		probably null	Het
Dock1	T	A	7: 134,700,456 (GRCm39)		probably null	Het
Dst	T	A	1: 34,191,552 (GRCm39)	Y291*	probably null	Het
Eif4g3	T	C	4: 137,898,442 (GRCm39)	I1071T	probably damaging	Het
Fblim1	T	C	4: 141,322,549 (GRCm39)	Q78R	probably damaging	Het
Fcamr	C	T	1: 130,739,284 (GRCm39)	P195S	probably benign	Het
Fcho1	G	A	8: 72,161,666 (GRCm39)	Q835*	probably null	Het
Frem3	A	G	8: 81,339,741 (GRCm39)	N678S	probably benign	Het
Frk	G	A	10: 34,483,878 (GRCm39)	R413H	probably benign	Het
Gm10619	C	A	7: 73,459,758 (GRCm39)		noncoding transcript	Het
Gm12185	G	A	11: 48,806,583 (GRCm39)	R203*	probably null	Het
Gm12886	A	G	4: 121,280,174 (GRCm39)	V34A	probably benign	Het
Gna12	A	T	5: 140,746,707 (GRCm39)	I246N	probably damaging	Het
Gpm6a	T	C	8: 55,507,867 (GRCm39)	M201T	probably benign	Het
Gpsm2	T	G	3: 108,608,225 (GRCm39)	D220A	probably benign	Het
Grip2	C	G	6: 91,760,623 (GRCm39)	V325L	probably benign	Het
Grk5	C	A	19: 61,065,200 (GRCm39)	A288D	probably damaging	Het
Herpud2	G	A	9: 25,021,953 (GRCm39)	A231V	possibly damaging	Het
Hmcn1	T	C	1: 150,624,834 (GRCm39)	S1024G	probably benign	Het
Hp1bp3	A	G	4: 137,957,820 (GRCm39)	D295G	probably damaging	Het
Igsf21	T	C	4: 139,761,703 (GRCm39)	H325R	probably damaging	Het
Ing2	T	A	8: 48,122,364 (GRCm39)	L61F	probably damaging	Het
Jak3	T	C	8: 72,138,590 (GRCm39)		probably benign	Het
Kcnn3	T	A	3: 89,516,712 (GRCm39)	C374S	probably benign	Het
Klk1b22	A	G	7: 43,765,775 (GRCm39)		probably benign	Het
Larp1	T	C	11: 57,940,764 (GRCm39)	M630T	possibly damaging	Het
Lhx5	T	A	5: 120,572,725 (GRCm39)	C115S	probably damaging	Het
Lmcd1	C	A	6: 112,305,712 (GRCm39)	T271K	probably benign	Het
Lpar1	G	A	4: 58,486,798 (GRCm39)	R158*	probably null	Het
Lyst	T	A	13: 13,821,668 (GRCm39)	C1347*	probably null	Het
Map3k8	G	A	18: 4,332,389 (GRCm39)	Q441*	probably null	Het
Mboat1	T	C	13: 30,403,633 (GRCm39)	V144A	probably damaging	Het
Mcur1	C	T	13: 43,713,491 (GRCm39)	G38S	unknown	Het
Med13	T	A	11: 86,220,177 (GRCm39)	M276L	probably benign	Het
Mefv	A	G	16: 3,526,528 (GRCm39)	S699P	possibly damaging	Het
Mfsd4a	C	A	1: 131,987,077 (GRCm39)	A62S	probably damaging	Het
Mmp27	A	G	9: 7,571,459 (GRCm39)	M1V	probably null	Het
Myo1c	C	T	11: 75,548,415 (GRCm39)	T58I	probably damaging	Het
Myom3	A	T	4: 135,538,066 (GRCm39)	D1316V	probably benign	Het
Naa25	T	A	5: 121,555,478 (GRCm39)	C235S	possibly damaging	Het
Naa25	C	A	5: 121,558,656 (GRCm39)	R333S	probably damaging	Het
Nav3	G	A	10: 109,539,233 (GRCm39)	T2056I	probably benign	Het
Nol4	A	G	18: 22,902,878 (GRCm39)	Y378H	probably damaging	Het
Npat	G	A	9: 53,463,589 (GRCm39)	R124Q	probably damaging	Het
Npr3	T	A	15: 11,848,665 (GRCm39)	E434V	probably benign	Het
Nptx2	A	G	5: 144,485,130 (GRCm39)	T208A	probably benign	Het
Obscn	C	T	11: 58,968,606 (GRCm39)	V2798M	probably damaging	Het
Odad4	C	A	11: 100,460,679 (GRCm39)		probably null	Het
Or10j7	A	T	1: 173,011,976 (GRCm39)	H8Q	probably benign	Het
Or52r1	A	G	7: 102,537,250 (GRCm39)	Y37H	probably benign	Het
Or5b122	C	T	19: 13,562,779 (GRCm39)	T37I	probably benign	Het
Padi1	G	A	4: 140,541,967 (GRCm39)	P652S	probably damaging	Het
Pcdh1	G	T	18: 38,331,938 (GRCm39)	P355Q	probably damaging	Het
Pck2	G	A	14: 55,781,422 (GRCm39)	R189H	possibly damaging	Het
Pcsk5	T	A	19: 17,432,114 (GRCm39)	K1500N	possibly damaging	Het
Phc3	A	T	3: 31,002,865 (GRCm39)	S218T	probably damaging	Het
Piezo2	T	A	18: 63,239,355 (GRCm39)	M510L	possibly damaging	Het
Polr1g	T	C	7: 19,091,904 (GRCm39)	T68A	possibly damaging	Het
Ppp1r3a	A	T	6: 14,754,717 (GRCm39)	Y177N	probably damaging	Het
Psme2b	A	T	11: 48,836,361 (GRCm39)	D195E	probably damaging	Het
Ptprr	T	C	10: 116,088,827 (GRCm39)	V463A	probably damaging	Het
Pwwp2b	G	A	7: 138,836,281 (GRCm39)	R574Q	probably damaging	Het
Rap1gds1	T	A	3: 138,756,314 (GRCm39)	T14S	possibly damaging	Het
Rbm11	A	T	16: 75,397,685 (GRCm39)	K205M	probably damaging	Het
Rfx1	T	A	8: 84,793,050 (GRCm39)		probably benign	Het
Rnasel	C	A	1: 153,630,169 (GRCm39)	H228Q	probably damaging	Het
Sap130	T	A	18: 31,831,640 (GRCm39)	I710K	probably benign	Het
Slc27a4	C	A	2: 29,695,733 (GRCm39)	D89E	probably benign	Het
Spata31d1b	T	C	13: 59,863,779 (GRCm39)	V309A	probably benign	Het
Syt7	T	G	19: 10,421,354 (GRCm39)	Y420D	probably damaging	Het
Tanc2	A	G	11: 105,515,859 (GRCm39)		probably null	Het
Tbc1d10b	A	G	7: 126,802,930 (GRCm39)	S333P	possibly damaging	Het
Tenm2	G	A	11: 35,914,209 (GRCm39)	P2442S	probably damaging	Het
Tenm3	C	T	8: 49,127,579 (GRCm39)	C33Y	probably damaging	Het
Timmdc1	A	G	16: 38,319,419 (GRCm39)	L245P	possibly damaging	Het
Tlr5	T	C	1: 182,800,012 (GRCm39)	F5L	probably benign	Het
Ttll4	T	A	1: 74,726,999 (GRCm39)	F784L	possibly damaging	Het
Tulp4	A	G	17: 6,189,387 (GRCm39)	T70A	possibly damaging	Het
Txndc17	T	A	11: 72,099,571 (GRCm39)	N81K	probably benign	Het
Ubr3	C	T	2: 69,830,895 (GRCm39)		probably benign	Het
Uri1	A	C	7: 37,681,116 (GRCm39)	V96G	probably damaging	Het
Uspl1	T	A	5: 149,150,246 (GRCm39)	I482N	probably damaging	Het
Vmn1r229	A	G	17: 21,034,974 (GRCm39)	N73S	possibly damaging	Het
Vwa7	G	T	17: 35,243,388 (GRCm39)	G689*	probably null	Het
Zfp114	T	A	7: 23,877,164 (GRCm39)		probably null	Het
Zfp618	A	G	4: 63,051,474 (GRCm39)	S659G	probably damaging	Het
Zfp872	A	G	9: 22,111,349 (GRCm39)	K275R	probably damaging	Het
Zzef1	C	T	11: 72,777,535 (GRCm39)	P1789S	probably damaging	Het

Other mutations in Arhgef10l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01420:Arhgef10l	APN	4	140,297,649 (GRCm39)	missense	probably damaging	0.98
IGL01732:Arhgef10l	APN	4	140,307,726 (GRCm39)	missense	probably damaging	0.99
IGL01988:Arhgef10l	APN	4	140,305,672 (GRCm39)	splice site	probably benign
IGL02031:Arhgef10l	APN	4	140,302,656 (GRCm39)	missense	probably damaging	1.00
IGL02253:Arhgef10l	APN	4	140,271,595 (GRCm39)	nonsense	probably null
IGL02445:Arhgef10l	APN	4	140,274,318 (GRCm39)	missense	probably benign	0.19
IGL02619:Arhgef10l	APN	4	140,321,504 (GRCm39)	missense	probably benign	0.07
IGL02798:Arhgef10l	APN	4	140,292,441 (GRCm39)	critical splice donor site	probably null
IGL03064:Arhgef10l	APN	4	140,306,590 (GRCm39)	missense	probably damaging	1.00
IGL03178:Arhgef10l	APN	4	140,271,739 (GRCm39)	missense	possibly damaging	0.92
IGL03236:Arhgef10l	APN	4	140,338,671 (GRCm39)	missense	probably damaging	1.00
IGL03352:Arhgef10l	APN	4	140,311,242 (GRCm39)	start codon destroyed	probably null	0.99
PIT4494001:Arhgef10l	UTSW	4	140,292,522 (GRCm39)	missense	probably damaging	0.98
R0057:Arhgef10l	UTSW	4	140,338,529 (GRCm39)	splice site	probably benign
R0062:Arhgef10l	UTSW	4	140,279,843 (GRCm39)	missense	probably damaging	1.00
R0109:Arhgef10l	UTSW	4	140,305,605 (GRCm39)	missense	probably benign	0.02
R0109:Arhgef10l	UTSW	4	140,305,605 (GRCm39)	missense	probably benign	0.02
R0114:Arhgef10l	UTSW	4	140,311,194 (GRCm39)	missense	probably benign	0.17
R0334:Arhgef10l	UTSW	4	140,311,237 (GRCm39)	nonsense	probably null
R0742:Arhgef10l	UTSW	4	140,264,156 (GRCm39)	missense	probably damaging	1.00
R1017:Arhgef10l	UTSW	4	140,242,617 (GRCm39)	missense	probably damaging	0.99
R1166:Arhgef10l	UTSW	4	140,302,581 (GRCm39)	unclassified	probably benign
R1397:Arhgef10l	UTSW	4	140,271,754 (GRCm39)	missense	probably damaging	0.98
R1521:Arhgef10l	UTSW	4	140,242,749 (GRCm39)	missense	possibly damaging	0.95
R1707:Arhgef10l	UTSW	4	140,291,600 (GRCm39)	missense	probably damaging	1.00
R2018:Arhgef10l	UTSW	4	140,271,695 (GRCm39)	missense	probably damaging	1.00
R2093:Arhgef10l	UTSW	4	140,297,601 (GRCm39)	missense	possibly damaging	0.57
R2098:Arhgef10l	UTSW	4	140,306,743 (GRCm39)	missense	probably damaging	1.00
R2310:Arhgef10l	UTSW	4	140,320,429 (GRCm39)	missense	probably damaging	1.00
R2879:Arhgef10l	UTSW	4	140,242,598 (GRCm39)	missense	probably benign	0.09
R2883:Arhgef10l	UTSW	4	140,244,113 (GRCm39)	missense	probably benign	0.02
R3732:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R3732:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R3861:Arhgef10l	UTSW	4	140,242,798 (GRCm39)	missense	possibly damaging	0.94
R4049:Arhgef10l	UTSW	4	140,242,762 (GRCm39)	missense	probably benign	0.05
R4322:Arhgef10l	UTSW	4	140,270,037 (GRCm39)	missense	probably benign	0.07
R4707:Arhgef10l	UTSW	4	140,264,194 (GRCm39)	missense	possibly damaging	0.63
R5395:Arhgef10l	UTSW	4	140,297,601 (GRCm39)	missense	probably benign	0.16
R5720:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R6066:Arhgef10l	UTSW	4	140,304,391 (GRCm39)	missense	probably damaging	1.00
R6190:Arhgef10l	UTSW	4	140,270,073 (GRCm39)	missense	possibly damaging	0.90
R6464:Arhgef10l	UTSW	4	140,314,126 (GRCm39)	missense	probably benign	0.05
R6476:Arhgef10l	UTSW	4	140,338,693 (GRCm39)	missense	probably damaging	1.00
R6478:Arhgef10l	UTSW	4	140,270,068 (GRCm39)	missense	possibly damaging	0.91
R6483:Arhgef10l	UTSW	4	140,344,226 (GRCm39)	missense	probably damaging	0.99
R6631:Arhgef10l	UTSW	4	140,245,058 (GRCm39)	intron	probably benign
R6721:Arhgef10l	UTSW	4	140,297,655 (GRCm39)	missense	probably damaging	1.00
R6890:Arhgef10l	UTSW	4	140,271,730 (GRCm39)	missense	probably damaging	1.00
R7098:Arhgef10l	UTSW	4	140,308,222 (GRCm39)	missense	probably benign	0.01
R7100:Arhgef10l	UTSW	4	140,244,126 (GRCm39)	missense	possibly damaging	0.60
R7117:Arhgef10l	UTSW	4	140,291,497 (GRCm39)	critical splice donor site	probably null
R7195:Arhgef10l	UTSW	4	140,338,721 (GRCm39)	missense	probably benign
R7222:Arhgef10l	UTSW	4	140,248,580 (GRCm39)	missense	probably damaging	1.00
R7397:Arhgef10l	UTSW	4	140,290,115 (GRCm39)	missense	probably damaging	1.00
R7776:Arhgef10l	UTSW	4	140,302,642 (GRCm39)	missense	probably damaging	1.00
R7801:Arhgef10l	UTSW	4	140,271,578 (GRCm39)	missense	probably benign	0.00
R7811:Arhgef10l	UTSW	4	140,242,335 (GRCm39)	missense	possibly damaging	0.63
R7832:Arhgef10l	UTSW	4	140,305,616 (GRCm39)	missense	possibly damaging	0.90
R7849:Arhgef10l	UTSW	4	140,311,245 (GRCm39)	critical splice acceptor site	probably null
R7963:Arhgef10l	UTSW	4	140,306,736 (GRCm39)	missense	probably damaging	1.00
R8434:Arhgef10l	UTSW	4	140,291,582 (GRCm39)	missense	possibly damaging	0.89
R8943:Arhgef10l	UTSW	4	140,292,550 (GRCm39)	missense	probably damaging	0.99
R9004:Arhgef10l	UTSW	4	140,279,921 (GRCm39)	missense	probably damaging	0.98
R9006:Arhgef10l	UTSW	4	140,271,659 (GRCm39)	missense	probably benign	0.04
R9033:Arhgef10l	UTSW	4	140,321,463 (GRCm39)	missense	probably damaging	0.99
R9302:Arhgef10l	UTSW	4	140,242,548 (GRCm39)	missense	probably benign	0.04
R9337:Arhgef10l	UTSW	4	140,338,624 (GRCm39)	missense	probably damaging	1.00
R9375:Arhgef10l	UTSW	4	140,319,265 (GRCm39)	missense	probably benign
R9454:Arhgef10l	UTSW	4	140,308,236 (GRCm39)	nonsense	probably null
Z1088:Arhgef10l	UTSW	4	140,309,046 (GRCm39)	missense	possibly damaging	0.53
Z1177:Arhgef10l	UTSW	4	140,244,083 (GRCm39)	missense	probably benign	0.28

Predicted Primers

PCR Primer
(F):5'- ATCTCGTAGATGGACCCGTC -3'
(R):5'- TCTTCAGAAGTCCTTGGGTGTC -3'

Sequencing Primer
(F):5'- GTCCTCCTCACTGTGTTCCAGAG -3'
(R):5'- TAACAAACACCCTGGTCTCTTGGG -3'

Posted On

2014-06-23